Cited by 283Tissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applications3D Printing in Biomedical Research

Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

Open access
Brown, Mika, Li, Jianyu, Moraes, Christopher, Tabrizian, Maryam, Li-Jessen, Nicole Y.K.·2022·Biomaterials

Abstract

Extracellular matrix is rich in biomolecules including structural proteins, glycosaminoglycans, and small molecules that are important for the maintenance and repair of tissue. Decellularized extracellular matrix (dECM) is expected to retain these key biomolecules and makes it a promising biomaterial candidate for regenerative medicine applications. To date, dECM-particle based biomaterials have been developed to engineer over 15 tissue types or organs, with the ultimate goal of mimicking specific biological and physical properties of the native tissue. The most common scaffold types are injectable hydrogels, electrospun scaffolds and bioprinted scaffolds. The purpose of this review paper is to highlight key challenges, fabrication methods and progress made for each tissue type, along with the discussion of other elements that are integral to push dECM biomaterials towards effective and specialized tissue repair.

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Crossref · 10.1016/j.biomaterials.2022.121786

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402 of 402 references verified0 citation errors · 0 not checkable

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Authors
Brown, M., Li, J., Moraes, C., Tabrizian, M., & Li-Jessen, N. Y. K.
Affiliations
McGill University (CA)
Corresponding author
Tabrizian, Maryam
Venue
Biomaterials
Publisher
Elsevier BV
Published
2022-10
Volume
289
Pages
121786
ISSN
0142-9612 (ISSN-L)
OpenAlex
W4294408764
Cited by
282
References
407
Citations by year
2026: 65 · 2025: 90 · 2024: 74 · 2023: 48 · 2022: 5
FWCI
12.89
Type
journal article
Language
en
Open access
Locations
  • Biomaterials (acceptedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • Natural Sciences and Engineering Research Council of Canada (ALLRP 548623-19, RGPIN-2018–03843)
  • Canada Research Chairs
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
decellularized extracellular matrix, tissue engineering scaffolds, regenerative medicine, injectable hydrogel, electrospun scaffolds, biomimetic scaffolds, tissue repair, scaffold fabrication techniques
MeSH terms
Decellularized Extracellular Matrix, Biocompatible Materials, Extracellular Matrix, Glycosaminoglycans, Hydrogels, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds

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