Cited by 74Estrogen and related hormone effectsProstate Cancer Treatment and ResearchBreast Cancer Treatment Studies

Targeting the glucocorticoid receptor in breast and prostate cancers

Open access
Kach, Jacob, Conzen, Suzanne D., Szmulewitz, Russell Z.·2015·Science Translational Medicine

Abstract

Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.

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Crossref · 10.1126/scitranslmed.aac7531

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  • Stress promotes the development of cancer.

    “Measures to reduce stress appear to be extremely important, as many studies have shown that stress promotes the development of cancer [62,63,64,65,66].”

    From The Effect of Vinyasa Yoga Practice on the Well-Being of Breast-Cancer Patients during COVID-19 Pandemic (2023) · cites this paper as [64]

    The Translational challenges and opportunities section discusses glucocorticoid receptor activity in the progression of existing breast and prostate cancers, not psychological stress causing cancer to develop. Searches for stress, stress-related cancer development, and cortisol found no passage establishing the attributed claim in our copy. (LLM, conf=0.76)

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Research works printed but not linked: 1

  1. [1]Szmulewitz RZ Nuclear Hormone Receptors Cancer Biology Review: A Case-Based Approach 85 86 2014

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Authors
Kach, J., Conzen, S. D., & Szmulewitz, R. Z.
Affiliations
University of Chicago (US)
Corresponding author
Szmulewitz, Russell Z.
Venue
Science Translational Medicine
Published
2015-09-16
Volume
7
Issue
305
Pages
305ps19-305ps19
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2221976755
Cited by
74
References
37
Citations by year
2026: 3 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 9 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 13 · 2016: 7 · 2015: 1
FWCI
5.69
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA089208, P50CA180995)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
glucocorticoid receptor, breast cancer, prostate cancer, androgen receptor, estrogen receptor, nuclear receptors, steroid hormone receptors, receptor cooperation, cancer therapy targets
MeSH terms
Animals, Breast Neoplasms, Cell Survival, Female, Humans, Male, Prognosis, Prostatic Neoplasms, Receptors, Androgen, Receptors, Glucocorticoid, Signal Transduction, Gene Expression Regulation, Neoplastic, Estrogen Receptor alpha, Translational Research, Biomedical

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