Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury.

Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease.

Krack, P., Batir, A., Blercom, N. V., Chabardès, S., Fraix, V., Ardouin, C., Koudsié, A., Limousin, P., Benazzouz, A., LeBas, J., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035275 · Cited by 2,208

Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study

Harkema, S., Gerasimenko, Y., Hodes, J., Burdick, J., Angeli, C., Chen, Y., Ferreira, C., Willhite, A., Rejc, E., Grossman, R. G., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60547-3 · Cited by 1,229

Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism

Rosin, B., Slovik, M., Mitelman, R., Rivlin-Etzion, M., Haber, S. N., Israel, Z., Vaadia, E., & Bergman, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.023 · Cited by 793

Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

van den Brand, R., Heutschi, J., Barraud, Q., DiGiovanna, J., Bartholdi, K., Huerlimann, M., Friedli, L., Vollenweider, I., Moraud, E. M., Duis, S., et al. (2012) · Science · doi:10.1126/science.1217416 · Cited by 767

Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans

Angeli, C. A., Edgerton, V. R., Gerasimenko, Y. P., & Harkema, S. J. (2014) · Brain · doi:10.1093/brain/awu038 · Cited by 750

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

Courtine, G., Gerasimenko, Y., van den Brand, R., Yew, A., Musienko, P., Zhong, H., Song, B., Ao, Y., Ichiyama, R. M., Lavrov, I., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2401 · Cited by 706

Probing and regulating dysfunctional circuits using deep brain stimulation

Lozano, A. M., & Lipsman, N. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.020 · Cited by 665

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury

Paz, J. T., Davidson, T. J., Frechette, E. S., Delord, B., Parada, I., Peng, K. K., Deisseroth, K. A., & Huguenard, J. R. (2012) · Nature Neuroscience · doi:10.1038/nn.3269 · Cited by 571

Restoration of grasp following paralysis through brain-controlled stimulation of muscles

Ethier, C., Oby, E. R., Bauman, M. J., & Miller, L. E. (2012) · Nature · doi:10.1038/nature10987 · Cited by 485

A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits

Capogrosso, M., Wenger, N., Raspopovic, S., Musienko, P., Beauparlant, J., Bassi Luciani, L., Courtine, G., & Micera, S. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1688-13.2013 · Cited by 435

Functional Electrical Stimulation

Lynch, C. L., & Popović, M. R. (2008) · IEEE Control Systems · doi:10.1109/mcs.2007.914689 · Cited by 342

Proprioception From a Spinocerebellar Perspective

Bosco, G., & Poppele, R. E. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.539 · Cited by 320

Training locomotor networks

Edgerton, V. R., Courtine, G., Gerasimenko, Y., Lavrov, I. A., Ichiyama, R. M., Fong, A. J., Cai, L. L., Otoshi, C. K., Tillakaratne, N. J. K., Burdick, J. W., et al. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.09.002 · Cited by 316

Stepping-like movements in humans with complete spinal cord injury induced by epidural stimulation of the lumbar cord: electromyographic study of compound muscle action potentials

Minassian, K., Jilge, B., Rattay, F., Pinter, M. M., Binder, H., Gerstenbrand, F., & Dimitrijevic, M. R. (2004) · Spinal Cord · doi:10.1038/sj.sc.3101615 · Cited by 307

Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease

Fuentes, R., Petersson, P., Siesser, W. B., Caron, M. G., & Nicolelis, M. A. L. (2009) · Science · doi:10.1126/science.1164901 · Cited by 298

Coordinated reset has sustained aftereffects in Parkinsonian monkeys

Tass, P. A., Li, Q., Hauptmann, C., Doveró, S., Bézard, E., Boraud, T., & Meissner, W. G. (2012) · Annals of Neurology · doi:10.1002/ana.23663 · Cited by 264

Spinal circuitry of sensorimotor control of locomotion

McCrea, D. A. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0041b.x · Cited by 257

Combined use of body weight support, functional electric stimulation, and treadmill training to improve walking ability in individuals with chronic incomplete spinal cord injury

Field-Fote, E. C. (2001) · Archives of Physical Medicine and Rehabilitation · doi:10.1053/apmr.2001.23752 · Cited by 246

Stimulation of the Human Lumbar Spinal Cord With Implanted and Surface Electrodes: A Computer Simulation Study

Ladenbauer, J., Minassian, K., Hofstoetter, U. S., Dimitrijevic, M. R., & Rattay, F. (2010) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2010.2054112 · Cited by 223

