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Cited by 131Cancer Immunotherapy and BiomarkersImmune cells in cancerImmunotherapy and Immune Responses

A biologic scaffold–associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy

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Wolf, Matthew T., Ganguly, Sudipto, Wang, Tony L., Anderson, Christopher W., Sadtler, Kaitlyn, Narain, Radhika, Cherry, Christopher, Parrillo, Alexis J. +6 more·2019·Science Translational Medicine
DOI 10.1126/scitranslmed.aat7973PMC PMC7254933
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Abstract

Biologic scaffolds synergize with immune checkpoint blockade to inhibit tumor growth in mice in a process requiring T cells and macrophages.

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Crossref · 10.1126/scitranslmed.aat7973

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  • ECM bioscaffold immune regulation is not only at the local level but also systemic.

    “research indicates that this immune regulation is not only at the local level, but also systemic, as suggested in studies with decellularized tissues [57,58], or MBV [76,168,197]”

    From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [58]

    The Discussion says the experiments examined the acute local immune response and that further investigation is needed to determine whether biologic scaffold implantation has systemic effects. Although the Results report IL-4 expression in draining lymph-node T cells, the paper does not present systemic immune regulation as an established finding. (LLM, conf=0.88)

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  • Wolf et al. reported M2-biased microenvironment created by ECM materials showed tumor-suppressive effects because phenotypes of M2 macrophages in dECM niche were distinct from traditional M2 macrophages.

    “Nonetheless, Wolf et al. reported that M2-biased microenvironment created by ECM materials showed tumor-suppressive effects because the phenotypes of M2 macrophages in the dECM niche were distinct from those of traditional M2 macrophages55.”

    From Bioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation (2023) · cites this paper as [55]

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Research works printed but not linked: 30

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Cited by

Sorted by citations

Authors
Wolf, M. T., Ganguly, S., Wang, T. L., Anderson, C. W., Sadtler, K., Narain, R., Cherry, C., Parrillo, A. J., Park, B. V., Wang, G., Pan, F., Sukumar, S., Pardoll, D. M., & Elisseeff, J. H.
Affiliations
  • Johns Hopkins University (US)
  • Yale University (US)
  • Boston Children's Hospital (US)
  • University of Illinois Chicago (US)
Corresponding author
Elisseeff, Jennifer H.
ORCID
Venue
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Published
2019-01-30
Volume
11
Issue
477
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
DOI
10.1126/scitranslmed.aat7973
PMC
PMC7254933
OpenAlex
W2914708864
Cited by
131
References
9
Citations by year
2026: 9 · 2025: 13 · 2024: 16 · 2023: 20 · 2022: 17 · 2021: 26 · 2020: 24 · 2019: 6
FWCI
7.63
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (RO1AI099300, RO1AI089830)
  • U.S. Department of Defense (PC130767, W81XWH-15-1-0017)
  • National Cancer Institute (P30CA006973)
  • Melanoma Research Alliance (Melanoma Research Alliance)
  • The Bloomberg~Kimmel Institute for Cancer Immunotherapy
  • Hartwell Foundation
  • ACell Inc
  • The Fetting Fund for Cancer Prevention Research
Topics
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
tumor microenvironment, Th2 immune response, biological scaffolds, tumor growth inhibition, PD-1/PD-L1 blockade, immunotherapy synergy, Th2 cells, macrophage phenotype, eosinophil infiltration, angiogenic factors, complement system
MeSH terms
Animals, Biocompatible Materials, Urinary Bladder, Extracellular Matrix, Immunotherapy, Inflammation, Lymphocyte Activation, Macrophages, Melanoma, Experimental, Phenotype, Wound Healing, Interleukin-4, Lymphocytes, Tumor-Infiltrating, Cell Polarity, Th2 Cells, Myeloid Cells, Cell Line, Tumor, Cell Proliferation, Mice, Tissue Scaffolds, Tumor Microenvironment, Carcinogenesis

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