The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance
Open accessAbstract
The management of infections due to Klebsiella pneumoniae has been complicated by the emergence of antimicrobial resistance, especially to carbapenems. Resistance to carbapenems in K. pneumoniae involves multiple mechanisms, including the production of carbapenemases (e.g., KPC, NDM, VIM, OXA-48-like), as well as alterations in outer membrane permeability mediated by the loss of porins and the upregulation of efflux systems. The latter two mechanisms are often combined with high levels of other types of β-lactamases (e.g., AmpC). K. pneumoniae sequence type 258 (ST258) emerged during the early to mid-2000s as an important human pathogen and has spread extensively throughout the world. ST258 comprises two distinct lineages, namely, clades I and II, and it seems that ST258 is a hybrid clone that was created by a large recombination event between ST11 and ST442. Incompatibility group F plasmids with bla KPC have contributed significantly to the success of ST258. The optimal treatment of infections due to carbapenemase-producing K. pneumoniae remains unknown. Some newer agents show promise for treating infections due to KPC producers; however, effective options for the treatment of NDM producers remain elusive.
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Cites
Carbapenemases: the Versatile β-Lactamases
Queenan, A. M., & Bush, K. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00001-07 · Cited by 2,499
Global Spread of Carbapenemase-producing Enterobacteriaceae
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Self-citationIdentification of plasmids by PCR-based replicon typing
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Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases
Munoz-Price, L. S., Poirel, L., Bonomo, R. A., Schwaber, M. J., Daikos, G. L., Cormican, M., Cornaglia, G., Garau, J., Gniadkowski, M., Hayden, M. K., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70190-7 · Cited by 1,627
Self-citationThe real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
Nordmann, P., Cuzon, G., & Naas, T. (2009) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(09)70054-4 · Cited by 1,579
Self-citationMetallo-β-Lactamases: the Quiet before the Storm?
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Self-citationResistance Plasmid Families in Enterobacteriaceae
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Carbapenem resistance in Enterobacteriaceae: here is the storm!
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Cited by
Epidemiology of β-Lactamase-Producing Pathogens
Bush, K., & Bradford, P. A. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00047-19 · Cited by 938
The Global Ascendency of OXA-48-Type Carbapenemases
Pitout, J. D. D., Peirano, G., Kock, M. M., Strydom, K.-A., & Matsumura, Y. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00102-19 · Cited by 478
Self-citationEmerging Antimicrobial-Resistant High-Risk Klebsiella pneumoniae Clones ST307 and ST147
Peirano, G., Chen, L., Kreiswirth, B. N., & Pitout, J. D. D. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01148-20 · Cited by 363
Self-citationPeirano, G., & Pitout, J. D. D. (2019) · Drugs · doi:10.1007/s40265-019-01180-3 · Cited by 328
Self-citationMusila, L., Kyany’a, C., Maybank, R., Stam, J., Oundo, V., & Sang, W. (2021) · PLOS ONE · doi:10.1371/journal.pone.0246937 · Cited by 55
Metadata
- Authors
- Pitout, J. D. D., Nordmann, P., & Poirel, L.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2015-10
- Volume
- 59
- Issue
- 10
- Pages
- 5873-5884
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W1951178169
- Cited by
- 852
- References
- 102
- FWCI
- 24.29
- Type
- journal article
- Language
- en
- Open access
- green
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