Cited by 105Viral Infections and Immunology Researchinterferon and immune responsesMosquito-borne diseases and control

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Fluoxetine Is a Potent Inhibitor of Coxsackievirus Replication

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Zuo, Jun, Quinn, Kevin K., Kye, Steve, Cooper, Paige, Damoiseaux, Robert, Krogstad, Paul·2012·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.00983-12PMC PMC3421851

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Abstract

No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life threatening. Molecular screening of small molecule libraries identified fluoxetine, a selective serotonin reuptake inhibitor, as a potent inhibitor of coxsackievirus replication. Fluoxetine did not interfere with either viral entry or translation of the viral genome. Instead, fluoxetine and its metabolite norfluoxetine markedly reduced the synthesis of viral RNA and protein. In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections.

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Authors: Zuo, J., Quinn, K. K., Kye, S., Cooper, P., Damoiseaux, R., & Krogstad, P.
Affiliations: University of California, Los Angeles (US)
California NanoSystems Institute (US)
ORCID: Damoiseaux, Robert
Krogstad, Paul
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2012-09
Volume: 56
Issue: 9
Pages: 4838-4844
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.00983-12
PMC: PMC3421851
OpenAlex: W2131952231
Cited by: 104
References: 49
Citations by year: 2026: 8 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 17 · 2021: 14 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 1 · 2016: 8 · 2015: 8 · 2014: 5 · 2013: 2
FWCI: 3.09
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Food and Drug Administration
Topics: Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
Keywords: fluoxetine, Coxsackie virus, enterovirus infection, antiviral agents, viral RNA synthesis, norfluoxetine, selective serotonin reuptake inhibitors, small molecule screening, viral replication inhibition
MeSH terms: Antidepressive Agents, Antiviral Agents, Enterovirus, Fluoxetine, HeLa Cells, Humans, RNA, Viral, Transfection, Virus Replication, Genes, Reporter, Inhibitory Concentration 50, Green Fluorescent Proteins, Small Molecule Libraries, High-Throughput Screening Assays

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Fluoxetine Is a Potent Inhibitor of Coxsackievirus Replication

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