Origin of the U87MG glioma cell line: Good news and bad news

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

Lee, J., Kotliarova, S. E., Kotliarov, Y., Li, A., Su, Q., Donin, N. M., Pastorino, S., Purow, B. W., Christopher, N., Zhang, W., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.030 · Cited by 2,345

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

Pollard, S. M., Yoshikawa, K., Clarke, I. D., Danovi, D., Stricker, S., Russell, R., Bayani, J., Head, R., Lee, M., Bernstein, M., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.03.014 · Cited by 1,025

LONG TERM CULTURE OF NORMAL AND NEOPLASTIC HUMAN GLIA

Pontén, J., & Macintyre, E. H. (1968) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/j.1699-0463.1968.tb03502.x · Cited by 721

Absence of HeLa Cell Contamination in 169 Cell Lines Derived From Human Tumors2

Fogh, J., Wright, W. C., & Loveless, J. D. (1977) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/58.2.209 · Cited by 663

Check your cultures! A list of cross‐contaminated or misidentified cell lines

Capes‐Davis, A., Theodosopoulos, G., Atkin, I., Drexler, H. G., Kohara, A., MacLeod, R. A. F., Masters, J. R., Nakamura, Y., Reid, Y. A., Reddel, R. R., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25242 · Cited by 520 · cited 1×

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

Xie, Y., Bergström, T., Jiang, Y., Johansson, P., Marinescu, V. D., Lindberg, N., Segerman, A., Wicher, G., Niklasson, M., Baskaran, S., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.08.026 · Cited by 329

Cell line misidentification: the beginning of the end

American Type Culture Collection Standards Development Organization Workgroup ASN-0002 (2010) · Nature Reviews Cancer · doi:10.1038/nrc2852 · Cited by 266

DNA fingerprinting in forensics: past, present, future

Roewer, L. (2013) · Investigative Genetics · doi:10.1186/2041-2223-4-22 · Cited by 182

The Beginning of the End

Schraer, L., Borum, I., & Sathyan, T. G. (1995) · Cited by 113

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

Xue, J., Zhao, Z., Zhang, L., Xue, L., Shen, S., Wen, Y., Wei, Z., Wang, L., Kong, L., Sun, H., et al. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.54 · Cited by 961

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

Gimple, R. C., Bhargava, S., Dixit, D., & Rich, J. N. (2019) · Genes & Development · doi:10.1101/gad.324301.119 · Cited by 514

Isolation and characterization of extracellular vesicle subpopulations from tissues

Crescitelli, R., Lässer, C., & Lötvall, J. O. (2021) · Nature Protocols · doi:10.1038/s41596-020-00466-1 · Cited by 524

The development of ruthenium( ii ) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

Poynton, F. E., Bright, S. A., Blasco, S., Williams, D. C., Kelly, J. M., & Gunnlaugsson, T. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00680b · Cited by 430

Metabolic Reprogramming in Glioma

Strickland, M., & Stoll, E. A. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00043 · Cited by 357

Glioma: experimental models and reality

Lenting, K., Verhaak, R. G. W., ter Laan, M., Wesseling, P., & Leenders, W. P. J. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1671-4 · Cited by 300

Integrated Analysis of Exosomal Protein Biomarkers on Alternating Current Electrokinetic Chips Enables Rapid Detection of Pancreatic Cancer in Patient Blood

Lewis, J. M., Vyas, A. D., Qiu, Y., Messer, K. S., White, R., & Heller, M. J. (2018) · ACS Nano · doi:10.1021/acsnano.7b08199 · Cited by 283

Genomic and phenotypic characterization of a broad panel of patient-derived xenografts reflects the diversity of glioblastoma

Vaubel, R. A., Tian, S., Remonde, D., Schroeder, M. A., Mladek, A. C., Kitange, G. J., Caron, A., Kollmeyer, T. M., Grove, R., Peng, S., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0909 · Cited by 227

Deciphering the complex role of thrombospondin-1 in glioblastoma development

Daubon, T., Léon, C., Clarke, K., Andrique, L., Salabert, L., Darbo, É., Pineau, R., Guérit, S., Maître, M., Dedieu, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08480-y · Cited by 219

