O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate
Open accessAbstract
Pharmacological ascorbate has been proposed as a potential anti-cancer agent when combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are hypothesized to involve the autoxidation of ascorbate leading to increased steady-state levels of H 2 O 2; however, the mechanism(s) for cancer cell-selective toxicity remain unknown. The current study shows that alterations in cancer cell mitochondrial oxidative metabolism resulting in increased levels of O 2⋅- and H 2 O 2 are capable of disrupting intracellular iron metabolism, thereby selectively sensitizing non-small-cell lung cancer (NSCLC) and glioblastoma (GBM) cells to ascorbate through pro-oxidant chemistry involving redox-active labile iron and H 2 O 2. In addition, preclinical studies and clinical trials demonstrate the feasibility, selective toxicity, tolerability, and potential efficacy of pharmacological ascorbate in GBM and NSCLC therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In lung and glioblastoma cancer cells, higher mitochondrial ROS raised intracellular labile iron by increasing transferrin receptor, making the cells more sensitive to ascorbate.
“an increased level of mitochondrial ROS in lung and glioblastoma cancer cells led to increased levels of intracellular labile iron through the upregulation of the Tf receptor (TfR), thus increasing the sensitivity of these cancer cells to ascorbate43.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [43]
Giving ascorbate by injection does not block the effects of chemotherapy or radiotherapy.
“Numerous preclinical and clinical studies indicate that parenteral injection of pharmacological ascorbate does not interfere with chemotherapy or radiotherapy and may even act synergistically43,104,105.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [43]
Giving ascorbate by injection may act synergistically with chemotherapy or radiotherapy.
“Numerous preclinical and clinical studies indicate that parenteral injection of pharmacological ascorbate does not interfere with chemotherapy or radiotherapy and may even act synergistically43,104,105.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [43]
In non-small-cell lung cancer and glioblastoma cells, pharmacological ascorbate selectively sensitizes the cells by generating redox-active labile iron and hydrogen peroxide, as shown in in vitro cell lines and mouse models.
“This study shows that pharmacological ascorbate selectively sensitizes non-small-cell lung cancer (NSCLC) and glioblastoma (GBM) cells by generating redox-active labile iron and H2O2 using in vitro cell lines and mouse models.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [43]
Ascorbate therapy combined with other chemotherapies has potential efficacy in patients with glioblastoma and non-small-cell lung cancer.
“In addition, it shows the potential efficacy of ascorbate therapy combined with other chemotherapies in patients with GBM and NSCLC.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [43]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
Eisenhauer, E. A., Therasse, P., Bogaerts, J., Schwartz, L. H., Sargent, D., Ford, R., Dancey, J., Arbuck, S., Gwyther, S., Mooney, M., et al. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2008.10.026 · Cited by 29,534 · see citing works
Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma
Stupp, R., Mason, W. P., van den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J. B., Belanger, K., Brandes, A. A., Marosi, C., Bogdahn, U., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043330 · Cited by 21,807 · see citing works
<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma
Hegi, M. E., Diserens, A.-C., Gorlia, T., Hamou, M.-F., de Tribolet, N., Weller, M., Kros, J. M., Hainfellner, J. A., Mason, W., Mariani, L., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043331 · Cited by 7,405 · see citing works
Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer
Sandler, A., Gray, R., Perry, M. C., Brahmer, J., Schiller, J. H., Dowlati, A., Lilenbaum, R., & Johnson, D. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061884 · Cited by 5,761 · see citing works
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994 · see citing works
Comparison of Four Chemotherapy Regimens for Advanced Non–Small-Cell Lung Cancer
Schiller, J. H., Harrington, D., Belani, C. P., Langer, C., Sandler, A., Krook, J., Zhu, J., & Johnson, D. H. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011954 · Cited by 4,955 · see citing works
DISC ELECTROPHORESIS‐I BACKGROUND AND THEORY*
Ornstein, L. (1964) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1964.tb14207.x · Cited by 4,575 · see citing works
COMPARISON OF FOUR CHEMOTHERAPY REGIMENS FOR ADVANCED NON-SMALL-CELL LUNG CANCER
Chiller, J. O. H. S., Arrington, D. A. H., Elani, C. H. P. B., Anger, C., Andler, A. L. S., Rook, J. A. K., Hu, J., & Ohnson, D. A. H. J. (2002) · Cited by 3,730 · see citing works
Production of large amounts of hydrogen peroxide by human tumor cells.
Szatrowski, T. P., & Nathan, C. (1991) · PubMed · Cited by 2,504 · see citing works
Response criteria for phase II studies of supratentorial malignant glioma.
