An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
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Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate telomeres. Here we show that TERT interacts with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome cartilage-hair hypoplasia. Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner. These observations identify a mammalian RdRP composed of TERT in complex with RMRP.
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TERT's enhancement of Wnt signaling explains its activation of bulge stem cells, since β-catenin overexpression in mouse skin causes a similar stem cell activation phenotype.
“The ability of TERT to enhance Wnt signaling explains how TERT activates bulge stem cells since overexpression of b-catenin in mouse skin causes a very similar stem cell-activation phenotype (150-152).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [151]
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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · see citing works
Creation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345 · see citing works
Self-citationTelomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256 · see citing works
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline
Vagin, V. V., Sigova, A. A., Li, C., Seitz, H., Gvozdev, V. A., & Zamore, P. D. (2006) · Science · doi:10.1126/science.1129333 · Cited by 1,342 · see citing works
On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing
Sijen, T., Fleenor, J., Simmer, F., Thijssen, K. L., Parrish, S., Timmons, L., Plasterk, R. H. A., & Fire, A. Z. (2001) · Cell · doi:10.1016/s0092-8674(01)00576-1 · Cited by 1,280 · see citing works
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
Watanabe, T., Totoki, Y., Toyoda, A., Kaneda, M., Kuramochi‐Miyagawa, S., Obata, Y., Chiba, H., Kohara, Y., Kono, T., Nakano, T., et al. (2008) · Nature · doi:10.1038/nature06908 · Cited by 1,115 · see citing works
Mourrain, P., Béclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J., Jouette, D., Lacombe, A.-M., Nikic, S., Picault, N., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80863-6 · Cited by 1,096 · see citing works
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
Tam, O. H., Aravin, A. A., Stein, P., Girard, A., Murchison, E. P., Cheloufi, S., Hodges, E. C., Anger, M., Sachidanandam, R., Schultz, R. M., et al. (2008) · Nature · doi:10.1038/nature06904 · Cited by 1,042 · see citing works
Inhibition of telomerase limits the growth of human cancer cells
Hahn, W. C., Stewart, S. A., Brooks, M. W., York, S. G., Eaton, E. N., Kurachi, A. L., Beijersbergen, R. L., Knoll, J. H. M., Meyerson, M. M., & Weinberg, R. A. (1999) · Nature Medicine · doi:10.1038/13495 · Cited by 1,032 · see citing works
Self-citationWeinrich, S. L., Pruzan, R., Ma, L., Ouellette, M. M., Tesmer, V. M., Holt, S. E., Bodnar, A. G., Lichtsteiner, S., Kim, N. W., Trager, J. B., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-498 · Cited by 963 · see citing works
Babiarz, J., Ruby, J. G., Wang, Y., Bartel, D. P., & Blelloch, R. H. (2008) · Genes & Development · doi:10.1101/gad.1705308 · Cited by 909 · see citing works
Telomerase maintains telomere structure in normal human cells
Kenichi, M., Yu, E. Y., Shilagardi, K., Ben‐Porath, I., Currier, J. L., Metz, G. B., Brooks, M. W., Kaneko, S., Seishi, M., DeCaprio, J. A., et al. (2006) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 738 · see citing works
Self-citationIdentification and properties of the RNA‐dependent RNA polymerase of hepatitis C virus.
