The exerkine apelin reverses age-associated sarcopenia

Frailty in relation to the accumulation of deficits

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Skeletal muscle fatigue: cellular mechanisms

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The healthcare costs of sarcopenia in the United States

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Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults: The LIFE Study Randomized Clinical Trial

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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

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Welcome to the ICD‐10 code for sarcopenia

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Sarcopenia: alternative definitions and associations with lower extremity function

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Frailty and cognitive impairment—A review of the evidence and causal mechanisms

Robertson, D. A., Savva, G. M., & Kenny, R. A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.06.004 · Cited by 759 · see citing works

Effects of a Physical Activity Intervention on Measures of Physical Performance: Results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study

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p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

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Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice

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Exercise Promotes Healthy Aging of Skeletal Muscle

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Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin

Medhurst, A. D., Jennings, C. A., Robbins, M. J., Davis, R. P., Ellis, C. E., Winborn, K. Y., Lawrie, K. W. M., Hervieu, G. J., Riley, G. J., Bolaky, J. E., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01587.x · Cited by 448 · see citing works

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

Fry, C. S., Lee, J. D., Mula, J., Kirby, T. J., Jackson, J. R., Liu, F., Yang, L., Mendias, C. L., Dupont-Versteegden, E. E., McCarthy, J. J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3710 · Cited by 432 · see citing works

Beneficial health effects of exercise – the role of IL-6 as a myokine

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Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

Sandri, M., Barberi, L., Bijlsma, A. Y., Blaauw, B., Dyar, K. A., Milan, G., Mammucari, C., Meskers, C. G. M., Pallafacchina, G., Paoli, A., et al. (2013) · Biogerontology · doi:10.1007/s10522-013-9432-9 · Cited by 340 · see citing works

Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders

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Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

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Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis

Chun, H. J., Ali, Z. A., Kojima, Y., Kundu, R. K., Sheikh, A. Y., Agrawal, R., Zheng, L., Leeper, N. J., Pearl, N., Patterson, A. J., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34871 · Cited by 329 · see citing works

Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure Overload

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Apelin, diabetes, and obesity

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Apelin is necessary for the maintenance of insulin sensitivity

Yue, P., Jin, H. H., Aillaud, M., Deng, A. C., Azuma, J., Asagami, T., Kundu, R. K., Reaven, G. M., Quertermous, T., & Tsao, P. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00385.2009 · Cited by 277 · see citing works

MAPT STUDY: A MULTIDOMAIN APPROACH FOR PREVENTING ALZHEIMER’S DISEASE: DESIGN AND BASELINE DATA

Vellas, B. J., Guyonnet, S., Touchon, J., DANTOINE, T. F., Dartigues, J., Cufi, M.-N., Bordes, S., Gasnier, Y., Robert, P. H., Bories, L., et al. (2014) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2014.34 · Cited by 257 · see citing works

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension

Yang, P. B., Read, C., Kuc, R. E., Buonincontri, G., Southwood, M. R., Torella, R., Upton, P. D., Crosby, A., Sawiak, S. J., Carpenter, T. A., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.023218 · Cited by 240 · see citing works

Mechanisms of skeletal muscle aging: insights from <i>Drosophila</i> and mammalian models

Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Disease Models &amp; Mechanisms · doi:10.1242/dmm.012559 · Cited by 238 · see citing works

Skeletal muscle aging and the mitochondrion

Johnson, M. L., Robinson, M. M., & Nair, K. S. (2013) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2012.12.003 · Cited by 233 · see citing works

Effect of endurance training on skeletal muscle myokine expression in obese men: Identification of apelin as a novel myokine

Besse-Patin, A., Montastier, E., Vinel, C., Castan-Laurell, I., Louche, K., Dray, C., Daviaud, D., Mir, L., Marques, M.-A., Thalamas, C., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.158 · Cited by 227 · see citing works

