Schneider, Rebekka K.

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell

Mesenchymal stem cell researchLiver physiology and pathology

Cited by 922

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

Krönke, J., Fink, E. C., Hollenbach, P. W., MacBeth, K. J., Hurst, S. N., Udeshi, N. D., Chamberlain, P. P., Mani, D. R., Man, H. W., Gandhi, A. K., et al. (2015) · Nature

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 863

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

Kowalczyk, M. S., Tirosh, I., Heckl, D., Rao, T. N., Dixit, A., Haas, B. J., Schneider, R. K., Wagers, A. J., Ebert, B. L., & Regev, A. (2015) · Genome Research

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomics

Cited by 778

Spatial multi-omic map of human myocardial infarction

Kuppe, C., Ramirez Flores, R. O., Li, Z., Hayat, S., Levinson, R. T., Liao, X., Hannani, M. T., Tanevski, J., Wünnemann, F., Nagai, J. S., et al. (2022) · Nature

Single-cell and spatial transcriptomicsCongenital heart defects research

Cited by 772

Decoding myofibroblast origins in human kidney fibrosis

Kuppe, C., Ibrahim, M. M., Kranz, J., Zhang, X., Ziegler, S., Perales-Patón, J., Jansen, J., Reimer, K. C., Smith, J. R., Dobie, R., et al. (2021) · Nature

Chronic Kidney Disease and DiabetesAcute Kidney Injury Research

Cited by 769

( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Losman, J.-A., Looper, R. E., Koivunen, P., Lee, S., Schneider, R. K., McMahon, C., Cowley, G. S., Root, D. E., Ebert, B. L., & Kaelin, W. G. (2013) · Science

Acute Myeloid Leukemia ResearchCancer, Hypoxia, and Metabolism

Cited by 703

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

Wolach, O., Sellar, R. S., Martinod, K., Cherpokova, D., McConkey, M., Chappell, R. J., Silver, A. J., Adams, D., Castellano, C. A., Schneider, R. K., et al. (2018) · Science Translational Medicine

Myeloproliferative Neoplasms: Diagnosis and TreatmentNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 481

Mesenchymal stem cells in fibrotic disease

El Agha, E., Kramann, R., Schneider, R. K., Li, X., Seeger, W., Humphreys, B. D., & Bellusci, S. (2017) · Cell stem cell

Mesenchymal stem cell researchTGF-β signaling in diseases

Cited by 430

Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation

Obeng, E. A., Chappell, R. J., Seiler, M., Chen, M. C., Campagna, D. R., Schmidt, P. J., Schneider, R. K., Lord, A. M., Wang, L., Gambe, R. G., et al. (2016) · Cancer Cell

RNA Research and SplicingAcute Myeloid Leukemia Research

Cited by 380

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation

Elf, S., Abdelfattah, N. S., Chen, E., Perales-Patón, J., Rosen, E. A., Ko, A., Peisker, F., Florescu, N., Giannini, S., Wolach, O., et al. (2016) · Cancer Discovery

Myeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia Research

Cited by 293

Core circadian clock genes regulate leukemia stem cells in AML

Puram, R. V., Kowalczyk, M. S., de Boer, C. G., Schneider, R. K., Miller, P. G., McConkey, M., Tothova, Z., Tejero, H., Heckl, D., Järås, M., et al. (2016) · Cell

Circadian rhythm and melatoninAcute Myeloid Leukemia Research

Cited by 274

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Jansen, J., Reimer, K. C., Nagai, J. S., Varghese, F. S., Overheul, G. J., de Beer, M., Roverts, R., Daviran, D., Fermin, L. A. S., Willemsen, B., et al. (2022) · Cell Stem Cell

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 259

Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS

Schneider, R. K., Ademà, V., Heckl, D., Järås, M., Mallo, M., Lord, A. M., Chu, L. P., McConkey, M. E., Kramann, R., Mullally, A., et al. (2014) · Cancer Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 188

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia

Järås, M., Miller, P. G., Chu, L. P., Puram, R. V., Fink, E. C., Schneider, R. K., Al-Shahrour, F., Peña, P., Breyfogle, L. J., Hartwell, K. A., et al. (2014) · Journal of Experimental Medicine

Acute Myeloid Leukemia ResearchCancer-related Molecular Pathways

Cited by 92

Inflammatory bone marrow microenvironment

Leimkühler, N. B., & Schneider, R. K. (2019) · Hematology

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 82

The identification of fibrosis-driving myofibroblast precursors reveals new therapeutic avenues in myelofibrosis

Kramann, R., & Schneider, R. K. (2018) · Blood

Myeloproliferative Neoplasms: Diagnosis and TreatmentAcute Myeloid Leukemia Research

Cited by 62

Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

Ribezzo, F., Snoeren, I. A. M., Ziegler, S., Stoelben, J., Olofsen, P. A., Henic, A., Ferreira, M. V., Chen, S., Stalmann, U. S. A., Buesche, G., et al. (2019) · Leukemia

Acute Myeloid Leukemia ResearchBlood disorders and treatments

Cited by 51

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target

Schneider, R. K., Mullally, A., Dugourd, A., Peisker, F., Hoogenboezem, R., Van Strien, P. M. H., Bindels, E. M., Heckl, D., Büsche, G., Fleck, D., et al. (2018) · Cell Stem Cell

Myeloproliferative Neoplasms: Diagnosis and TreatmentMesenchymal stem cell research

Cited by 34

Understanding deregulated cellular and molecular dynamics in the haematopoietic stem cell niche to develop novel therapeutics for bone marrow fibrosis

Gleitz, H. F., Kramann, R., & Schneider, R. K. (2018) · The Journal of Pathology

Myeloproliferative Neoplasms: Diagnosis and TreatmentHematopoietic Stem Cell Transplantation

Cited by 23