Behrens, S., Tomei, L., & Francesco, R. D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00329.x · Cited by 699 · see citing works
Protein Composition of Catalytically Active Human Telomerase from Immortal Cells
Cohen, S. B., Graham, M. E., Lovrecz, G. O., Bache, N., Robinson, P. J., & Reddel, R. R. (2007) · Science · doi:10.1126/science.1138596 · Cited by 669 · see citing works
Smardon, A. M., Spoerke, J. M., Stacey, S. C., Klein, M. E., Mackin, N. A., & Maine, E. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00323-7 · Cited by 538 · see citing works
A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., & Artandi, S. E. (2009) · Science · doi:10.1126/science.1165357 · Cited by 522 · see citing works
Ridanpää, M., van Eenennaam, H., Pelin, K., Chadwick, R. B., Johnson, C. K. H., Yuan, B., vanVenrooij, W. J., Pruijn, G. J. M., Salmela, R., Rockas, S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00205-7 · Cited by 511 · see citing works
Evidence that siRNAs Function as Guides, Not Primers, in the Drosophila and Human RNAi Pathways
Schwarz, D. S., Hutvágner, G., Haley, B., & Zamore, P. D. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00651-2 · Cited by 471 · see citing works
Function and synthesis of small nucleolar RNAs
Tollervey, D. W., & Kiss, T. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80005-1 · Cited by 467 · see citing works
Molecular Biology Of Picornaviruses
Semler, B. L., & Wimmer, E. (2002) · Cited by 449 · see citing works
Conditional telomerase induction causes proliferation of hair follicle stem cells
Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., Artandi, M. K., Oro, A. E., & Artandi, S. E. (2005) · Nature · doi:10.1038/nature03836 · Cited by 425 · see citing works
Yang, N., & Kazazian, H. H. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1141 · Cited by 398 · see citing works
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
Masutomi, K., Possemato, R., Wong, J. M. Y., Currier, J. L., Tóthová, Z., Manola, J. B., Ganesan, S., Lansdorp, P. M., Collins, K., & Hahn, W. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503095102 · Cited by 381 · see citing works
Self-citationGonzález‐Suárez, E., Samper, E., Ramírez, A., Flores, J. M., Martín‐Caballero, J., Jorcano, J. L., & Blasco, M. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2619 · Cited by 372 · see citing works
RNAi as Random Degradative PCR
Lipardi, C., Qin, W., & Paterson, B. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00537-2 · Cited by 369 · see citing works
Choi, J., Southworth, L. K., Sarin, K. Y., Venteicher, A. S., Ma, W., Chang, W., Cheung, P., Jun, S., Artandi, M. K., Shah, N., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040010 · Cited by 336 · see citing works
Venteicher, A. S., Meng, Z., Mason, P. J., Veenstra, T. D., & Artandi, S. E. (2008) · Cell · doi:10.1016/j.cell.2008.01.019 · Cited by 329 · see citing works
Constitutive telomerase expression promotes mammary carcinomas in aging mice
Artandi, S. E., Alson, S., Tietze, M. K., Sharpless, N. E., Ye, S., Greenberg, R. A., Castrillon, D. H., Horner, J. W., Weiler, S. R., Carrasco, R. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112515399 · Cited by 317 · see citing works
New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin
Chan, S. W.-L., & Blackburn, E. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205082 · Cited by 304 · see citing works
Sugiyama, T., Cam, H. P., Verdel, A., Moazed, D., & Grewal, S. I. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407641102 · Cited by 298 · see citing works
Structure of the Tribolium castaneum telomerase catalytic subunit TERT
Gillis, A., Schuller, A. P., & Skordalakes, E. (2008) · Nature · doi:10.1038/nature07283 · Cited by 281 · see citing works
The RNA-Induced Silencing Complex Is a Mg2+-Dependent Endonuclease
Schwarz, D. S., Tomari, Y., & Zamore, P. D. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.008 · Cited by 268 · see citing works
RNA silencing and genome regulation
Almeida, R., & Allshire, R. C. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.03.006 · Cited by 260 · see citing works
Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing
Azuma-Mukai, A., Oguri, H., Mitsuyama, T., Qian, Z. R., Asai, K., Siomi, H., & Siomi, M. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800334105 · Cited by 249 · see citing works
Yamashita, T., Kaneko, S., Shirota, Y., Qin, W., Nomura, T., KOBAYASHI, K. P., & Murakami, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15479 · Cited by 241 · see citing works
In vitro analyses of the production and activity of secondary small interfering RNAs in C. elegans
Aoki, K., Moriguchi, H., Yoshioka, T., Okawa, K., & Tabara, H. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601910 · Cited by 230 · see citing works
Fu, D., & Collins, K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.023 · Cited by 229 · see citing works
Telomere maintenance and human bone marrow failure
Calado, R. T., & Young, N. S. (2008) · Blood · doi:10.1182/blood-2007-08-019729 · Cited by 220 · see citing works
Smardon, A. M., Spoerke, J. M., Stacey, S. C., Klein, M. E., Mackin, N. A., & Maine, E. M. (2000) · Current Biology · Cited by 220 · see citing works
Makeyev, E. V., & Bamford, D. H. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00780-3 · Cited by 191 · see citing works
Characterization of endogenous human argonautes and their miRNA partners in RNA silencing
向井, あ., & 東, あ. (2008) · Medical Entomology and Zoology · Cited by 179 · see citing works
Nishikura, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00581-5 · Cited by 174 · see citing works
Ribosomes and marrow failure: coincidental association or molecular paradigm?
