Cited by 61Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration MechanismsNeuropeptides and Animal Physiology

Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease

Open access
Mykicki, Nadine, Herrmann, Alexander M., Schwab, Nicholas, Deenen, René, Sparwasser, Tim, Limmer, Andreas, Wachsmuth, Lydia, Klotz, Luisa +6 more·2016·Science Translational Medicine

Abstract

The approved drug NDP-MSH ameliorates neurodegeneration in mouse models of neuroinflammatory disease.

Integrity signals

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Crossref · 10.1126/scitranslmed.aaf8732

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59 of 59 references verified0 citation errors · 0 not checkable

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Authors
Mykicki, N., Herrmann, A. M., Schwab, N., Deenen, R., Sparwasser, T., Limmer, A., Wachsmuth, L., Klotz, L., Köhrer, K., Faber, C., Wiendl, H., Luger, T. A., Meuth, S. G., & Loser, K.
Affiliations
  • University of Münster (DE)
  • Heinrich Heine University Düsseldorf (DE)
  • Center for Experimental and Clinical Infection Research (DE)
  • University Hospital Bonn (DE)
Corresponding author
  • Meuth, Sven G.
  • Loser, Karin
Venue
Science Translational Medicine
Published
2016-10-26
Volume
8
Issue
362
Pages
362ra146-362ra146
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2540640315
Cited by
60
References
60
Citations by year
2026: 1 · 2025: 5 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 4
FWCI
5.14
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • HZI (Helmholtz Centre for Infection Research) (submittedVersion, cc-by-nc-sa)
Funders
  • Deutsche Forschungsgemeinschaft (TR‐128, Lo2/004/16, SFB 1009, SFB TR‐128)
  • Westfälische Wilhelms-Universität Münster
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
MC1R, neuroprotection, neuroinflammatory diseases, experimental autoimmune encephalomyelitis, NDP-MSH, blood-brain barrier integrity, immune cell infiltration, excitotoxicity, action potential firing, multiple sclerosis, relapsing-remitting multiple sclerosis
MeSH terms
Action Potentials, alpha-MSH, Animals, Blood-Brain Barrier, Bone Marrow Cells, Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Flow Cytometry, Hippocampus, Magnetic Resonance Imaging, Mice, Inbred C57BL, Neurons, Protein Binding, Disease Progression, Neuroprotective Agents, Glutamic Acid, Gene Expression Profiling, Receptor, Melanocortin, Type 1, Cell Proliferation, T-Lymphocytes, Regulatory, Mice

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