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A mec A -Negative Strain of Methicillin-Resistant S taphylococcus aureus with High-Level β-Lactam Resistance Contains Mutations in Three Genes
Abstract
We previously generated a ceftobiprole-resistant S taphylococcus aureus strain after high inoculum serial passage of a mec A -negative variant of strain COL (R. Banerjee, M. Gretes, L. Basuino, N. Strynadka, and H. F. Chambers, Antimicrob. Agents Chemother. 52:2089-2096, 2008). Genome resequencing of this strain, CRB, revealed that it differs from its parent by five single-nucleotide polymorphisms in three genes, specifically, those encoding PBP4, a low-molecular-weight penicillin-binding protein, GdpP, a predicted signaling protein, and AcrB, a cation multidrug efflux transporter. CRB displayed resistance to a variety of β-lactams but was hypersusceptible to cefoxitin.
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“The presence of the above-mentioned mutations resulted in CRB strain resistance to beta-lactam antibiotics: ceftobiprole (MIC = 128 mg/L), ceftriaxone (MIC = 256 mg/L), cefazolin (MIC > 256 mg/L), nafcillin (MIC = 128 mg/L), ampicillin (MIC = 256 mg/L). Only the MIC of cefoxitin was relatively low (8 mg/L) [71].”
From Molecular Mechanisms of Drug Resistance in Staphylococcus aureus (2022) · cites this paper as [71]
In the citing paper
“Resistance to ceftobiprole was described in S. aureus strain CRB (a derivative of strain COL). The strain lacked the mecA gene, but had substitution in PBP4 protein (E183A, F241R), GdpP signaling protein (N182K) and the ArcB/D/F cations efflux pump protein (I960V).”
From Molecular Mechanisms of Drug Resistance in Staphylococcus aureus (2022) · cites this paper as [71]
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Cited by
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus
Mlynarczyk-Bonikowska, B., Kowalewski, C., Krolak-Ulinska, A., & Marusza, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158088 · Cited by 412
Cyclic di-AMP: another second messenger enters the fray
Corrigan, R. M., & Gründling, A. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3069 · Cited by 375
Cyclic di-AMP Signaling in Bacteria
Stülke, J., & Krüger, L. (2020) · Annual Review of Microbiology · doi:10.1146/annurev-micro-020518-115943 · Cited by 161
Metadata
- Authors
- Banerjee, R., Gretes, M., Harlem, C., Basuino, L., & Chambers, H. F.
- Affiliations
- Division of Pediatric Infectious Diseases, Mayo Clinic, 200 First Street, Rochester, Minnesota 55905
- Department of Biochemistry and Molecular Biology, University of British Colombia, Vancouver, Canada
- Division of Infectious Diseases, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, California 94110
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2010-11
- Volume
- 54
- Issue
- 11
- Pages
- 4900-4902
- ISSN
- 0066-4804
- 1098-6596
- Cited by
- 112
- References
- 0
- Language
- en
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
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- CoChat. (2026). Citation check: A mec A -Negative Strain of Methicillin-Resistant S taphylococcus aureus with High-Level β-Lactam Resistance Contains Mutations in Three Genes. https://app.cochat.ai/papers/10.1128/aac.00594-10
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- Banerjee, R., Gretes, M., Harlem, C., Basuino, L., & Chambers, H. F. (2010). A mec A -Negative Strain of Methicillin-Resistant S taphylococcus aureus with High-Level β-Lactam Resistance Contains Mutations in Three Genes. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00594-10
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