Macdonald, D. R., Cascino, T. L., Schold, S. C., & Cairncross, J. G. (1990) · Journal of Clinical Oncology · doi:10.1200/jco.1990.8.7.1277 · Cited by 2,409 · see citing works
Iron and cancer: more ore to be mined
Torti, S. V., & Torti, F. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3495 · Cited by 1,621 · see citing works
Chen, Q., Espey, M. G., Krishna, M. C., Mitchell, J. B., Corpe, C. P., Buettner, G. R., Shacter, E., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506390102 · Cited by 1,075 · see citing works
Self-citationVitamin C pharmacokinetics: Implications for oral and intravenous use
Padayatty, S. J., Sun, H., Wang, Y., Riordan, H. D., Hewitt, S. M., Katz, A., Wesley, R. A., & Levine, M. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00010 · Cited by 992 · see citing works
Design and Analysis of Phase I Clinical Trials
Storer, B. E. (1989) · Biometrics · doi:10.2307/2531693 · Cited by 939 · see citing works
Yun, J., Mullarky, E., Lu, C., Bosch, K. N., Kavalier, A., Rivera, K., Roper, J., Chio, I. I. C., Giannopoulou, E. G., Rago, C., et al. (2015) · Science · doi:10.1126/science.aaa5004 · Cited by 913 · see citing works
Catalytic Metals, Ascorbate and Free Radicals: Combinations to Avoid
Buettner, G. R., & Jurkiewicz, B. A. (1996) · Radiation Research · doi:10.2307/3579271 · Cited by 884 · see citing works
Self-citationChen, Q., Espey, M. G., Sun, A. Y., Pooput, C., Kirk, K. L., Krishna, M. C., Khosh, D. B., Drisko, J., & Levine, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804226105 · Cited by 854 · see citing works
Cameron, E., & Pauling, L. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3685 · Cited by 710 · see citing works
Chen, Q., Espey, M. G., Sun, A. Y., Lee, J.-H., Krishna, M. C., Shacter, E., Choyke, P. L., Pooput, C., Kirk, K. L., Buettner, G. R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702854104 · Cited by 676 · see citing works
Self-citationMoertel, C. G., Fleming, T. R., Creagan, E. T., Rubin, J., O'Connell, M. J., & Ames, M. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120301 · Cited by 637 · see citing works
Accelerated Titration Designs for Phase I Clinical Trials in Oncology
Simon, R. M., Rubinstein, L., Arbuck, S. G., Christian, M. C., Freidlin, B., & Collins, J. M. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.15.1138 · Cited by 634 · see citing works
Creagan, E. T., Moertel, C. G., O'Fallon, J. R., Schutt, A. J., O'Connell, M. J., Rubin, J., & Frytak, S. (1979) · New England Journal of Medicine · doi:10.1056/nejm197909273011303 · Cited by 584 · see citing works
Dickinson, B. C., Huynh, C., & Chang, C. J. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1014103 · Cited by 513 · see citing works
Buettner, G. R. (1988) · Journal of Biochemical and Biophysical Methods · doi:10.1016/0165-022x(88)90100-5 · Cited by 510 · see citing works
Self-citationMa, Y., Chapman, J., Levine, M., Polireddy, K., Drisko, J., & Chen, Q. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007154 · Cited by 501 · see citing works
Glucose Transporter Isoforms GLUT1 and GLUT3 Transport Dehydroascorbic Acid
Rumsey, S. C., Kwon, O., Xu, G. W., Burant, C., Simpson, I. A., & Levine, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18982 · Cited by 474 · see citing works
Aykin‐Burns, N., Ahmad, I. M., Zhu, Y., Oberley, L. W., & Spitz, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20081258 · Cited by 433 · see citing works
Self-citationLow oxygen concentration extends the lifespan of cultured human diploid cells
Packer, L., & FUEHR, K. (1977) · Nature · doi:10.1038/267423a0 · Cited by 393 · see citing works
Fluorescence analysis of the labile iron pool of mammalian cells
Epsztejn, S., Kakhlon, O., Glickstein, H., Breuer, W., & Cabantchik, Z. I. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2126 · Cited by 391 · see citing works
Spitz, D. R., Sim, J. E., Ridnour, L. A., Galoforo, S., & Lee, Y. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06199.x · Cited by 331 · see citing works
Self-citationMechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer
Du, J., Martin, S. M., Levine, M., Wagner, B. A., Buettner, G. R., Wang, S.-H., Taghiyev, A. F., Du, C., Knudson, C. M., & Cullen, J. J. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1713 · Cited by 316 · see citing works
Self-citationWelsh, J. L., Wagner, B. A., Erve, T. J. V. ‘., Zehr, P. S., Berg, D., Halfdanarson, T. R., Yee, N. S., Bodeker, K. L., Du, J., Roberts, L. J., et al. (2013) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-013-2070-8 · Cited by 310 · see citing works
Self-citationDoskey, C. M., Buranasudja, V., Wagner, B. A., Wilkes, J. G., Du, J., Cullen, J. J., & Buettner, G. R. (2016) · Redox Biology · doi:10.1016/j.redox.2016.10.010 · Cited by 301 · see citing works
Self-citationBirch‐Machin, M. A., Briggs, H. L., Saborido, A. A., Bindoff, L. A., & Turnbull, D. M. (1994) · Biochemical Medicine and Metabolic Biology · doi:10.1006/bmmb.1994.1004 · Cited by 277 · see citing works
Monti, D., Mitchell, E. P., Bazzan, A. J., Littman, S. J., Zabrecky, G. P., Yeo, C. J., Pillai, M. V., Newberg, A. B., Deshmukh, S., & Levine, M. N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029794 · Cited by 270 · see citing works
Liou, G.-Y., Döppler, H., DelGiorno, K. E., Zhang, L., Leitges, M., Crawford, H. C., Murphy, M. P., & Storz, P. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.029 · Cited by 270 · see citing works
A Technique for Serial Collection of Cerebrospinal Fluid from the Cisterna Magna in Mouse
