Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide
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Avasopasem manganese enhances tumor cell killing after ablative hypofractionated radiation through the generation of hydrogen peroxide.
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Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696 · see citing works
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works
A SPECTROPHOTOMETRIC METHOD FOR MEASURING THE BREAKDOWN OF HYDROGEN PEROXIDE BY CATALASE
Beers, R. F., & Sizer, I. W. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50881-x · Cited by 6,781 · see citing works
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335 · see citing works
Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences
Soneson, C., Love, M. I., & Robinson, M. D. (2015) · F1000Research · doi:10.12688/f1000research.7563.1 · Cited by 3,929 · see citing works
Stereotactic Body Radiation Therapy for Inoperable Early Stage Lung Cancer
Timmerman, R. D. (2010) · JAMA · doi:10.1001/jama.2010.261 · Cited by 2,536 · see citing works
Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences
Soneson, C., Love, M. I., & Robinson, M. D. (2016) · F1000Research · doi:10.12688/f1000research.7563.2 · Cited by 1,936 · see citing works
Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360 · see citing works
Mitochondrial ROS-induced ROS release: An update and review
Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.04.029 · Cited by 1,081 · see citing works
Role of superoxide dismutase in cancer: a review.
Oberley, L. W., & Buettner, G. R. (1979) · PubMed · Cited by 982 · see citing works
Kim, H.-S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.023 · Cited by 785 · see citing works
Self-citationSpitz, D. R., Azzam, E. I., Jian Li, J., & Gius, D. (2004) · Cancer and Metastasis Reviews · doi:10.1023/b:canc.0000031769.14728.bc · Cited by 710 · see citing works
A Nonpeptidyl Mimic of Superoxide Dismutase with Therapeutic Activity in Rats
Salvemini, D., Wang, Z., Zweier, J. L., Samouilov, A., Macarthur, H., Misko, T. P., Currie, M. G., Cuzzocrea, S., Sikorski, J. A., & Riley, D. P. (1999) · Science · doi:10.1126/science.286.5438.304 · Cited by 502 · see citing works
Self-citationNarayanan, P. K., Goodwin, E. H., & Lehnert, B. E. (1997) · PubMed · Cited by 454 · see citing works
Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.018 · Cited by 443 · see citing works
Self-citationFunctional Mimics of Superoxide Dismutase Enzymes as Therapeutic Agents
Riley, D. P. (1999) · Chemical Reviews · doi:10.1021/cr980432g · Cited by 434 · see citing works
Self-citationReactive Oxygen Species in Normal and Tumor Stem Cells
Zhou, D., Shao, L., & Spitz, D. R. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-420117-0.00001-3 · Cited by 400 · see citing works
Self-citationLi, S., Yan, T., Yang, J., Oberley, T. D., & Oberley, L. W. (2000) · PubMed · Cited by 332 · see citing works
Mitochondrial O2⋅¯ and H2O2 Mediate Glucose Deprivation-induced Stress in Human Cancer Cells
Ahmad, I. M., Aykin‐Burns, N., Sim, J. E., Walsh, S. A., Higashikubo, R., Buettner, G. R., Venkataraman, S., Mackey, M. A., Flanagan, S. W., Oberley, L. W., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411662200 · Cited by 246 · see citing works
Self-citationUncoupling Nuclear Receptor LXR and Cholesterol Metabolism in Cancer
Bovenga, F., Sabbà, C., & Moschetta, A. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.002 · Cited by 209 · see citing works
Buettner, G. R., Ng, C. F., Wang, M., Rodgers, V. G. J., & Schafer, F. Q. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.015 · Cited by 198 · see citing works
Redox Control of Skeletal Muscle Regeneration
Moal, E. L., Pialoux, V., Juban, G., Groussard, C., Zouhal, H., Chazaud, B., & Mounier, R. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6782 · Cited by 197 · see citing works
Statistical determination of synergy based on Bliss definition of drugs independence
Demidenko, E., & Miller, T. W. (2019) · PLOS ONE · doi:10.1371/journal.pone.0224137 · Cited by 187 · see citing works
Oxysterols and Their Cellular Effectors
Olkkonen, V. M., Béaslas, O., & Nissilä, E. (2012) · Biomolecules · doi:10.3390/biom2010076 · Cited by 178 · see citing works
Enhancement of tumor radioresponse in vivo by gemcitabine.