Subpopulations of extracellular vesicles from human metastatic melanoma tissue identified by quantitative proteomics after optimized isolation

Crescitelli, R., Lässer, C., Jang, S. C., Cvjetkovic, A., Malmhäll, C., Karimi, N., Höög, J. L., Johansson, I., Fuchs, J., Thorsell, A., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1722433 · Cited by 219

Patient-derived xenografts of different grade gliomas retain the heterogeneous histological and genetic features of human gliomas

Zeng, W., Tang, Z., Li, Y., Yin, G., Liu, Z., Gao, J., Chen, Y., & Chen, F. (2020) · Cancer Cell International · doi:10.1186/s12935-019-1086-5 · Cited by 209

Mouse models of glioblastoma for the evaluation of novel therapeutic strategies

Haddad, A. F., Young, J. S., Amara, D., Berger, M. S., Raleigh, D. R., Aghi, M. K., & Butowski, N. A. (2021) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdab100 · Cited by 223

Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: Present and future

Li, S.-R., Man, Q., Gao, X., Lin, H., Wang, J., Su, F., Wang, H., Bu, L., Liu, B., & Chen, G. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12175 · Cited by 206

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

Ioannidis, J. P. A., Kim, B. Y. S., & Trounson, A. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0314-y · Cited by 175

Guidance Document on Good In Vitro Method Practices (GIVIMP)

OECD (2018) · OECD Series on Testing and Assessment · doi:10.1787/9789264304796-en · Cited by 161

Patient-Derived Glioma Models: From Patients to Dish to Animals

da Hora, C. C., Schweiger, M. W., Würdinger, T., & Tannous, B. A. (2019) · Cells · doi:10.3390/cells8101177 · Cited by 154

Behaviors of Glioblastoma Cells in in Vitro Microenvironments

Diao, W., Tong, X., Cheng, Y., Zhang, F., Bao, C., Chen, H., Liu, L., Li, M., Ye, F., Fan, Q., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-36347-7 · Cited by 139

Experimental models and tools to tackle glioblastoma

Robertson, F., Marqués‐Torrejón, M. Á., Morrison, G. M., & Pollard, S. M. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.040386 · Cited by 127

Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field

Shen, Y., Wu, C., Uyeda, T. Q. P., Plaza, G. R., Liu, B., Han, Y., Lesniak, M. S., & Cheng, Y. (2017) · Theranostics · doi:10.7150/thno.18352 · Cited by 119

Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery

Hu, S., Kang, H., Baek, Y., Fakhri, G. E., Kuang, A., & Choi, H. S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800066 · Cited by 116

Evolution of Experimental Models in the Study of Glioblastoma: Toward Finding Efficient Treatments

Gómez‐Oliva, R., Domínguez‐García, S., Carrascal, L., Ábalos-Martínez, J., Pardillo-Díaz, R., Verástegui, C., Castro, C., Nunez‐Abades, P., & Geribaldi‐Doldán, N. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.614295 · Cited by 114

Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?

Ledur, P. F., Onzi, G. R., Zong, H., & Lenz, G. (2017) · Oncotarget · doi:10.18632/oncotarget.20193 · Cited by 106

Branched‐chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype

Silva, L. S., Poschet, G., Nonnenmacher, Y., Becker, H. M., Sapcariu, S. C., Gaupel, A., Schlotter, M., Wu, Y., Kneisel, N., Seiffert, M., et al. (2017) · EMBO Reports · doi:10.15252/embr.201744154 · Cited by 110

Utility of Glioblastoma Patient-Derived Orthotopic Xenografts in Drug Discovery and Personalized Therapy

Patrizii, M., Bartucci, M., Pine, S. R., & Sabaawy, H. E. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00023 · Cited by 107

Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping

Lane, R., Simon, T., Vintu, M., Solkin, B., Koch, B., Stewart, N. A., Benstead-Hume, G., Pearl, F. M. G., Critchley, G. R., Stebbing, J., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0560-x · Cited by 98

Glioblastoma Organoids: Pre-Clinical Applications and Challenges in the Context of Immunotherapy

Klein, E., Hau, A., Oudin, A., Golebiewska, A., & Niclou, S. P. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.604121 · Cited by 102

Integrating the Glioblastoma Microenvironment Into Engineered Experimental Models

