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Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms
Open accessAbstract
Thrombosis in myeloproliferative neoplasms is associated with increased NETosis that can be targeted with JAK inhibitors.
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“Furthermore, JAK2 mutations prime neutrophils to form neutrophil extracellular traps, leading to thrombosis, which may also contribute to poor cardiovascular outcomes 82.”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [82]
In the citing paper
“In a separate study (83), individuals with CHIP-associated JAK2 mutations were reported to have a ~12 times greater risk of developing venous thrombosis than those without CHIP, whereas individuals with mutations in other CHIP-associated genes had a doubling of the risk 82.”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [82]
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“Furthermore, JAK2 mutations prime neutrophils to form neutrophil extracellular traps, leading to thrombosis, whichmay also contribute to poor cardiovascular outcomes (83).”
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Metadata
- Authors
- Wolach, O., Sellar, R. S., Martinod, K., Cherpokova, D., McConkey, M., Chappell, R. J., Silver, A. J., Adams, D., Castellano, C. A., Schneider, R. K., Padera, R. F., DeAngelo, D. J., Wadleigh, M., Steensma, D. P., Galinsky, I., Stone, R. M., Genovese, G., McCarroll, S. A., Iliadou, B., Hultman, C., Neuberg, D., Mullally, A., Wagner, D. D., & Ebert, B. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Broad Institute (US)
- Boston Children's Hospital (US)
- Dana-Farber Cancer Institute (US)
- Karolinska Institutet (SE)
- Corresponding author
- Wolach, Ofir
- Sellar, Rob S.
- Ebert, Benjamin L.
- ORCID
- Wolach, Ofir
- Sellar, Rob S.
- Martinod, Kimberly
- McConkey, Marie
- Silver, Alexander J.
- Castellano, Cecilia A.
- Schneider, Rebekka K.
- Padera, Robert F.
- DeAngelo, Daniel J.
- Wadleigh, Martha
- Steensma, David P.
- Galinsky, Ilene
- Stone, Richard M.
- Genovese, Giulio
- McCarroll, Steven A.
- Hultman, Christina
- Neuberg, Donna
- Mullally, Ann
- Wagner, Denisa D.
- Ebert, Benjamin L.
- Venue
- Science Translational Medicine
- Published
- 2018-04-11
- Volume
- 10
- Issue
- 436
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6442466
- OpenAlex
- W2796704538
- Cited by
- 481
- References
- 41
- Citations by year
- 2026: 50 · 2025: 58 · 2024: 66 · 2023: 58 · 2022: 73 · 2021: 69 · 2020: 48 · 2019: 44 · 2018: 13
- FWCI
- 24.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- National Institutes of Health (R01HL082945)
- Howard Hughes Medical Institute
- Leukemia and Lymphoma Society
- Topics
- Health Sciences › Medicine › Hematology › Myeloproliferative Neoplasms: Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- neutrophil extracellular traps, thrombosis, myeloproliferative neoplasms, JAK2 inhibition, neutrophil function, NETosis
- MeSH terms
- Protein-Arginine Deiminase Type 4, Animals, Female, Hydrolases, Myeloproliferative Disorders, Nitriles, Pyrazoles, Pyrimidines, Thrombosis, Signal Transduction, Case-Control Studies, Hematologic Neoplasms, Cell Proliferation, STAT Transcription Factors, Mice, Janus Kinases, Janus Kinase 2, Extracellular Traps
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