Liu, L., & Duff, K. (2008) · Journal of Visualized Experiments · doi:10.3791/960 · Cited by 268 · see citing works
Mitochondrial O2⋅¯ and H2O2 Mediate Glucose Deprivation-induced Stress in Human Cancer Cells
Ahmad, I. M., Aykin‐Burns, N., Sim, J. E., Walsh, S. A., Higashikubo, R., Buettner, G. R., Venkataraman, S., Mackey, M. A., Flanagan, S. W., Oberley, L. W., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411662200 · Cited by 246 · see citing works
Self-citationVerrax, J., & Calderón, P. B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.016 · Cited by 232 · see citing works
Clement, M., Ramalingam, J. K., Long, L. H., & Halliwell, B. B. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601750100687 · Cited by 230 · see citing works
Spitz, D. R., Dewey, W. C., & Li, G. C. (1987) · Journal of Cellular Physiology · doi:10.1002/jcp.1041310308 · Cited by 216 · see citing works
Self-citationCorazao-Rozas, P., Guerreschi, P., Jendoubi, M., André, F., Jonneaux, A., Scalbert, C., Garçon, G., Malet‐Martino, M., Balayssac, S., Rocchi, S., et al. (2013) · Oncotarget · doi:10.18632/oncotarget.1420 · Cited by 179 · see citing works
Sunaga, N., Shames, D. S., Girard, L., Peyton, M., Larsen, J. E., Imai, H., Soh, J., Sato, M., Yanagitani, N., Kaira, K., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0750 · Cited by 175 · see citing works
Ascorbate Autoxidation in the Presence of Iron and Copper Chelates
Buettner, G. R., & Czapski, G. (1986) · Free Radical Research Communications · doi:10.3109/10715768609051638 · Cited by 171 · see citing works
Self-citationPantopoulos, K., Mueller, S., Atzberger, A., Ansorge, W. J., Stremmel, W., & Hentze, M. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9802 · Cited by 163 · see citing works
Superoxide ion as a primary reductant in ascorbate-mediated ferretin iron release
Boyer, R. F., & McCleary, C. J. (1987) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(87)90017-7 · Cited by 156 · see citing works
Janmaat, M. L., Rodríguez, J. A., Gallegos-Ruiz, M. I., Kruyt, F. A. E., & Giaccone, G. (2005) · International Journal of Cancer · doi:10.1002/ijc.21290 · Cited by 149 · see citing works
Nath, K. A., Ngo, E. O., Hebbel, R. P., Croatt, A. J., Zhou, B., & Nutter, L. M. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.268.1.c227 · Cited by 139 · see citing works
Superoxide dismutase and superoxide radical in Morris hepatomas.
Bize, I., Oberley, L. W., & Morris, H. P. (1980) · PubMed · Cited by 138 · see citing works
Matsubara, D., Kishaba, Y., Ishikawa, S., Sakatani, T., Oguni, S., Tamura, T., Hoshino, H., Sugiyama, Y., Endo, S., Murakami, Y., et al. (2012) · Cancer Science · doi:10.1111/cas.12065 · Cited by 132 · see citing works
Zwacka, R. M., Dudus, L., Epperly, M. W., Greenberger, J. S., & Engelhardt, J. F. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.9-1381 · Cited by 127 · see citing works
Cell differentation, aging and cancer: The possible roles of superoxide and superoxide dismutases
Oberley, L. W., Oberley, T. D., & Buettner, G. R. (1980) · Medical Hypotheses · doi:10.1016/0306-9877(80)90123-1 · Cited by 127 · see citing works
Self-citationKukulj, S., Jaganjac, M., Boranić, M., Križanac, Š., Šantić, Ž., & Poljak‐Blaži, M. (2009) · Medical Oncology · doi:10.1007/s12032-009-9203-2 · Cited by 121 · see citing works
Modulation of Cellular Iron Metabolism by Hydrogen Peroxide
Caltagirone, A., Weiß, G., & Pantopoulos, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100245200 · Cited by 118 · see citing works
Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent
Riordan, N. H., Riordan, H. D., Meng, X., Li, Y., & Jackson, J. A. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90137-x · Cited by 116 · see citing works
Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer
Du, J., Cieslak, J. A., Welsh, J. L., Sibenaller, Z. A., Allen, B. G., Wagner, B. A., Kalen, A. L., Doskey, C. M., Strother, R. K., Button, A. M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1707 · Cited by 112 · see citing works
Self-citationCase, A. J., McGill, J. L., Tygrett, L. T., Shirasawa, T., Spitz, D. R., Waldschmidt, T. J., Legge, K. L., & Domann, F. E. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.025 · Cited by 107 · see citing works
Self-citationA simple and sensitive assay for ascorbate using a plate reader
Vislisel, J. M., Schafer, F. Q., & Buettner, G. R. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2007.03.002 · Cited by 78 · see citing works
Self-citationRole of labile iron in the toxicity of pharmacological ascorbate
Du, J., Wagner, B. A., Buettner, G. R., & Cullen, J. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.033 · Cited by 67 · see citing works
Self-citationCampbell, E. J., Vissers, M. C. M., Wohlrab, C., Hicks, K. O., Strother, R. M., Bozonet, S. M., Robinson, B. A., & Dachs, G. U. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.08.027 · Cited by 67 · see citing works
Extracellular iron diminishes anticancer effects of vitamin C: An in vitro study
Mojić, M., Pristov, J. B., Maksimović‐Ivanić, D., Jones, D. R., Stanić, M., Mijatović, S., & Spasojević, I. (2014) · Scientific Reports · doi:10.1038/srep05955 · Cited by 65 · see citing works
Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture
Doskey, C. M., Erve, T. J. V. ‘., Wagner, B. A., & Buettner, G. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132572 · Cited by 62 · see citing works
Self-citationASCORBIC ACID, CELL PROLIFERATION, AND CANCER
