An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse
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CaVβ1E boosts downstream growth differentiation factor 5 signaling to counteract muscle mass loss in denervated or aged mouse muscles.
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BMP signaling converges on Smad4 and controls muscle mass.
“Another pathway that converges on Smad4 and controls muscle mass is BMP signaling19,20.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [20]
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Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
Sartori, R., Romanello, V., & Sandri, M. (2021) · Nature Communications · doi:10.1038/s41467-020-20123-1 · Cited by 940 · see citing works
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- Authors
- Traoré, M., Gentil, C., Benedetto, C., Hogrel, J.-Y., De la Grange, P., Cadot, B., Benkhelifa-Ziyyat, S., Julien, L., Lemaitre, M., Ferry, A., Piétri-Rouxel, F., & Falcone, S.
- Affiliations
- Inovarion (France) (FR)
- Inserm (FR)
- Institut de Myologie (FR)
- GenoSplice, F-75005 Paris, France.
- Sorbonne Université, Centre de Recherche en Myologie, UM76, INSERM U974, Institut de Myologie, F-75013, Paris, France.
- Sorbonne Université, INSERM, UMS28, F-75013 Paris, France.
- Corresponding author
- Traoré, Massiré
- Gentil, Christel
- Falcone, Sestina
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-11-06
- Volume
- 11
- Issue
- 517
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2985330064
- Cited by
- 36
- References
- 52
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 3
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- sarcopenia, muscle denervation, sciatic nerve, excitation-contraction coupling, muscle innervation, muscle aging, muscle atrophy
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Animals, Atrophy, Denervation, Embryo, Mammalian, Exons, Female, Humans, Male, Muscles, Neuromuscular Junction, Organ Size, Physical Conditioning, Animal, RNA Splicing, Signal Transduction, Gene Expression Regulation, Developmental, Protein Isoforms, Calcium Channels, L-Type, Mice, Growth Differentiation Factor 5, Young Adult
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