The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
New Plasmid-Mediated Quinolone Resistance Gene, qnrC , Found in a Clinical Isolate of Proteus mirabilis
Open accessAbstract
Since the discovery of qnrA in 1998, two additional qnr genes, qnrB and qnrS , have been described. These three plasmid-mediated genes contribute to quinolone resistance in gram-negative pathogens worldwide. A clinical strain of Proteus mirabilis was isolated from an outpatient with a urinary tract infection and was susceptible to most antimicrobials but resistant to ampicillin, sulfamethoxazole, and trimethoprim. Plasmid pHS10, harbored by this strain, was transferred to azide-resistant Escherichia coli J53 by conjugation. A transconjugant with pHS10 had low-level quinolone resistance but was negative by PCR for the known qnr genes, aac(6′)-Ib-cr and qepA . The ciprofloxacin MIC for the clinical strain and a J53/pHS10 transconjugant was 0.25 μg/ml, representing an increase of 32-fold relative to that for the recipient, J53. The plasmid was digested with HindIII, and a 4.4-kb DNA fragment containing the new gene was cloned into pUC18 and transformed into E. coli TOP10. Sequencing showed that the responsible 666-bp gene, designated qnrC , encoded a 221-amino-acid protein, QnrC, which shared 64%, 42%, 59%, and 43% amino acid identity with QnrA1, QnrB1, QnrS1, and QnrD, respectively. Upstream of qnrC there existed a new IS 3 family insertion sequence, IS Pmi1 , which encoded a frameshifted transposase. qnrC could not be detected by PCR, however, in 2,020 strains of Enterobacteriaceae . A new quinolone resistance gene, qnrC , was thus characterized from plasmid pHS10 carried by a clinical isolate of P . mirabilis .
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Quinolone resistance from a transferable plasmid
Martínez-Martínez, L., Pascual, A., & Jacoby, G. A. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07322-4 · Cited by 1,100
The worldwide emergence of plasmid-mediated quinolone resistance
Robicsek, A., Jacoby, G. A., & Hooper, D. C. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70599-0 · Cited by 966
Self-citationInitiation of Protein Synthesis in Bacteria
Laursen, B. S., Sørensen, H. P., Mortensen, K. K., & Sperling-Petersen, H. U. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.1.101-123.2005 · Cited by 616
Mechanism of plasmid-mediated quinolone resistance
Tran, J. H., & Jacoby, G. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082092899 · Cited by 564
Plasmid-Mediated Quinolone Resistance in Clinical Isolates of Escherichia coli from Shanghai, China
Wang, M., Tran, J. H., Jacoby, G. A., Zhang, Y., Wang, F., & Hooper, D. C. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.7.2242-2248.2003 · Cited by 467
Self-citationCavaco, L. M., Hasman, H., Xia, S., & Aarestrup, F. M. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00997-08 · Cited by 441
qnrB , Another Plasmid-Mediated Gene for Quinolone Resistance
Jacoby, G. A., Walsh, K. E., Mills, D. M., Walker, V. J., Oh, H., Robicsek, A., & Hooper, D. C. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.4.1178-1182.2006 · Cited by 400
Self-citationOrigin of Plasmid-Mediated Quinolone Resistance Determinant QnrA
Poirel, L., Rodriguez-Martinez, J.-M., Mammeri, H., Liard, A., & Nordmann, P. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.8.3523-3525.2005 · Cited by 394
Cloning of a Novel Gene for Quinolone Resistance from a Transferable Plasmid in Shigella flexneri 2b
Hata, M., Suzuki, M., Matsumoto, M., Takahashi, M., Sato, K., Ibe, S., & Sakae, K. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.801-803.2005 · Cited by 287
Interaction of the Plasmid-Encoded Quinolone Resistance Protein Qnr with Escherichia coli DNA Gyrase
Tran, J. H., Jacoby, G. A., & Hooper, D. C. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.1.118-125.2005 · Cited by 283
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Cited by
Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat
Strahilevitz, J., Jacoby, G. A., Hooper, D. C., & Robicsek, A. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-09 · Cited by 928
Self-citationTopoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance
Hooper, D. C., & Jacoby, G. A. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025320 · Cited by 553
Self-citationPlasmid-mediated quinolone resistance: an update
Rodríguez-Martínez, J. M., Velasco, C., Pascual, Á., Cano, M. E., Martínez-Martínez, L., Martínez-Martínez, L., & Pascual, Á. (2011) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-010-0120-2 · Cited by 306
Metadata
- Authors
- Wang, M., Guo, Q., Xu, X., Wang, X., Ye, X., Wu, S., Hooper, D. C., & Wang, M.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2009-05
- Volume
- 53
- Issue
- 5
- Pages
- 1892-1897
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2086939553
- Cited by
- 324
- References
- 28
- FWCI
- 12.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, M., Guo, Q., Xu, X., Wang, X., Ye, X., Wu, S., Hooper, D. C., & Wang, M. (2009). New Plasmid-Mediated Quinolone Resistance Gene, qnrC , Found in a Clinical Isolate of Proteus mirabilis. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.01400-08
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