Fibrosis and adipose tissue dysfunction.
Open accessAbstract
Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in turn leads to a potent profibrotic transcriptional program. The pathophysiological impact of adipose tissue fibrosis is likely to play an equally important role on systemic metabolic alterations as fibrotic conditions play in the liver, heart, and kidney. Here, we discuss recent advances in our understanding of the genesis, modulation, and systemic impact of excessive extracellular matrix (ECM) accumulation in adipose tissue of both rodents and humans and the ensuing impact on metabolic dysfunction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In dysfunctional AT, HIF-1α fails to promote angiogenesis, inducing dysregulated ECM remodeling, resulting in fibrosis that disrupts proper angiogenesis and further exacerbates hypoxia.
“in dysfunctional AT, HIF-1α fails to promote angiogenesis, inducing instead dysregulated ECM remodeling, resulting in fibrosis that disrupts proper angiogenesis, further exacerbating hypoxia in AT”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Sun et al., 2013
In “The role of HIF1α” (page unavailable), the paper says HIF1α fails to induce an effective angiogenic response in adipose tissue and instead promotes ECM synthesis and fibrosis. “Relationship to angiogenesis” says excess ECM can impede capillary proliferation, but it does not establish the claimed final step—that fibrosis thereby further exacerbates hypoxia. It notes that a direct link between local hypoxia and fibrosis in human adipose tissue has not been established. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Bariatric Surgery: A Systematic Review and Meta-analysis
Buchwald, H., Avidor, Y., Braunwald, E., Jensen, M. D., Pories, W., Fahrbach, K., & Schoelles, K. (2004) · JAMA · doi:10.1001/jama.292.14.1724 · Cited by 6,800 · see citing works
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941 · see citing works
Self-citationYuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884 · see citing works
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
Wynn, T. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31487 · Cited by 1,451 · see citing works
Cancello, R., Henegar, C., Viguerie, N., Taleb, S., Poitou, C., Rouault, C., Coupaye, M., Pelloux, V., Hugol, D., Bouillot, J.-L., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2277 · Cited by 1,164 · see citing works
Extracellular matrix remodelling: the role of matrix metalloproteinases
Stamenkovic, I. (2003) · The Journal of Pathology · doi:10.1002/path.1400 · Cited by 1,142 · see citing works
Disordered lipid metabolism and the pathogenesis of insulin resistance.
Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00024.2006 · Cited by 1,107 · see citing works
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
Khan, T., Muise, E. S., Iyengar, P., Wang, Z. V., Chandalia, M., Abate, N., Zhang, B. B., Bonaldo, P., Chua, S., & Scherer, P. E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01300-08 · Cited by 1,053 · see citing works
Self-citationSookoian, S. C., & Pirola, C. J. (2011) · Hepatology · doi:10.1002/hep.24283 · Cited by 917 · see citing works
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., Wang, Z. V., Landskroner-Eiger, S., Dineen, S., Magalang, U. J., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-09 · Cited by 896 · see citing works
Self-citationLiu, J., Divoux, A., Sun, J., Zhang, J., Clément, K., Glickman, J. N., Sukhova, G. K., Wolters, P. J., Du, J., Gorgun, C. Z., et al. (2009) · Nature Medicine · doi:10.1038/nm.1994 · Cited by 796 · see citing works
Self-citationAdipocyte Turnover: Relevance to Human Adipose Tissue Morphology
