Molecular Biology of Picornavirus

VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION

Kew, O. M., Sutter, R. W., de Gourville, E. M., Dowdle, W. R., & Pallansch, M. A. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123625 · Cited by 703 · see citing works

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

Maida, Y., Yasukawa, M., Furuuchi, M., Lassmann, T., Possemato, R., Okamoto, N., Kasim, V., Hayashizaki, Y., Hahn, W. C., & Masutomi, K. (2009) · Nature · doi:10.1038/nature08283 · Cited by 384 · see citing works

Structural basis for proteolysis‐dependent activation of the poliovirus RNA‐dependent RNA polymerase

Thompson, A. A., & Peersen, O. B. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600357 · Cited by 232 · see citing works

Translation of poliovirus rna in vitro: Changes in cleavage pattern and initiation sites by ribosomal salt wash

Brown, B. A., & Ehrenfeld, E. (1979) · Virology · doi:10.1016/0042-6822(79)90350-7 · Cited by 177 · see citing works

Human SCARB2-Dependent Infection by Coxsackievirus A7, A14, and A16 and Enterovirus 71

Yamayoshi, S., Iizuka, S., Yamashita, T., et al. (2012) · Journal of Virology · doi:10.1128/jvi.00020-12 · Cited by 171 · see citing works

Bidirectional Increase in Permeability of Nuclear Envelope upon Poliovirus Infection and Accompanying Alterations of Nuclear Pores

Belov, G. A., Lidsky, P. V., Mikitas, O. V., Egger, D., Lukyanov, K. A., Bienz, K., & Agol, V. I. (2004) · Journal of Virology · doi:10.1128/jvi.78.18.10166-10177.2004 · Cited by 116 · see citing works

A Sabin 3-derived poliovirus recombinant contained a sequence homologous with indigenous human enterovirus species C in the viral polymerase coding region

Arita, M., Zhu, S.-L., Yoshida, H., Yoneyama, T., Miyamura, T., & Shimizu, H. (2005) · Journal of Virology · doi:10.1128/jvi.79.20.12650-12657.2005 · Cited by 95 · see citing works

Partitioning the Genetic Diversity of a Virus Family: Approach and Evaluation through a Case Study of Picornaviruses

Lauber, C., & Gorbalenya, A. E. (2012) · Journal of Virology · doi:10.1128/jvi.07173-11 · Cited by 88 · see citing works

Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses

Zhang, P., Mueller, S., Morais, M. C., Bator, C. M., Bowman, V. D., Hafenstein, S. L., Wimmer, E., & Rossmann, M. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807848105 · Cited by 90 · see citing works

Amplicon Sequencing and Improved Detection of Human Rhinovirus in Respiratory Samples

Deffernez, C., Wunderli, W., Thomas, Y., Yerly, S., Perrin, L. H., & Kaiser, L. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.7.3212-3218.2004 · Cited by 78 · see citing works

Human Rhinovirus Type 89 Variants Use Heparan Sulfate Proteoglycan for Cell Attachment

Vlasak, M., Goesler, I., & Blaas, D. (2005) · Journal of Virology · doi:10.1128/jvi.79.10.5963-5970.2005 · Cited by 77 · see citing works

Biased Mutation and Selection in RNA Viruses

Kustin, T., & Stern, A. (2020) · Molecular Biology and Evolution · doi:10.1093/molbev/msaa247 · Cited by 77 · see citing works

Toward Genetics-Based Virus Taxonomy: Comparative Analysis of a Genetics-Based Classification and the Taxonomy of Picornaviruses

Lauber, C., & Gorbalenya, A. E. (2012) · Journal of Virology · doi:10.1128/jvi.07174-11 · Cited by 65 · see citing works

Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68)

Musharrafieh, R. G., Zhang, J., Tuohy, P. J., Kitamura, N., Bellampalli, S. S., Hu, Y., Khanna, R., & Wang, J. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00115 · Cited by 70 · see citing works

