Cited by 51Redox biology and oxidative stressEffects of Radiation ExposureRadiation Therapy and Dosimetry

Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

Open access
Sishc, Brock J., Ding, Lianghao, Nam, Taek-Keun, Heer, Collin D., Rodman, Samuel N., Schoenfeld, Joshua D., Fath, Melissa A., Saha, Debabrata +7 more·2021·Science Translational Medicine

Abstract

Avasopasem manganese enhances tumor cell killing after ablative hypofractionated radiation through the generation of hydrogen peroxide.

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Crossref · 10.1126/scitranslmed.abb3768

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Authors
Sishc, B. J., Ding, L., Nam, T.-K., Heer, C. D., Rodman, S. N., Schoenfeld, J. D., Fath, M. A., Saha, D., Pulliam, C. F., Langen, B., Beardsley, R. A., Riley, D. P., Keene, J. L., Spitz, D. R., & Story, M. D.
Affiliations
  • Harold C. Simmons Comprehensive Cancer Center (US)
  • University of Iowa (US)
  • Galera Therapeutics, Inc. (United States) (US)
Corresponding author
  • Spitz, Douglas R.
  • Story, Michael D.
Venue
Science Translational Medicine
Published
2021-05-12
Volume
13
Issue
593
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W3163303814
Cited by
51
References
65
Citations by year
2026: 5 · 2025: 12 · 2024: 18 · 2023: 4 · 2022: 11 · 2021: 1
FWCI
2.67
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • International Parkinson and Movement Disorder Society (T32 CA078586, P30CA086862, P01CA217797, R44CA206795)
  • Galera Therapeutics
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
Keywords
superoxide dismutase mimetic, oxidative metabolism, radiosensitization, catalase, glutathione metabolism, thioredoxin, buthionine sulfoximine, auranofin, non-small cell lung cancer, head and neck squamous cell carcinoma, pancreatic ductal adenocarcinoma, mammary adenocarcinoma, TNF-α, apoptosis, stereotactic body radiotherapy, radiation-induced mucositis
MeSH terms
Animals, Carcinoma, Non-Small-Cell Lung, Humans, Hydrogen Peroxide, Lung Neoplasms, Organometallic Compounds, Superoxide Dismutase, Mice

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