Targeting the glucocorticoid receptor in breast and prostate cancers
Open accessAbstract
Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.
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Stress promotes the development of cancer.
“Measures to reduce stress appear to be extremely important, as many studies have shown that stress promotes the development of cancer [62,63,64,65,66].”
From The Effect of Vinyasa Yoga Practice on the Well-Being of Breast-Cancer Patients during COVID-19 Pandemic (2023) · cites this paper as [64]
The Translational challenges and opportunities section discusses glucocorticoid receptor activity in the progression of existing breast and prostate cancers, not psychological stress causing cancer to develop. Searches for stress, stress-related cancer development, and cortisol found no passage establishing the attributed claim in our copy. (LLM, conf=0.76)
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- Authors
- Kach, J., Conzen, S. D., & Szmulewitz, R. Z.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Szmulewitz, Russell Z.
- Venue
- Science Translational Medicine
- Published
- 2015-09-16
- Volume
- 7
- Issue
- 305
- Pages
- 305ps19-305ps19
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4807967
- OpenAlex
- W2221976755
- Cited by
- 74
- References
- 37
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 3 · 2022: 9 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 13 · 2016: 7 · 2015: 1
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA089208, P50CA180995)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- glucocorticoid receptor, breast cancer, prostate cancer, androgen receptor, estrogen receptor, nuclear receptors, steroid hormone receptors, receptor cooperation, cancer therapy targets
- MeSH terms
- Animals, Breast Neoplasms, Cell Survival, Female, Humans, Male, Prognosis, Prostatic Neoplasms, Receptors, Androgen, Receptors, Glucocorticoid, Signal Transduction, Gene Expression Regulation, Neoplastic, Estrogen Receptor alpha, Translational Research, Biomedical
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