A Naturally Occurring Recombinant Enterovirus Expresses a Torovirus Deubiquitinase

Shang, P., Misra, S., Hause, B. M., & Fāng, Y. (2017) · Journal of Virology · doi:10.1128/jvi.00450-17 · Cited by 55 · see citing works

Additive Promotion of Viral Internal Ribosome Entry Site-Mediated Translation by Far Upstream Element-Binding Protein 1 and an Enterovirus 71-Induced Cleavage Product

Hung, C.-T., Kung, Y.-A., Li, M., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005959 · Cited by 45 · see citing works

RNA silencing in viral infections: insights from poliovirus

Saleh, M., van Rij, R. P., & Andino, R. (2004) · Virus Research · doi:10.1016/j.virusres.2004.01.010 · Cited by 41 · see citing works

Plasma Membrane-porating Domain in Poliovirus 2B Protein. A Short Peptide Mimics Viroporin Activity

Madan, V., Sánchez-Martínez, S., Vedovato, N., et al. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.09.058 · Cited by 39 · see citing works

Twelve receptor molecules attach per viral particle of human rhinovirus serotype 2 via multiple modules

Konecsni, T., Kremser, L., Snyers, L., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.015 · Cited by 34 · see citing works

Paralytic Poliomyelitis Associated With Sabin Monovalent and Bivalent Oral Polio Vaccines in Hungary

Estívariz, C. F., Molnar, Z., Venczel, L., Kapusinszky, B., Zingeser, J. A., Lipskaya, G. Y., Kew, O. M., Berencsi, G., & Csohan, A. (2011) · American Journal of Epidemiology · doi:10.1093/aje/kwr070 · Cited by 31 · see citing works

Labeling of Capsid Proteins and Genomic RNA of Human Rhinovirus with Two Different Fluorescent Dyes for Selective Detection by Capillary Electrophoresis

Kremser, L., Petsch, M., Blaas, D., et al. (2004) · Analytical Chemistry · doi:10.1021/ac048999m · Cited by 32 · see citing works

Translation of Viral mRNA without Active eIF2: The Case of Picornaviruses

Welnowska, E., Sanz, M. Á., Redondo, N., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022230 · Cited by 31 · see citing works

The presence of viral-induced proteins in nuclei from poliovirus-infected hela cells

Fernandez-Tomas, C. B. (1982) · Virology · doi:10.1016/0042-6822(82)90154-4 · Cited by 29 · see citing works

Viral polypeptides associated with the RNA replication complex in poliovirus-infected cells

Etchison, D. O., & Ehrenfeld, E. (1980) · Virology · doi:10.1016/0042-6822(80)90279-2 · Cited by 31 · see citing works

Fluorescence Labeling of Human Rhinovirus Capsid and Analysis by Capillary Electrophoresis

Kremser, L., Konecsni, T., Blaas, D., et al. (2004) · Analytical Chemistry · doi:10.1021/ac049842x · Cited by 29 · see citing works

Polarized Entry of Human Parechoviruses in the Airway Epithelium

Karelehto, E., Cristella, C., Yu, X., Sridhar, A., Hulsdouw, R., de Haan, K., van Eijk, H., Koekkoek, S., Pajkrt, D., de Jong, M. D., et al. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00294 · Cited by 26 · see citing works

Physicochemical property consensus sequences for functional analysis, design of multivalent antigens and targeted antivirals

Schein, C. H., Bowen, D. M., Lewis, J. A., Choi, K., Paul, A. V., van Noort, G. J. V. D. H., Lu, W., & Filippov, D. V. (2012) · BMC Bioinformatics · doi:10.1186/1471-2105-13-s13-s9 · Cited by 28 · see citing works

First detection of novel enterovirus G recombining a torovirus papain‐like protease gene associated with diarrhoea in swine in South Korea

Lee, S.-H., & Lee, C. (2018) · Transboundary and Emerging Diseases · doi:10.1111/tbed.13073 · Cited by 27 · see citing works

