Neutrophil elastase‐deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis

Neutrophil Extracellular Traps Kill Bacteria

Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268 · see citing works

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992 · see citing works

Cytokine-mediated regulation of CXCR4 expression in human neutrophils

Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713 · see citing works

Extracellular DNA traps promote thrombosis

Fuchs, T. A., Brill, A. G., Duerschmied, D., Schatzberg, D., Monestier, M., Myers, D. D., Wrobleski, S. K., Wakefield, T. W., Hartwig, J. H., & Wagner, D. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005743107 · Cited by 2,517 · see citing works

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103 · see citing works

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

von Brühl, M.-L., Stark, K., Steinhart, A., Chandraratne, S., Konrad, I., Lorenz, M., Khandoga, A. G., Tirniceriu, A., Coletti, R., Köllnberger, M., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112322 · Cited by 1,827 · see citing works

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

Urban, C. F., Ermert, D., Schmid, M., Abed, U. A., Goosmann, C., Nacken, W. K. F., Brinkmann, V., Jungblut, P. R., & Zychlinsky, A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000639 · Cited by 1,677 · see citing works

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

Li, P., Li, M., Lindberg, M. R., Kennett, M. J., Xiong, N., & Wang, Y. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100239 · Cited by 1,495 · see citing works

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

Cools-Lartigue, J., Spicer, J., McDonald, B., Gowing, S., Chow, S., Giannias, B., Bourdeau, F., Kubes, P., & Ferri, L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67484 · Cited by 1,395 · see citing works

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

Warnatsch, A., Ιωάννου, Μ., Wang, Q., & Papayannopoulos, V. (2015) · Science · doi:10.1126/science.aaa8064 · Cited by 1,280 · see citing works

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

Maßberg, S., Grahl, L., von Bruehl, M., Manukyan, D., Pfeiler, S., Goosmann, C., Brinkmann, V., Lorenz, M., Bidzhekov, K., Khandagale, A. B., et al. (2010) · Nature Medicine · doi:10.1038/nm.2184 · Cited by 1,212 · see citing works

Neutrophil extracellular traps promote deep vein thrombosis in mice

Brill, A. G., Fuchs, T. A., Savchenko, A. S., Thomas, G. M., Martinod, K., Meyer, S. F. D., Bhandari, A. A., & Wagner, D. D. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04544.x · Cited by 900 · see citing works

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

Demers, M., Krause, D. S., Schatzberg, D., Martinod, K., Voorhees, J. R., Fuchs, T. A., Scadden, D. T., & Wagner, D. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200419109 · Cited by 883 · see citing works

Thrombosis: tangled up in NETs

Martinod, K., & Wagner, D. D. (2013) · Blood · doi:10.1182/blood-2013-10-463646 · Cited by 875 · see citing works

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Lewis, H. D., Liddle, J., Coote, J., Atkinson, S. J., Barker, M. D., Bax, B. D., Bicker, K. L., Bingham, R. P., Campbell, M. J., Chen, Y. H., et al. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1735 · Cited by 794 · see citing works

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

Metzler, K. D., Goosmann, C., Lubojemska, A., Zychlinsky, A., & Papayannopoulos, V. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.044 · Cited by 741 · see citing works

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

Belaaouaj, A., McCarthy, R., Baumann, M. L., Gao, Z., Ley, T. J., Abraham, S. N., & Shapiro, S. D. (1998) · Nature Medicine · doi:10.1038/nm0598-615 · Cited by 691 · see citing works

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

Kolaczkowska, E., Jenne, C. N., Surewaard, B. G. J., Thanabalasuriar, A., Lee, W.-Y., Sanz, M.-J., Mowen, K., Opdenakker, G., & Kubes, P. (2015) · Nature Communications · doi:10.1038/ncomms7673 · Cited by 584 · see citing works

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

Martinod, K., Demers, M., Fuchs, T. A., Wong, S. L., Brill, A. G., Gallant, M., Hu, J., Wang, Y., & Wagner, D. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301059110 · Cited by 532 · see citing works

von Willebrand factor–mediated platelet adhesion is critical for deep vein thrombosis in mouse models