Xiao, W., Sohrabi, A., & Seidlits, S. K. (2017) · Future Science OA · doi:10.4155/fsoa-2016-0094 · Cited by 98

G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects

Riccardi, C., Napolitano, E., Platella, C., Musumeci, D., & Montesarchio, D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107649 · Cited by 94

A Flexi‐PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy

Teh, D. B. L., Bansal, A., Chai, C., Toh, T. B., Tucker, R. A. J., Gammad, G. G. L., Yeo, Y., Lei, Z., Zheng, X., Yang, F., et al. (2020) · Advanced Materials · doi:10.1002/adma.202001459 · Cited by 93

Optical blood-brain-tumor barrier modulation expands therapeutic options for glioblastoma treatment

Cai, Q., Li, X., Xiong, H., Fan, H., Gao, X., Vemireddy, V., Margolis, R., Li, J., Ge, X., Giannotta, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40579-1 · Cited by 95

Enhancing the anti-tumour activity of 177Lu-DOTA-octreotate radionuclide therapy in somatostatin receptor-2 expressing tumour models by targeting PARP

Cullinane, C. M., Waldeck, K., Kirby, L., Rogers, B. E., Eu, P., Tothill, R. W., & Hicks, R. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-67199-9 · Cited by 89

Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy

Sperry, J., Condro, M. C., Guo, L., Braas, D., VanderVeer-Harris, N., Kim, K. K. O., Pope, W. B., Divakaruni, A. S., Lai, A., Christofk, H. R., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101453 · Cited by 88

Advances in Research of Adult Gliomas

Finch, A., Solomou, G., Wykes, V., Pohl, U., Bardella, C., & Watts, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020924 · Cited by 91

A Combination of Species Identification and STR Profiling Identifies Cross-contaminated Cells from 482 Human Tumor Cell Lines

Bian, X., Yang, Z., Feng, H., Sun, H., & Liu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-09660-w · Cited by 86

Organoid Models of Glioblastoma and Their Role in Drug Discovery

Rybin, M. J., Ivan, M. E., Ayad, N. G., & Zeier, Z. R. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.605255 · Cited by 83

Temozolomide sensitivity of malignant glioma cell lines – a systematic review assessing consistencies between in vitro studies

Poon, M. T. C., Bruce, M., Simpson, J. E., Hannan, C. J., & Brennan, P. M. (2021) · BMC Cancer · doi:10.1186/s12885-021-08972-5 · Cited by 78

Glioblastoma’s Next Top Model: Novel Culture Systems for Brain Cancer Radiotherapy Research

Caragher, S. P., Chalmers, A. J., & Gomez-Roman, N. (2019) · Cancers · doi:10.3390/cancers11010044 · Cited by 80

Wnt/β-catenin signaling pathway inhibits the proliferation and apoptosis of U87 glioma cells via different mechanisms

Gao, L., Chen, B., Li, J., Yang, F., Cen, X., Liao, Z., & Long, X.-A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181346 · Cited by 77

Neurotrophin receptor tyrosine kinases regulated with near-infrared light

Leopold, A. V., Chernov, K. G., Shemetov, A. A., & Verkhusha, V. V. (2019) · Nature Communications · doi:10.1038/s41467-019-08988-3 · Cited by 74

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

Johansson, P., Krona, C. C., Kundu, S., Doroszko, M., Baskaran, S., Schmidt, L., Vinel, C., Almstedt, E., Elgendy, R., Elfineh, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107897 · Cited by 70

Fatal correlation between YAP1 expression and glioma aggressiveness: clinical and molecular evidence

Guichet, P., Masliantsev, K., Tachon, G., Petropoulos, C., Godet, J., Ciron, D. L., Milin, S., Wager, M., & Karayan, L. (2018) · The Journal of Pathology · doi:10.1002/path.5133 · Cited by 68

Targeting Glioblastoma: Advances in Drug Delivery and Novel Therapeutic Approaches

Yeini, E., Ofek, P., Albeck, N., Ajamil, D. R., Neufeld, L., Eldar‐Boock, A., Kleiner, R., Vaskovich‐Koubi, D., Koshrovski‐Michael, S., Dangoor, S. I., et al. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000124 · Cited by 70

GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance

Kuang, R., Jahangiri, A., Mascharak, S., Nguyen, A. T., Chandra, A., Flanigan, P. M., Yagnik, G., Wagner, J. R., Lay, M. D. D., Carrera, D. A., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.88815 · Cited by 67

EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma

An, Z., Knobbe-Thomsen, C. B., Wan, X., Fan, Q. W., Reifenberger, G., & Weiss, W. A. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3551 · Cited by 66

Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway

Huang, H., Song, J., Liu, Z., Li, P., & Xu, G. (2017) · Oncology Letters · doi:10.3892/ol.2017.7446 · Cited by 65

Organoid models of glioblastoma: advances, applications and challenges.

Zhang, C., Jin, M.-Z., Zhao, J., Chen, J., & Jin, W. (2020) · PubMed Central · Cited by 66

Luteolin suppresses tumor proliferation through inducing apoptosis and autophagy via MAPK activation in glioma

You, Y., Wang, R., Shao, N., Zhi, F., & Yang, Y. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s191158 · Cited by 63

Rat and Mouse Brain Tumor Models for Experimental Neuro-Oncology Research

Sahu, U., Barth, R. F., Otani, Y., McCormack, R., & Kaur, B. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac021 · Cited by 61

Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2

Iwasawa, T., Zhang, P., Ohkawa, Y., Momota, H., Wakabayashi, T., Ohmi, Y., Bhuiyan, R. H., Furukawa, K., & Furukawa, K. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4266 · Cited by 63

Long non-coding RNA MEG3 contributes to cisplatin-induced apoptosis via inhibition of autophagy in human glioma cells

Ma, B., Gao, Z., Lou, J., Zhang, H., Yuan, Z., Wu, Q., Li, X., & Zhang, B. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6897 · Cited by 60

TRIM59 Promotes Gliomagenesis by Inhibiting TC45 Dephosphorylation of STAT3

Sang, Y., Li, Y., Song, L., Alvarez, A. A., Zhang, W., Lv, D., Tang, J., Liu, F., Chang, Z., Hatakeyama, S., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-2774 · Cited by 60

Characterization and comparison of human glioblastoma models

Schulz, J., Rodgers, L. T., Kryscio, R. J., Hartz, A. M. S., & Bauer, B. (2022) · BMC Cancer · doi:10.1186/s12885-022-09910-9 · Cited by 59

Single cell polarity in liquid phase facilitates tumour metastasis

Lorentzen, A., Becker, P. F., Kosla, J., Saini, M., Weidele, K., Ronchi, P., Klein, C., Wolf, M. J., Geist, F., Seubert, B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03139-6 · Cited by 59

Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma

Lei, K., Gu, X., Alvarado, A. G., Du, Y., Luo, S., Ahn, E. H., Kang, S. S., Ji, B., Liu, X., Mao, H. Z., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00979-y · Cited by 58

Antitumor Effect by Either FLASH or Conventional Dose Rate Irradiation Involves Equivalent Immune Responses

Almeida, A., Godfroid, C., Leavitt, R., Montay‐Gruel, P., Petit, B., Romero, J. F., Ollivier, J., Meziani, L., Sprengers, K., Paisley, R., et al. (2023) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2023.10.031 · Cited by 62

Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways

Ivanov, V. N., Wu, J., & Hei, T. K. (2017) · Oncotarget · doi:10.18632/oncotarget.18240 · Cited by 61

A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

Gedeon, P. C., Schaller, T. H., Chitneni, S. K., Choi, B. D., Kuan, C., Suryadevara, C. M., Snyder, D. J., Schmittling, R. J., Szafranski, S. E., Cui, X., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0126 · Cited by 58

Crosslink between Temozolomide and PD-L1 immune-checkpoint inhibition in glioblastoma multiforme

Heynckes, S., Daka, K., Franco, P., Gaebelein, A., Frenking, J. H., Doria-Medina, R., Mader, I., Delev, D., Schnell, O., & Heiland, D. H. (2019) · BMC Cancer · doi:10.1186/s12885-019-5308-y · Cited by 59

Cytotoxicity of Medicinal Plant Species Used by Traditional Healers in Treating People Suffering From HIV/AIDS in Uganda