Arner, E., Westermark, P. O., Spalding, K. L., Britton, T., Rydén, M., Frisén, J., Bernard, S., & Arner, P. (2010) · Diabetes · doi:10.2337/db09-0942 · Cited by 645 · see citing works
Divoux, A., Tordjman, J., Lacasa, D., Veyrie, N., Hugol, D., Aissat, A., Basdevant, A., Guerre-Millo, M., Poitou, C., Zucker, J., et al. (2010) · Diabetes · doi:10.2337/db10-0585 · Cited by 620 · see citing works
Self-citationAdipocyte extracellular matrix composition, dynamics and role in obesity
Mariman, E. C. M., & Wang, P. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0263-4 · Cited by 559 · see citing works
Mathurin, P., Hollebecque, A., Arnalsteen, L., Buob, D., Leteurtre, E., Caiazzo, R. J., Pigeyre, M., Verkindt, H., Dharancy, S., Louvet, A., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.052 · Cited by 483 · see citing works
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471 · see citing works
Self-citationSong, E., Ouyang, N., Hörbelt, M., Antus, B., Wang, M., & Exton, M. S. (2000) · Cellular Immunology · doi:10.1006/cimm.2000.1687 · Cited by 447 · see citing works
Dichotomous effects of VEGF-A on adipose tissue dysfunction
Sun, K., Asterholm, I. W., Kusminski, C. M., Bueno, A. C., Wang, Z. V., Pollard, J. W., Brekken, R. A., & Scherer, P. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200447109 · Cited by 417 · see citing works
Self-citationA Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue
Chun, T.-H., Hotary, K. B., Sabeh, F., Saltiel, A. R., Allen, E. D., & Weiss, S. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.050 · Cited by 378 · see citing works
Obesity Decreases Perioperative Tissue Oxygenation
Kabon, B., Nagele, A., Reddy, D., Eagon, C., Fleshman, J. W., Sessler, D. I., & Kurz, A. (2004) · Anesthesiology · doi:10.1097/00000542-200402000-00015 · Cited by 376 · see citing works
Adipocyte-derived endotrophin promotes malignant tumor progression
Park, J., & Scherer, P. E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63930 · Cited by 350 · see citing works
Self-citationBlood Flow through Human Adipose Tissue Determined with Radioactive Xenon
Larsen, O. A., Lassen, N. A., & QUAADE, F. (1966) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1966.tb03208.x · Cited by 339 · see citing works
Adipose Tissue Collagen VI in Obesity
Pasarica, M., Gawrońska‐Kozak, B., Burk, D. H., Remedios, I., Hymel, D., Gimble, J., Ravussin, É., Bray, G. A., & Smith, S. R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0947 · Cited by 338 · see citing works
Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P., Konings, E., Jocken, J. W. E., Čajlaković, M., Ribitsch, V., Clément, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.027813 · Cited by 324 · see citing works
Self-citationKrishnan, J., Danzer, C. F., Simka, T., Ukropec, J., Walter, K., Kumpf, S., Mirtschink, P., Ukropcová, B., Gašperíková, D., Pedrazzini, T., et al. (2012) · Genes & Development · doi:10.1101/gad.180406.111 · Cited by 316 · see citing works
Adipose Tissue Extracellular Matrix and Vascular Abnormalities in Obesity and Insulin Resistance
Spencer, M. L., Ünal, R., Zhu, B., Rasouli, N., McGehee, R. E., Peterson, C. A., & Kern, P. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1567 · Cited by 291 · see citing works
Klein, S., Mittendorfer, B., Eagon, J. C., Patterson, B. W., Grant, L. M., Feirt, N. M., Seki, E., Brenner, D. A., Korenblat, K., & McCrea, J. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.01.042 · Cited by 288 · see citing works
Clouthier, D. E., Comerford, S. A., & Hammer, R. E. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119815 · Cited by 282 · see citing works
Macrophage-Secreted Factors Promote a Profibrotic Phenotype in Human Preadipocytes
