Genetic Basis of Azole and Echinocandin Resistance in Clinical Candida glabrata in Japan
Open accessAbstract
Infections caused by Candida glabrata have caused worldwide concern, especially when they are associated with increasing echinocandin and azole resistance. In this study, we analyzed the molecular mechanisms of azole and echinocandin resistance in C. glabrata isolates obtained from hospitalized patients in Japan from 1997 to 2019. All isolates were checked phenotypically for resistance and genotypically for mutations in PDR1 , ERG11 , hot spot 1 (HS1), HS2, and HS3 of FKS1 , and HS1 and HS2 of FKS2 , and all isolates were genotyped by multilocus sequence typing (MLST).
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C. glabrata has decreased susceptibility to azoles and a propensity to acquire resistance during antifungal therapy.
“Candida glabrata (or Nakaseomyces glabratus) standing out as a particularly concerning pathogen due to its decreased susceptibility to azoles and its propensity to acquire resistance during antifungal therapy [2, 3].”
From Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in <i>Candida Glabrata</i> (2026) · cites this paper as [3]
Cites
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Meng, Q., Wang, H., Xiao, W., Mai, W., Liu, Y., Xiao, Y., Wang, P., Sui, J., He, X., Yin, F., et al. (2025) · Mycology · doi:10.1080/21501203.2025.2461725 · Cited by 8 · see citing works
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- Authors
- Khalifa, H. O., Arai, T., Majima, H., Watanabe, A., & Kamei, K.
- Affiliations
- Kafrelsheikh University (EG)
- Chiba University (JP)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2020-08-20
- Volume
- 64
- Issue
- 9
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC7449192
- OpenAlex
- W3036087281
- Cited by
- 42
- References
- 5
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 8
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Agency for Medical Research and Development (JP19jm0110015, JP19fk0108094)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida glabrata, azole resistance, echinocandin resistance, drug resistance mechanisms, PDR1, ERG11, multilocus sequence typing, clinical isolates, antifungal resistance, Japan
- MeSH terms
- Antifungal Agents, Azoles, Fungal Proteins, Humans, Japan, Microbial Sensitivity Tests, Mutation, Drug Resistance, Fungal, Candida glabrata, Echinocandins, Multilocus Sequence Typing
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