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Ubiquitin–proteasome system in the different stages of dominantly inherited Alzheimer's disease

Liu, H., Bui, Q. V. P., Hassenstab, J. J., Gordon, B. A., Benzinger, T. L. S., Timsina, J., Sung, Y. J., Karch, C. M. M., Renton, A. E., Daniels, A. J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70243 · Cited by 12 · see citing works

Global analysis of the heparin-enriched plasma proteome captures matrisome-associated proteins in Alzheimer’s diseasePreprint

Guo, Q. J., Ping, L., Dammer, E. B., Duong, D. M., Yin, L., Xu, K., Shantaraman, A., Fox, E. J., Johnson, E. C. B., Roberts, B. R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.06.565824 · Cited by 11 · see citing works

Coupling CZE, Liquid‐Phase Ion Mobility, to MS/MS for Quantitative Top‐Down Proteomics: Revealing Significant Proteoform Differences Between Healthy and Alzheimer's Disease Brains

Askarani, M. F., Fang, F., Counts, S. E., & Sun, L.-L. (2025) · Proteomics · doi:10.1002/pmic.70041 · Cited by 10 · see citing works

Differences in Blood and Cerebrospinal Fluid Between Parkinson’s Disease and Related Diseases

Ma, J., Tang, Z., Wu, Y., Zhang, J., Wu, Z., Huang, L., Liu, S., & Wang, Y. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01523-z · Cited by 10 · see citing works

Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer’s disease: associations with Aβ, tau, synaptic proteins and APOE ε4

Nussbaumer, J., Barve, A., Zufferey, V., Espourteille, J., Kirabali, T., Konietzko, U., Razansky, D., Rominger, A., Nordberg, A. K., Buée, L., et al. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00508-2 · Cited by 11 · see citing works

Clonal CD8 T cells in the leptomeninges are locally controlled and influence microglia in human neurodegenerationPreprint

Hobson, R., Lévy, S., Flaherty, D., Xiao, H., Ciener, B., Reddy, H., Singal, C. M. S., Teich, A. F., Shneider, N. A., Bradshaw, E. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.13.548931 · Cited by 10 · see citing works

Proteomic Network Analysis of Alzheimer’s Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE ε4 Genotype and Atomoxetine TreatmentPreprint

Dammer, E. B., Shantaraman, A., Ping, L., Duong, D. M., Gerasimov, E. S., Ravindran, S. P., Guðmundsdóttir, V., Frick, E. A., Gómez, G., Walker, K. A., et al. (2023) · medRxiv · doi:10.1101/2023.10.29.23297651 · Cited by 10 · see citing works

Systematic proteomics in Autosomal dominant Alzheimer’s disease reveals decades-early changes of CSF proteins in neuronal death, and immune pathwaysPreprint

Shen, Y., Ali, M., Timsina, J., Wang, C., Do, A. N., Western, D., Liu, M., Gorijala, P., Budde, J., Liu, H., et al. (2024) · medRxiv · doi:10.1101/2024.01.12.24301242 · Cited by 10 · see citing works

Rethinking neurodegeneration through a co-proteinopathy lens

Zhang, Y. P., Kedia, S., & Klenerman, D. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.10.006 · Cited by 10 · see citing works

15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN

Daniels, A. J., McDade, E., Llibre-Guerra, J., Xiong, C.-J., Perrin, R., Ibanez, L., Supnet-Bell, C., Cruchaga, C., Goate, A., Renton, A. E., et al. (2026) · npj Dementia · doi:10.1038/s44400-025-00047-7 · Cited by 2 · see citing works

Multi-Omic Blood Biomarkers as Dynamic Risk Predictors in Late-Onset Alzheimer’s Disease

Bhalala, O. G., Watson, R., & Yassi, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021231 · Cited by 10 · see citing works

The selfish network: how the brain preserves behavioral function through shifts in neuronal network state

Stroh, A., Schweiger, S., Ramirez, J., & Tüscher, O. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.02.005 · Cited by 10 · see citing works

Atlas of proteomic signatures of brain structure and its links to brain disorders

