Prevalence, drug resistance and genetic diversity of Candida glabrata in the reproductive tract of pregnant women in Hainan and comparison with global multilocus sequence data
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This study investigates the prevalence, drug resistance, and genetic diversity of Candida glabrata, a significant non-albicans Candida species, among pregnant women in Hainan, China. We collected 3,806 reproductive tract secretion samples from women with vaginal discomfort and isolated 594 Candida strains, including C. albicans (45.1%), C. glabrata (36.2%), C. dubliniensis (12.2%), C. parapsilosis (2.7%), C. tropicalis (2.7%), and C. krusei (1.2%). Antifungal susceptibility testing showed that 64.5% of the isolates were intermediate or resistant to at least one of four antifungal agents: fluconazole, itraconazole, voriconazole, and amphotericin B. Among 215 C. glabrata isolates, 81.4% were intermediate or resistant to at least one antifungal, with 10% showing resistance to multiple agents. Multilocus sequence typing (MLST) of 52 C. glabrata strains from the reproductive tract, 53 from oral cavities, and 17 from environmental sources revealed 14 sequence types (STs), with six STs shared among these niches, indicating a highly clonal population structure. Comparisons with the global MLST database showed both shared and distinct characteristics among C. glabrata populations in Hainan and other regions, highlighting significant differentiation. We discuss the implications of these findings to the epidemiology and evolution of this pathogen.
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ST7 is the most prevalent genotype of C. glabrata in Asia.
“Notably, MLST analysis indicates that CG4 belongs to ST7, the most prevalent genotype in Asia (Meng et al., 2025).”
From Uncovering the connection between tunicamycin-induced respiratory deficiency and reduced fluconazole tolerance in Candida glabrata (2025) · cites this paper as Meng et al., 2025
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- Authors
- Meng, Q., Wang, H., Xiao, W., Mai, W., Liu, Y., Xiao, Y., Wang, P., Sui, J., He, X., Yin, F., Xu, J., & Wu, J.
- Affiliations
- Hainan Medical University (CN)
- Hainan Medical University
- Hainan Maternal and Child Health Hospital (CN)
- Corresponding author
- Xu, Jianping
- Wu, Jinyan
- Venue
- Mycology
- Publisher
- Informa UK Limited
- Published
- 2025-02-18
- Volume
- 16
- Issue
- 3
- Pages
- 1400-1417
- ISSN
- 2150-1203 (ISSN-L)
- 2150-1211
- PMC
- PMC12558380
- OpenAlex
- W4407757790
- Cited by
- 8
- References
- 60
- Citations by year
- 2026: 3 · 2025: 5
- FWCI
- 6.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Mycology: An International Journal on Fungal Biology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Science Foundation of Hainan Province (822RC708, 2019RC227)
- Innovation and Entrepreneurship Training Program for College Students of Hainan Medical University (S202211810023)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida glabrata, antifungal resistance, genetic diversity, multilocus sequence typing, sequence types, clonal population structure, vaginal candidiasis, pregnant women, reproductive tract, non-albicans Candida, Candida albicans, Candida dubliniensis, Candida parapsilosis, Candida tropicalis, Candida krusei, oral candidiasis, environmental isolates, Hainan
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