Cited by 121Osteoarthritis Treatment and MechanismsTissue Engineering and Regenerative MedicineKnee injuries and reconstruction techniques

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Orchestrated biomechanical, structural, and biochemical stimuli for engineering anisotropic meniscus

Zhang, Zheng-Zheng, Chen, You-Rong, Wang, Shao-Jie, Zhao, Feng, Wang, Xiao-Gang, Yang, Fei, Shi, Jin-Jun, Ge, Zi-Gang, Ding, Wen-Yu, Yang, Yu-Chen, Zou, Tong-Qiang, Zhang, Ji-Ying, Yu, Jia-Kuo, Jiang, Dong·2019·Science Translational Medicine

DOI 10.1126/scitranslmed.aao0750

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Abstract

Anisotropic meniscus engineered using biomechanical, biochemical, and structural cues demonstrates long-term knee chondroprotection in rabbits.

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Organoids
Zhao, Z., Chen, X., Dowbaj, A. M., Sljukic, A., Bratlie, K., Lin, L., Fong, E. L. S., Balachander, G. M., Chen, Z., Soragni, A., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00174-y · Cited by 1,082

See all 121

Authors: Zhang, Z.-Z., Chen, Y.-R., Wang, S.-J., Zhao, F., Wang, X.-G., Yang, F., Shi, J.-J., Ge, Z.-G., Ding, W.-Y., Yang, Y.-C., Zou, T.-Q., Zhang, J.-Y., Yu, J.-K., & Jiang, D.
Affiliations: Knee Surgery Department of the Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing 100191, P.R. China.
Peking University Third Hospital (CN)
Beihang University (CN)
Chinese Academy of Sciences (CN)
Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, P.R. China.
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, P.R. China.
Corresponding author: Yu, Jia-Kuo
Jiang, Dong
ORCID: Zhang, Zheng-Zheng
Chen, You-Rong
Wang, Shao-Jie
Zhao, Feng
Yang, Fei
Shi, Jin-Jun
Ge, Zi-Gang
Zou, Tong-Qiang
Yu, Jia-Kuo
Jiang, Dong
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-04-10
Volume: 11
Issue: 487
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aao0750
OpenAlex: W2940173861
Cited by: 121
References: 53
Citations by year: 2026: 12 · 2025: 13 · 2024: 21 · 2023: 21 · 2022: 19 · 2021: 18 · 2020: 11 · 2019: 6
FWCI: 10.24
Type: journal article
Language: en
Open access: closed
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
Keywords: meniscus tissue engineering, meniscus reconstruction, mesenchymal stem cells, type I collagen, type II collagen, growth factors, biomimetic scaffolds, rabbit model
MeSH terms: Meniscus, Animals, Biomechanical Phenomena, Cartilage, Cell Differentiation, Gene Expression Regulation, Joints, Male, Rabbits, Regeneration, Anisotropy, Chondrocytes, Finite Element Analysis, Tissue Engineering, Tissue Scaffolds

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Orchestrated biomechanical, structural, and biochemical stimuli for engineering anisotropic meniscus

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