Anywar, G., Kakudidi, E. K., Oryem‐Origa, H., Schubert, A., & Jassoy, C. (2022) · Frontiers in Toxicology · doi:10.3389/ftox.2022.832780 · Cited by 56

Glioblastoma, from disease understanding towards optimal cell-based in vitro models

Boccellato, C., & Rehm, M. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00684-7 · Cited by 56

Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress

Godoy, P. R. D. V., Khavari, A. P., Rizzo, M., Sakamoto‐Hojo, E. T., & Haghdoost, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2534643 · Cited by 57

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

Joshi, A. D., Botham, R. C., Schlein, L. J., Roth, H. S., Mangraviti, A., Borodovsky, A., Tyler, B., Joslyn, S. K., Looper, J., Podell, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19085 · Cited by 55

About the OECD

OECD (2018) · OECD series on testing and assessment · doi:10.1787/9789264304796-1-en · Cited by 54

In Vitro/In Silico Study on the Role of Doubling Time Heterogeneity among Primary Glioblastoma Cell Lines

Oraiopoulou, M., Tzamali, E., Tzedakis, G., Vakis, A. F., Papamatheakis, J. D., & Sakkalis, V. (2017) · BioMed Research International · doi:10.1155/2017/8569328 · Cited by 56

The impact of fraudulent and irreproducible data to the translational research crisis – solutions and implementation

Schulz, J. B., Cookson, M. R., & Hausmann, L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13844 · Cited by 52

Silencing of histone deacetylase 2 suppresses malignancy for proliferation, migration, and invasion of glioblastoma cells and enhances temozolomide sensitivity

Zhang, Z., Wang, Y., Chen, J., Tan, Q., Xie, C., Li, C., Zhan, W., & Wang, M. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-016-3188-2 · Cited by 52

Inhibitors of GLUT/SLC2A Enhance the Action of BCNU and Temozolomide against High-Grade Gliomas

Azzalin, A., Nato, G., Parmigiani, E., Garello, F., Buffo, A., & Magrassi, L. (2017) · Neoplasia · doi:10.1016/j.neo.2017.02.009 · Cited by 52

The promise of DNA damage response inhibitors for the treatment of glioblastoma

Majd, N., Yap, T. A., Koul, D., Balasubramaniyan, V., Li, X., Khan, S., Gandy, K. S., Yung, W. K. A., & de Groot, J. (2021) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdab015 · Cited by 53

ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration

Fròsina, G., Profumo, A., Marubbi, D., Marcello, D., Ravetti, J. L., & Daga, A. (2018) · Radiation Oncology · doi:10.1186/s13014-018-1020-3 · Cited by 51

Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells

Jia, W., Jiang, X., Liu, W., Wang, L., Zhu, B., Zhu, H., Liu, X., Zhong, M., Xie, D., Huang, W. J., et al. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4330 · Cited by 50

Gene expression profiling of glioblastoma cell lines depending on TP53 status after tumor-treating fields (TTFields) treatment

Lee, Y., Seo, H. W., Baek, J.-H., Lim, S. H., Hwang, S., & Kim, E. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-68473-6 · Cited by 54

Mucin-Like Domain of Ebola Virus Glycoprotein Enhances Selective Oncolytic Actions against Brain Tumors

Zhang, X., Zhang, T., Davis, J. N., Marzi, A., Marchese, A. M., Robek, M. D., & van den Pol, A. N. (2020) · Journal of Virology · doi:10.1128/jvi.01967-19 · Cited by 49

Practical Review on Preclinical Human 3D Glioblastoma Models: Advances and Challenges for Clinical Translation

Soubéran, A., & Tchoghandjian, A. (2020) · Cancers · doi:10.3390/cancers12092347 · Cited by 52

A Xenotransplant Model of Human Brain Tumors in Wild-Type Mice

Hoffmann, N., Fernández, V., Pereira, R. C., Rancati, S., Pelizzoli, R., & Tonelli, D. D. P. (2019) · iScience · doi:10.1016/j.isci.2019.100813 · Cited by 49

On-chip perivascular niche supporting stemness of patient-derived glioma cells in a serum-free, flowable culture