[125I]‐(Pyr1)Apelin‐13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man

KATUGAMPOLA, S. D., Maguire, J. J., Matthewson, S. R., & Davenport, A. P. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703939 · Cited by 216 · see citing works

Apelin (65‐77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells

Masri, B., Morin, N., Cornu, M., Knibiehler, B., & Audigier, Y. (2004) · The FASEB Journal · doi:10.1096/fj.04-1930fje · Cited by 211 · see citing works

Relationship Between Frailty and Cognitive Decline in Older Mexican Americans

Samper‐Ternent, R., Snih, S. A., Raji, M. A., Markides, K. S., & Ottenbacher, K. J. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01947.x · Cited by 204 · see citing works

International Union of Basic and Clinical Pharmacology. LXXIV. Apelin Receptor Nomenclature, Distribution, Pharmacology, and Function

Pitkin, S. L., Maguire, J. J., Bonner, T. I., & Davenport, A. P. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002949 · Cited by 198 · see citing works

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

Dray, C., Debard, C., Jager, J., Disse, E., Daviaud, D., Martin, P. G. P., Attané, C., Wanecq, E., Guigné, C., Bost, F., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00598.2009 · Cited by 171 · see citing works

Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ.

Castan‐Laurell, I., Šiklová, M., Daviaud, D., Dray, C., Kováčiková, M., Kováčová, Z., Hejnová, J., Štich, V., & Valet, P. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0039 · Cited by 161 · see citing works

Sarcopenia as a Determinant of Blood Pressure in Older Koreans: Findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008–2010

Han, K., Park, Y., Kwon, H., Ko, S., Lee, S., Yim, H. W., Lee, W.-C., Park, Y. G., Kim, M. K., & Park, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086902 · Cited by 158 · see citing works

Mitochondrial Involvement and Impact in Aging Skeletal Muscle

Hepple, R. T. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00211 · Cited by 155 · see citing works

Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells

García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2013) · The FEBS Journal · doi:10.1111/febs.12221 · Cited by 152 · see citing works

Construction and analysis of compact muscle-specific promoters for AAV vectors

Wang, B., Li, J., Fu, F. H., Chen, C., Zhu, X., Zhou, L., Jiang, X. L., & Xiao, X. (2008) · Gene Therapy · doi:10.1038/gt.2008.104 · Cited by 149 · see citing works

Responsiveness of muscle size and strength to physical training in very elderly people: A systematic review

Stewart, V. H., Saunders, D. H., & Greig, C. A. (2013) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12123 · Cited by 137 · see citing works

Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?

Giannoulis, M. G., Martin, F. C., Nair, K. S., Umpleby, A. M., & Sonksen, P. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1002 · Cited by 132 · see citing works

Emerging Roles of ROS/RNS in Muscle Function and Fatigue

Westerblad, H., & Allen, D. G. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3909 · Cited by 126 · see citing works

Apelin inhibits the proliferation and migration of rat PASMC s via the activation of PI3K/Akt/m TOR signal and the inhibition of autophagy under hypoxia

Zhang, H., Gong, Y., Wang, Z., Jiang, L., Chen, R., Fan, X., Zhu, H.-M., Han, L., Li, X., Xiao, J., et al. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12208 · Cited by 115 · see citing works

Apelin protects myocardial injury induced by isoproterenol in rats

Jia, Y.-X., Pan, C., Zhang, J., Geng, B., Zhao, J., Gerns, H., Yang, J., Chang, J., Tang, C., & Qi, Y.-F. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.09.033 · Cited by 115 · see citing works

Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo

Attané, C., Daviaud, D., Dray, C., Dusaulcy, R., Masseboeuf, M., Prévot, D., Carpéné, C., Castan‐Laurell, I., & Valet, P. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0105 · Cited by 109 · see citing works

The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men

Snijders, T., Verdijk, L. B., Smeets, J. S. J., McKay, B. R., Senden, J. M., Hartgens, F., Parise, G., Greenhaff, P. L., & van Loon, L. J. C. (2014) · AGE · doi:10.1007/s11357-014-9699-z · Cited by 106 · see citing works

Sarcopenia and the Common Mental Disorders: a Potential Regulatory Role of Skeletal Muscle on Brain Function?