Milas, L., Fujii, T., Hunter, N. R., et al. (1999) · PubMed · Cited by 163 · see citing works
Batinic̈‐Haberle, I., Tovmasyan, A. G., & Spasojević, I. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7453 · Cited by 152 · see citing works
Liu, R., Oberley, T. D., & Oberley, L. W. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.5-585 · Cited by 139 · see citing works
Potential Therapeutic Applications of MnSODs and SOD‐Mimetics
Bonetta, R. (2017) · Chemistry - A European Journal · doi:10.1002/chem.201704561 · Cited by 134 · see citing works
Anderson, C. M., Lee, C. M., Saunders, D., Curtis, A. E., Dunlap, N., Nangia, C. S., Lee, A. S., Gordon, S. M., Kovoor, P., Arevalo-Araujo, R., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.19.01507 · Cited by 126 · see citing works
Hydrogen Peroxide Activates NF κ B and the Interleukin-6 Promoter Through NF κ B-Inducing Kinase
Zhang, J., Johnston, G., Stebler, B. S., & Keller, E. T. (2001) · Antioxidants and Redox Signaling · doi:10.1089/15230860152409121 · Cited by 125 · see citing works
Sridharan, D. M., Asaithamby, A., Bailey, S. M., Costes, S. V., Doetsch, P. W., Dynan, W. S., Kronenberg, A., Rithidech, K. N., Saha, J., Snijders, A. M., et al. (2015) · Radiation Research · doi:10.1667/rr13804.1 · Cited by 124 · see citing works
Fath, M. A., Ahmad, I. M., Smith, C. J., Spence, J., & Spitz, D. R. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0736 · Cited by 114 · see citing works
Self-citationMaximizing therapeutic gain with gemcitabine and fractionated radiation
Mason, K. A., Milas, L., Hunter, N. R., et al. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00134-0 · Cited by 106 · see citing works
Oxygen toxicity in control and H2O2-resistant Chinese hamster fibroblast cell lines
Spitz, D. R., Elwell, J. H., Sun, Y., et al. (1990) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(90)90489-l · Cited by 103 · see citing works
Self-citationEnhancement of the potentiation of radiotherapy by platinum drugs in a mouse tumor
Douple, E. B., & Richmond, R. C. (1982) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(82)90670-8 · Cited by 95 · see citing works
Murphy, C. K., Fey, E. G., Watkins, B. A., Wong, V., Rothstein, D., & Sonis, S. T. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4669 · Cited by 85 · see citing works
Anderson, C. M., Sonis, S. T., Lee, C. M., Adkins, D. R., Allen, B. G., Sun, W., Agarwala, S. S., Venigalla, M. L., Chen, Y., Zhen, W. K., et al. (2017) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2017.10.019 · Cited by 80 · see citing works
Extracellular Redox State Regulates Features Associated with Prostate Cancer Cell Invasion
Chaiswing, L., Zhong, W., Cullen, J. J., Oberley, L. W., & Oberley, T. D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0162 · Cited by 79 · see citing works
Potential Mechanisms for the Inhibition of Tumor Cell Growth by Manganese Superoxide Dismutase
Kim, K.-H., Rodriguez, A. M., Carrico, P. M., & Melendez, J. A. (2001) · Antioxidants and Redox Signaling · doi:10.1089/15230860152409013 · Cited by 77 · see citing works
Ashcraft, K. A., Boss, M., Tovmasyan, A. G., et al. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.07.2283 · Cited by 73 · see citing works
Overgaard, J., Overgaard, M., Nielsen, O. S., et al. (1982) · British Journal of Cancer · doi:10.1038/bjc.1982.300 · Cited by 69 · see citing works
Extracellular localization of catalase is associated with the transformed state of malignant cells
Böhm, B., Heinzelmann, S., Motz, M., & Bauer, G. (2015) · Biological Chemistry · doi:10.1515/hsz-2014-0234 · Cited by 67 · see citing works
Rugo, R. E., Secretan, B., & Schiestl, R. H. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)158[0210:xrcapi]2.0.co;2 · Cited by 59 · see citing works
Milas, L., Fang, F.-M., Mason, K. A., et al. (2007) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2006.09.044 · Cited by 57 · see citing works
Zhu, Y., Zou, X., Dean, A. E., Brien, J. O., Gao, Y., Tran, E. L., Park, S., Liu, G., Kieffer, M. B., Jiang, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10352-4 · Cited by 57 · see citing works
Inhibition of oral cancer cell growth by adenovirusMnSOD plus BCNU treatment
Weydert, C. J. D., Smith, B. B., Xu, L., et al. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01245-5 · Cited by 56 · see citing works
A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells
Borrelli, A., Schiattarella, A., Mancini, R., Morrica, B., Cerciello, V., Mormile, M., d'Alesio, V., Bottalico, L., Morelli, F., D'Armiento, M., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.10.030 · Cited by 54 · see citing works