Gerigk, M., Bulstrode, H. J. C. J., Shi, H., Tönisen, F., Cerutti, C., Morrison, G. M., Rowitch, D. H., & Huang, Y. Y. S. (2021) · Lab on a Chip · doi:10.1039/d1lc00271f · Cited by 51

Using Light for Therapy of Glioblastoma Multiforme (GBM)

Vasilev, A., Sofi, R., Rahman, R., Smith, S. J., Teschemacher, A. G., & Kasparov, S. (2020) · Brain Sciences · doi:10.3390/brainsci10020075 · Cited by 48

Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies

Tarpley, M., Oladapo, H. O., Strepay, D., Caligan, T. B., Chdid, L., Shehata, H., Roques, J., Thomas, R., Laudeman, C. P., Onyenwoke, R. U., et al. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105821 · Cited by 48

Considering the Experimental Use of Temozolomide in Glioblastoma Research

Herbener, V. J., Burster, T., Goreth, A., Pruss, M., von Bandemer, H., Baisch, T., Fitzel, R., Siegelin, M. D., Karpel‐Massler, G., Debatin, K., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8060151 · Cited by 50

T lymphocyte-targeted immune checkpoint modulation in glioma

Kelly, W., Giles, A. J., & Gilbert, M. R. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000379 · Cited by 47

Critical role of Aquaporin-1 and telocytes in infantile hemangioma response to propranolol beta blockade

Moisan, F., Ouchérif, S., Kaulanjan‐Checkmodine, P., Prey, S., Rousseau, B., Bonneu, M., Claverol, S., Gontier, É., Lacomme, S., Dousset, L., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2018690118 · Cited by 46

Integrative Analysis of Next-Generation Sequencing for Next-Generation Cancer Research toward Artificial Intelligence

Park, Y., Heider, D., & Hauschild, A.-C. (2021) · Cancers · doi:10.3390/cancers13133148 · Cited by 46

Preclinical models of glioblastoma: limitations of current models and the promise of new developments

Liu, P., Griffiths, S., Veljanoski, D., Vaughn-Beaucaire, P. C., Speirs, V., & Brüning‐Richardson, A. (2021) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2021.20 · Cited by 47

Glioma Stem Cells as Promoter of Glioma Progression: A Systematic Review of Molecular Pathways and Targeted Therapies

Agosti, E., Antonietti, S., Ius, T., Fontanella, M. M., Zeppieri, M., & Panciani, P. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147979 · Cited by 44

Involvement of NOS2 Activity on Human Glioma Cell Growth, Clonogenic Potential, and Neurosphere Generation

Palumbo, P., Lombardi, F., Siragusa, G., Dehcordi, S. R., Luzzi, S., Cimini, A., Cifone, M. G., & Cinque, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092801 · Cited by 44

CISD2 promotes the proliferation of glioma cells via suppressing beclin-1-mediated autophagy and is targeted by microRNA-449a

Sun, A., Meng, F., & Wang, M.-G. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7642 · Cited by 42

Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors

Xu, C., Liu, X., Geng, Y., Bai, Q., Pan, C., Sun, Y., Chen, X., Yu, H., Wu, Y., Zhang, P., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19656 · Cited by 41

TRPM7 Induces Mechanistic Target of Rap1b Through the Downregulation of miR-28-5p in Glioma Proliferation and Invasion

Wan, J., Guo, A. A., Chowdhury, I., Guo, S., Hibbert, J. M., Wang, G., & Liu, M. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01413 · Cited by 41

Magnetosomes Extracted from Magnetospirillum gryphiswaldense as Theranostic Agents in an Experimental Model of Glioblastoma

Mannucci, S., Tambalo, S., Conti, G., Ghin, L., Milanese, A., Carboncino, A., Nicolato, E., Marinozzi, M. R., Benati, D., Bassi, R., et al. (2018) · Contrast Media & Molecular Imaging · doi:10.1155/2018/2198703 · Cited by 39

A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells

Li, J., Garavaglia, S., Ye, Z., Moretti, A., Belyaeva, O. V., Beiser, A., Ibrahim, M., Wilk, A. M., McClellan, S., Klyuyeva, A. V., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02949-7 · Cited by 40

Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation

Lee, S. B., Ko, A., Oh, Y. T., Shi, P., D’Angelo, F., Frangaj, B., Koller, A. A., Chen, E. I., Cardozo, T. J., Iavarone, A., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.06.021 · Cited by 38

miR‑7‑5p inhibits cell migration and invasion in glioblastoma through targeting SATB1

Yin, C., Kong, W., Jiang, J., Xu, H., & Zhao, W. (2018) · Oncology Letters · doi:10.3892/ol.2018.9777 · Cited by 37

The histone H3 Lys 27 demethylase KDM6B promotes migration and invasion of glioma cells partly by regulating the expression of SNAI1

Sui, A., Yongbing, X., Yang, J., Pan, B., Wu, J., Guo, T., Shen, Y., & Guo, X. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.01.006 · Cited by 38

Synergistic combination of chemo‑phototherapy based on temozolomide/ICG‑loaded iron oxide nanoparticles for brain cancer treatment

Kwon, Y., Je, J., Cha, S., Oh, Y., & Cho, W. (2019) · Oncology Reports · doi:10.3892/or.2019.7289 · Cited by 37

Expression and function of chondroitin 4‐sulfate and chondroitin 6‐sulfate in human glioma

Pan, H., Xue, W., Zhao, W., & Schachner, M. (2019) · The FASEB Journal · doi:10.1096/fj.201901621rrr · Cited by 37

G-protein-coupled receptors as therapeutic targets for glioblastoma

Byrne, K., Pal, A., Curtin, J. F., Stephens, J. C., & Kinsella, G. K. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.07.008 · Cited by 37

Targeting the Urokinase-Type Plasminogen Activator Receptor (uPAR) in Human Diseases With a View to Non-invasive Imaging and Therapeutic Intervention

Leth, J. M., & Ploug, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.732015 · Cited by 39

MV1035 Overcomes Temozolomide Resistance in Patient-Derived Glioblastoma Stem Cell Lines

Malacrida, A., Domizio, A. D., Bentivegna, A., Cislaghi, G., Messuti, E., Tabano, S. M., Giussani, C. G., Zuliani, V., Rivara, M., & Nicolini, G. (2022) · Biology · doi:10.3390/biology11010070 · Cited by 37

The Subventricular Zone in Glioblastoma: Genesis, Maintenance, and Modeling

Beiriger, J., Habib, A., Jovanovich, N., Kodavali, C. V., Edwards, L., Amankulor, N., & Zinn, P. O. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.790976 · Cited by 38

Molecular Characterization of Temozolomide-Treated and Non Temozolomide-Treated Glioblastoma Cells Released Extracellular Vesicles and Their Role in the Macrophage Response

Panzarini, E., Tacconi, S., Carata, E., Mariano, S., Tata, A. M., & Dini, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218353 · Cited by 36

MFSD6 is an entry receptor for enterovirus D68

Varanese, L., Xu, L., Peters, C. E., Pintilie, G. D., Roberts, D. S., Raj, S. V. A., Liu, M., Ooi, Y. S., Diep, J., Qiao, W., et al. (2025) · Nature · doi:10.1038/s41586-025-08908-0 · Cited by 38

การแสดงออกของยนและคณลกษณะของเซลลตนกำเนดมะเรงในประชากรเซลลไลน U87MG glioblastoma

บุตรศรี, ร. (2020) · doi:10.58837/chula.the.2020.685

Increasing the accuracy of glioblastoma subtypes: Factoring in the tumor's cell of origin

Nelander, S. (2017) · Molecular & Cellular Oncology · doi:10.1080/23723556.2017.1302907 · Cited by 1

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Y., Marinescu, V. D., Xie, Y., Jarvius, M., Maturi, N. P., Haglund, C., Olofsson, S. K., Lindberg, N., Olofsson, T., Leijonmarck, C., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.053 · Cited by 14

Establishment of attached and non‐attached cell lines from an uncommon human glioma

Westermark, B., Larsson, E., Brunk, U. T., Lubitz, W., & Mark, J. (1981) · International Journal of Cancer · doi:10.1002/ijc.2910280314 · Cited by 17

A study of the origin of human glioma based on cell lines and tumor specimens

Timin, G., Лахина, Ю. С., Gulyaev, D. A., & Tolkunova, E. N. (2016) · Cell and Tissue Biology · doi:10.1134/s1990519x16020103