Liu, J. M., & Ellis, S. R. (2006) · Blood · doi:10.1182/blood-2005-12-4831 · Cited by 154 · see citing works
TERT promotes cellular and organismal survival independently of telomerase activity
Lee, J., Sung, Y. H., Cheong, C., Choi, Y. S., Jeon, H. K., Sun, W., Hahn, W. C., Ishikawa, F., & Lee, H.-W. (2008) · Oncogene · doi:10.1038/sj.onc.1211037 · Cited by 145 · see citing works
Self-citationMoriarty, T. J., Huard, S., Dupuis, S., & Autexier, C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1253-1265.2002 · Cited by 112 · see citing works
Telomerase Can Inhibit the Recombination-based Pathway of Telomere Maintenance in Human Cells
Ford, L. P., Zou, Y. S., Pongracz, K., Gryaznov, S. M., Shay, J. W., & Wright, W. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104469200 · Cited by 92 · see citing works
The Structure of an RNAi Polymerase Links RNA Silencing and Transcription
Salgado, P. S., Koivunen, M. R. L., Makeyev, E. V., Bamford, D. H., Stuart, D. I., & Grimes, J. M. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040434 · Cited by 92 · see citing works
Telomerase Maintains Telomere Structure in Normal Human Cells
Masutomi, K., Yu, E. Y., Khurts, S., Ben-Porath, I., Currier, J. L., Metz, G. B., Brooks, M. W., Kaneko, S., Murakami, S., DeCaprio, J. A., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00550-6 · Cited by 70 · see citing works
Self-citationMolecular Biology of Picornavirus
(2002) · doi:10.1128/9781555817916 · Cited by 70 · see citing works
Telomerase can act as a template- and RNA-independent terminal transferase
Lue, N. F., Bosoy, D., Moriarty, T. J., Autexier, C., Altman, B. J., & Leng, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502252102 · Cited by 49 · see citing works
Won, J., Chang, S., Oh, S., & Kim, T. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401801101 · Cited by 44 · see citing works
Bone marrow transplantation for cartilage-hair-hypoplasia
Guggenheim, R., Somech, R., Grunebaum, E., Atkinson, A. R., & Roifman, C. M. (2006) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705520 · Cited by 39 · see citing works
Tumor Cells Fail to trans -Induce Telomerase in Human Umbilical Vein Endothelial Cell Cultures
Pascale, E., Reale, G. C., & D’Ambrosio, E. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1711 · Cited by 1 · see citing works
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Zack, T. I., Schumacher, S. E., Carter, S. L., Cherniack, A. D., Saksena, G., Tabak, B., Lawrence, M. S., Zhang, C., Wala, J. A., Mermel, C. H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2760 · Cited by 1,843 · see citing works
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Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319 · see citing works
Long non-coding RNAs: A new frontier in the study of human diseases
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Long non-coding RNAs and cancer: a new frontier of translational research?