Brill, A. G., Fuchs, T. A., Chauhan, A. K., Yang, J. J., Meyer, S. F. D., Köllnberger, M., Wakefield, T. W., Lämmle, B., Maßberg, S., & Wagner, D. D. (2010) · Blood · doi:10.1182/blood-2010-05-287623 · Cited by 475 · see citing works

Impaired Immunity and Enhanced Resistance to Endotoxin in the Absence of Neutrophil Elastase and Cathepsin G

Tkalcevic, J., Novelli, M. R., Phylactides, M., Iredale, J. P., Segal, A. W., & Roes, J. (2000) · Immunity · doi:10.1016/s1074-7613(00)80173-9 · Cited by 379 · see citing works

ONO-5046, a novel inhibitor of human neutrophil elastase

Kawabata, K., Suzuki, M., Sugitani, M., Imaki, K., Toda, M., & Miyamoto, T. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91862-7 · Cited by 359 · see citing works

Tissue factor expressed by circulating cancer cell‐derived microparticles drastically increases the incidence of deep vein thrombosis in mice

Thomas, G. M., Brill, A. G., Mezouar, S., Crescence, L., Gallant, M., Dubois, C., & Wagner, D. D. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13002 · Cited by 153 · see citing works

A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice

Takemasa, A., Ishii, Y., & Fukuda, T. (2012) · European Respiratory Journal · doi:10.1183/09031936.00127011 · Cited by 140 · see citing works

AZD9668: Pharmacological Characterization of a Novel Oral Inhibitor of Neutrophil Elastase

Stevens, T., Ekholm, K., Gränse, M., Lindahl, M., Kozma, V., Jungar, C., Ottosson, T., Håkansson, H. F., Churg, A., Wright, J. R., et al. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.182139 · Cited by 120 · see citing works

A SerpinB1 Regulatory Mechanism Is Essential for Restricting Neutrophil Extracellular Trap Generation

Farley, K., Stolley, J. M., Zhao, P., Cooley, J., & Remold‐O’Donnell, E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201167 · Cited by 104 · see citing works

SerpinB1 protects the mature neutrophil reserve in the bone marrow

Benarafa, C., LeCuyer, T. E., Baumann, M., Stolley, J. M., Cremona, T. P., & Remold‐O’Donnell, E. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0810461 · Cited by 69 · see citing works

Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice

Fujino, N., Kubo, H., Suzuki, T., He, M. T., Suzuki, T., Yamada, M., Takahashi, T., Ota, C., & Yamaya, M. (2011) · Experimental Lung Research · doi:10.3109/01902148.2011.633306 · Cited by 36 · see citing works

Neutrophil Elastase Inhibitor Attenuates Lipopolysaccharide-Induced Hepatic Microvascular Dysfunction in Mice

Ishii, K., Ito, Y., Katagiri, H., Matsumoto, Y., Kakita, A., & Majima, M. (2002) · Shock · doi:10.1097/00024382-200208000-00013 · Cited by 28 · see citing works

The neutrophil elastase inhibitor sivelestat suppresses accelerated gastrointestinal tumor growth via peritonitis after cecal ligation and puncture.

Kumagai, K., Saikawa, Y., Takeuchi, H., Suda, K., Fukuda, K., Nakamura, R., Takahashi, T., Kawakubo, H., Wada, N., Miyasho, T., et al. (2013) · PubMed · Cited by 18 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Neutrophil extracellular traps in immunity and disease

Papayannopoulos, V. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.105 · Cited by 3,428 · see citing works

An emerging role for neutrophil extracellular traps in noninfectious disease

Jorch, S. K., & Kubes, P. (2017) · Nature Medicine · doi:10.1038/nm.4294 · Cited by 1,244 · see citing works

Cellular Mechanisms of NETosis

Thiam, H. R., Wong, S. L., Wagner, D. D., & Waterman, C. M. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-111016 · Cited by 624 · see citing works