Kéophiphath, M., Achard, V., Hénégar, C., Rouault, C., Clément, K., & Lacasa, D. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0183 · Cited by 278 · see citing works
Self-citationJiang, C., Qu, A., Matsubara, T., Chanturiya, T., Jou, W., Gavrilova, O., Shah, Y. M., & Gonzalez, F. J. (2011) · Diabetes · doi:10.2337/db11-0174 · Cited by 268 · see citing works
Aron-Wisnewsky, J., Minville, C., Tordjman, J., Lévy, P., Bouillot, J.-L., Basdevant, A., Bedossa, P., Clément, K., & Pépin, J.-L. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.04.022 · Cited by 255 · see citing works
Mechanisms of obesity and related pathologies: The macro‐ and microcirculation of adipose tissue
Rutkowski, J. M., Davis, K. E., & Scherer, P. E. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07303.x · Cited by 254 · see citing works
Self-citationSelective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction
Sun, K., Halberg, N., Khan, M., Magalang, U. J., & Scherer, P. E. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00951-12 · Cited by 231 · see citing works
Self-citationNon-alcoholic steatohepatitis: effect of Roux-en-Y gastric bypass surgery
Barker, K. B., Palekar, N. A., Bowers, S. P., Goldberg, J. E., Pulcini, J. P., & Harrison, S. A. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00419.x · Cited by 218 · see citing works
Dixon, J., Bhathal, P., & O'Brien, P. (2006) · Obesity Surgery · doi:10.1381/096089206778663805 · Cited by 212 · see citing works
Modulation of Angiogenesis during Adipose Tissue Development in Murine Models of Obesity
Vörös, G., Maquoi, E., Demeulemeester, D., Clerx, N., Collen, D., & LIJNEN, H. R. (2005) · Endocrinology · doi:10.1210/en.2005-0532 · Cited by 203 · see citing works
Systemic Fate of the Adipocyte-Derived Factor Adiponectin
Halberg, N., Schraw, T., Wang, Z. V., Kim, J., Yi, J., Hamilton, M. P., Luby‐Phelps, K., & Scherer, P. E. (2009) · Diabetes · doi:10.2337/db08-1750 · Cited by 198 · see citing works
Self-citationMast Cells in Human Adipose Tissue: Link with Morbid Obesity, Inflammatory Status, and Diabetes
Divoux, A., Moutel, S., Poitou, C., Lacasa, D., Veyrie, N., Aissat, A., Arock, M., Guerre-Millo, M., & Clément, K. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1532 · Cited by 187 · see citing works
Self-citationKarpe, F., Fielding, B. A., Ilic, V., Macdonald, I. A., Summers, L. K. M., & Frayn, K. N. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2467 · Cited by 177 · see citing works
Factors associated with weight loss after gastric bypass
Campos, G. M. (2008) · Archives of Surgery · doi:10.1001/archsurg.143.9.877 · Cited by 172 · see citing works
The Evolution of Severe Steatosis After Bariatric Surgery Is Related to Insulin Resistance
Mathurin, P., Gonzalez, F., Kerdraon, O., Leteurtre, E., Arnalsteen, L., Hollebecque, A., Louvet, A., Dharancy, S., Cocq, P., Jany, T., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.024 · Cited by 157 · see citing works
Alligier, M., Meugnier, E., Debard, C., Lambert-Porcheron, S., Chanséaume, E., Sothier, M., Loizon, E., Hssain, A. A., Brozek, J., Scoazec, J., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2314 · Cited by 154 · see citing works
Metabolic Signatures of Human Adipose Tissue Hypoxia in Obesity
Hodson, L., Humphreys, S. M., Karpe, F., & Frayn, K. N. (2012) · Diabetes · doi:10.2337/db12-1032 · Cited by 134 · see citing works
Tam, C. S., Viardot, A., Clément, K., Tordjman, J., Tonks, K. T. T., Greenfield, J. R., Campbell, L. V., Samocha‐Bonet, D., & Heilbronn, L. K. (2010) · Diabetes · doi:10.2337/db10-0162 · Cited by 126 · see citing works