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Artandi, S. E., & DePinho, R. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp268 · Cited by 823 · see citing works
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Park, O. H., Ha, H., Lee, Y., Boo, S. H., Kwon, D. H., Song, H. K., & Kim, Y. K. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.034 · Cited by 574 · see citing works
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
Martínez, P., & Blasco, M. A. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3025 · Cited by 530 · see citing works
Telomerase directly regulates NF-κB-dependent transcription
Ghosh, A., Saginc, G., Leow, S. C., Khattar, E., Shin, E. M., Yan, T. D., Wong, M., Zhang, Z., Li, G., Sung, W.-K., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2621 · Cited by 378 · see citing works
Arita, H., Narita, Y., Fukushima, S., Tateishi, K., Matsushita, Y., Yoshida, A., Miyakita, Y., Ohno, M., Collins, V. P., Kawahara, N., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1141-6 · Cited by 371 · see citing works
A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis
Tefferi, A., Lasho, T. L., Begna, K. H., Patnaik, M. M., Zblewski, D., Finke, C. M., Laborde, R. R., Wassie, E. A., Schimek, L., Hanson, C. A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1310523 · Cited by 323 · see citing works
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Arita, H., Yamasaki, K., Matsushita, Y., Nakamura, T., Shimokawa, A., Takami, H., Tanaka, S., Mukasa, A., Shirahata, M., Shimizu, S., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0351-2 · Cited by 252 · see citing works
Parameswaran, P., Sklan, E. H., Wilkins, C. R., Burgon, T. B., Samuel, M. A., Lu, R., Ansel, K. M., Heissmeyer, V., Einav, S., Jackson, W. T., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000764 · Cited by 251 · see citing works
Estrada, J. C., Torres, Y., Benguría, A., Dopazo, A., Roche, E., Carrera-Quintanar, L., Acín‐Pérez, R., Enrı́quez, J. A., Torres-Ruiz, R., Ramírez, J. C., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.211 · Cited by 229 · see citing works
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Shao, Y., Ye, M., Li, Q., Sun, W., Ye, G., Zhang, X., Yang, Y., Xiao, B., & Guo, J. (2016) · Oncotarget · doi:10.18632/oncotarget.9336 · Cited by 170 · see citing works
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Yin, H., Chen, L., Piao, S., Wang, Y., Li, Z., Lin, Y., Tang, X., Zhang, H., Zhang, H., & Wang, X. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00888-8 · Cited by 150 · see citing works
Bianchessi, V., Badi, I., Bertolotti, M., Nigro, P., D’Alessandra, Y., Capogrossi, M. C., Zanobini, M., Pompilio, G., Raucci, A., & Lauri, A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.012 · Cited by 149 · see citing works
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Strong, M. A., Vidal-Cardenas, S. L., Karim, B. O., Yu, H. M., Guo, N., & Greider, C. W. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05312-11 · Cited by 134 · see citing works
Zheng, Q., Ryvkin, P., Li, F., Dragomir, I. C., Valladares, O., Yang, J., Cao, K., Wang, L., & Gregory, B. D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001141 · Cited by 137 · see citing works
Tomecki, R., Sikorski, P. J., & Zakrzewska‐Placzek, M. (2017) · FEBS Letters · doi:10.1002/1873-3468.12682 · Cited by 131 · see citing works
Ding, D., Peng, X., Zhou, J., Wang, M., & Cong, Y. (2013) · The FASEB Journal · doi:10.1096/fj.13-230904 · Cited by 129 · see citing works
Flores, R., Grubb, D., Elleuch, A., Nohales, M. A., Delgado, S., & Gago‐Zachert, S. (2011) · RNA Biology · doi:10.4161/rna.8.2.14238 · Cited by 126 · see citing works
The role of small non-coding RNAs in genome stability and chromatin organization
van Wolfswinkel, J. C., & Ketting, R. F. (2010) · Journal of Cell Science · doi:10.1242/jcs.061713 · Cited by 122 · see citing works
Archaeal/Eukaryal RNase P: subunits, functions and RNA diversification
Jarrous, N., & Gopalan, V. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq701 · Cited by 115 · see citing works
New prospects for targeting telomerase beyond the telomere
Arndt, G. M., & MacKenzie, K. L. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.55 · Cited by 120 · see citing works
Mitochondria, Telomeres and Telomerase Subunits
Zheng, Q., Huang, J., & Wang, G. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00274 · Cited by 110 · see citing works
The regulations of telomerase reverse transcriptase (TERT) in cancer
Liu, M.-D., Zhang, Y., Jian, Y.-P., Gu, L.-T., Zhang, D., Zhou, H.-L., Wang, Y.-S., & Xu, Z.-X. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06454-7 · Cited by 116 · see citing works
Kovalenko, O. A., Caron, M. J., Ulema, P., Medrano, C., Thomas, A. P., Kimura, M., Bonini, M. G., Herbig, U., & Santos, J. H. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00551.x · Cited by 108 · see citing works
Growth control and ribosomopathies
Teng, T., Thomas, G., & Mercer, C. A. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.02.001 · Cited by 106 · see citing works
Novel modulators of senescence, aging, and longevity: Small non-coding RNAs enter the stage.