Cameron, E., & Rotman, D. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90215-2 · Cited by 62 · see citing works
Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity
Olney, K., Du, J., Erve, T. J. V. ‘., Witmer, J. R., Sibenaller, Z. A., Wagner, B. A., Buettner, G. R., & Cullen, J. J. (2012) · Free Radical Research · doi:10.3109/10715762.2012.755263 · Cited by 59 · see citing works
Self-citationPharmacokinetic modeling of ascorbate diffusion through normal and tumor tissue
Kuiper, C., Vissers, M. C. M., & Hicks, K. O. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.09.023 · Cited by 45 · see citing works
Ibrahim, W. H., Habib, H. M., Kamal, H., Clair, D. K. S., & Chow, C. K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.026 · Cited by 43 · see citing works
Measurement of Mn SOD and Cu Zn SOD Activity in Mammalian Tissue Homogenates
Spitz, D. R., & Oberley, L. W. (2001) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx0705s08 · Cited by 43 · see citing works
Self-citationPharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer
Moser, J. C., Rawal, M., Wagner, B. A., Du, J., Cullen, J. J., & Buettner, G. R. (2013) · Redox Biology · doi:10.1016/j.redox.2013.11.005 · Cited by 41 · see citing works
Self-citationDirect spectrophotometric measurement of supra-physiological levels of ascorbate in plasma
Witmer, J. R., Wetherell, B. J., Wagner, B. A., Du, J., Cullen, J. J., & Buettner, G. R. (2016) · Redox Biology · doi:10.1016/j.redox.2016.02.004 · Cited by 37 · see citing works
Self-citationAhmad, I. M., Abdalla, M. Y., Aykin‐Burns, N., Simons, A. L., Oberley, L. W., Domann, F. E., & Spitz, D. R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.11.007 · Cited by 36 · see citing works
Self-citationSOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD
Cramer-Morales, K. L., Heer, C. D., Mapuskar, K. A., & Domann, F. E. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.017 · Cited by 36 · see citing works
Self-citationSpringer, E. (1980) · PubMed · Cited by 33 · see citing works
Mutational analysis of the BRAF gene in human tumor cells
Ueda, M., Eisaku, T. O. J. I., Nunobiki, O., Izuma, S., Okamoto, Y., Torii, K., & Noda, S. (2008) · Human Cell · doi:10.1111/j.1749-0774.2008.00046.x · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Stupp R Mason WP van den Bent MJ Weller M Fisher B Taphoorn MJB Belanger K Brandes AA Marosi C Bogdahn U 2005b Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma N Engl J Med 352 987 996 15758009
Cited by
Sorted by citations
Jomova, K., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03696-4 · Cited by 1,445 · see citing works
The Complex Interplay between Antioxidants and ROS in Cancer
Harris, I. S., & DeNicola, G. M. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.03.002 · Cited by 638 · see citing works
Dixon, S. J., & Stockwell, B. R. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055844 · Cited by 588 · see citing works
Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
Nakamura, T., Naguro, I., & Ichijo, H. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.06.010 · Cited by 522 · see citing works
Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent
Kaźmierczak-Barańska, J., Boguszewska, K., Adamus-Grabicka, A., & Karwowski, B. T. (2020) · Nutrients · doi:10.3390/nu12051501 · Cited by 455 · see citing works
Torti, S. V., Manz, D. H., Paul, B. T., Blanchette-Farra, N., & Torti, F. M. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051732 · Cited by 426 · see citing works
Targeting cancer vulnerabilities with high-dose vitamin C
Ngo, B., Van Riper, J. M., Cantley, L. C., & Yun, J. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0135-7 · Cited by 423 · see citing works
Recent Advances in the Application of Vitamin E TPGS for Drug Delivery
Yang, C., Wu, T., Qi, Y., & Zhang, Z. (2017) · Theranostics · doi:10.7150/thno.22711 · Cited by 408 · see citing works
Transferrin receptor 1 in cancer: a new sight for cancer therapy.
Shen, Y., Li, X., Dong, D., Zhang, B., Xue, Y., & Shang, P. (2018) · Europe PMC (PubMed Central) · Cited by 357 · see citing works
Spitz, D. R., Buettner, G. R., Petronek, M. S., St‐Aubin, J., Flynn, R. T., Waldron, T. J., & Limoli, C. L. (2019) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2019.03.028 · Cited by 310 · see citing works
Self-citationOxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy
Aboelella, N. S., Brandle, C., Kim, T., Ding, Z., & Zhou, G. (2021) · Cancers · doi:10.3390/cancers13050986 · Cited by 295 · see citing works
High-dose vitamin C enhances cancer immunotherapy
Magrì, A., Germano, G., Lorenzato, A., Lamba, S., Chilà, R., Montone, M., Amodio, V., Ceruti, T., Sassi, F., Arena, S., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay8707 · Cited by 285 · see citing works
Emerging therapies in cancer metabolism
Xiao, Y., Yu, T., Xu, Y., Ding, R., Wang, Y.-P., Jiang, Y., & Shao, Z. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.07.006 · Cited by 266 · see citing works
Iron and thiol redox signaling in cancer: an exquisite balance to escape ferroptosis
Toyokuni, S., Ito, F., Yamashita, K., Okazaki, Y., & Akatsuka, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.024 · Cited by 252 · see citing works
Endogenous Labile Iron Pool-Mediated Free Radical Generation for Cancer Chemodynamic Therapy
Lin, L., Wang, S., Deng, H., Yang, W., Rao, L., Tian, R., Liu, Y., Yu, G., Zhou, Z., Song, J., et al. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c05604 · Cited by 250 · see citing works
Drug-induced oxidative stress in cancer treatments: Angel or devil?