Epidural stimulation: Comparison of the spinal circuits that generate and control locomotion in rats, cats and humans

Gerasimenko, Y., Roy, R. R., & Edgerton, V. R. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.07.015 · Cited by 210

Human lumbar cord circuitries can be activated by extrinsic tonic input to generate locomotor-like activity

Minassian, K., Persy, I., Rattay, F., Pinter, M. M., Kern, H., & Dimitrijevic, M. R. (2007) · Human Movement Science · doi:10.1016/j.humov.2007.01.005 · Cited by 203

Heel and Toe Clearance Estimation for Gait Analysis Using Wireless Inertial Sensors

Mariani, B., Rochat, S., Büla, C., & Aminian, K. (2012) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2012.2216263 · Cited by 197

Personalized Neuroprosthetics

Borton, D., Micera, S., Millán, J. D. R., & Courtine, G. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005968 · Cited by 171

Epidural Stimulation Induced Modulation of Spinal Locomotor Networks in Adult Spinal Rats

Lavrov, I. A., Dy, C. J., Fong, A. J., Gerasimenko, Y., Courtine, G., Zhong, H., Roy, R. R., & Edgerton, V. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0080-08.2008 · Cited by 156

Controlling Specific Locomotor Behaviors through Multidimensional Monoaminergic Modulation of Spinal Circuitries

Евгеньевич, М. П., van den Brand, R., Märzendorfer, O., Roy, R. R., Gerasimenko, Y., Edgerton, V. R., & Courtine, G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5796-10.2011 · Cited by 153

A translational platform for prototyping closed-loop neuromodulation systems

Afshar, P., Khambhati, A. N., Stanslaski, S. R., Carlson, D., Jensen, R., Linde, D., Dani, S., Lazarewicz, M. T., Cong, P., Giftakis, J., et al. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00117 · Cited by 150

Kinematic and EMG Determinants in Quadrupedal Locomotion of a Non-Human Primate (Rhesus)

Courtine, G., Roy, R. R., Hodgson, J. A., McKay, H. M., Raven, J., Zhong, H., Yang, H. S., Tuszynski, M. H., & Edgerton, V. R. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01073.2004 · Cited by 149

Modulation of multisegmental monosynaptic responses in a variety of leg muscles during walking and running in humans

Courtine, G., Harkema, S. J., Dy, C. J., Gerasimenko, Y. P., & Dyhre‐Poulsen, P. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.128447 · Cited by 145

On the Origin of Planar Covariation of Elevation Angles During Human Locomotion

Ivanenko, Y. P., d’Avella, A., Poppele, R. E., & Lacquaniti, F. (2008) · Journal of Neurophysiology · doi:10.1152/jn.01308.2007 · Cited by 143

Novel and Direct Access to the Human Locomotor Spinal Circuitry

Gerasimenko, Y., Gorodnichev, R., Machueva, E., Pivovarova, E. A., Semyenov, D., Savochin, A., Roy, R. R., & Edgerton, V. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4751-09.2010 · Cited by 130

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Beauparlant, J., van den Brand, R., Barraud, Q., Friedli, L., Musienko, P., Dietz, V., & Courtine, G. (2013) · Brain · doi:10.1093/brain/awt204 · Cited by 130

Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease

Brocker, D. T., Swan, B. D., Turner, D. A., Gross, R. E., Tatter, S. B., Koop, M. M., Bronte-Stewart, H. M., & Grill, W. M. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.09.008 · Cited by 128

Degradation of neuronal function following a spinal cord injury: mechanisms and countermeasures

Dietz, V. H. (2004) · Brain · doi:10.1093/brain/awh255 · Cited by 120

Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders

Dominici, N., Keller, U., Vallery, H., Friedli, L., van den Brand, R., Starkey, M. L., Евгеньевич, М. П., Riener, R., & Courtine, G. (2012) · Nature Medicine · doi:10.1038/nm.2845 · Cited by 105

Multidirectional transparent support for overground gait training

Vallery, H., Lutz, P., Zitzewitz, J. V., Rauter, G., Fritschi, M., Everarts, C., Ronsse, R., Curt, A. E. P., & Bolliger, M. (2013) · International Conference on Rehabilitation Robotics · doi:10.1109/icorr.2013.6650512 · Cited by 85

Reanimating the arm and hand with intraspinal microstimulation

Zimmermann, J. B., Seki, K., & Andrew, J. O. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/5/054001 · Cited by 84

Spinal cord stimulation for chronic pain improved motor function in a patient with Parkinson’s disease