Pasco, J. A., Williams, L. J., Jacka, F. N., Stupka, N., Brennan-Olsen, S. L., Holloway‐Kew, K. L., & Berk, M. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0279-7 · Cited by 99 · see citing works

Analysis of Muscle Creatine Kinase Regulatory Elements in Recombinant Adenoviral Vectors

Hauser, M. A., Robinson, A. S., Hartigan-O’Connor, D. J., Williams-Gregory, D., Buskin, J. N., Apone, S., Kirk, C. J., Hardy, S. F., Hauschka, S. D., & Chamberlain, J. S. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0089 · Cited by 99 · see citing works

Myostatin-deficient mice lose more skeletal muscle mass than wild-type controls during hindlimb suspension

McMahon, C. D., Popović, L., Oldham, J. M., Jeanplong, F., Smith, H. K., Kambadur, R., Sharma, M., Maxwell, L., & Bass, J. J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00275.2002 · Cited by 96 · see citing works

Frequency of sarcopenia and associated factors among hospitalized elderly patients

Martinez, B. P., Batista, A. K. M. S., Gomes, I. B., Olivieri, F. M., Camelier, F. W. R., & Camelier, A. A. (2015) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-015-0570-x · Cited by 95 · see citing works

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

Rai, R., Ghosh, A. K., Eren, M., Mackie, A. R., Levine, D. C., Kim, S., Cedernaes, J., Ramirez, V., Procissi, D., Smith, L. H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.057 · Cited by 90 · see citing works

Reduction of Arterial Stiffness by Exercise Training Is Associated with Increasing Plasma Apelin Level in Middle-Aged and Older Adults

Fujie, S. J., Sato, K., Miyamoto‐Mikami, E., Hasegawa, N., Fujita, S., Sanada, K., Hamaoka, T., & Iemitsu, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093545 · Cited by 79 · see citing works

Randomized Controlled Trials Involving Multidisciplinary Interventions in the Community

Pahor, M. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.5.472 · Cited by 73 · see citing works

The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men

Papachristou, E., Ramsay, S. E., LENNON, L. T., Papacosta, O., Iliffe, S., Whincup, P. H., & Wannamethee, S. G. (2015) · BMC Geriatrics · doi:10.1186/s12877-015-0169-y · Cited by 73 · see citing works

Apelin-transgenic mice exhibit a resistance against diet-induced obesity by increasing vascular mass and mitochondrial biogenesis in skeletal muscle

Yamamoto, T., Habata, Y., Matsumoto, Y., Yasuhara, Y., Hashimoto, T., Hamajyo, H., Anayama, H., Fujii, R., Fuse, H., Shintani, Y., et al. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.05.004 · Cited by 66 · see citing works

Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy

Xie, F., Liu, W., Feng, F., Li, X., He, L., Lv, D., Qin, X., Li, L., Li, L., & Chen, L. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv111 · Cited by 66 · see citing works

A single bout of exercise activates skeletal muscle satellite cells during subsequent overnight recovery

Snijders, T., Verdijk, L. B., Beelen, M., McKay, B. R., Parise, G., Kadi, F., & van Loon, L. J. C. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2011.063313 · Cited by 63 · see citing works

Effects of Dietary Eicosapentaenoic Acid (EPA) Supplementation in High-Fat Fed Mice on Lipid Metabolism and Apelin/APJ System in Skeletal Muscle

Bertrand, C., Pignalosa, A., Wanecq, E., Rancoule, C., Batut, A., Deleruyelle, S., Lionetti, L., Valet, P., & Castan‐Laurell, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078874 · Cited by 61 · see citing works