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

Wolach, O., Sellar, R. S., Martinod, K., Cherpokova, D., McConkey, M., Chappell, R. J., Silver, A. J., Adams, D., Castellano, C. A., Schneider, R. K., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan8292 · Cited by 481 · see citing works

Neutrophil Extracellular Traps Participate in Cardiovascular Diseases

Döring, Y., Libby, P., & Soehnlein, O. (2020) · Circulation Research · doi:10.1161/circresaha.120.315931 · Cited by 415 · see citing works

Neutrophil Extracellular Traps

Thålin, C., Hisada, Y., Lundström, S., Mackman, N., & Wallén, H. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312463 · Cited by 408 · see citing works

Neutrophil extracellular traps: from physiology to pathology

Hidalgo, A., Libby, P., Soehnlein, O., Aramburu, I. V., Papayannopoulos, V., & Silvestre-Roig, C. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab329 · Cited by 404 · see citing works

NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps

Adrover, J. M., McDowell, S. A. C., He, X., Quail, D. F., & Egeblad, M. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.001 · Cited by 349 · see citing works

Patients with COVID-19: in the dark-NETs of neutrophils

Ackermann, M., Anders, H., Bilyy, R. O., Bowlin, G. L., Daniel, C., LORENZO, R. D., Egeblad, M., Henneck, T., Hidalgo, A., Hoffmann, M. H., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00805-z · Cited by 307 · see citing works

The role of leukocytes in thrombosis

Swystun, L. L., & Liaw, P. C. (2016) · Blood · doi:10.1182/blood-2016-05-718114 · Cited by 301 · see citing works

Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses

Fousert, E., Toes, R. E. M., & Desai, J. (2020) · Cells · doi:10.3390/cells9040915 · Cited by 286 · see citing works

Neutrophil extracellular traps in cancer

Cristinziano, L., Modestino, L., Antonelli, A., Marone, G., Simon, H., Varricchi, G., & Galdiero, M. R. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.011 · Cited by 247 · see citing works

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

Hilscher, M. B., Sehrawat, T., Arab, J. P., Zeng, Z., Gao, J., Liu, M., Kostallari, E., Gao, Y., Simonetto, D. A., Yaqoob, U., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.03.013 · Cited by 240 · see citing works

A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination

Konig, M. F., & Andrade, F. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00461 · Cited by 240 · see citing works

The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens

Ulfig, A., & Leichert, L. I. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03591-y · Cited by 239 · see citing works

The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis

Kimball, A., Obi, A. T., Diaz, J. A., & Henke, P. K. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00236 · Cited by 237 · see citing works

Neutrophil Extracellular Traps and Their Implications in Cardiovascular and Inflammatory Disease

Klopf, J., Brostjan, C., Eilenberg, W. H., & Neumayer, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020559 · Cited by 237 · see citing works

The role of neutrophil extracellular traps in rheumatic diseases

Apel, F., Zychlinsky, A., & Kenny, E. F. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0039-z · Cited by 233 · see citing works

The role of neutrophil extracellular traps in acute lung injury

Scozzi, D., Liao, F., Krupnick, A. S., Kreisel, D., & Gelman, A. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.953195 · Cited by 220 · see citing works

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

Wilk, A. J., Lee, M. J., Wei, B., Parks, B. E., Pi, R., Martínez-Colón, G. J., Ranganath, T., Zhao, N. Q., Taylor, S., Becker, W. R., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210582 · Cited by 208 · see citing works

The role of neutrophils in host defense and disease

Lehman, H. K., & Segal, B. H. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.02.038 · Cited by 218 · see citing works

In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review

Hoppenbrouwers, T., Autar, A. S. A., Sultan, A. R., Abraham, T. E., van Cappellen, W. A., Houtsmuller, A. B., van Wamel, W. J. B., van Beusekom, H. M. M., van Neck, J. W., & de Maat, M. P. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176472 · Cited by 206 · see citing works

Caught in a Trap? Proteomic Analysis of Neutrophil Extracellular Traps in Rheumatoid Arthritis and Systemic Lupus Erythematosus

Chapman, E. A., Lyon, M., Simpson, D. M., Mason, D. Y., Beynon, R. J., Moots, R. J., & Wright, H. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00423 · Cited by 205 · see citing works

Neutrophil extracellular traps: protagonists of cancer progression?

