Hyaluronan in adipose tissue: Beyond dermal filler and therapeutic carrier
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Adipose hyaluronan may be a therapeutic target for adipose tissue dysfunction during nutrient oversupply.
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Hyaluronic acid accumulates in insulin-resistant adipose tissue of obese mice and is thought to negatively regulate adipocyte insulin signaling.
“Additionally, HA accumulates in insulin-resistant AT in obese mice and is thought to negatively regulate adipocyte insulin signaling (96).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [96]
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- Authors
- Zhu, Y., Crewe, C., & Scherer, P. E.
- Affiliations
- Eli Lilly (United States) (US)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Scherer, Philipp E.
- Venue
- Science Translational Medicine
- Published
- 2016-01-27
- Volume
- 8
- Issue
- 323
- Pages
- 323ps4-323ps4
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6475916
- OpenAlex
- W2272472492
- Cited by
- 39
- References
- 18
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 9 · 2017: 4 · 2016: 3
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. National Institutes of Health (R01-DK55758, R01-DK099110, P01-DK088761)
- Cancer Prevention and Research Institute of Texas (RP140412)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- hyaluronic acid, adipose tissue, adipose tissue fibrosis, metabolic dysfunction, dermal fillers, adipose tissue dysfunction
- MeSH terms
- Dermal Fillers, Adipose Tissue, Animals, Hypoxia, Collagen, Extracellular Matrix, Fibrosis, Humans, Hyaluronic Acid, Hyaluronoglucosaminidase, Immune System, Neovascularization, Pathologic, Obesity, Polysaccharides, Proteoglycans, Adiposity, Adipokines
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