Cited by 142Malaria Research and ControlMonoclonal and Polyclonal Antibodies ResearchBlood groups and transfusion

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

Suscovich, Todd J., Fallon, Jonathan K., Das, Jishnu, Demas, Allison R., Crain, Jonathan, Linde, Caitlyn H., Michell, Ashlin, Natarajan, Harini +24 more·2020·Science Translational Medicine

Abstract

A combination of two Fc antibody features that leverage innate immune function predicts protection from malaria challenge after RTS,S/AS01 vaccination.

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Crossref · 10.1126/scitranslmed.abb4757

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95 of 95 references verified0 citation errors · 0 not checkable

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  • Human challenge studies have been used to demonstrate the role of antibodies in protection against malaria and typhoid.

    “human challenge studies offer the opportunity to efficiently assess correlates of protection (Box 2) under controlled circumstances36, and they have been used to demonstrate the role of antibodies in protection against malaria37 and typhoid38.”

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Authors
Suscovich, T. J., Fallon, J. K., Das, J., Demas, A. R., Crain, J., Linde, C. H., Michell, A., Natarajan, H., Arevalo, C., Broge, T., Linnekin, T., Kulkarni, V., Lu, R., Slein, M. D., Luedemann, C., Marquette, M., March, S., Weiner, J., Gregory, S., Coccia, M., Flores-Garcia, Y., Zavala, F., Ackerman, M. E., Bergmann-Leitner, E., Hendriks, J., Sadoff, J., Dutta, S., Bhatia, S. N., Lauffenburger, D. A., Jongert, E., Wille-Reece, U., & Alter, G.
Affiliations
  • Ragon Institute of MGH, MIT and Harvard (US)
  • Dartmouth College (US)
  • Massachusetts Institute of Technology (US)
  • PATH’s Malaria Vaccine Initiative, Washington, DC 20001, USA.
  • GlaxoSmithKline (Belgium) (BE)
  • Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
  • Johns Hopkins University (US)
  • Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
  • Janssen (Netherlands) (NL)
  • Walter Reed Army Institute of Research (US)
  • Broad Institute (US)
  • Koch Institute for Integrative Cancer Research At MIT (US)
Corresponding author
  • Suscovich, Todd J.
  • Fallon, Jonathan K.
  • Das, Jishnu
  • Demas, Allison R.
  • Jongert, Erik
  • Wille-Reece, Ulrike
  • Alter, Galit
Venue
Science Translational Medicine
Published
2020-07-22
Volume
12
Issue
553
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W3044993434
Cited by
142
References
95
Citations by year
2026: 10 · 2025: 19 · 2024: 25 · 2023: 22 · 2022: 26 · 2021: 36 · 2020: 4
FWCI
16.47
Type
journal article
Language
en
Open access
closed
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Massachusetts General Hospital (Research Scholars Program)
  • PATH (GAT.0888-30-01617579-COL)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
  • Health Sciences › Medicine › Hematology › Blood groups and transfusion
Keywords
RTS,S/AS01, malaria vaccine, antibody-mediated phagocytosis, controlled human malaria infection, vaccine-induced antibodies, Plasmodium falciparum, monoclonal antibodies
MeSH terms
Antibodies, Protozoan, Humans, Malaria, Plasmodium falciparum, Prospective Studies, Vaccination, Malaria, Falciparum, Receptors, IgG, Malaria Vaccines

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