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Transferable Resistance to Aminoglycosides by Methylation of G1405 in 16S rRNA and to Hydrophilic Fluoroquinolones by QepA-Mediated Efflux in Escherichia coli
Open accessAbstract
Plasmid pIP1206 was detected in Escherichia coli strain 1540 during the screening of clinical isolates of Enterobacteriaceae for high-level resistance to aminoglycosides. The sequence of this IncFI conjugative plasmid of ca. 100 kb was partially determined. pIP1206 carried the rmtB gene for a ribosome methyltransferase that was shown to modify the N7 position of nucleotide G1405, located in the A site of 16S rRNA. It also contained the qepA ( q uinolone e fflux p ump) gene that encodes a 14-transmembrane-segment putative efflux pump belonging to the major facilitator superfamily of proton-dependent transporters. Disruption of membrane proton potential by the efflux pump inhibitor carbonyl cyanide m -chlorophenylhydrazone in a transconjugant harboring the qepA gene resulted in elevation of norfloxacin accumulation. The transporter conferred resistance to the hydrophilic quinolones norfloxacin and ciprofloxacin.
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Cited by
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Ruppé, É., Woerther, P.-L., & Barbier, F. (2015) · Annals of Intensive Care · doi:10.1186/s13613-015-0061-0 · Cited by 490
Cavaco, L. M., Hasman, H., Xia, S., & Aarestrup, F. M. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00997-08 · Cited by 441
Persistence of antibiotic resistance in bacterial populations
Andersson, D. I., & Hughes, D. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00289.x · Cited by 435
Plasmid-mediated quinolone resistance: an update
Rodríguez-Martínez, J. M., Velasco, C., Pascual, Á., Cano, M. E., Martínez-Martínez, L., Martínez-Martínez, L., & Pascual, Á. (2011) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-010-0120-2 · Cited by 306
Le Hello, S., Hendriksen, R. S., Doublet, B., Fisher, I., Nielsen, E. M., Whichard, J. M., Bouchrif, B., Fashae, K., Granier, S. A., Jourdan-Da Silva, N., et al. (2011) · Journal of Infectious Diseases · doi:10.1093/infdis/jir409 · Cited by 277
Metadata
- Authors
- Périchon, B., Courvalin, P., & Galimand, M.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2007-07
- Volume
- 51
- Issue
- 7
- Pages
- 2464-2469
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2110867309
- Cited by
- 266
- References
- 0
- FWCI
- 14.38
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Transferable Resistance to Aminoglycosides by Methylation of G1405 in 16S rRNA and to Hydrophilic Fluoroquinolones by QepA-Mediated Efflux in Escherichia coli. https://app.cochat.ai/papers/10.1128/aac.00143-07
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- Périchon, B., Courvalin, P., & Galimand, M. (2007). Transferable Resistance to Aminoglycosides by Methylation of G1405 in 16S rRNA and to Hydrophilic Fluoroquinolones by QepA-Mediated Efflux in Escherichia coli. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00143-07
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