Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination
Abstract
A combination of two Fc antibody features that leverage innate immune function predicts protection from malaria challenge after RTS,S/AS01 vaccination.
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Human challenge studies have been used to demonstrate the role of antibodies in protection against malaria and typhoid.
“human challenge studies offer the opportunity to efficiently assess correlates of protection (Box 2) under controlled circumstances36, and they have been used to demonstrate the role of antibodies in protection against malaria37 and typhoid38.”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [37]
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Antibody-dependent CD56+ T cell responses are functionally impaired in long-term HIV-1 infection
Fan, X., Zhu, L.-Y., Liang, H. L., et al. (2016) · Retrovirology · doi:10.1186/s12977-016-0313-6 · Cited by 7 · see citing works
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A guide to vaccinology: from basic principles to new developments
Pollard, A. J., & Bijker, E. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00479-7 · Cited by 1,593 · see citing works
Discrete SARS-CoV-2 antibody titers track with functional humoral stability
Bartsch, Y. C., Fischinger, S., Siddiqui, S. M., Chen, Z., Yu, J., Gebre, M., Atyeo, C., Gorman, M. J., Zhu, A. L., Kang, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21336-8 · Cited by 82 · see citing works
Self-citation
- Authors
- Suscovich, T. J., Fallon, J. K., Das, J., Demas, A. R., Crain, J., Linde, C. H., Michell, A., Natarajan, H., Arevalo, C., Broge, T., Linnekin, T., Kulkarni, V., Lu, R., Slein, M. D., Luedemann, C., Marquette, M., March, S., Weiner, J., Gregory, S., Coccia, M., Flores-Garcia, Y., Zavala, F., Ackerman, M. E., Bergmann-Leitner, E., Hendriks, J., Sadoff, J., Dutta, S., Bhatia, S. N., Lauffenburger, D. A., Jongert, E., Wille-Reece, U., & Alter, G.
- Affiliations
- Ragon Institute of MGH, MIT and Harvard (US)
- Dartmouth College (US)
- Massachusetts Institute of Technology (US)
- PATH’s Malaria Vaccine Initiative, Washington, DC 20001, USA.
- GlaxoSmithKline (Belgium) (BE)
- Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
- Johns Hopkins University (US)
- Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
- Janssen (Netherlands) (NL)
- Walter Reed Army Institute of Research (US)
- Broad Institute (US)
- Koch Institute for Integrative Cancer Research At MIT (US)
- Corresponding author
- Suscovich, Todd J.
- Fallon, Jonathan K.
- Das, Jishnu
- Demas, Allison R.
- Jongert, Erik
- Wille-Reece, Ulrike
- Alter, Galit
- ORCID
- Suscovich, Todd J.
- Fallon, Jonathan K.
- Das, Jishnu
- Demas, Allison R.
- Linde, Caitlyn H.
- Michell, Ashlin
- Natarajan, Harini
- Arevalo, Claudia
- Kulkarni, Viraj
- Slein, Matthew D.
- Marquette, Meghan
- March, Sandra
- Weiner, Joshua
- Gregory, Scott
- Coccia, Margherita
- Zavala, Fidel
- Ackerman, Margaret E.
- Bergmann-Leitner, Elke
- Hendriks, Jenny
- Sadoff, Jerald
- Dutta, Sheetij
- Bhatia, Sangeeta N.
- Lauffenburger, Douglas A.
- Alter, Galit
- Venue
- Science Translational Medicine
- Published
- 2020-07-22
- Volume
- 12
- Issue
- 553
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W3044993434
- Cited by
- 142
- References
- 95
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 25 · 2023: 22 · 2022: 26 · 2021: 36 · 2020: 4
- FWCI
- 16.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Massachusetts General Hospital (Research Scholars Program)
- PATH (GAT.0888-30-01617579-COL)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Keywords
- RTS,S/AS01, malaria vaccine, antibody-mediated phagocytosis, controlled human malaria infection, vaccine-induced antibodies, Plasmodium falciparum, monoclonal antibodies
- MeSH terms
- Antibodies, Protozoan, Humans, Malaria, Plasmodium falciparum, Prospective Studies, Vaccination, Malaria, Falciparum, Receptors, IgG, Malaria Vaccines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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