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Expression of Multidrug Efflux Pump Genes acrAB-tolC , mdfA , and norE in Escherichia coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance
Open accessAbstract
In a single quantitative study, we measured acrA , acrB , tolC , mdfA , and norE expression in Escherichia coli clinical isolates by using real-time PCR. acrA and acrB overexpression strongly correlated with fluoroquinolone and multidrug resistance; tolC , mdfA , and norE expression did not. The order of abundance of efflux pump transcripts in all fluoroquinolone-susceptible isolates was tolC (highest), then acrA and acrB , and then mdfA and norE. Our findings suggest acrAB overexpression is an indicator of multidrug resistance.
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Cites
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Cited by
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Zgurskaya, H. I., López, C. A., & Gnanakaran, S. (2015) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5b00097 · Cited by 580
Ma, L., Xia, Y., Li, B., Yang, Y., Li, L.-G., Tiedje, J. M., & Zhang, T. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b03522 · Cited by 423
Carlson-Banning, K. M., Chou, A., Liu, Z., Hamill, R. J., Song, Y., & Zechiedrich, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069646 · Cited by 73
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Metadata
- Authors
- Swick, M. C., Morgan-Linnell, S. K., Carlson, K. M., & Zechiedrich, L.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2011-02
- Volume
- 55
- Issue
- 2
- Pages
- 921-924
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2118589790
- Cited by
- 219
- References
- 1
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Expression of Multidrug Efflux Pump Genes acrAB-tolC , mdfA , and norE in Escherichia coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance. https://app.cochat.ai/papers/10.1128/aac.00996-10
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- Swick, M. C., Morgan-Linnell, S. K., Carlson, K. M., & Zechiedrich, L. (2011). Expression of Multidrug Efflux Pump Genes acrAB-tolC , mdfA , and norE in Escherichia coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00996-10
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