Ren, P., Hou, X., Li, Z., You, J., Li, Y., Zhang, W., Gong, W., Zhang, B., Wu, B., Wang, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60185-7 · Cited by 10 · see citing works

Semaglutide attenuates neuroinflammation in male mice

Rausch, D. M., Ludwig, M. Q., Bentsen, M. A., Hansen, S. N., Secher, A., Holst, D., Moreno, J., Das, V., Egerod, K. L., Bjerregaard, A.-M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-74038-4 · Cited by 9 · see citing works

Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer’s disease

Lu, L., Binette, A. P., Hristovska, I., Janelidze, S., Smets, B., Cumplido-Mayoral, I., Vasanthakumar, A., Milkovich, B., An, L., Ossenkoppele, R., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01123-0 · Cited by 7 · see citing works

APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia

Philippi, S. M., Kailash, B. P., Raj, T., & Castellano, J. M. (2024) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.52250 · Cited by 6 · see citing works

Large-scale CSF and plasma proteomics reveal immune, synaptic, and extracellular matrix disruptions across neurodegenerative diseases

Ali, M., Timsina, J., Xu, Y., Chen, Y., Gong, K., Western, D., Heo, G., Liu, M., Budde, J., Pottier, C. P., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.02.035 · Cited by 6 · see citing works

Blood‐Based Proteomics for Adult‐Onset Focal Dystonias

Timsina, J., Dinasarapu, A. R., Kilic‐Berkmen, G., Budde, J., Sung, Y. J., Klein, A. M., Cruchaga, C., & Jinnah, H. A. (2024) · Annals of Neurology · doi:10.1002/ana.26929 · Cited by 6 · see citing works

Biomarkers for synaptic dysfunction in Alzheimer’s disease

Ni, R. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01227 · Cited by 6 · see citing works

Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer’s DiseasePreprint

McDade, E., Liu, H., Bui, Q. V. P., Hassenstab, J. J., Gordon, B. A., Benzinger, T. L. S., Shen, Y., Timsina, J., Wang, L., Sung, Y. J., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4202125/v1 · Cited by 6 · see citing works

Species-specific sensitivity to intracerebroventricular streptozotocin in rats and mice highlights pathways and proteins relevant to Alzheimer’s disease

Homolak, J., Marković, P., Virag, D., Knezović, A., Barilar, J. O., Loncar, A., Šalković‐Petrišić, M., & Perhoč, A. B. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-02952-w · Cited by 5 · see citing works

Plasma proteomic Alzheimer's risk score: Biological age clock and pseudotime trajectory

Liu, S., Huang, Y.-N., Park, T., Lee, E. H., Chaudhuri, S., Adzibolosu, N. K., Bice, P. J., Dage, J. L., Brosch, J. R., Gao, S., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70851 · Cited by 4 · see citing works

Development of Plasma Protein Classification Models for Alzheimer’s Disease Using Multiple Machine Learning Approaches

Tsurumi, A., Cahill, C. M., Liu, A., Chatterjee, P., Das, S., & Kobayashi, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311673 · Cited by 4 · see citing works

Aging‐related matrix metallopeptidase 10 and osteopontin levels are associated with pathology, cognitive decline, and age at onset in Alzheimer's disease

Ng, B., Kodosaki, E., Veleva, E., Keshavan, A., Schott, J. M., Heslegrave, A., Fox, N. C., & Zetterberg, H. (2025) · medRxiv · doi:10.1002/alz.71082 · Cited by 2 · see citing works

Integrative analysis of proteomic and MRI data reveals protein associations with brain imaging features in Alzheimer’s disease

Afxenti, S., Bourdakou, M. M., Loizidou, E. M., Zachariou, M., Lambrianides, A., Pantzaris, M., & Spyrou, G. M. (2025) · Expert Review of Proteomics · doi:10.1080/14789450.2025.2584129 · Cited by 3 · see citing works

CSF proteomic profiling with amyloid and tau pathology identifies distinctive sex‐specific alteration of multiple proteins involved in Alzheimer's disease

Do, A. N., Song, S., Ali, M., Timsina, J., Wang, L., Western, D., Liu, M., Sanford, J., Rosende-Roca, M., Boada, M., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71063 · Cited by 4 · see citing works