Jiang, H., Zuo, J., Li, B., Chen, R., Luo, K., Xiang, X., Lu, S., Huang, C., Liu, L., Tang, J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102754 · Cited by 242 · see citing works
High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer
Böttger, F., Vallés‐Martí, A., Cahn, L., & Jiménez, C. R. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02134-y · Cited by 216 · see citing works
Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis
Wen, R., Dong, X., Zhuang, H., Pang, F.-X., Ding, S.-C., Li, N., Mai, Y., Zhou, S., Wang, J., & Zhang, J. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154881 · Cited by 213 · see citing works
Self-citationAscorbic Acid in Cancer Treatment: Let the Phoenix Fly
Shenoy, N. K., Creagan, E. T., Witzig, T. E., & Levine, M. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.07.014 · Cited by 207 · see citing works
Vitamin C in stem cell reprogramming and cancer
Cimmino, L., Neel, B. G., & Aifantis, I. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.04.001 · Cited by 197 · see citing works
Coordinatively Unsaturated Fe 3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors
Zhang, P., Hou, Y., Zeng, J., Li, Y., Wang, Z., Zhu, R., Ma, T., & Gao, M. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201904880 · Cited by 191 · see citing works
Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines
Zhang, Y., Kong, Y., Ma, Y., Ni, S., Wikerholmen, T., Xi, K., Zhao, F., Zhao, Z., Wang, J., Huang, B., et al. (2021) · Oncogene · doi:10.1038/s41388-020-01622-3 · Cited by 191 · see citing works
Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence
Vissers, M. C. M., & Das, A. B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00809 · Cited by 188 · see citing works
Ye, S., Hananya, N., Green, O., Chen, H., Zhao, A. Q., Shen, J., Shabat, D., & Yang, D. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202005429 · Cited by 186 · see citing works
Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment
Lin, X., Xiao, Z., Chen, T., Liang, S. H., & Guo, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00317 · Cited by 176 · see citing works
Torti, S. V., & Torti, F. M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2017 · Cited by 176 · see citing works
Pawłowska, E., Szczepańska, J., & Błasiak, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7286737 · Cited by 174 · see citing works
The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma
Goenka, A., Tiek, D., Song, X., Huang, T., Hu, B., & Cheng, S.-Y. (2021) · Cells · doi:10.3390/cells10030484 · Cited by 169 · see citing works
Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome
Boretti, A. A., & Banik, B. K. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100190 · Cited by 168 · see citing works
Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
Tano, M. D., Raucci, F., Vernieri, C., Caffa, I., Buono, R., Fanti, M., Brandhorst, S., Curigliano, G., Nencioni, A., de Braud, F., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16243-3 · Cited by 154 · see citing works
Polireddy, K., Dong, R., Reed, G. A., Yu, J., Chen, P., Williamson, S. K., Violet, P.-C., Pessetto, Z. Y., Godwin, A. K., Fan, F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17568-8 · Cited by 153 · see citing works
Current Use of Fenton Reaction in Drugs and Food
Abe, C., Miyazawa, T., & Miyazawa, T. (2022) · Molecules · doi:10.3390/molecules27175451 · Cited by 153 · see citing works
The Role of Iron in Cancer Progression
Guo, Q., Li, L., Hou, S., Yuan, Z., Li, C., Zhang, W., Zheng, L., & Li, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.778492 · Cited by 150 · see citing works
Implications of reactive oxygen species on cancer formation and its treatment
Shah, M. A., & Rogoff, H. A. (2021) · Seminars in Oncology · doi:10.1053/j.seminoncol.2021.05.002 · Cited by 149 · see citing works
Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer
Chaiswing, L., Clair, W. H. S., & Clair, D. K. S. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7485 · Cited by 147 · see citing works
Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
Zhou, W., & Wahl, D. R. (2019) · Cancers · doi:10.3390/cancers11091231 · Cited by 146 · see citing works
Ferroptosis at the crossroads of infection, aging and cancer
Toyokuni, S., Yanatori, I., Kong, Y., Zheng, H., Motooka, Y., & Jiang, L. (2020) · Cancer Science · doi:10.1111/cas.14496 · Cited by 142 · see citing works
Redox control of cancer cell destruction
Hegedűs, C., Kovács, K. É., Polgár, Z., Regdon, Z., Szabó, É., Robaszkiewicz, A., Forman, H. J., Martner, A., & Virág, L. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.015 · Cited by 137 · see citing works
Regulation of antioxidants in cancer
Hecht, F., Zocchi, M., Alimohammadi, F., & Harris, I. S. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.11.001 · Cited by 135 · see citing works
Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge
Carr, A. C., & Cook, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01182 · Cited by 133 · see citing works
Alexander, M. S., Wilkes, J. G., Schroeder, S. R., Buettner, G. R., Wagner, B. A., Du, J., Gibson-Corley, K. N., O’Leary, B. R., Spitz, D. R., Buatti, J. M., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1680 · Cited by 129 · see citing works
