Reprogramming the Chromatin Landscape: Interplay of the Estrogen and Glucocorticoid Receptors at the Genomic Level

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Possible roles for glucocorticoid signalling in breast cancer

McNamara, K. M., Kanai, A., & Sasano, H. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.07.004 · Cited by 35 · see citing works

The Three Ds of Transcription Activation by Glucagon: Direct, Delayed, and Dynamic

Goldstein, I., & Hager, G. L. (2017) · Endocrinology · doi:10.1210/en.2017-00521 · Cited by 32 · see citing works

Meta-analysis of Chromatin Programming by Steroid Receptors

Paakinaho, V., Swinstead, E. E., Presman, D. M., Grøntved, L., & Hager, G. L. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.039 · Cited by 33 · see citing works

Bisphenol S induces brown adipose tissue whitening and aggravates diet-induced obesity in an estrogen-dependent manner

Wen, X., Xiao, Y., Xiao, H., Tan, X., Wu, B., Li, Z., Wang, R., Xu, X., & Li, T. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113504 · Cited by 29 · see citing works

Epigenetics in Inflammatory Breast Cancer: Biological Features and Therapeutic Perspectives

Faldoni, F. L. C., Rainho, C. A., & Rogatto, S. R. (2020) · Cells · doi:10.3390/cells9051164 · Cited by 29 · see citing works

Sex difference in adrenal developmental toxicity induced by dexamethasone and its intrauterine programming mechanism

Chen, Y., Xu, D., Xia, X., Chen, G., Xiao, H., Chen, L., & Wang, H. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105942 · Cited by 29 · see citing works

Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies

Hancock, G. R., Gertz, J., Jeselsohn, R. M., & Fanning, S. W. (2024) · Endocrinology · doi:10.1210/endocr/bqae051 · Cited by 27 · see citing works

Mechanisms behind context-dependent role of glucocorticoids in breast cancer progression

Butz, H., & Patócs, A. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10047-1 · Cited by 27 · see citing works

Genome-Wide Identification of Basic Helix–Loop–Helix and NF-1 Motifs Underlying GR Binding Sites in Male Rat Hippocampus

Pooley, J., Flynn, B., Grøntved, L., Baek, S., Guertin, M. J., Kershaw, Y. M., Birnie, M. T., Pellatt, A., Rivers, C. A., Schiltz, R., et al. (2017) · Endocrinology · doi:10.1210/en.2016-1929 · Cited by 27 · see citing works

The Evolution of Epigenetics

Felsenfeld, G. (2014) · Perspectives in biology and medicine · doi:10.1353/pbm.2014.0004 · Cited by 26 · see citing works

Dynamic enhancer function in the chromatin context

Goldstein, I., & Hager, G. L. (2018) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1390 · Cited by 25 · see citing works

Hormone therapy and breast cancer: emerging steroid receptor mechanisms

Perkins, M., Toit, R. L.-D., & Africander, D. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-18-0094 · Cited by 25 · see citing works

Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids

Caratti, G., Desgeorges, T., Juban, G., Stifel, U., Fessard, A., Koenen, M., Caratti, B., Théret, M., Skurk, C., Chazaud, B., et al. (2022) · EMBO Reports · doi:10.15252/embr.202255363 · Cited by 23 · see citing works

Possible role of lymphocytes in glucocorticoid-induced increase in trabecular bone mineral density

Grahnemo, L., Jochéms, C., Andersson, A., Engdahl, C., Ohlsson, C., Islander, U., & Carlsten, H. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0508 · Cited by 24 · see citing works

Expression of glucocorticoid receptor is associated with aggressive primary endometrial cancer and increases from primary to metastatic lesions

Tangen, I. L., Veneris, J. T., Halle, M. K., Werner, H. M. J., Trovik, J., Akslen, L. A., Salvesen, H. B., Conzen, S. D., Fleming, G. F., & Krakstad, C. (2017) · Gynecologic Oncology · doi:10.1016/j.ygyno.2017.09.013 · Cited by 24 · see citing works

Suppression of Nuclear Factor-κB by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells

Fan, P., Siwak, D. R., Abderrahman, B., Agboke, F. A., Yerrum, S., & Jordan, V. C. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-1363 · Cited by 24 · see citing works

Chromatin structure and gene regulation: a dynamic view of enhancer function

Stavreva, D. A., & Hager, G. L. (2015) · Nucleus · doi:10.1080/19491034.2015.1107689 · Cited by 24 · see citing works

Chromatin reprogramming in breast cancer

Swinstead, E. E., Paakinaho, V., & Hager, G. L. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0033 · Cited by 23 · see citing works

Dual activation of estrogen receptor alpha and glucocorticoid receptor upregulate CRTh2‐mediated type 2 inflammation; mechanism driving asthma severity in women?

Vijeyakumaran, M., Jawhri, M. A., Fortunato, J., Solomon, L. A., Palikhe, N. S., Vliagoftis, H., & Cameron, L. (2022) · Allergy · doi:10.1111/all.15543 · Cited by 22 · see citing works

Minireview: Conversing With Chromatin: The Language of Nuclear Receptors

Biddie, S. C., & John, S. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1247 · Cited by 22 · see citing works

Estrogen Receptor on the move: Cistromic plasticity and its implications in breast cancer.