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Zhu, G., Rodriguez, D. A. A., Gould, N., Ivanov, A. R., Jooß, K., & Sun, L. (2026) · Mass Spectrometry Reviews · doi:10.1002/mas.70028 · Cited by 3 · see citing works

Advances in neurofilament light chain analysis

Uzgiris, A. J., Ladic, L., & Pfister, S. X. (2025) · Advances in clinical chemistry · doi:10.1016/bs.acc.2025.01.006 · Cited by 3 · see citing works

Top‐Down Proteomics Study of Aging and Sexual Dimorphism of Zebrafish Brains

Askarani, M. F., Poulos, W., Dashtaki, M. R., Sadeghi, S., Cibelli, J., Fang, F., & Sun, L.-L. (2025) · Journal of Mass Spectrometry · doi:10.1002/jms.70009 · Cited by 2 · see citing works

Understanding Neurodegenerative Diseases From the −Omics Perspective: Lessons Learnt

Ibáñez, L., Pottier, C. P., Beric, A., Western, D., Ali, M., & Cruchaga, C. (2026) · Annals of Neurology · doi:10.1002/ana.78170 · Cited by 4 · see citing works

APOE ‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Li, F., Chen, Y., Western, D., Ali, M., Liu, M., Gong, K., Xu, Y., Lowery, J., Holtzman, D. M., Robins, C., et al. (2026) · Advanced Science · doi:10.1002/advs.202513872 · Cited by 3 · see citing works

Ultrasensitive Saliva-Based Detection of Early Alzheimer’s Disease Biomarkers via Nanoparticle-Enhanced Evanescent Scattering Microscopy

Dallari, C., Ladurner, G., Kendrisic, M., Caria, F. F., Manzl, C., Ponticelli, L., Perego, L., Goretti, F., Credi, C., Prokesch, M., et al. (2026) · ACS Sensors · doi:10.1021/acssensors.5c04842 · Cited by 2 · see citing works

Neuroinflammatory stress preferentially impacts synaptic MAPK signaling and mitochondria in excitatory neurons

Espinosa‐García, C., Srivastava, U., Kumar, P., Kour, D., Malepati, S., Tobin, B. R., Xiao, H., Sunna, S., Bowen, C. A., Cheng, L., et al. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00024-1 · Cited by 2 · see citing works

Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of studies using ADNI data (2023 to June 2025)

Kanoria, S., Veitch, D. P., Miller, M. J., Aisen, P. S. S., Beckett, L. A., Green, R. C., Harvey, D. J., Jack, C. R., Jagust, W. J., Lee, E. B., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71353 · Cited by 2 · see citing works

Advancing proteomic analysis for understanding disease biology and biomarker discovery

Cruchaga, C. (2025) · Cell · doi:10.1016/j.cell.2025.04.040 · Cited by 2 · see citing works

Glia inflammation and cell death pathways drive disease progression in preclinical and early AD

Woo, M. S., Therriault, J., Hosseini, S. A., Wang, Y.-T., Macedo, A. C., Rahmouni, N., Aumont, É., Servaes, S., Tissot, C., Arias, J. F., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00316-1 · Cited by 2 · see citing works

Novel Missing Data Imputation Approaches Enhance Quantitative Trait Loci Discovery in Multi-Omics AnalysisPreprint

Qi, Z., Pelletier, A., Willwerscheid, J., Cao, X., Wen, X., Cruchaga, C., Jager, P. L. D., Julia, T. C. W., & Wang, G. T. (2023) · medRxiv · doi:10.1101/2023.11.29.23299181 · Cited by 2 · see citing works

Protein-based Diagnosis and Analysis of Co-pathologies Across Neurodegenerative Diseases: Large-Scale AI-Boosted CSF and Plasma ClassificationPreprint

Xu, Y., Western, D., Heo, G., Nho, K. T., Huang, Y.-N., Liu, S., Oh, H. S., Chen, Y., Timsina, J., Liu, M., et al. (2025) · medRxiv · doi:10.1101/2025.07.09.25331192 · Cited by 2 · see citing works