Grillari, J., & Grillari-Voglauer, R. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.007 · Cited by 112 · see citing works
A Matter of Time: Small RNAs Regulate the Duration of Epigenetic Inheritance
Houri-Zeevi, L., & Rechavi, O. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.11.001 · Cited by 107 · see citing works
Conserved chromosomal functions of RNA interference
Gutbrod, M. J., & Martienssen, R. A. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-019-0203-6 · Cited by 100 · see citing works
Separation of telomerase functions by reverse genetics
Mukherjee, S., Firpo, E. J., Wang, Y., & Roberts, J. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112414108 · Cited by 100 · see citing works
New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism
Kapranov, P., Ozsolak, F., Kim, S. W., Foissac, S., Lipson, D., Hart, C., Roels, S., Borel, C., Antonarakis, S. E., Monaghan, A. P., et al. (2010) · Nature · doi:10.1038/nature09190 · Cited by 98 · see citing works
Telomerase and drug resistance in cancer
Lipińska, N., Romaniuk-Drapała, A., Paszel-Jaworska, A., Totoń, E., Kopczyński, P., & Rubiś, B. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2573-2 · Cited by 99 · see citing works
Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria
Chiodi, I., & Mondello, C. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00133 · Cited by 96 · see citing works
Telomere Length Dynamics in Vascular Disease: A Review
Butt, H. Z., Atturu, G., London, N. J. M., Sayers, R. D., & Bown, M. J. (2010) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2010.04.012 · Cited by 95 · see citing works
Ribosomopathies: Mechanisms of Disease
Nakhoul, H. N., Ke, J., Zhou, X. Y., Liao, W., Zeng, S. X., & Lu, H. (2014) · Plasmatology · doi:10.4137/cmbd.s16952 · Cited by 92 · see citing works
Protection from Feed-Forward Amplification in an Amplified RNAi Mechanism
Pak, J., Maniar, J. M., Mello, C. C., & Fire, A. Z. (2012) · Cell · doi:10.1016/j.cell.2012.10.022 · Cited by 92 · see citing works
A widespread class of reverse transcriptase-related cellular genes
Gladyshev, E. A., & Arkhipova, I. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100266108 · Cited by 89 · see citing works
Rogler, L. E., Kosmyna, B., Moskowitz, D. M., Bebawee, R. S., Rahimzadeh, J., Kutchko, K. M., Laederach, A., Notarangelo, L. D., Giliani, S. C., Bouhassira, E. E., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt427 · Cited by 88 · see citing works
Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish
Carneiro, M. C., Henriques, C. M., Nabais, J., Ferreira, T., Carvalho, T., & Ferreira, M. G. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005798 · Cited by 82 · see citing works
RNA polymerase III transcription as a disease factorPreprint
Yeganeh, M., & Hernandez, N. (2020) · Genes & Development · doi:10.1101/gad.333989.119 · Cited by 85 · see citing works
Hukezalie, K. R., Thumati, N. R., Côté, H. C. F., & Wong, J. M. Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047505 · Cited by 84 · see citing works
Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches
Jeandard, D., Smirnova, A., Tarassov, I., Barrey, É., Smirnov, A., & Entelis, N. (2019) · Cells · doi:10.3390/cells8030286 · Cited by 86 · see citing works
Non-coding RNAs and disease: the classical ncRNAs make a comeback
de Almeida, R. A., Fraczek, M. G., Parker, S., Delneri, D., & O’Keefe, R. T. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160089 · Cited by 83 · see citing works
Evolutionary mechanism unifies the hallmarks of cancer
Horne, S. D., Pollick, S. A., & Heng, H. H. (2014) · International Journal of Cancer · doi:10.1002/ijc.29031 · Cited by 81 · see citing works
The mitochondrial genome in aging and senescence
Lauri, A., Pompilio, G., & Capogrossi, M. C. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.07.001 · Cited by 80 · see citing works
The role of long non-coding RNAs in the pathogenesis of hereditary diseases
Sparber, P. A., Filatova, A. Y., Khantemirova, M., & Skoblov, M. Y. (2019) · BMC Medical Genomics · doi:10.1186/s12920-019-0487-6 · Cited by 80 · see citing works
