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Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains
Abstract
We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF -mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.
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“Resistance or reduced sensitivity to daptomycin is probably related to mutations in the mprF gene encoding lysyl-phosphatidylglycerol synthetase (N352K substitution in MprF), dltABCD operon responsible for D-alanine attachment to teichoic acids in the cell wall (substitutions of N276S in DltB and P309L inDltD), vraSR regulatory genes and clpP (ATP-dependent Clp protease; G74S substitution), rpoC (”
From Molecular Mechanisms of Drug Resistance in Staphylococcus aureus (2022) · cites this paper as [177]
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Research works printed but not linked: 17
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Cited by
Antimicrobial Peptides Targeting Gram-Positive Bacteria
Malanovic, N., & Lohner, K. (2016) · Pharmaceuticals · doi:10.3390/ph9030059 · Cited by 420
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus
Mlynarczyk-Bonikowska, B., Kowalewski, C., Krolak-Ulinska, A., & Marusza, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158088 · Cited by 412
Genetic Basis for In Vivo Daptomycin Resistance in Enterococci
Arias, C. A., Panesso, D., McGrath, D. M., Qin, X., Mojica, M. F., Miller, C., Diaz, L., Tran, T. T., Rincon, S., Barbu, E. M., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011138 · Cited by 377
Pogliano, J., Pogliano, N., & Silverman, J. A. (2012) · Journal of Bacteriology · doi:10.1128/jb.00011-12 · Cited by 319
Bayer, A. S., Schneider, T., & Sahl, H. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06819.x · Cited by 311
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Metadata
- Authors
- Yang, S.-J., Xiong, Y. Q., Dunman, P. M., Schrenzel, J., François, P., Peschel, A., & Bayer, A. S.
- Affiliations
- Los Angeles Biomedical Research Institute, Torrance, California
- Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska
- Department of Internal Medicine, University Hospitals, Geneva, Switzerland
- Cellular and Molecular Microbiology, Medical Microbiology and Hygiene, University of Tübingen, Germany
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2009-06
- Volume
- 53
- Issue
- 6
- Pages
- 2636-2637
- ISSN
- 0066-4804
- 1098-6596
- Cited by
- 98
- References
- 0
- Language
- en
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
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- CoChat. (2026). Citation check: Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains. https://app.cochat.ai/papers/10.1128/aac.01415-08
- The paper
- Yang, S.-J., Xiong, Y. Q., Dunman, P. M., Schrenzel, J., François, P., Peschel, A., & Bayer, A. S. (2009). Regulation of mprF in Daptomycin-Nonsusceptible Staphylococcus aureus Strains. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.01415-08
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