Blood biomarkers of Alzheimer’s disease: findings from proteomics

Wang, Y., Niu, X., Zhen, W., Zhang, B., Chen, L., Liu, Y., Sun, W., & Peng, D. (2025) · Postgraduate Medical Journal · doi:10.1093/postmj/qgaf039 · Cited by 1 · see citing works

Multi-omics analysis of plasma and CSF in spontaneous diabetic cynomolgus monkeys: Unravelling and validating the key molecular markers that predict the preclinical pathological formation of Alzheimer's disease

Huang, X., Xu, Z., Fu, F., Song, J., Zeng, J., Huang, S., & Yue, F. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.110849 · Cited by 1 · see citing works

Integrative genetic and liver transcriptomic analyses identify TRIB1AL as a target for steatotic liver disease

Gobeil, É., Bourgault, J., Gagnon, É., Samson, N., Ruel, L., Côté, V., Mitchell, P. L., Gotti, C., Roux‐Dalvai, F., Droit, A., et al. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag043 · Cited by 1 · see citing works

Semaglutide Attenuates Neuroinflammation in MicePreprint

Belmont-Rausch, D. M., Ludwig, M. Q., Bentsen, M. A., Hansen, S. N., Secher, A., Holst, D., Moreno, J., Das, V., Egerod, K. L., Bjerregaard, A.-M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.10.698763 · Cited by 1 · see citing works

CSF turnover reshapes biomarker interpretation in neurodegeneration studiesPreprint

García‐González, P., Puerta, R., Dehairs, J., Yang, C., Wang, C., Timsina, J., de Rojas, I., Olivé, C., Valenzuela, A., Bayón-Buján, P., et al. (2026) · medRxiv · doi:10.64898/2026.02.02.26345363 · Cited by 2 · see citing works

Diagnostic and progression biomarkers in cerebrospinal fluid of Alzheimer’s disease patients

Chatanaka, M. K., Prassas, I., & Diamandis, E. P. (2024) · BMC Medicine · doi:10.1186/s12916-024-03270-w

Associations of Multimorbidity with Cerebrospinal Fluid Biomarkers for Neurodegenerative Disorders in Early Parkinson's Disease: A Crosssectional and Longitudinal Study

Zhang, M., Sun, Y. P., Chen, Y., Guo, F., Gao, P., Tan, L., & Tan, M. (2024) · Current Alzheimer Research · doi:10.2174/0115672050314397240708060314

Healthy lifestyles, plasma proteomic profile and long-term risk of dementiaPreprint

Shen, J., Wu, M., Huang, Y., Yan, M., Yang, Y., Xu, X., Zong, G., Yang, J., Li, X., Chen, H., et al. (2024) · medRxiv · doi:10.1101/2024.12.01.24317800

Reduced levels of synaptic vesicle protein 2A in the extracellular vesicles and brain of Alzheimer’s disease- associations with Aβ, tau and synaptophysinPreprint

Nussbaumer, J., Barve, A., Zufferey, V., Espourteille, J., Kirabali, T., Konietzko, U., Razansky, D., Rominger, A., Nordberg, A. K., Buée, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.21.634009

The long non-coding RNA TRIB1AL links metabolic dysfunction-associated steatotic liver disease, cardiometabolic risk and human lifespanPreprint

Gobeil, É., Bourgault, J., Gagnon, É., Samson, N., Ruel, L., Côté, V., Mitchell, P. L., Couture, C., Gotti, C., Roux‐Dalvai, F., et al. (2025) · medRxiv · doi:10.1101/2025.06.11.25329423

Learning Human T Cell Behaviors Through Generative AI Embeddings of T Cell ReceptorsPreprint

Chen, D. G., Su, Y., & Heath, J. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.16.660016

Identifying a proteomics signature of cognitive impairment and dementia in blood and cerebrospinal fluid through a mediation analysis framework

Acosta, G. T., Yang, S., Calvo-Marín, J., Moghekar, A., Kamalian, A., & Lutz, M. W. (2025) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2025.10.004

Xanthohumol promotes cognitive function-associated neuroprotein changes in two mouse models of Alzheimer’s diseasePreprint

