Cited by 196Tissue Engineering and Regenerative MedicineBone Tissue Engineering MaterialsHydrogels: synthesis, properties, applications

Extracellular Matrix-Based Biomaterials and Their Influence Upon Cell Behavior

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Cramer, Madeline C., Badylak, Stephen F.·2020·Annals of Biomedical Engineering

Abstract

Biologic scaffold materials composed of allogeneic or xenogeneic extracellular matrix (ECM) are commonly used for the repair and remodeling of injured tissue. The clinical outcomes associated with implantation of ECM-based materials range from unacceptable to excellent. The variable clinical results are largely due to differences in the preparation of the material, including characteristics of the source tissue, the method and efficacy of decellularization, and post-decellularization processing steps. The mechanisms by which ECM scaffolds promote constructive tissue remodeling include mechanical support, degradation and release of bioactive molecules, recruitment and differentiation of endogenous stem/progenitor cells, and modulation of the immune response toward an anti-inflammatory phenotype. The methods of ECM preparation and the impact of these methods on the quality of the final product are described herein. Examples of favorable cellular responses of immune and stem cells associated with constructive tissue remodeling of ECM bioscaffolds are described.

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Crossref · 10.1007/s10439-019-02408-9

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  • In the absence of infection, metabolic disorder, or pharmacological immunosuppression, the immune response to an implanted ECM bioscaffold is primarily determined by the material's biochemical composition, structural integrity, and associated molecular cues.

    “In the absence of infection, metabolic disorder, or pharmacological immunosuppression, the immune response to an implanted ECM bioscaffold is primarily determined by the material's biochemical composition, structural integrity, and associated molecular cues [1,99].”

    From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [1]

    The Favorable Cellular Response and Immune Cells sections (page not provided) link scaffold source, processing, retained structure, and bioactive components to the host immune response. They do not establish that these material properties are the primary determinants specifically in the absence of infection, metabolic disorder, or pharmacological immunosuppression. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • The immunomodulatory properties of ECM bioscaffolds depend on source tissue and decellularization methods.

    “However, the immunomodulatory properties of ECM bioscaffolds are dependent on the source tissue and, critically, on the methods used for decellularization.”
  • ECM bioscaffolds have demonstrated therapeutic potential across clinical and preclinical applications for tissue repair and regeneration.

    “Extracellular matrix (ECM) bioscaffolds have demonstrated therapeutic potential across a variety of clinical and preclinical applications for tissue repair and regeneration.”
  • ECM bioscaffolds and their components can modulate the immune response.

    “In parallel, these scaffolds and their components have shown the capacity to modulate the immune response.”

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Cites

1 retracted

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Research works printed but not linked: 4

  1. [24]Berger A Th1 and Th2 responses: what are they ? BMJ 321: 424, 2000. 10938051 PMC27457
  2. [141]Kramer J Chapter 17: Extracellular Matrix In: C. elegans II, edited by Riddle D, Blumenthal T, and Meyer B. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1997. 21413233
  3. [230]Sikin AM, and Rizvi SSH. Recent. Pat. Food Nutr. Agric, 2011. 21846321
  4. [283]Young DA, Bajaj V, and Christman KL. Decellularized adipose matrix hydrogels stimulate in vivo neovascularization and adipose formation. J. Biomed. Mater. Res. - Part A 102: 1641– 1651, 2014. 24510423

Cited by

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Authors
Cramer, M. C., & Badylak, S. F.
Affiliations
University of Pittsburgh (US)
Corresponding author
Badylak, Stephen F.
Venue
Annals of Biomedical Engineering
Published
2019-11-18
Volume
48
Issue
7
Pages
2132-2153
ISSN
  • 0090-6964 (ISSN-L)
  • 1573-9686
OpenAlex
W2984209949
Cited by
196
References
305
Citations by year
2026: 23 · 2025: 35 · 2024: 33 · 2023: 34 · 2022: 27 · 2021: 29 · 2020: 14 · 2019: 1
FWCI
16.96
Type
journal article
Language
en
Open access
Locations
  • Annals of Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (5T32HL076124-12)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
extracellular matrix scaffolds, decellularization, tissue engineering biomaterials, tissue remodeling, stem cell recruitment, progenitor cell differentiation, immunomodulation, anti-inflammatory phenotype, mechanical support
MeSH terms
Animals, Biocompatible Materials, Cell Differentiation, Extracellular Matrix, Humans, Stem Cells, Tissue Engineering, Tissue Scaffolds

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