Erpenbeck, L., & Schön, M. P. (2017) · Oncogene · doi:10.1038/onc.2016.406 · Cited by 199 · see citing works

Extracellular DNA NET-Works With Dire Consequences for Health

Sorvillo, N., Cherpokova, D., Martinod, K., & Wagner, D. D. (2019) · Circulation Research · doi:10.1161/circresaha.119.314581 · Cited by 196 · see citing works

Neutrophil Extracellular Traps in Host DefensePreprint

Burgener, S. S., & Schroder, K. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037028 · Cited by 193 · see citing works

Platelets: New Bricks in the Building of Neutrophil Extracellular Traps

Carestia, A., Kaufman, T., & Schattner, M. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00271 · Cited by 183 · see citing works

Roles of neutrophil granule proteins in orchestrating inflammation and immunity

Othman, A., Sekheri, M., & Filep, J. G. (2021) · FEBS Journal · doi:10.1111/febs.15803 · Cited by 184 · see citing works

Neutrophils: back in the thrombosis spotlight

Noubouossie, D. F., Reeves, B., Strahl, B. D., & Key, N. S. (2019) · Blood · doi:10.1182/blood-2018-10-862243 · Cited by 177 · see citing works

The pathway of neutrophil extracellular traps towards atherosclerosis and thrombosis

Moschonas, I. C., & Tselepis, A. D. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.06.919 · Cited by 165 · see citing works

Untangling “NETosis” from NETs

Yousefi, S., Stojkov, D., Germič, N., Simon, D., Wang, X., Benarafa, C., & Simon, H. (2019) · European Journal of Immunology · doi:10.1002/eji.201747053 · Cited by 160 · see citing works

Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA

Dyer, M., Chen, Q., Haldeman, S., Yazdani, H. O., Hoffman, R. A., Loughran, P., Tsung, A., Zuckerbraun, B. S., Simmons, R. L., & Neal, M. D. (2018) · Scientific Reports · doi:10.1038/s41598-018-20479-x · Cited by 162 · see citing works

Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging

Wong, S. L., & Wagner, D. D. (2018) · The FASEB Journal · doi:10.1096/fj.201800691r · Cited by 145 · see citing works

Propagation of thrombosis by neutrophils and extracellular nucleosome networks

Pfeiler, S., Stark, K., Maßberg, S., & Engelmann, B. (2016) · Haematologica · doi:10.3324/haematol.2016.142471 · Cited by 142 · see citing works

Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation

Yan, H., Zhou, H., Akk, A. M., Hu, Y., Springer, L. E., Ennis, T. L., & Pham, C. T. N. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307786 · Cited by 137 · see citing works

Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis

Liu, Y., Carmona‐Rivera, C., Moore, E., Seto, N. L., Knight, J. S., Pryor, M., Yang, Z., Hemmers, S., Remaley, A. T., Mowen, K. A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01680 · Cited by 122 · see citing works

The neutrophil: constant defender and first responder

Fine, N., Tasevski, N., McCulloch, C. A., Tenenbaum, H. C., & Glogauer, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.571085 · Cited by 115 · see citing works

Progression of Cystic Fibrosis Lung Disease from Childhood to Adulthood: Neutrophils, Neutrophil Extracellular Trap (NET) Formation, and NET Degradation

Khan, M. A., Ali, Z. S., Sweezey, N., Grasemann, H., & Palaniyar, N. (2019) · Genes · doi:10.3390/genes10030183 · Cited by 113 · see citing works

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense during Klebsiella pneumoniae–Induced Pneumonia-Derived Sepsis

Claushuis, T. A. M., van der Donk, L. E. H., Luitse, A. L., van Veen, H. A., van der Wel, N. N., van Vught, L. A., Roelofs, J. J. T. H., de Boer, O. J., Lankelma, J. M., Boon, L., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800314 · Cited by 110 · see citing works