Mayayo-Peralta, I., Preković, S., & Zwart, W. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100939 · Cited by 16 · see citing works

Family Matters: Collaboration and Conflict Among the Steroid Receptors Raises a Need for Group Therapy

Sikora, M. J. (2016) · Endocrinology · doi:10.1210/en.2016-1778 · Cited by 21 · see citing works

DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin

Coons, L. A., Hewitt, S. C., Burkholder, A., McDonnell, D. P., & Korach, K. S. (2017) · Endocrinology · doi:10.1210/en.2017-00468 · Cited by 20 · see citing works

Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells

Whirledge, S., Senbanjo, L. T., & Cidlowski, J. A. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1408437 · Cited by 20 · see citing works

Glucocorticoid receptor action in prostate cancer: the role of transcription factor crosstalk

Hiltunen, J., Helminen, L., & Paakinaho, V. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1437179 · Cited by 18 · see citing works

Coordinated transcriptional regulation by thyroid hormone and glucocorticoid interaction in adult mouse hippocampus-derived neuronal cells

Bagamasbad, P., Espina, J. E. C., Knoedler, J. R., Subramani, A., Harden, A. J., & Denver, R. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220378 · Cited by 18 · see citing works

Region-specific glucocorticoid receptor promoter methylation has both positive and negative prognostic value in patients with estrogen receptor-positive breast cancer

Snider, H., Villavarajan, B., Peng, Y., Shepherd, L. E., Robinson, A. C., & Mueller, C. R. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0750-x · Cited by 18 · see citing works

Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells

Whirledge, S., Kisanga, E. P., Taylor, R. N., & Cidlowski, J. A. (2017) · Endocrinology · doi:10.1210/en.2017-00361 · Cited by 17 · see citing works

Anti-proliferative transcriptional effects of medroxyprogesterone acetate in estrogen receptor positive breast cancer cells are predominantly mediated by the progesterone receptor

Moore, N. L. T., Hanson, A. R., Ebrahimie, E., Hickey, T. E., & Tilley, W. D. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105548 · Cited by 17 · see citing works

Glucocorticoid induced loss of oestrogen receptor alpha gene methylation and restoration of sensitivity to fulvestrant in triple negative breast cancer

Intabli, H., Gee, J. M. W., Oesterreich, S., Yeoman, M. S., Allen, M. C., Qattan, A. T., & Flint, M. S. (2022) · Gene · doi:10.1016/j.gene.2022.147022 · Cited by 15 · see citing works

Wild‐type and specific mutant androgen receptor mediates transcription via 17β‐estradiol in sex hormone‐sensitive cancer cells

Susa, T., Ikaga, R., Kajitani, T., Iizuka, M., Okinaga, H., Tamamori‐Adachi, M., & Okazaki, T. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24906 · Cited by 14 · see citing works

Type 1 Nuclear Receptor Activity in Breast Cancer: Translating Preclinical Insights to the Clinic

Kumar, S. S., Freelander, A., & Lim, E. (2021) · Cancers · doi:10.3390/cancers13194972 · Cited by 14 · see citing works

Ontogeny of hypothalamic glucocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in mice

Laryea, G. N., Arnett, M. G., & Muglia, L. J. (2015) · Stress · doi:10.3109/10253890.2015.1046832 · Cited by 13 · see citing works

17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes

Jallow, F., Brockman, J. L., Helzer, K. T., Rugowski, D. E., Goffin, V., Alarid, E. T., & Schuler, L. A. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2017-00399 · Cited by 12 · see citing works

Glucocorticoid receptor-mediated oncogenic activity is dependent on breast cancer subtype

Clark, A. B., & Conzen, S. D. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106518 · Cited by 11 · see citing works

Glucocorticoid receptors orchestrate a convergence of host and cellular stress signals in triple negative breast cancer

Posani, S. H., Gillis, N. E., & Lange, C. A. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106575 · Cited by 12 · see citing works

How far have we come in terms of estrogens in breast cancer? [Review]

McNamara, K. M., Guestini, F., Sakurai, M., Kikuchi, K., & Sasano, H. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0022 · Cited by 11 · see citing works

Glucocorticoid Receptor Activation in Lobular Breast Cancer Is Associated with Reduced Cell Proliferation and Promotion of Metastases

Porter, B. A., Frerich, C., Lainé, M., Clark, A. B., Durdana, I., Lee, J., Taya, M., Sahoo, S., Greene, G. L., Bennett, L. B., et al. (2023) · Cancers · doi:10.3390/cancers15194679 · Cited by 10 · see citing works

Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways

Mianesaz, H., Göczi, L., Nagy, G., Póliska, S., Fadel, L., Bojcsuk, D., Penyige, A., Szirák, K., AlHaman, F., Nagy, L., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf230 · Cited by 10 · see citing works