The Intestinal Glucose–Apelin Cycle Controls Carbohydrate Absorption in Mice

Dray, C., Sakar, Y., Vinel, C., Daviaud, D., Masri, B., Garrigues, L., Wanecq, E., Galvani, S., Nègre‐Salvayre, A., Barak, L. S., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.004 · Cited by 60 · see citing works

Effects of aging and gender on muscle mass and regulation of Akt-mTOR-p70s6k related signaling in the F344BN rat model

Paturi, S., Gutta, A. K., Katta, A., Kakarla, S. K., Arvapalli, R. K., Gadde, M. K., Nalabotu, S. K., Rice, K. M., Wu, M., & Blough, E. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.01.008 · Cited by 54 · see citing works

Gαi2 Signaling Is Required for Skeletal Muscle Growth, Regeneration, and Satellite Cell Proliferation and Differentiation

Minetti, G., Feige, J. N., Bombard, F., Heier, A., Morvan, F., Nürnberg, B., Leiss, V., Birnbaumer, L., Glass, D. J., & Fornaro, M. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00957-13 · Cited by 48 · see citing works

Fast-twitch glycolytic skeletal muscle is predisposed to age-induced impairments in mitochondrial function.

Jacobs, R., Díaz, V., Soldini, L., Haider, T., Thomassen, M., Nordsborg, N., Gassmann, M., & Lundby, C. (2013) · The journals of gerontology. Series A, Biological sciences and medical sciences · doi:10.1093/gerona/gls335 · Cited by 41 · see citing works

Myocardial Apelin Production is Reduced in Humans With Left Ventricular Systolic Dysfunction

Chandrasekaran, B., Kalra, P. R., Donovan, J., Hooper, J., Clague, J. R., & McDonagh, T. A. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.02.004 · Cited by 39 · see citing works

Effects of exercise‐induced apelin levels on skeletal muscle and their capillarization in type 2 diabetic rats

Son, J. S., Kim, H., Son, Y., Lee, H., Chae, S. A., Seong, J. K., & Song, W. J. (2017) · Muscle & Nerve · doi:10.1002/mus.25596 · Cited by 38 · see citing works

Muscle weakness during aging: a deficiency state involving declining angiogenesis

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Differentiation and fiber type-specific activity of a muscle creatine kinase intronic enhancer

Tai, P. W. L., Fisher-Aylor, K. I., Himeda, C. L., Smith, C. L., MacKenzie, A. P., Helterline, D., Angello, J. C., Welikson, R. E., Wold, B. J., & Hauschka, S. D. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-25 · Cited by 33 · see citing works

Sarcopenia

Cruz-Jentoft, A. J., & Sayer, A. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31138-9 · Cited by 3,905 · see citing works

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

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Exerkines in health, resilience and disease

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Physical activity and exercise: Strategies to manage frailty

Angulo, J., El Assar, M., Álvarez-Bustos, A., & Rodríguez-Mañas, L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101513 · Cited by 771 · see citing works

Control of satellite cell function in muscle regeneration and its disruption in ageing

Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476 · see citing works

Approaches to Assessment of Muscle Mass and Myosteatosis on Computed Tomography: A Systematic Review

Amini, B., Boyle, S. P., Boutin, R. D., & Lenchik, L. (2019) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glz034 · Cited by 391 · see citing works

Biomarkers of aging

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Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

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Aging disrupts muscle stem cell function by impairing matricellular WISP1 secretion from fibro-adipogenic progenitors

Lukjanenko, L., Karaz, S., Stuelsatz, P., Gurriaran-Rodriguez, U., Michaud, J., Dammone, G., Sizzano, F., Mashinchian, O., Ancel, S., Migliavacca, E., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2018.12.014 · Cited by 374 · see citing works

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

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Exercise Metabolism and Adaptation in Skeletal Muscle

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Tissue Stem Cells: Architects of Their Niches

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A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update

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