Pharmacological Characterization of the Mechanism of Action of R523062, a Promising Antiviral for Enterovirus D68

Ma, C., Hu, Y., Zhang, J., et al. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00383 · Cited by 27 · see citing works

Minor group human rhinovirus–receptor interactions: Geometry of multimodular attachment and basis of recognition

Querol‐Audí, J., Konecsni, T., Pous, J., et al. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.12.014 · Cited by 27 · see citing works

Capillary electrophoresis of affinity complexes between subviral 80S particles of human rhinovirus and monoclonal antibody 2G2

Kremser, L., Petsch, M., Blaas, D., & Kenndler, E. (2006) · Electrophoresis · doi:10.1002/elps.200600066 · Cited by 26 · see citing works

Rhinovirus‐stabilizing activity of artificial VLDL‐receptor variants defines a new mechanism for virus neutralization by soluble receptors

Nicodemou, A., Petsch, M., Konecsni, T., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.013 · Cited by 25 · see citing works

Pressure for Pattern-Specific Intertypic Recombination between Sabin Polioviruses: Evolutionary Implications

Korotkova, E., Laassri, M., Zagorodnyaya, T., Petrovskaya, S., Rodionova, E., Cherkasova, E., Gmyl, A., Ivanova, O., Eremeeva, T., Lipskaya, G., et al. (2017) · Viruses · doi:10.3390/v9110353 · Cited by 23 · see citing works

A GCUA tetranucleotide loop found in the poliovirus oriL by in vivo SELEX (un)expectedly forms a YNMG-like structure: Extending the YNMG family with GYYA

Melchers, W. J. G., Zoll, J., Tessari, M., Bakhmutov, D. V., Gmyl, A. P., Agol, V. I., & Heus, H. A. (2006) · RNA · doi:10.1261/rna.113106 · Cited by 22 · see citing works

Homology Modeling and Analysis of Structure Predictions of the Bovine Rhinitis B Virus RNA Dependent RNA Polymerase (RdRp)

Rai, D. K., & Rieder, E. A. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13078998 · Cited by 22 · see citing works

Biochemical and structural characterization of hepatitis A virus 2C reveals an unusual ribonuclease activity on single-stranded RNA

Chen, P., Wojdyla, J. A., Colasanti, O., Li, Z., Qin, B., Wang, M., Lohmann, V., & Cui, S. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac671 · Cited by 22 · see citing works

Host factors required for internal initiation of translation on poliovirus RNA

Toyoda, H., Koide, N., Kamiyama, M., et al. (1994) · Archives of Virology · doi:10.1007/bf01310034 · Cited by 22 · see citing works

Molecular Recognition of Ligands by Native Viruses and Virus-Like Particles as Studied by NMR Experiments

Rademacher, C., & Peters, T. (2008) · Topics in current chemistry · doi:10.1007/128_2007_19 · Cited by 22 · see citing works

An investigation into causes of resistance of a cloned line of BHK cells to a strain of foot-and-mouth disease virus

Clarke, J., & Spier, R. E. (1983) · Veterinary Microbiology · doi:10.1016/0378-1135(83)90078-0 · Cited by 20 · see citing works

Enteroviral Pathogenesis of Type 1 Diabetes: The Role of Natural Killer Cells

Nekoua, M. P., Dechaumes, A., Sané, F., Alidjinou, E. K., Moutairou, K. A., Yessoufou, A., & Hober, D. (2020) · Microorganisms · doi:10.3390/microorganisms8070989 · Cited by 18 · see citing works

Identification of poliovirions and subviral particles by capillary electrophoresis

Halewyck, H., Oita, I., Thys, B., et al. (2010) · Electrophoresis · doi:10.1002/elps.201000274 · Cited by 18 · see citing works

Regulation of enterovirus 2A protease-associated viral IRES activities by the cell's ERK signaling cascade: Implicating ERK as an efficiently antiviral target

