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Role of Fks1p and Matrix Glucan in Candida albicans Biofilm Resistance to an Echinocandin, Pyrimidine, and Polyene
Open accessAbstract
Candida infections frequently involve drug-resistant biofilm growth on device surfaces. Glucan synthase gene FKS1 has been linked to triazole resistance in Candida biofilms. We tested the impact of FKS1 modulation on susceptibility to additional antifungal classes. Reduction of FKS1 expression rendered biofilms more susceptible to amphotericin B, anidulafungin, and flucytosine. Increased resistance to anidulafungin and amphotericin B was observed for biofilms overexpressing FKS1 . These findings suggest that Candida biofilm glucan sequestration is a multidrug resistance mechanism.
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“Genes involved in production and delivery of β-1,3-glucans include the synthase-encoding gene FKS1 and the genes BGL2, XOG1, and PHR1, which encode proteins involved in the modification and transport of β-glucans (132, 189).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [132]
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Metadata
- Authors
- Nett, J. E., Crawford, K., Marchillo, K., & Andes, D. R.
- Affiliations
- University of Wisconsin–Madison (US)
- Departments of Medicine
- Corresponding author
- Andes, David R.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2010-08
- Volume
- 54
- Issue
- 8
- Pages
- 3505-3508
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC2916329
- OpenAlex
- W2157946772
- Cited by
- 207
- References
- 22
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 14 · 2023: 16 · 2022: 11 · 2021: 10 · 2020: 17 · 2019: 13 · 2018: 11 · 2017: 17 · 2016: 16 · 2015: 19 · 2014: 14 · 2013: 10 · 2012: 9
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (T32HL007899)
- National Institute of Allergy and Infectious Diseases (R01AI073289)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
- Keywords
- Candida albicans, biofilm, FKS1, glucan synthase, echinocandin resistance, anidulafungin, amphotericin B, 5-fluorocytosine, triazole resistance, antifungal resistance, multidrug resistance, antifungal susceptibility
- MeSH terms
- Anidulafungin, Amphotericin B, Antifungal Agents, Candida albicans, Flucytosine, Fungal Proteins, Glucans, Glucosyltransferases, Humans, Microbial Sensitivity Tests, Polyenes, Pyrimidines, Biofilms, Drug Resistance, Fungal, Echinocandins
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