Self-citationFlancbaum, L., Choban, P. S., Bradley, L. R., & Burge, J. C. (1997) · Surgery · doi:10.1016/s0039-6060(97)90336-6 · Cited by 116 · see citing works
Park, J., Morley, T. S., & Scherer, P. E. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202006 · Cited by 111 · see citing works
Self-citationJansson, Larsson, & LÖnnroth (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00360.x · Cited by 102 · see citing works
Beyond the fourth wave of genome-wide obesity association studies
Sandholt, C. H., Hansen, T. F., & Pedersen, O. B. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.9 · Cited by 87 · see citing works
Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles
Mutch, D. M., Tordjman, J., Pelloux, V., Hanczar, B., Hénégar, C., Poitou, C., Veyrie, N., Zucker, J., & Clément, K. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26802 · Cited by 82 · see citing works
Self-citationBéréziat, V., Cervera, P., Dour, C. L., Verpont, M., Dumont, S., Vantyghem, M., Capeau, J., & Vigouroux, C. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.07.049 · Cited by 76 · see citing works
Adiponectin Regulation of Stellate Cell Activation via PPARγ-Dependent and -Independent Mechanisms
Shafiei, M. S., Shetty, S., Scherer, P. E., & Rockey, D. C. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.02.035 · Cited by 62 · see citing works
Self-citationPermanence of molecular features of obesity in subcutaneous adipose tissue of ex-obese subjects
Cancello, R., Zulian, A., Gentilini, D., Mencarelli, M., Barba, A. D., Maffei, M., Vitti, P., Invitti, C., Liuzzi, A., & Blasio, A. M. D. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.7 · Cited by 54 · see citing works
Miranda, M., Escoté, X., Ceperuelo‐Mallafré, V., Megía, A., Caubet, E., Näf, S., Gómez, J. M., González‐Clemente, J. M., Vicente, V., & Vendrell, J. J. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.290 · Cited by 27 · see citing works
Cancello, R., Zulian, A., Gentilini, D., et al. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.44 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hypoxia and the extracellular matrix: drivers of tumour metastasis
Gilkes, D. M., Semenza, G. L., & Wirtz, D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3726 · Cited by 1,520 · see citing works
Type 2 immunity in tissue repair and fibrosis
Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055 · see citing works
Magkos, F., Fraterrigo, G., Yoshino, J., Luecking, C., Kirbach, K., Kelly, S. C., de las Fuentes, L., He, S., Okunade, A. L., Patterson, B. W., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.005 · Cited by 886 · see citing works
Targeting adipose tissue in the treatment of obesity-associated diabetes
Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works
Self-citationIdentification of a mesenchymal progenitor cell hierarchy in adipose tissue
Merrick, D., Sakers, A., Irgebay, Z., Okada, C., Calvert, C., Morley, M. P., Percec, I., & Seale, P. (2019) · Science · doi:10.1126/science.aav2501 · Cited by 664 · see citing works
Contribution of adipogenesis to healthy adipose tissue expansion in obesity
Vishvanath, L., & Gupta, R. K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129191 · Cited by 558 · see citing works
The cell biology of fat expansion
Rutkowski, J. M., Stern, J. H., & Scherer, P. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201409063 · Cited by 541 · see citing works
Self-citationAdipose tissue plasticity: how fat depots respond differently to pathophysiological cues
Pellegrinelli, V., Carobbio, S., & Vidal-Puig, A. (2016) · Diabetologia · doi:10.1007/s00125-016-3933-4 · Cited by 432 · see citing works
Leeners, B., Geary, N., Tobler, P. N., & Asarian, L. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmw045 · Cited by 407 · see citing works
Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction
Sun, K., Park, J., Gupta, O. T., Holland, W. L., Auerbach, P., Zhang, N., Goncalves Marangoni, R., Nicoloro, S. M., Czech, M. P., Varga, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms4485 · Cited by 364 · see citing works
Self-citationMarangoni, R. G., Korman, B. D., Wei, J., Wood, T. A., Graham, L. V., Whitfield, M. L., Scherer, P. E., Tourtellotte, W. G., & Varga, J. (2015) · Arthritis & Rheumatology · doi:10.1002/art.38990 · Cited by 337 · see citing works
Self-citationFrühbeck, G., Busetto, L., Dicker, D., Yumuk, V., Goossens, G. H., Hebebrand, J., Halford, J. G. C., Farpour-Lambert, N. J., Blaak, E. E., Woodward, E., et al. (2019) · Obesity Facts · doi:10.1159/000497124 · Cited by 311 · see citing works
The extracellular matrix and insulin resistance
Williams, A. S., Kang, L., & Wasserman, D. H. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.05.006 · Cited by 228 · see citing works
Mechanisms of weight regain after weight loss — the role of adipose tissue
van Baak, M. A., & Mariman, E. C. M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0148-4 · Cited by 203 · see citing works
Dalmas, E., Toubal, A., Alzaid, F., Blazek, K., Eames, H. L., Lebozec, K., Pini, M., Hainault, I., Montastier, E., Denis, R. G. P., et al. (2015) · Nature Medicine · doi:10.1038/nm.3829 · Cited by 205 · see citing works
Self-citationImmunologic and endocrine functions of adipose tissue: implications for kidney disease
Zhu, Q., & Scherer, P. E. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.157 · Cited by 200 · see citing works
Self-citationThe initiation of metabolic inflammation in childhood obesity
Singer, K., & Lumeng, C. N. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88882 · Cited by 194 · see citing works
Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194 · see citing works
Contribution of adipose tissue to development of cancer
Cozzo, A. J., Fuller, A. M., & Makowski, L. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c170008 · Cited by 188 · see citing works
The regulation of adipose tissue health by estrogens
Steiner, B. M., & Berry, D. C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.889923 · Cited by 171 · see citing works
A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution
Maida, A., Zota, A., Sjøberg, K. A., Schumacher, J., Sijmonsma, T. P., Pfenninger, A., Christensen, M. M., Gantert, T., Fuhrmeister, J., Rothermel, U., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85946 · Cited by 170 · see citing works
PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity
Iwayama, T., Steele, C., Yao, L., Dozmorov, M. G., Karamichos, D., Wren, J. D., & Olson, L. E. (2015) · Genes & Development · doi:10.1101/gad.260554.115 · Cited by 164 · see citing works
Vila, I. K., Badin, P.-M., Marques, M.-A., Monbrun, L., Lefort, C., Mir, L., Louche, K., Bourlier, V., Roussel, B., Gui, P., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.062 · Cited by 165 · see citing works
Iron and the pathophysiology of diabetes
Harrison, A. V., Lorenzo, F. R., & McClain, D. A. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022522-102832 · Cited by 161 · see citing works
Hypoxia-inducible factors and diabetes
Gunton, J. E. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137556 · Cited by 159 · see citing works
Scherer, P. E. (2016) · Diabetes · doi:10.2337/db16-0339 · Cited by 133 · see citing works
“We know from both genetic and pharmacological studies that the modulation of the extracellular matrix environment plays a vital role in the health of adipose tissue, both at steady state and during expansion (10).”