Chatterjee, A., Zhu, Y., Tong, Q., Kosmacek, E. A., Lichter, E. Z., & Oberley‐Deegan, R. E. (2018) · Antioxidants · doi:10.3390/antiox7010021 · Cited by 53 · see citing works
Heer, C. D., Davis, A. B., Riffe, D., Wagner, B. A., Falls, K. C., Allen, B. G., Buettner, G. R., Beardsley, R., Riley, D. P., & Spitz, D. R. (2018) · Antioxidants · doi:10.3390/antiox7010018 · Cited by 48 · see citing works
Self-citationTimmerman, R. D. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.5165 · Cited by 47 · see citing works
Brandt, K. E., Falls, K. C., Schoenfeld, J. D., Rodman, S. N., Gu, Z., Zhan, F., Cullen, J. J., Wagner, B. A., Buettner, G. R., Allen, B. G., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.017 · Cited by 46 · see citing works
Self-citationMapuskar, K. A., Flippo, K. H., Schoenfeld, J. D., Riley, D. P., Strack, S., Hejleh, T. A., Furqan, M., Monga, V., Domann, F. E., Buatti, J. M., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0106 · Cited by 39 · see citing works
Self-citationMechanism of the Antitumor and Radiosensitizing Effects of a Manganese Porphyrin, MnHex-2-PyP
Shin, S.-W., Choi, C., Lee, G.-H., Son, A.-R., Kim, S.-H., Park, H. C., Batinic̈‐Haberle, I., & Park, W. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6889 · Cited by 37 · see citing works
Mitigation of radiation‐induced skin injury by AAV2‐mediated MnSOD gene therapy
Yan, S., Brown, S. L., Kolozsvary, A. J. J., Freytag, S. O., Lü, M., & Kim, J. H. (2008) · The Journal of Gene Medicine · doi:10.1002/jgm.1226 · Cited by 35 · see citing works
THOMPSON, J. S., Chu, Y., Glass, J., Tapp, A. A., & Brown, S. A. (2010) · Free Radical Research · doi:10.3109/10715761003649578 · Cited by 35 · see citing works
Stereotactic body radiation therapy for early-stage non-small-cell lung cancer
Lo, S. S.-M., Fakiris, A. J., Papiez, L. S., et al. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.8.1.87 · Cited by 34 · see citing works
Tong, Q., Zhu, Y., Galaske, J. W., Kosmacek, E. A., Chatterjee, A., Dickinson, B. C., & Oberley‐Deegan, R. E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.019 · Cited by 34 · see citing works
Elmahdy, M., Alzarie, Y. A., Hemann, C. F., Badary, O. A., Nofal, S., & Zweier, J. L. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.032 · Cited by 34 · see citing works
Liu, Q., He, X., Liu, Y., Du, B.-B., Wang, X., Zhang, W., Jia, P., Dong, J., Ma, J., Wang, X., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.067 · Cited by 26 · see citing works
Epperly, M. W., Lai, S. Y., Kanai, A., et al. (2010) · PubMed · Cited by 25 · see citing works
Epperly, M. W., Franicola, D., Zhang, X., Nie, S., & Greenberger, J. S. (2006) · PubMed · Cited by 15 · see citing works
Kavanagh, B. D., Abdulrahman, R., Camidge, D. R., et al. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2010.07.077 · Cited by 3 · see citing works
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- Authors
- Sishc, B. J., Ding, L., Nam, T.-K., Heer, C. D., Rodman, S. N., Schoenfeld, J. D., Fath, M. A., Saha, D., Pulliam, C. F., Langen, B., Beardsley, R. A., Riley, D. P., Keene, J. L., Spitz, D. R., & Story, M. D.
- Affiliations
- Harold C. Simmons Comprehensive Cancer Center (US)
- University of Iowa (US)
- Galera Therapeutics, Inc. (United States) (US)
- Corresponding author
- Spitz, Douglas R.
- Story, Michael D.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2021-05-12
- Volume
- 13
- Issue
- 593
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8314936
- OpenAlex
- W3163303814
- Cited by
- 51
- References
- 65
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 18 · 2023: 4 · 2022: 11 · 2021: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- International Parkinson and Movement Disorder Society (T32 CA078586, P30CA086862, P01CA217797, R44CA206795)
- Galera Therapeutics
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Keywords
- superoxide dismutase mimetic, oxidative metabolism, radiosensitization, catalase, glutathione metabolism, thioredoxin, buthionine sulfoximine, auranofin, non-small cell lung cancer, head and neck squamous cell carcinoma, pancreatic ductal adenocarcinoma, mammary adenocarcinoma, TNF-α, apoptosis, stereotactic body radiotherapy, radiation-induced mucositis
- MeSH terms
- Animals, Carcinoma, Non-Small-Cell Lung, Humans, Hydrogen Peroxide, Lung Neoplasms, Organometallic Compounds, Superoxide Dismutase, Mice
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