Quantitative assessment of telomerase components in cancer cell lines
Akıncılar, S. C., Low, K. C., Liu, C. Y., Yan, T. D., Oji, A., Ikawa, M., Li, S., & Tergaonkar, V. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.02.035 · Cited by 79 · see citing works
The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity
Smalheiser, N. R. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0504 · Cited by 77 · see citing works
Hirashima, K., & Seimiya, H. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv063 · Cited by 76 · see citing works
Taylor, J. M., & Pelchat, M. (2010) · Future Microbiology · doi:10.2217/fmb.10.15 · Cited by 75 · see citing works
Differential expression of long non-coding RNAs in bleomycin-induced lung fibrosis
Cao, G., Zhang, J., Wang, M., Song, X., Liu, W., MAO, C., & Lv, C. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1404 · Cited by 74 · see citing works
Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics
Yuan, X., & Xu, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133338 · Cited by 75 · see citing works
Roles of RNase P and Its Subunits
Jarrous, N. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.06.006 · Cited by 72 · see citing works
Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species
Mathew, R., Bhadra, M. P., & Bhadra, U. (2017) · Biogerontology · doi:10.1007/s10522-016-9670-8 · Cited by 75 · see citing works
Functional lability of RNA-dependent RNA polymerases in animals
Pinzón, N., Bertrand, S., Subirana, L., Busseau, I., Escrivá, H., & Seitz, H. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007915 · Cited by 70 · see citing works
Characterization of Human Pseudogene-Derived Non-Coding RNAs for Functional Potential
Guo, X., Lin, M., Rockowitz, S., Lachman, H. M., & Zheng, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093972 · Cited by 70 · see citing works
Burroughs, A. M., Ando, Y., & Aravind, L. (2013) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1210 · Cited by 67 · see citing works
Telomeres, NAFLD and Chronic Liver Disease
Donati, B., & Valenti, L. V. C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030383 · Cited by 68 · see citing works
New Roles for the Nucleolus in Health and Disease
Núñez-Villacís, L., Wong, M. S., Ferguson, L. L., Hein, N., George, A. J., & Hannan, K. M. (2018) · BioEssays · doi:10.1002/bies.201700233 · Cited by 66 · see citing works
Hepatitis Delta Virus RNA Replication
Tseng, C.-H., & Lai, M. M. C. (2009) · Viruses · doi:10.3390/v1030818 · Cited by 67 · see citing works
Mitochondrial noncoding RNA transport
Kim, K. M., Noh, J. H., Abdelmohsen, K., & Gorospe, M. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.4.013 · Cited by 67 · see citing works
Non-canonical Functions of Telomerase Reverse Transcriptase: Emerging Roles and Biological Relevance
Thompson, C. A. H., & Wong, J. M. Y. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200131125110 · Cited by 65 · see citing works
Mattijssen, S., Welting, T. J. M., & Pruijn, G. J. M. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.9 · Cited by 65 · see citing works
Similarities between long interspersed element-1 (LINE-1) reverse transcriptase and telomerase
Kopera, H. C., Moldovan, J. B., Morrish, T. A., Garcia-Perez, J. L., & Moran, J. V. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100275108 · Cited by 66 · see citing works
The emerging importance of ribosomal dysfunction in the pathogenesis of hematologic disorders
Raiser, D. M., Narla, A., & Ebert, B. L. (2013) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2013.812786 · Cited by 64 · see citing works
Telomere Lengthening and Other Functions of Telomerase
Rubtsova, M. P., Vasilkova, D. P., Malyavko, A. N., Нарайкина, Ю. В., Zvereva, M. I., & Донцова, О. А. (2012) · Acta Naturae · doi:10.32607/20758251-2012-4-2-44-61 · Cited by 66 · see citing works
hTERT promotes cell adhesion and migration independent of telomerase activity
Liu, H., Liu, Q., Ge, Y., Zhao, Q., Zheng, X., & Zhao, Y. B. (2016) · Scientific Reports · doi:10.1038/srep22886 · Cited by 65 · see citing works
Machitani, M., Yasukawa, M., Nakashima, J., Furuichi, Y., & Masutomi, K. (2020) · Cancer Science · doi:10.1111/cas.14618 · Cited by 61 · see citing works
