Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease
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The approved drug NDP-MSH ameliorates neurodegeneration in mouse models of neuroinflammatory disease.
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CREB activation and JNK inhibition are involved in the anti-inflammatory and neuroprotective action of melanocortins in models of ischemic and inflammatory processes in the brain.
“It should be noted that CREB activation and JNK inhibition are involved in the anti-inflammatory and neuroprotective action of melanocortins in models of ischemic and inflammatory processes in the brain [4,60].”
From Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4–7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia–Reperfusion (2021) · cites this paper as [4]
In models of brain ischaemia and inflammation, α-MSH exhibits strong anti-inflammatory, neurogenic and neuroprotective effects.
“Additionally, in models of brain ischaemia and inflammation, α-MSH exhibits strong anti-inflammatory, neurogenic and neuroprotective effects [65,66,67].”
From Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats (2020) · cites this paper as [67]
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- Authors
- Mykicki, N., Herrmann, A. M., Schwab, N., Deenen, R., Sparwasser, T., Limmer, A., Wachsmuth, L., Klotz, L., Köhrer, K., Faber, C., Wiendl, H., Luger, T. A., Meuth, S. G., & Loser, K.
- Affiliations
- University of Münster (DE)
- Heinrich Heine University Düsseldorf (DE)
- Center for Experimental and Clinical Infection Research (DE)
- University Hospital Bonn (DE)
- Corresponding author
- Meuth, Sven G.
- Loser, Karin
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2016-10-26
- Volume
- 8
- Issue
- 362
- Pages
- 362ra146-362ra146
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2540640315
- Cited by
- 60
- References
- 60
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 4
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- HZI (Helmholtz Centre for Infection Research) (submittedVersion, cc-by-nc-sa)
- Funders
- Deutsche Forschungsgemeinschaft (TR‐128, Lo2/004/16, SFB 1009, SFB TR‐128)
- Westfälische Wilhelms-Universität Münster
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- MC1R, neuroprotection, neuroinflammatory diseases, experimental autoimmune encephalomyelitis, NDP-MSH, blood-brain barrier integrity, immune cell infiltration, excitotoxicity, action potential firing, multiple sclerosis, relapsing-remitting multiple sclerosis
- MeSH terms
- Action Potentials, alpha-MSH, Animals, Blood-Brain Barrier, Bone Marrow Cells, Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Flow Cytometry, Hippocampus, Magnetic Resonance Imaging, Mice, Inbred C57BL, Neurons, Protein Binding, Disease Progression, Neuroprotective Agents, Glutamic Acid, Gene Expression Profiling, Receptor, Melanocortin, Type 1, Cell Proliferation, T-Lymphocytes, Regulatory, Mice
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