The DOI matches its Crossref record; 14 of the 15 references it cites were found in a registry or an index.
Origin of the U87MG glioma cell line: Good news and bad news
Abstract
The DNA profile of the publicly available and widely used glioma cell line U87MG is quite different from that of the original cell line.
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“studies using the classic U87MG and U251MG glioma cell lines have shown that when grown in serum-containing medium these glioma cells exhibit transcrip-tomic deviation from the original tumour from which they were derived63.”
From How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation (2018) · cites this paper as [63]
Citations
Cites
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950
Lee, J., Kotliarova, S. E., Kotliarov, Y., Li, A., Su, Q., Donin, N. M., Pastorino, S., Purow, B. W., Christopher, N., Zhang, W., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.030 · Cited by 2,345
Pollard, S. M., Yoshikawa, K., Clarke, I. D., Danovi, D., Stricker, S., Russell, R., Bayani, J., Head, R., Lee, M., Bernstein, M., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.03.014 · Cited by 1,025
LONG TERM CULTURE OF NORMAL AND NEOPLASTIC HUMAN GLIA
Pontén, J., & Macintyre, E. H. (1968) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/j.1699-0463.1968.tb03502.x · Cited by 721
Absence of HeLa Cell Contamination in 169 Cell Lines Derived From Human Tumors2
Fogh, J., Wright, W. C., & Loveless, J. D. (1977) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/58.2.209 · Cited by 663
Check your cultures! A list of cross‐contaminated or misidentified cell lines
Capes‐Davis, A., Theodosopoulos, G., Atkin, I., Drexler, H. G., Kohara, A., MacLeod, R. A. F., Masters, J. R., Nakamura, Y., Reid, Y. A., Reddel, R. R., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25242 · Cited by 520 · cited 1×
“Theproblemof themisidentification of cell lines has beenhighlighted in several reports (11, 12), and a number of scientific journals now want the identity of the samples and cell lines used in their publication to be confirmed.”
BackgroundXie, Y., Bergström, T., Jiang, Y., Johansson, P., Marinescu, V. D., Lindberg, N., Segerman, A., Wicher, G., Niklasson, M., Baskaran, S., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.08.026 · Cited by 329
Self-citationCell line misidentification: the beginning of the end
American Type Culture Collection Standards Development Organization Workgroup ASN-0002 (2010) · Nature Reviews Cancer · doi:10.1038/nrc2852 · Cited by 266
DNA fingerprinting in forensics: past, present, future
Roewer, L. (2013) · Investigative Genetics · doi:10.1186/2041-2223-4-22 · Cited by 182
Schraer, L., Borum, I., & Sathyan, T. G. (1995) · Cited by 113
DNA fingerprinting of glioma cell lines and considerations on similarity measurements
Bady, P., Diserens, A.-C., Castella, V., Kalt, S., Heinimann, K., Hamou, M.-F., Delorenzi, M., & Hegi, M. E. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos072 · Cited by 57
Analysis of the Putative Remains of a European Patron Saint–St. Birgitta
Nilsson, M. E., Possnert, G., Edlund, H., Budowle, B., Kjellström, A., & Allen, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008986 · Cited by 36
Self-citationSchmidt, L., Kling, T., Monsefi, N., Olsson, M. M., Hansson, C., Baskaran, S., Lundgren, B., Märtens, U., Häggblad, M., Westermark, B., et al. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not111 · Cited by 23
Self-citationWestermark, B. (1973) · Experimental Cell Research · doi:10.1016/0014-4827(73)90126-2 · Cited by 11
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1 of the 15 references couldn’t be matched to a known paper.
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Xue, J., Zhao, Z., Zhang, L., Xue, L., Shen, S., Wen, Y., Wei, Z., Wang, L., Kong, L., Sun, H., et al. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.54 · Cited by 961
Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer
Gimple, R. C., Bhargava, S., Dixit, D., & Rich, J. N. (2019) · Genes & Development · doi:10.1101/gad.324301.119 · Cited by 514
Isolation and characterization of extracellular vesicle subpopulations from tissues
Crescitelli, R., Lässer, C., & Lötvall, J. O. (2021) · Nature Protocols · doi:10.1038/s41596-020-00466-1 · Cited by 524
Poynton, F. E., Bright, S. A., Blasco, S., Williams, D. C., Kelly, J. M., & Gunnlaugsson, T. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00680b · Cited by 430
Metabolic Reprogramming in Glioma
Strickland, M., & Stoll, E. A. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00043 · Cited by 357
Metadata
- Authors
- Allen, M., Bjerke, M., Edlund, H., Nelander, S., & Westermark, B.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Westermark, Bengt
- Venue
- Science Translational Medicine
- Published
- 2016-08-31
- Volume
- 8
- Issue
- 354
- Pages
- 354re3-354re3
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2509121458
- Cited by
- 466
- References
- 15
- Citations by year
- 2026: 28 · 2025: 33 · 2024: 43 · 2023: 36 · 2022: 49 · 2021: 41 · 2020: 59 · 2019: 51 · 2018: 84 · 2017: 37 · 2016: 5
- FWCI
- 42.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swedish Cancer Society
- Swedish Crime Victim Compensation and Support Authority
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Keywords
- glioma cell lines, glioblastoma, tumor origin, genetic profiling, gene expression profiling, cell line misidentification, translational oncology
- MeSH terms
- Brain Neoplasms, DNA, Mitochondrial, DNA, Neoplasm, Glioblastoma, Glioma, Humans, DNA Fingerprinting, Microsatellite Repeats, Cell Culture Techniques, Gene Expression Profiling, Cell Line, Tumor, Translational Research, Biomedical
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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