Self-citationTelomerase as a Therapeutic Target in Cardiovascular Disease
Hoffmann, J., Richardson, G. D., Haendeler, J., Altschmied, J., Andrés, V., & Spyridopoulos, I. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315695 · Cited by 65 · see citing works
Telomeres and Telomerase: From Discovery to Clinical Trials
Corey, D. R. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.12.001 · Cited by 64 · see citing works
RMRP Is a Non-Coding RNA Essential for Early Murine Development
Rosenbluh, J., Nijhawan, D., Chen, Z., Wong, K., Masutomi, K., & Hahn, W. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026270 · Cited by 63 · see citing works
Self-citationTelomerase reverse transcriptase in the regulation of gene expression
Zhou, J., Ding, D., Wang, M., & Cong, Y. (2014) · BMB Reports · doi:10.5483/bmbrep.2014.47.1.284 · Cited by 63 · see citing works
BMS1 Is Mutated in Aplasia Cutis Congenita
Marneros, A. G. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003573 · Cited by 62 · see citing works
Takahashi, M., Miki, S., Fujimoto, K., Fukuoka, K., Matsushita, Y., Maida, Y., Yasukawa, M., Hayashi, M., Shinkyo, R., Kikuchi, K., et al. (2019) · Cancer Science · doi:10.1111/cas.14067 · Cited by 62 · see citing works
Self-citationTelomerase: Key regulator of inflammation and cancer
Wu, L., Fidan, K., Um, J., & Ahn, K. S. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104726 · Cited by 61 · see citing works
CDK1 dependent phosphorylation of hTERT contributes to cancer progression
Yasukawa, M., Ando, Y., Yamashita, T., Matsuda, Y., Shoji, S., Morioka, M. S., Kawaji, H., Shiozawa, K., Machitani, M., Abe, T., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15289-7 · Cited by 62 · see citing works
Self-citationRNA Dust: Where are the Genes?
Carninci, P. (2010) · DNA Research · doi:10.1093/dnares/dsq006 · Cited by 60 · see citing works
Venturi, G., & Montanaro, L. (2020) · Cells · doi:10.3390/cells9102300 · Cited by 57 · see citing works
RNA Interference and Heterochromatin AssemblyPreprint
Volpe, T. A., & Martienssen, R. A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003731 · Cited by 60 · see citing works
Implications of telomere‐independent activities of telomerase reverse transcriptase in human cancer
Ding, D., Zhou, J., Wang, M., & Cong, Y. (2013) · FEBS Journal · doi:10.1111/febs.12258 · Cited by 59 · see citing works
- Authors
- Maida, Y., Yasukawa, M., Furuuchi, M., Lassmann, T., Possemato, R., Okamoto, N., Kasim, V., Hayashizaki, Y., Hahn, W. C., & Masutomi, K.
- Affiliations
- National Cancer Center Research Institute (JP)
- RIKEN (JP)
- Brigham and Women's Hospital (US)
- Broad Institute (US)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Hahn, William C.
- Masutomi, Kenkichi
- ORCID
- Venue
- Nature
- Published
- 2009-08-23
- Volume
- 461
- Issue
- 7261
- Pages
- 230-235
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2755635
- OpenAlex
- W2058499120
- Cited by
- 384
- References
- 53
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 16 · 2023: 10 · 2022: 14 · 2021: 21 · 2020: 19 · 2019: 25 · 2018: 15 · 2017: 18 · 2016: 27 · 2015: 26 · 2014: 30 · 2013: 40 · 2012: 32
- FWCI
- 23.71
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-01-28)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Uehara Memorial Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- National Institutes of Health
- Japan Society for the Promotion of Science (19791141, 19689010)
- National Institute on Aging (R01AG023145, R01 AG23145)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- telomerase reverse transcriptase, RMRP, RNA-dependent RNA polymerase, telomerase, cartilage-hair hypoplasia, ribonucleoprotein complexes, siRNA, Dicer, double-stranded RNA, telomere homeostasis
- MeSH terms
- Cell Line, Endoribonucleases, Gene Expression Regulation, HeLa Cells, Humans, Protein Binding, Ribonucleoproteins, RNA-Dependent RNA Polymerase, RNA, Double-Stranded, Telomerase, RNA, Untranslated, RNA, Small Interfering, Ribonuclease III, RNA, Long Noncoding
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