Self-citationOn the Clinical Pharmacology of Reactive Oxygen Species
Casas, A. I., Nogales, C., Mucke, H. A., Petraina, A., Cuadrado, A., Rojo, A. I., Ghezzi, P., Jaquet, V., Augsburger, F., Dufrasne, F., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019422 · Cited by 128 · see citing works
Yang, B., & Shi, J. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c09984 · Cited by 127 · see citing works
Metabolic interplays between the tumour and the host shape the tumour macroenvironment
Altea‐Manzano, P., Decker-Farrell, A. R., Janowitz, T., & Erez, A. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-024-00786-4 · Cited by 127 · see citing works
Reprogramming the epigenome with vitamin C
Lee Chong, T., Ahearn, E. L., & Cimmino, L. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00128 · Cited by 120 · see citing works
Chong, Y., Dai, X., Ge, F., Wu, R., Zhao, L., Ma, X., Tian, X., Lee, S., Zhang, C., Chen, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07257-z · Cited by 116 · see citing works
Metabolic Regulation of Redox Balance in Cancer
Purohit, V., Simeone, D. M., & Lyssiotis, C. A. (2019) · Cancers · doi:10.3390/cancers11070955 · Cited by 115 · see citing works
Hassouni, B. E., Granchi, C., Vallés‐Martí, A., Supadmanaba, I. G. P., Bononi, G., Tuccinardi, T., Funel, N., Jiménez, C. R., Peters, G. J., Giovannetti, E., et al. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.025 · Cited by 110 · see citing works
Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials
Nauman, G., Gray, J. C., Parkinson, R., Levine, M., & Paller, C. J. (2018) · Antioxidants · doi:10.3390/antiox7070089 · Cited by 107 · see citing works
The Warburg Effect, Lactate, and Nearly a Century of Trying to Cure Cancer
Spencer, N. Y., & Stanton, R. C. (2019) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2019.04.007 · Cited by 107 · see citing works
Nuclear and Cytoplasmic Functions of Vitamin C
Zhitkovich, A. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00348 · Cited by 106 · see citing works
TET family dioxygenases and the TET activator vitamin C in immune responses and cancer
Yue, X., & Rao, A. (2020) · Blood · doi:10.1182/blood.2019004158 · Cited by 105 · see citing works
Epigenetic Regulation of Genomic Stability by Vitamin C
Brabson, J. P., Leesang, T. E., Mohammad, S., & Cimmino, L. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.675780 · Cited by 105 · see citing works
Zhang, Q., Qu, Y., Zhang, Q., Li, F., Li, B., Li, Z., Dong, Y., Lu, L., & Cai, X. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09684-z · Cited by 103 · see citing works
Toyokuni, S. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.401 · Cited by 102 · see citing works
Alterations in Cellular Iron Metabolism Provide More Therapeutic Opportunities for Cancer
Zhou, L., Zhao, B., Zhang, L., Wang, S., Dong, D., Lv, H., & Shang, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051545 · Cited by 102 · see citing works
Jiang, L., Zheng, H., Lyu, Q., Hayashi, S., Sato, K., Sekido, Y., Nakamura, K., Tanaka, H., Ishikawa, K., Kajiyama, H., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101989 · Cited by 101 · see citing works
Vitamin C – A new player in regulation of the cancer epigenome
Gillberg, L., Ørskov, A. D., Liu, M., Harsløf, L. B. S., Jones, P. A., & Grønbæk, K. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.001 · Cited by 100 · see citing works
Cantor, J. R. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.08.009 · Cited by 100 · see citing works
YTHDF1-enhanced iron metabolism depends on TFRC m 6 A methylation
Ye, J., Wang, Z., Chen, X., Jiang, X., Dong, Z., Hu, S., Li, W., Liu, Y., Liao, B., Han, W., et al. (2020) · Theranostics · doi:10.7150/thno.51231 · Cited by 100 · see citing works
Antioxidants in brain tumors: current therapeutic significance and future prospects
Qi, X., Jha, S. K., Jha, N. K., Dewanjee, S., Dey, A., Deka, R., Pritam, P., Ramgopal, K., Liu, W.-T., & Hou, K. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01668-9 · Cited by 100 · see citing works
Auranofin/Vitamin C: A Novel Drug Combination Targeting Triple-Negative Breast Cancer
Hatem, E., Azzi, S., Banna, N. E., He, T., Heneman-Masurel, A., Vernis, L., Baïlle, D., Masson, V., Dingli, F., Loew, D., et al. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy149 · Cited by 96 · see citing works
Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress
Port, J., Muthalagu, N., Raja, M., Ceteci, F., Monteverde, T., Kruspig, B., Hedley, A., Kalna, G., Lilla, S., Neilson, L. J., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0533 · Cited by 94 · see citing works
Berretta, M., Quagliariello, V., Maurea, N., Francia, R. D., Sharifi, S., Facchini, G., Rinaldi, L., Piezzo, M., Manuela, C., Nunnari, G., et al. (2020) · Antioxidants · doi:10.3390/antiox9121182 · Cited by 91 · see citing works
Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation
Mastrangelo, D., Pelosi, E., Castelli, G., Lo‐Coco, F., & Testa, U. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.09.005 · Cited by 89 · see citing works