Nuclear envelope rupture and NET formation is driven by PKCα‐mediated lamin B disassembly

Li, Y., Li, M., Weigel, B., Mall, M., Werth, V. P., & Liu, M. (2020) · EMBO Reports · doi:10.15252/embr.201948779 · Cited by 106 · see citing works

Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

Yao, M., Ma, J., Wu, D.-W., Fang, C., Wang, Z.-L., Guo, T., & Mo, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1198952 · Cited by 89 · see citing works

NETosis: At the crossroads of rheumatoid arthritis, lupus, and vasculitis

Berthelot, J., Goff, B. L., Néel, A., Maugars, Y., & Hamidou, M. A. (2016) · Joint Bone Spine · doi:10.1016/j.jbspin.2016.05.013 · Cited by 95 · see citing works

Neutrophil Extracellular Traps Tied to Rheumatoid Arthritis: Points to Ponder

Song, W., Ye, J., Pan, N., Tan, C., & i, M. H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.578129 · Cited by 90 · see citing works

The Fatal Circle of NETs and NET-Associated DAMPs Contributing to Organ Dysfunction

Block, H., Rossaint, J., & Zarbock, A. (2022) · Cells · doi:10.3390/cells11121919 · Cited by 90 · see citing works

P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals

Sil, P., Hayes, C. P., Reaves, B. J., Breen, P., Quinn, S. P., Sokolove, J. B., & Rada, B. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600766 · Cited by 87 · see citing works

The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

Bennett, J. A., Mastrangelo, M. A., Ture, S. K., Smith, C. O., Loelius, S. G., Berg, R. A., Shi, X. D., Burke, R. M., Spinelli, S. L., Cameron, S. J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17254-w · Cited by 87 · see citing works

Substrate stiffness induces neutrophil extracellular trap (NET) formation through focal adhesion kinase activation

Abaricia, J. O., Shah, A. H., & Olivares‐Navarrete, R. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120715 · Cited by 86 · see citing works

Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil extracellular traps

Kwak, S.-B., Kim, S. J., Kim, J., Kang, Y.-L., Ko, C. W., Kim, I., & Park, J. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00784-2 · Cited by 85 · see citing works

Age is the work of art? Impact of neutrophil and organism age on neutrophil extracellular trap formation

Ortmann, W., & Kolaczkowska, E. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2751-4 · Cited by 80 · see citing works

Neutrophil Extracellular Traps: A Potential Therapeutic Target in MPO-ANCA Associated Vasculitis?

O’Sullivan, K. M., & Holdsworth, S. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.635188 · Cited by 76 · see citing works

Neutrophil‐mediated vascular barrier injury: Role of neutrophil extracellular traps

Meegan, J. E., Yang, X., Coleman, D. C., Jannaway, M., & Yuan, S. Y. (2017) · Microcirculation · doi:10.1111/micc.12352 · Cited by 81 · see citing works

Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin‐2 and neutrophil extracellular traps

Li, H., Feng, D., Cai, Y., Liu, Y., Xu, M., Xiang, X., Zhou, Z., Xia, Q., Kaplan, M. J., Kong, X., et al. (2018) · Hepatology · doi:10.1002/hep.29919 · Cited by 77 · see citing works

Inhibitors of Serine Proteases in Regulating the Production and Function of Neutrophil Extracellular Traps

Majewski, P., Majchrzak-Gorecka, M., Grygier, B., Skrzeczyńska-Moncznik, J., Osiecka, O., & Cichy, J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00261 · Cited by 77 · see citing works

Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio as Risk Factors for Venous Thrombosis

Artoni, A., Abbattista, M., Bucciarelli, P., Gianniello, F., Scalambrino, E., Pappalardo, E. M., Peyvandi, F., & Martinelli, I. (2017) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029617733039 · Cited by 70 · see citing works

NETosis – Does It Really Represent Nature’s “Suicide Bomber”?