Duan, H., Zhu, M. T., Xiong, Q., Wang, Y., Xu, C., Sun, J., Wang, C., Zhang, H., Xu, P., & Peng, Y. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.03.018 · Cited by 18 · see citing works

Functional and Structural Characterization of 2B Viroporin Membranolytic Domains

Sánchez-Martínez, S., Huarte, N., Maeso, R., et al. (2008) · Biochemistry · doi:10.1021/bi800997a · Cited by 16 · see citing works

A peptide based on the pore-forming domain of pro-apoptotic poliovirus 2B viroporin targets mitochondria

Madan, V., Sánchez-Martínez, S., Carrasco, L., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.10.013 · Cited by 16 · see citing works

Identification of the Human Rhinovirus Serotype 1A Binding Site on the Murine Low-Density Lipoprotein Receptor by Using Human-Mouse Receptor Chimeras

Herdy, B., Snyers, L., Reithmayer, M., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.13.6766-6774.2004 · Cited by 16 · see citing works

Mengovirus-induced inhibition of cell protein synthesis and subsequent recovery of cellular activity in interferon-pretreated cells

FALCOFF, R., & Sancéau, J. (1979) · Virology · doi:10.1016/0042-6822(79)90565-8 · Cited by 16 · see citing works

The substitution U475 → C with Sabin3-like mutation within the IRES attenuate Coxsackievirus B3 cardiovirulence

M’hadheb-Gharbi, M. B., Paulous, S., Aouni, M., Kean, K. M., & Gharbi, J. (2007) · Molecular Biotechnology · doi:10.1007/s12033-007-0019-z · Cited by 15 · see citing works

The design of antiviral agents based on strategic sequences in viral RNA and antiviral effects of single stranded polynucleotides

STEBBING, N. (1979) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(79)90050-0 · Cited by 14 · see citing works

Effect of interferon on transient shut-off of cellular RNA and protein synthesis induced by mengo virus infection

Vaquero, C., Aujean-Rigaud, O., Sancéau, J., et al. (1981) · Antiviral Research · doi:10.1016/0166-3542(81)90038-3 · Cited by 13 · see citing works

Oncolytic viruses: a potential breakthrough immunotherapy for multiple myeloma patients

Raimondi, V., Vescovini, R., Dessena, M., Donofrío, G., Storti, P., & Giuliani, N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1483806 · Cited by 9 · see citing works

Rhinovirus RNA Polymerase

Nirwan, S., & Kakkar, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-815422-9.00011-5 · Cited by 9 · see citing works

Elucidating the structural dynamics induced by active site mutations in 3C protease of foot-and-mouth disease virus

Sahoo, S., Lee, H., & Shin, D. (2025) · PLoS ONE · doi:10.1371/journal.pone.0321079 · Cited by 8 · see citing works

Receptor Arrays for the Selective and Efficient Capturing of Viral Particles

Pollheimer, P. D., Kastner, M., Ebner, A., Blaas, D., Hinterdorfer, P., Gruber, H. J., & Howorka, S. (2009) · Bioconjugate Chemistry · doi:10.1021/bc800357j · Cited by 8 · see citing works

Detection of Viral −RNA and +RNA Strands in Enterovirus-Infected Cells and Tissues

Salmikangas, S., Laiho, J. E., Kalander, K., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8121928 · Cited by 7 · see citing works

Experimental and mathematical insights on the competition between poliovirus and a defective interfering genomePreprint

Shirogane, Y., Rousseau, E., Voznica, J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/519751 · Cited by 7 · see citing works

First isolation and genomic characterization of bovine parechovirus from faecal samples of cattle in Japan

Oba, M., Sakaguchi, S., Wu, H. Y., et al. (2022) · Journal of General Virology · doi:10.1099/jgv.0.001718 · Cited by 6 · see citing works

Quand un entérovirus émerge

Kairis, B., Sauter, P., Goffard, A., Fronval, S., Sané, F., & Hober, D. (2009) · Pathologie Biologie · doi:10.1016/j.patbio.2008.06.001 · Cited by 5 · see citing works