Androgen receptor–mediated assisted loading of the glucocorticoid receptor modulates transcriptional responses in prostate cancer cellsPreprint

Hiltunen, J., Helminen, L., Aaltonen, N., Launonen, K., Laakso, H., Malinen, M., Niskanen, E. A., Palvimo, J. J., & Paakinaho, V. (2025) · Genome Research · doi:10.1101/gr.280224.124 · Cited by 10 · see citing works

Imbalanced glucocorticoid and mineralocorticoid stress hormone receptor function has sex-dependent and independent regulatory effects in the mouse hippocampus

Oakley, R. H., Riddick, N. V., Moy, S. S., & Cidlowski, J. A. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100589 · Cited by 9 · see citing works

Glucocorticoids—timing, binding and environment

Lightman, S. L., & George, C. L. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.257 · Cited by 9 · see citing works

Predisposition of Women to Cardiovascular Diseases: A Side-Effect of Increased Glucocorticoid Signaling During the COVID-19 Pandemic?

Dhaibar, H. A., & Cruz‐Topete, D. (2021) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.606833 · Cited by 8 · see citing works

Context-Dependent Role of Glucocorticoid Receptor Alpha and Beta in Breast Cancer Cell Behaviour

Butz, H., Saskői, É., Krokker, L., Vereczki, V., Alpár, A., Likó, I., Tóth, E., Szőcs, E., Cserepes, M., Nagy, K., et al. (2023) · Cells · doi:10.3390/cells12050784 · Cited by 7 · see citing works

Flightless-I mediates the repression of estrogen receptor α target gene expression by the glucocorticoid receptor in MCF-7 cells

Liu, Y., & Jeong, K. W. (2018) · Endocrine Journal · doi:10.1507/endocrj.ej18-0343 · Cited by 7 · see citing works

Estrogen-regulated miRs in bone enhance osteoblast differentiation and matrix mineralization

Emch, M. J., Wicik, Z., Aspros, K. G. M., Vukajlovic, T., Pitel, K. S., Narum, A. K., Weivoda, M. M., Tang, X., Kalari, K. R., Turner, R. T., et al. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.05.026 · Cited by 7 · see citing works

Altered Hippocampal GR/KCC2 Signaling Mediates Susceptibility to Convulsion in Male Offspring Following Dexamethasone Exposure During Pregnancy in Rats

Xie, L., Jiao, Z., Zhang, H., Wang, T., Qin, J., Zhang, S., Luo, M., Lu, M., Yao, B., Wang, H., et al. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2022.05.004 · Cited by 6 · see citing works

BAF complexes and the glucocorticoid receptor in breast cancers

Dietrich, N., Hoffman, J. A., & Archer, T. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.07.001 · Cited by 6 · see citing works

Gene activation and repression by the glucocorticoid receptor are mediated by sequestering Ep300 and two modes of chromatin bindingPreprint

Sarusi-Portuguez, A., Grbeša, I., Tal, M., Deitch, R., Raz, D., Weismann, R., Schwartz, M., Loza, O., Sung, M., Kaplan, T., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/764480 · Cited by 6 · see citing works

Regulatory mechanisms of steroid hormone receptors on gene transcription through chromatin interaction and enhancer reprogramming

Sun, G., Zhao, C., Han, J., Wu, S., Chen, Y., Yao, J., & Li, L. (2024) · Cellular Oncology · doi:10.1007/s13402-024-01011-y · Cited by 5 · see citing works

Abstract 1075: Steroid receptor reprogramming of the chromatin landscape: crosstalk at the genomic level.

Miranda, T. B., Voss, T. C., Sung, M., Baek, S., John, S., Hawkins, M. E., Grøntved, L., Schiltz, R. L., & Hager, G. L. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-1075

Genome-wide crosstalk between steroid receptors in breast and prostate cancers

Paakinaho, V., & Palvimo, J. J. (2021) · Endocrine Related Cancer · doi:10.1530/erc-21-0038 · Cited by 55 · see citing works

Clinical and Genomic Crosstalk between Glucocorticoid Receptor and Estrogen Receptor α In Endometrial Cancer

Vahrenkamp, J. M., Yang, C.-H., Rodriguez, A. C., Almomen, A. A., Berrett, K. C., Trujillo, A., Guillen, K. P., Welm, B. E., Jarboe, E. A., Janat-Amsbury, M. M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.076 · Cited by 72 · see citing works

The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells

Ogara, M. F., Rodríguez‐Seguí, S. A., Marini, M., Nacht, A. S., Stortz, M., Levi, V., Presman, D. M., Vicent, G. P., & Pecci, A. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz857 · Cited by 45 · see citing works

Abstract PS2-12-15: Glucocorticoid receptor activation leads to remodeling of the chromatin landscape in infiltrating lobular carcinoma cells and changes in estrogen receptor-mediated gene expression

Briceno, A., Porter, B., Bennett, L. B., & Conzen, S. D. (2026) · Clinical Cancer Research · doi:10.1158/1557-3265.sabcs25-ps2-12-15