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Big data and black-box medical algorithms
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New machine-learning techniques entering medicine present challenges in validation, regulation, and integration into practice.
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“For example, the kernels or intermediate features of a trained neural network may shed light on the learned structure in different layers of the network, giving rise to methods like class activation mapping (CAM).67”
From Addressing bias in big data and AI for health care: A call for open science (2021) · cites this paper as [67]
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“We propose that another important barrier to adoption of medical AI is its perceived opacity, that it is a 'black box' 13,14 .”
From Understanding, explaining, and utilizing medical artificial intelligence (2021) · cites this paper as [13]
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Metadata
- Authors
- Price, W. N.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Price, W. Nicholson
- ORCID
- Price, W. Nicholson
- Venue
- Science Translational Medicine
- Published
- 2018-12-12
- Volume
- 10
- Issue
- 471
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6345162
- OpenAlex
- W2905322176
- Cited by
- 254
- References
- 12
- Citations by year
- 2026: 30 · 2025: 36 · 2024: 46 · 2023: 29 · 2022: 38 · 2021: 46 · 2020: 17 · 2019: 12
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (1-R01-CA-214829-01-A1)
- Novo Nordisk Fonden (NNF17SA0027784)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Physical Sciences › Computer Science › Artificial Intelligence › Explainable Artificial Intelligence (XAI)
- Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
- Keywords
- big data, black-box algorithms, machine learning in medicine, algorithm validation, integration into clinical practice, algorithmic transparency
- MeSH terms
- Machine Learning, Big Data, Algorithms, Social Control, Formal, Reproducibility of Results
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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