Gillberg, L., Ørskov, A. D., Nasif, A., Ohtani, H., Madaj, Z., Hansen, J. W., Rapin, N., Mogensen, J. B., Liu, M., Dufva, I. H., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0739-5 · Cited by 89 · see citing works
Allen, B. G., Bodeker, K. L., Smith, M. C., Monga, V., Sandhu, S., Hohl, R. J., Carlisle, T. L., Brown, H. A., Hollenbeck, N. J., Vollstedt, S., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0594 · Cited by 85 · see citing works
Self-citationKuang, Y., & Wang, Q. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.08.007 · Cited by 84 · see citing works
Therapeutic Use of Vitamin C in Cancer: Physiological Considerations
Roa, F. J., Peña, E., Gatica, M., Escobar‐Acuña, K., Saavedra, P., Maldonado, M., Cuevas, M. E., Moraga‐Cid, G., Rivas, C. I., & Muñoz-Montesino, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00211 · Cited by 81 · see citing works
High-Dose Vitamin C for Cancer Therapy
Mussa, A., Idris, R. A. M., Ahmed, N., Ahmad, S., Murtadha, A. H., Din, T. A. D. A. T., Yean, C. Y., Rahman, W. F. W. A., Lazim, N. M., Uskoković, V., et al. (2022) · Pharmaceuticals · doi:10.3390/ph15060711 · Cited by 81 · see citing works
Targeting Cancer Stem Cell Redox Metabolism to Enhance Therapy Responses
Luo, M., & Wicha, M. S. (2018) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2018.10.003 · Cited by 81 · see citing works
Ma, E., Chen, P., Wilkins, H. M., Wang, T., Swerdlow, R. H., & Chen, Q. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.09.008 · Cited by 79 · see citing works
The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome
Traber, M. G., Buettner, G. R., & Bruno, R. S. (2018) · Redox Biology · doi:10.1016/j.redox.2018.101091 · Cited by 79 · see citing works
Self-citationVitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer
Ding, P., Ge, G., Gong, Y., Zhan, Y., He, S., Guan, B., Li, Y., Xu, Z., Hao, H., He, Z., et al. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0527-7 · Cited by 78 · see citing works
Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy
Zhu, Y., Dean, A. E., Horikoshi, N., Heer, C. D., Spitz, D. R., & Gius, D. R. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120844 · Cited by 78 · see citing works
Self-citationThe potential role of vitamin C in empowering cancer immunotherapy
Bedhiafi, T., Inchakalody, V. P., Fernandes, Q., Mestiri, S., Billa, N., Shahab Uddin, M. S., Merhi, M., & Dermime, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112553 · Cited by 77 · see citing works
Lorenzato, A., Magrì, A., Matafora, V., Audrito, V., Arcella, P., Lazzari, L., Montone, M., Lamba, S., Deaglio, S., Siena, S., et al. (2020) · Cancers · doi:10.3390/cancers12030685 · Cited by 75 · see citing works
The role of iron homeostasis and iron-mediated ROS in cancer.
Ying, J., Lu, Z.-B., Fu, L., Tong, Y., Wang, Z., Li, W., & Mou, X. (2021) · PubMed Central · Cited by 74 · see citing works
Understanding the Therapeutic Potential of Ascorbic Acid in the Battle to Overcome Cancer
Reang, J., Sharma, P. C., Thakur, V. K., & Majeed, J. (2021) · Biomolecules · doi:10.3390/biom11081130 · Cited by 73 · see citing works
The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review
Villagrán, M., Ferreira, J. L., Martorell, M., & Mardones, L. (2021) · Antioxidants · doi:10.3390/antiox10121894 · Cited by 73 · see citing works
Redox Systems Biology: Harnessing the Sentinels of the Cysteine Redoxome
Held, J. M. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7725 · Cited by 73 · see citing works
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate
Goncalves, J., Moog, S., Morin, A., Gentric, G., Müller, S., Morrell, A. P., Kľučková, K., Stewart, T. J., Andoniadou, C. L., Lussey‐Lepoutre, C., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2936 · Cited by 72 · see citing works
Metabolic heterogeneity and adaptability in brain tumors
Badr, C. E., Silver, D. J., Siebzehnrübl, F. A., & Deleyrolle, L. P. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03569-w · Cited by 71 · see citing works
High-Dose Vitamin C in Advanced-Stage Cancer Patients
Zasowska‐Nowak, A., Nowak, P. J., & Ciałkowska-Rysz, A. D. (2021) · Nutrients · doi:10.3390/nu13030735 · Cited by 69 · see citing works
GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment
Worley, B. L., Kim, Y. S., Mardini, J., Zaman, R., Leon, K. E., Vallur, P. G., Nduwumwami, A. J., Warrick, J. I., Timmins, P. F., III, Kesterson, J. P., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2018.11.009 · Cited by 68 · see citing works
Targeting metabolism to enhance immunotherapy within tumor microenvironment
Liang, X., Chen, X., Yan, Y., Cheng, A.-Y., Lin, J.-Y., Jiang, Y.-X., Chen, H., Jin, J., & Luan, X. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01304-w · Cited by 68 · see citing works
Veskoukis, A. S., Kerasioti, E., Priftis, A., Kouka, P., Spanidis, Y., Makri, S., & Kouretas, D. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.10.001 · Cited by 66 · see citing works
Lu, Y., Wu, Q.-N., Chen, D.-L., Chen, L.-Z., Wang, Z., Ren, C., Mo, H., Ya, C., Sheng, H., Wang, Y.-N., et al. (2018) · Theranostics · doi:10.7150/thno.21745 · Cited by 65 · see citing works