Fénelon, G., Goujon, C., Gurruchaga, J.-M., Cesaro, P., Jarraya, B., Palfi, S., & Lefaucheur, J.-P. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2011.07.015 · Cited by 82

Functional Electrical Stimulation Control of Standing and Stepping After Spinal Cord Injury: A Review of Technical Characteristics

Braz, G. P., Russold, M., & Davis, G. M. (2009) · Neuromodulation Technology at the Neural Interface · doi:10.1111/j.1525-1403.2009.00213.x · Cited by 79

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

Borton, D. A., Bonizzato, M., Beauparlant, J., DiGiovanna, J., Moraud, E. M., Wenger, N., Евгеньевич, М. П., Minev, I. R., Lacour, S. P., Millán, J. D. R., et al. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.10.001 · Cited by 60

Real-time control of walking using recordings from dorsal root ganglia

Holinski, B. J., Everaert, D. G., Mushahwar, V. K., & Stein, R. B. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/5/056008 · Cited by 58

Principles of Force Gradation in Skeletal Muscles

Kernell, D. (2003) · Neural Plasticity · doi:10.1155/np.2003.69 · Cited by 48

Neuromodulation of motor-evoked potentials during stepping in spinal rats

Gad, P. N., Lavrov, I. A., Shah, P. K., Zhong, H., Roy, R. R., Edgerton, V. R., & Gerasimenko, Y. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00169.2013 · Cited by 35

Facilitation of postural limb reflexes in spinal rabbits by serotonergic agonist administration, epidural electrical stimulation, and postural training

Lyalka, V. F., Hsu, L., Karayannidou, A., Zelenin, P. V., Orlovsky, G. N., & Deliagina, T. G. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00115.2011 · Cited by 24

Pharmacological Approaches to Chronic Spinal Cord Injury

Steuer, I., Rouleau, P., & Guertin, P. A. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319240009 · Cited by 14

DeepLabCut: markerless pose estimation of user-defined body parts with deep learning

Mathis, A., Mamidanna, P., Cury, K. M., Abe, T., Murthy, V. N., Mathis, M. W., & Bethge, M. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0209-y · Cited by 5,187

Targeted neurotechnology restores walking in humans with spinal cord injury

Wagner, F. B., Mignardot, J.-B., Le Goff-Mignardot, C. G., Demesmaeker, R., Komi, S., Capogrosso, M., Rowald, A., Seáñez, I., Caban, M., Pirondini, E., et al. (2018) · Nature · doi:10.1038/s41586-018-0649-2 · Cited by 1,087

Walking naturally after spinal cord injury using a brain–spine interface

Lorach, H., Galvez, A., Spagnolo, V., Martel, F., Karakas, S., Intering, N., Vat, M., Faivre, O., Harte, C., Komi, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06094-5 · Cited by 631

A brain–spine interface alleviating gait deficits after spinal cord injury in primates

Capogrosso, M., Milekovic, T., Borton, D., Wagner, F., Moraud, E. M., Mignardot, J.-B., Buse, N., Gandar, J., Barraud, Q., Xing, D., et al. (2016) · Nature · doi:10.1038/nature20118 · Cited by 635

Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia

Gill, M. L., Grahn, P. J., Calvert, J. S., Linde, M. B., Lavrov, I. A., Strommen, J. A., Beck, L. A., Sayenko, D. G., Van Straaten, M. G., Drubach, D. I., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0175-7 · Cited by 574

Neuroprosthetic system to restore locomotion after neuromotor disorder

Wenger, N. (2014) · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · doi:10.5075/epfl-thesis-6408

Closing the loop on neuroprosthetic control

Frisk, M. L. (2014) · Science · doi:10.1126/science.345.6204.1574-f

Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury

Bonizzato, M., Pidpruzhnykova, G., DiGiovanna, J., Shkorbatova, P., Pavlova, N., Micera, S., & Courtine, G. (2018) · Nature Communications · doi:10.1038/s41467-018-05282-6 · Cited by 149

Sensor Inputs and Closed-Loop Neuromodulation in Spinal Cord Injury: From Animal Models to Clinical Translation

Rosado, E., Shon, A., & Wu, W. (2026) · Sensors · doi:10.3390/s26144480

Dynamic control of spinal locomotion circuits

Vogelstein, R. J., Etienne‐Cummings, R., Thakor, N. V., & Cohen, A. H. (2006) · IEEE International Symposium on Circuits and Systems proceedings · doi:10.1109/iscas.2006.1693592 · Cited by 7