Self-citationObesity: A neuroimmunometabolic perspective
Larabee, C. M., Neely, O. C., & Domingos, A. I. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0283-6 · Cited by 123 · see citing works
Abildgaard, J., Ploug, T., Al-Saoudi, E., Wagner, T., Thomsen, C., Ewertsen, C., Bzorek, M., Pedersen, B. K., Pedersen, A. T., & Lindegaard, B. (2021) · Scientific Reports · doi:10.1038/s41598-021-94189-2 · Cited by 116 · see citing works
Kolnes, K. J., Petersen, M. H., Lien-Iversen, T., Højlund, K., & Jensen, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.737709 · Cited by 112 · see citing works
Macrophages and the Regulation of Adipose Tissue Remodeling
Martinez-Santibañez, G., & Nien-Kai Lumeng, C. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161113 · Cited by 111 · see citing works
Camastra, S., Vitali, A., Anselmino, M., Gastaldelli, A., Bellini, R., Berta, R., Severi, I., Baldi, S., Astiarraga, B., Barbatelli, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08444-6 · Cited by 93 · see citing works
Netto, B. D. M., Bettini, S. C., Clemente, A. P. G., de Carvalho Ferreira, J. P., Boritza, K., de Fátima Souza, S., Von der Heyde, M. E., Earthman, C. P., & Dâmaso, A. R. (2015) · Obesity Surgery · doi:10.1007/s11695-014-1484-7 · Cited by 74 · see citing works
Adipose tissue aging is regulated by an altered immune system
Zhang, Y.-X., Ou, M.-Y., Yang, Z.-H., Sun, Y., Li, Q.-F., & Zhou, S.-B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125395 · Cited by 62 · see citing works
Chen, Q., Lai, S. M., Xu, S., Tan, Y., Leong, K., Liu, D., Tan, J. C., Naik, R. R., Barron, A. M., Adav, S. S., et al. (2021) · The EMBO Reports · doi:10.15252/embr.202152835 · Cited by 56 · see citing works
How does adipose tissue contribute to inflammageing?
Zamboni, M., Nori, N., Brunelli, A., & Zoico, E. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2020.111162 · Cited by 55 · see citing works
GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction
Pastel, E., McCulloch, L. J., Ward, R., Joshi, S., Gooding, K. M., Shore, A. C., & Kos, K. (2017) · Clinical Science · doi:10.1042/cs20160803 · Cited by 49 · see citing works
Hyaluronan in adipose tissue: Beyond dermal filler and therapeutic carrier
Zhu, Y., Crewe, C., & Scherer, P. E. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad6793 · Cited by 39 · see citing works
Self-citationOstinelli, G., Laforest, S., Denham, S. G., Gauthier, M.-F., Drolet-Labelle, V., Scott, E., Hould, F.-S., Marceau, S., Homer, N. Z. M., Bégin, C., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac261 · Cited by 30 · see citing works
Ma, Y., Nenkov, M., Chen, Y., & Gaßler, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158352 · Cited by 28 · see citing works
Rocha-Rodrigues, S., Matos, A., Afonso, J., Mendes-Ferreira, M., Abade, E., Teixeira, E., Silva, B., Murawska-Ciałowicz, E., Oliveira, M. J., & Ribeiro, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094469 · Cited by 17 · see citing works
Association of omental adipocyte hypertrophy and fibrosis with human obesity and type 2 diabetes
Liu, F., He, J., Liu, B., Zhang, P., Wang, H., Sun, X., Chu, X., Guan, W., Feng, W., Bi, Y., et al. (2021) · Obesity · doi:10.1002/oby.23155 · Cited by 9 · see citing works
- Authors
- Sun, K., Tordjman, J., Clément, K., & Scherer, P. E.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Inserm (FR)
- Corresponding author
- Scherer, Philipp E.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 18
- Issue
- 4
- Pages
- 470-477
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3795900
- OpenAlex
- W1994809630
- Cited by
- 960
- References
- 58
- Citations by year
- 2026: 66 · 2025: 69 · 2024: 73 · 2023: 85 · 2022: 114 · 2021: 99 · 2020: 86 · 2019: 79 · 2018: 71 · 2017: 70 · 2016: 65 · 2015: 48 · 2014: 31 · 2013: 4
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 55758, R01DK055758, P01DK088761, R01DK099110)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipose tissue fibrosis, adipose tissue dysfunction, hypoxia, HIF-1α, extracellular matrix accumulation, metabolic dysfunction, obesity
- MeSH terms
- Adipose Tissue, Fibrosis, Humans, Insulin Resistance, Obesity, Cytokines, Hypoxia-Inducible Factor 1, alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