Yousefi, S., & Simon, H. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00328 · Cited by 68 · see citing works

Neutrophil extracellular traps: The core player in vascular complications of diabetes mellitus

Berezin, A. Е. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.07.010 · Cited by 68 · see citing works

Neutrophils as effectors of vascular inflammation

Gómez‐Moreno, D., Adrover, J. M., & Hidalgo, A. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12940 · Cited by 66 · see citing works

CRISPR/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients

Nasri, M., Ritter, M. U., Mir, P., Dannenmann, B., Aghaallaei, N., Amend, D., Makaryan, V., Xu, Y., Fletcher, B., Bernhard, R., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.221804 · Cited by 63 · see citing works

Recent progress in the mechanistic understanding of NET formation in neutrophils

Liu, M., Lyu, X., & Werth, V. P. (2021) · FEBS Journal · doi:10.1111/febs.16036 · Cited by 67 · see citing works

Cross talk between intracellular pathogens and cell death

Demarco, B., Chen, K. W., & Brož, P. (2020) · Immunological Reviews · doi:10.1111/imr.12892 · Cited by 60 · see citing works

Pioneer neutrophils release chromatin within in vivo swarms

Isles, H. M., Loynes, C. A., Alasmari, S., Kon, F. C., Henry, K. M., Kadochnikova, A., Hales, J., Muir, C. F., Keightley, M.-C., Kadirkamanathan, V., et al. (2021) · eLife · doi:10.7554/elife.68755 · Cited by 63 · see citing works

On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little

Santocki, M., & Kołaczkowska, E. (2020) · Cells · doi:10.3390/cells9092079 · Cited by 63 · see citing works

Neutral serine proteases of neutrophils

Kettritz, R. (2016) · Immunological Reviews · doi:10.1111/imr.12441 · Cited by 63 · see citing works

A Narrative Review: The Role of NETs in Acute Respiratory Distress Syndrome/Acute Lung Injury

Zhou, X., Jin, J., Lv, T., & Song, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031464 · Cited by 62 · see citing works

Networks that stop the flow: A fresh look at fibrin and neutrophil extracellular traps

Varjú, I., & Kolev, K. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.08.003 · Cited by 57 · see citing works

Platelet–Neutrophil Crosstalk in Thrombosis

Mereweather, L. J., Constantinescu‐Bercu, A., Crawley, J. T. B., & Salles‐Crawley, I. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021266 · Cited by 58 · see citing works

NEC is likely a NETs dependent process and markers of NETosis are predictive of NEC in mice and humans

Vincent, D., Klinke, M., Eschenburg, G., Trochimiuk, M., Appl, B., Tiemann, B., Bergholz, R., Reinshagen, K., & Boettcher, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-31087-0 · Cited by 52 · see citing works

Novel mechanisms of thrombo-inflammation during infection: spotlight on neutrophil extracellular trap-mediated platelet activation

Colicchia, M., Perrella, G., Gant, P., & Rayes, J. (2023) · Research and Practice in Thrombosis and Haemostasis · doi:10.1016/j.rpth.2023.100116 · Cited by 52 · see citing works

Small but mighty: Platelets as central effectors of host defense

Ishikawa-Ankerhold, H. C., Steffen, M., Stocker, T. J., & Schulz, C. (2017) · Thrombosis and Haemostasis · doi:10.1160/th16-12-0921 · Cited by 51 · see citing works

IL-17A promotes the formation of deep vein thrombosis in a mouse model

Ding, P., Zhang, S., Yu, M., Feng, Y., Long, Q., Yang, H., Li, J., & Wang, M. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.02.006 · Cited by 52 · see citing works

Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation

Tokuhiro, T., Akane, I., Sato, H., Takita, S., Yoshikawa, A., Anzai, R., Sato, S., Aoyagi, R., Arita, M., Shibuya, T., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.718586 · Cited by 48 · see citing works

Antibody-modified DNase I micelles specifically recognize the neutrophil extracellular traps (NETs) and promote their degradation

Filipczak, N., Li, X., Saawant, G. R., Yalamarty, S. S. K., Luther, E., & Torchilin, V. P. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.062 · Cited by 48 · see citing works

Neutrophil Elastase Defects in Congenital Neutropenia

Rydzyńska, Z., Pawlik, B., Krzyżanowski, D., Mlynarski, W. M., & Madzio, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.653932 · Cited by 48 · see citing works

A Fragile Balance: Does Neutrophil Extracellular Trap Formation Drive Pulmonary Disease Progression?