Molecular characterization and pathogenicity evaluation of enterovirus G isolated from diarrheic piglets

Ibrahim, Y. M., Zhang, W., Wang, X., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.02643-23 · Cited by 5 · see citing works

A Mutation in the First Ligand-Binding Repeat of the Human Very-Low-Density Lipoprotein Receptor Results in High-Affinity Binding of the Single V1 Module to Human Rhinovirus 2

Nizet, S., Wruss, J., Landstetter, N., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14730-14736.2005 · Cited by 5 · see citing works

Synthetic Biology Approaches for Vaccine Development

Shen, S. H., Futcher, B., Yang, C., & Wimmer, E. (2014) · Wiley-VCH eBooks · doi:10.1002/3527600906.mcb.20120059 · Cited by 3 · see citing works

Picornaviruses

Neubauer, D., Steinberger, J., & Skern, T. (2009) · Springer eBooks · doi:10.1007/978-90-481-2348-3_6 · Cited by 3 · see citing works

Sequences and Structures of Viral Proteins Linked to the Genomes (VPg) of RNA Viruses

Schein, C. H. (2025) · Viruses · doi:10.3390/v17050645 · Cited by 3 · see citing works

(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase

de Castro, S., Ferrer‐Orta, C., Mills, A., et al. (2019) · Molecules · doi:10.3390/molecules24132360 · Cited by 2 · see citing works

Biodiversity and evolution ofPicorna-like viruses

Sanfaçon, H. (2006) · Biodiversity · doi:10.1080/14888386.2006.9712794 · Cited by 2 · see citing works

Gene Expression and Replication of Picornaviruses

Cornell, C. T., & Semler, B. L. (2006) · Encyclopedia of Molecular Cell Biology and Molecular Medicine · doi:10.1002/3527600906.mcb.200300167 · Cited by 2 · see citing works

Cells, Bureaucracy and Corruption

Adler, F. R. (2026) · Bulletin of Mathematical Biology · doi:10.1007/s11538-026-01664-w · Cited by 2 · see citing works

Characterization of Mutational Tolerance of a Viral RNA–Protein Interaction

Prostova, M. A., Smertina, E., Bakhmutov, D. V., Gasparyan, A. A., Khitrina, E. V., Kolesnikova, M. S., Shishova, А. A., Gmyl, A. P., & Agol, V. I. (2019) · Viruses · doi:10.3390/v11050479 · Cited by 1 · see citing works

X-ray crystallography of virus-receptor complexes: structure of a minor group rhinovirus bound to its cellular receptor protein

Querol‐Audí, J., Fita, I., & Verdaguer, N. (2005) · Crystallography Reviews · doi:10.1080/08893110500078704 · Cited by 1 · see citing works

Picornaviridae: Enterovirus

Anwar, Z. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818731-9.00154-3 · Cited by 1 · see citing works

The Replication of Viruses

Rowlands, D. J. (2010) · doi:10.1002/9780470688618.taw0213

Molecular Events Leading to Picornavirus Genome Replication

Wimmer, E., Kuhn, R. J., Pincus, S., et al. (1987) · Journal of Cell Science · doi:10.1242/jcs.1987.supplement_7.18 · Cited by 51 · see citing works

New picornavirus vaccines for hepatitis A, and lessons from the control of poliomyelitis by the prototype picornavirus vaccines.

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Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses

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Analysis of the human T-cell response to picornaviruses: identification of T-cell epitopes close to B-cell epitopes in poliovirus

Graham, S., Wang, E. C. Y., Jenkins, O. F., et al. (1993) · Journal of Virology · doi:10.1128/jvi.67.3.1627-1637.1993 · Cited by 66 · see citing works

Strategy for construction of live picornavirus vaccines

Nomoto, A., Iizuka, N., Kohara, M., & Arita, M. (1988) · Vaccine · doi:10.1016/s0264-410x(88)80015-x · Cited by 24 · see citing works