Schoenfeld, J. D., Alexander, M. S., Waldron, T. J., Sibenaller, Z. A., Spitz, D. R., Buettner, G. R., Allen, B. G., & Cullen, J. J. (2018) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2018.10.006 · Cited by 65 · see citing works
Self-citationSzarka, A., Kapuy, O., Lőrincz, T., & Bánhegyi, G. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7897 · Cited by 64 · see citing works
Low-intensity focused ultrasound-augmented Cascade chemodynamic therapy via boosting ROS generation
Deng, L., Liu, M., Sheng, D., Luo, Y., Wang, D., Yu, X., Wang, Z., Ran, H., & Li, P. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120710 · Cited by 63 · see citing works
Zhang, T., Liu, Z., Tang, W., Zhu, D., Lyu, M., Lam, J. W. Y., Huang, Q., & Tang, B. Z. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101620 · Cited by 63 · see citing works
Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia
Wyart, E., Hsu, M. Y., Sartori, R., Mina, E., Rausch, V., Pierobon, E. S., Mezzanotte, M., Pezzini, C., Bindels, L. B., Lauria, A., et al. (2022) · EMBO Reports · doi:10.15252/embr.202153746 · Cited by 62 · see citing works
Bajor, M., Zych, A. O., Graczyk‐Jarzynka, A., Muchowicz, A., Firczuk, M., Trzeciak, L., Gaj, P., Domagała, A., Kłopotowska, M., Zagożdżon, A., et al. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0263-y · Cited by 62 · see citing works
The role of vitamin C in epigenetic cancer therapy
Mikkelsen, S. U., Gillberg, L., Lykkesfeldt, J., & Grønbæk, K. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.017 · Cited by 61 · see citing works
Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Bradley, M. D., Wagner, B. A., Buettner, G. R., Monga, V., Milhem, M. M., Spitz, D. R., & Allen, B. G. (2017) · Redox Biology · doi:10.1016/j.redox.2017.09.012 · Cited by 61 · see citing works
Self-citationVitamin C for Type 2 Diabetes Mellitus and Hypertension
Das, U. N. (2019) · Archives of Medical Research · doi:10.1016/j.arcmed.2019.05.004 · Cited by 61 · see citing works
Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism
Petronek, M. S., Spitz, D. R., Buettner, G. R., & Allen, B. G. (2019) · Cancers · doi:10.3390/cancers11081077 · Cited by 61 · see citing works
Self-citationDu, J., Hou, K., Mi, S., Ji, H., Ma, S., Ba, Y., Hu, S., Xie, R., & Chen, L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00208 · Cited by 60 · see citing works
Live or let die: Neuroprotective and anti-cancer effects of nutraceutical antioxidants
Mao, X., Jin, M.-Z., Chen, J., Zhou, H., & Jin, W. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.012 · Cited by 58 · see citing works
- Authors
- Schoenfeld, J. D., Sibenaller, Z. A., Mapuskar, K. A., Wagner, B. A., Cramer-Morales, K. L., Furqan, M., Sandhu, S., Carlisle, T. L., Smith, M. C., Abu Hejleh, T., Berg, D. J., Zhang, J., Keech, J., Parekh, K. R., Bhatia, S., Monga, V., Bodeker, K. L., Ahmann, L., Vollstedt, S., Brown, H., Shanahan Kauffman, E. P., Schall, M. E., Hohl, R. J., Clamon, G. H., Greenlee, J. D., Howard, M. A., Schultz, M. K., Smith, B. J., Riley, D. P., Domann, F. E., Cullen, J. J., Buettner, G. R., Buatti, J. M., Spitz, D. R., & Allen, B. G.
- Affiliations
- University of Iowa (US)
- Galera Therapeutics, Inc. (United States) (US)
- Corresponding author
- Spitz, Douglas R.
- Allen, Bryan G.
- ORCID
- Schoenfeld, Joshua D.
- Sibenaller, Zita A.
- Mapuskar, Kranti A.
- Wagner, Brett A.
- Furqan, Muhammad
- Sandhu, Sonia
- Smith, Mark C.
- Berg, Daniel J.
- Zhang, Jun
- Keech, John
- Parekh, Kalpaj R.
- Monga, Varun
- Bodeker, Kellie L.
- Vollstedt, Sandy
- Brown, Heather
- Greenlee, Jeremy D.
- Howard, Matthew A.
- Schultz, Michael K.
- Riley, Dennis P.
- Domann, Frederick E.
- Cullen, Joseph J.
- Buettner, Garry R.
- Buatti, John M.
- Spitz, Douglas R.
- Allen, Bryan G.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 31
- Issue
- 4
- Pages
- 487-500.e8
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC5497844
- OpenAlex
- W2597494578
- Cited by
- 443
- References
- 74
- Citations by year
- 2026: 27 · 2025: 34 · 2024: 44 · 2023: 52 · 2022: 59 · 2021: 56 · 2020: 61 · 2019: 45 · 2018: 45 · 2017: 20
- FWCI
- 38.88
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-08-14)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Society for Radiation Oncology (JF2014-1)
- Carver Research Program of Excellence in Redox Biology
- US NIH (R01-CA182804, R01-CA184051, R01-CA169046, U01-CA166800)
- IBM
- CCSG (P30-CA086862)
- University of Iowa Medical Scientist Training Program (T32-GM007337, T32-CA078586)
- Galera Therapeutics
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- pharmacological ascorbate, reactive oxygen species, superoxide, hydrogen peroxide, mitochondrial oxidative metabolism, non-small cell lung cancer, glioblastoma
- MeSH terms
- Animals, Antineoplastic Combined Chemotherapy Protocols, Ascorbic Acid, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Female, Glioblastoma, Humans, Hydrogen Peroxide, Iron, Lung Neoplasms, Male, Mice, Nude, Oxygen, Radiation-Sensitizing Agents, Xenograft Model Antitumor Assays, Cell Line, Tumor, Chemoradiotherapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