Block, H., & Zarbock, A. (2021) · Cells · doi:10.3390/cells10081932 · Cited by 46 · see citing works

CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia

Tran, N. T., Graf, R., Wulf-Goldenberg, A., Stecklum, M., Strauß, G., Kühn, R., Kocks, C., Rajewsky, K., & Chu, V. T. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.08.004 · Cited by 46 · see citing works

The emerging role of neutrophilic extracellular traps in intestinal disease

Chen, F., Liu, Y., Shi, Y., Zhang, J., Liu, X., Liu, Z., Lv, J., & Leng, Y. (2022) · Gut Pathogens · doi:10.1186/s13099-022-00497-x · Cited by 47 · see citing works

Itaconate Suppresses Formation of Neutrophil Extracellular Traps (NETs): Involvement of Hypoxia-Inducible Factor 1α (Hif-1α) and Heme Oxygenase (HO-1)

Burczyk, G., Cichoń, I., & Kołaczkowska, E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.864638 · Cited by 44 · see citing works

Clinical significance of neutrophil extracellular traps biomarkers in thrombosis

Xu, X., Wu, Y., Xu, S., Yin, Y., Ageno, W., Stefano, V. D., Zhao, Q., & Qi, X. (2022) · Thrombosis Journal · doi:10.1186/s12959-022-00421-y · Cited by 45 · see citing works

Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension

Taylor, S., Isobe, S., Cao, A., Contrepois, K., Benayoun, B. A., Jiang, L., Wang, L., Melemenidis, S., Ozen, M. O., Otsuki, S., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202102-0446oc · Cited by 43 · see citing works

Significance of Mast Cell Formed Extracellular Traps in Microbial Defense

Komi, D. E. A., & Kuebler, W. M. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08861-6 · Cited by 42 · see citing works

Neutrophil extracellular traps participate in the development of cancer-associated thrombosis in patients with gastric cancer

Li, J., Zou, X., Yang, S., Jin, J., Zhu, L., Li, C., Yang, H., Zhang, A.-G., Zhao, T.-Q., & Chen, C. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i26.3132 · Cited by 41 · see citing works

Microbes and the fate of neutrophils

Kobayashi, S. D., DeLeo, F. R., & Quinn, M. T. (2022) · Immunological Reviews · doi:10.1111/imr.13163 · Cited by 43 · see citing works

Role of Neutrophils and NETs in Animal Models of Thrombosis

Carminita, E., Crescence, L., Panicot‐Dubois, L., & Dubois, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031411 · Cited by 39 · see citing works

Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation

Agarwal, S., Loder, S. J., Cholok, D. J., Li, J., Bian, G., Yalavarthi, S., Li, S., Carson, W. F., Hwang, C. D., Marini, S., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02148 · Cited by 37 · see citing works

Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype

Akk, A. M., Springer, L. E., & Pham, C. T. N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00325 · Cited by 37 · see citing works

Targeting neutrophil extracellular traps in severe acute pancreatitis treatment

Hu, J., Kang, H., Chen, H., Yao, J., Yi, X.-L., Tang, W., & Wan, M. (2020) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284820974913 · Cited by 37 · see citing works

Neutrophil extracellular traps in dermatology: Caught in the NET

Hoffmann, J. H. O., & Enk, A. (2016) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2016.07.001 · Cited by 37 · see citing works

NETs Are Double-Edged Swords with the Potential to Aggravate or Resolve Periodontal Inflammation

Vitkov, L., Minnich, B., Knopf, J., Schauer, C., Hannig, M., & i, M. H. (2020) · Cells · doi:10.3390/cells9122614 · Cited by 36 · see citing works

NLRP3-Induced NETosis: A Potential Therapeutic Target for Ischemic Thrombotic Diseases?