Liu, W., Xu, B., Ren, X., Chen, Y., Li, G., Zhang, Z., Yang, X., & Liu, J. (2025) · Research Square · doi:10.21203/rs.3.rs-8035932/v1

Brain‐peripheral proteome crosstalk in Alzheimer's disease with and without diabetes mellitus

Meir, A. Y., Wang, X.-Y., Tasaki, S., Sarsani, V., Buchman, A., Arnold, S., Bennett, D. A., Petyuk, V., Liang, L.-M., Capuano, A., et al. (2026) · Alzheimer's & Dementia · doi:10.1002/alz.70959

Reproducibility-driven discovery and systematic benchmarking reveal a robust cerebrospinal fluid proteomic signature in Alzheimer’s diseasePreprint

Zambrano‐Astorga, M. F., Moreno‐Ulloa, A., & Initiative, T. A. D. N. (2026) · medRxiv · doi:10.64898/2026.04.26.26351766

Peroxiredoxin-Mediated Redox Regulation in Neurons: From Neurite Development to Degeneration

Kim, G., 이재연, Kwon, S., Yeom, E., & Lee, D. (2026) · Antioxidants · doi:10.3390/antiox15050604

Bidirectional causal relationships between plasma proteins, neuroimaging metrics and risk of Alzheimer's disease

Xu, X., Li, L., Huang, W., Yang, Y., Li, X., Wang, P., Zhao, M., Zhang, H., & Yuan, C. (2026) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2026.100619

SPP1 (osteopontin): a key regulator orchestrating cancer progression and non-cancerous pathologies - therapeutic opportunities and future directions

Pang, B., Sun, H., Ouyang, M., & Hu, C. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1912468

The impact of structural variation on Alzheimer’s disease in the Alzheimer’s disease sequencing project

Lee, S., English, A. C., Peloso, G. M., Bis, J. C., Boerwinkle, E., Choi, S. H., Heard‐Costa, N. L., Lin, H., Xia, R., Seshadri, S. S., et al. (2026) · Genome biology · doi:10.1186/s13059-026-04206-8

Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer’s disease

Steigmeyer, A. D., Battison, A. S., Liebman, I. R., van Dyck, C. H., Slusher, B. S., Arnsten, A. F. T., Malaker, S. A., & Datta, D. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02442-4

Xanthohumol promotes cognitive function-associated neuroprotein changes in two mouse models of Alzheimer’s disease

Liu, W., Xu, B., Yang, C., Li, G., & Yang, X. (2026) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2026.10.013

Multi-tissue proteomics identifies molecular signatures for sporadic and genetically defined Alzheimer disease casesPreprint

Cruchaga, C., Sung, Y. J., Yang, C., Wang, F., Suhy, A., Norton, J. B., Novotny, B. C., Eteleeb, A. M., Fagan, A. M., Bateman, R. J., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-923492/v1 · Cited by 4 · see citing works

Multi‐tissue proteomic profiling for genetically defined Alzheimer disease cases

Sung, Y. J., Yang, C., Suhy, A., Rhinn, H., Norton, J. B., Wang, F., Bradley, J. L., Farias, F., Benítez, B. A., Harari, O., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.054301 · Cited by 1 · see citing works

CSF proteomics in autosomal dominant Alzheimer’s disease highlights parallels with sporadic disease

van der Ende, E. L., Veld, S. G. J. G. I. ‘., Hanskamp, I., van der Lee, S. J., Dijkstra, J. I. R., Swieten, J. C. V., Irwin, D. J., Chen‐Plotkin, A. S., Hu, W. T., Lemstra, A. W., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.073682 · Cited by 8 · see citing works

Proteomic signatures for sporadic and genetically defined Alzheimer's disease

Sung, Y. J. (2023) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.8028621

Multi-tissue proteomic signatures of Alzheimer’s disease: a systematic investigation in brain, CSF, blood and an exploratory study in tearsPreprint

Shen, J., Huang, Y., Wu, M., Yan, M., Sun, J., Chen, H., Xu, X., Song, P., Yao, P., Xu, Q., et al. (2025) · medRxiv · doi:10.1101/2025.01.14.25320538 · Cited by 1 · see citing works