Kumar, R. K., Patil, G., & Dayal, S. (2023) · Cells · doi:10.3390/cells12232709 · Cited by 35 · see citing works

Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential

Li, C., Wu, C., Li, F., Xu, W., Zhang, X., Huang, Y., & Xia, D. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s460333 · Cited by 33 · see citing works

Effect of Pressure-Controlled Ventilation-Volume Guaranteed on One-Lung Ventilation in Elderly Patients Undergoing Thoracotomy

Yao, W., Yang, M., Cheng, Q., Shan, S., Yang, B., Han, Q., & Ma, J. (2020) · Medical Science Monitor · doi:10.12659/msm.921417 · Cited by 32 · see citing works

Role of Neutrophils on the Ocular Surface

Mun, Y., Hwang, J. S., & Shin, Y. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910386 · Cited by 33 · see citing works

Tissue factor: a neglected role in cancer biology

Li, H., Yu, Y., Gao, L., Peng, Z., Liu, X., & Chen, H. H. (2022) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-022-02662-0 · Cited by 32 · see citing works

Exploring the involvement of serine proteases in neutrophil extracellular traps: a review of mechanisms and implications

Korba-Mikołajczyk, A., Służalska, K. D., & Kasperkiewicz, P. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07857-w · Cited by 34 · see citing works

Cytonemes Versus Neutrophil Extracellular Traps in the Fight of Neutrophils with Microbes

Galkina, S. I., Fedorova, N. V., Golenkina, E. A., Stadnichuk, V. I., & Sud’ina, G. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020586 · Cited by 31 · see citing works

Exogenous hydrogen sulfide protects from endothelial cell damage, platelet activation, and neutrophils extracellular traps formation in hyperhomocysteinemia rats

Zhao, Z., Liu, X., Shi, S., Hong, L., Gao, F., Zhong, X., & Wang, Y. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.07.007 · Cited by 30 · see citing works

A vein wall cell atlas of murine venous thrombosis determined by single-cell RNA sequencing

DeRoo, E., Zhou, T., Yang, H. M., Stranz, A., Henke, P. K., & Liu, B. (2023) · Communications Biology · doi:10.1038/s42003-023-04492-z · Cited by 30 · see citing works

Fibrin Modulates Shear-Induced NETosis in Sterile Occlusive Thrombi Formed under Haemodynamic Flow

Yu, X., & Diamond, S. L. (2019) · Thrombosis and Haemostasis · doi:10.1055/s-0039-1678529 · Cited by 30 · see citing works

NETosis in ischemic/reperfusion injuries: An organ-based review

Hashemi, P., Nouri‐Vaskeh, M., Alizadeh, L., Baghbanzadeh, A., Badalzadeh, R., Askari, E., & Baradaran, B. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120158 · Cited by 29 · see citing works

Neutrophil extracellular traps in thrombosis and inflammation

Martinod, K. (2014) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Abstract 54: Peptidylarginine Deiminase 4-dependent Generation of Neutrophil Extracellular Traps is Crucial for Deep Vein Thrombosis in Mice

Martinod, K., Demers, M., Fuchs, T. A., Wong, S. L., Brill, A. G., Gallant, M., Wang, Y., & Wagner, D. D. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.33.suppl_1.a54

Abstract 17883: Neutrophil Extracellular Traps as an Interface Between Inflammation and Thrombosis in DVT

Stark, K., von Brühl, M.-L., Steinhart, A., Chandraratne, S., Köllnberger, M., Lorenz, M., Pfeiler, S., Manukyan, D., Bergmeier, W., Wagner, D. D., et al. (2011) · Circulation · doi:10.1161/circ.124.suppl_21.a17883

Neutrophil extracellular traps promote deep vein thrombosis in mice

Brill, A. G., Fuchs, T. A., Savchenko, A. S., Thomas, G. M., Martinod, K., Meyer, S. F. D., Bhandari, A. A., & Wagner, D. D. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04544.x · Cited by 900 · see citing works

Thrombosis: tangled up in NETs

Martinod, K., & Wagner, D. D. (2013) · Blood · doi:10.1182/blood-2013-10-463646 · Cited by 875 · see citing works