The C 2 H 2 Transcription Factor SltA Contributes to Azole Resistance by Coregulating the Expression of the Drug Target Erg11A and the Drug Efflux Pump Mdr1 in Aspergillus fumigatus

Aspergillus fumigatus and Aspergillosis in 2019

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Pathogenesis of <i>Aspergillus fumigatus</i> in Invasive Aspergillosis

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Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches

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What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis

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A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

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The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus

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Azole-resistance in Aspergillus: Proposed nomenclature and breakpoints

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Triazole resistance in Aspergillus fumigatus: recent insights and challenges for patient management

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Isolation of the ace1 Gene Encoding a Cys2-His2 Transcription Factor Involved in Regulation of Activity of the Cellulase Promoter cbh1of Trichoderma reesei

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ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

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SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus

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Azole resistance mechanisms in Aspergillus: update and recent advances

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Wild-Type MIC Distributions and Epidemiological Cutoff Values for Amphotericin B and Aspergillus spp. for the CLSI Broth Microdilution Method (M38-A2 Document)

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The ergosterol biosynthesis pathway, transporter genes, and azole resistance in<i>Aspergillus fumigatus</i>

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A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions

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Triazole Resistance in Aspergillus Species: An Emerging Problem

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The antifungal arsenal: alternative drugs and future targets

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Paralogous cyp51 genes in Fusarium graminearum mediate differential sensitivity to sterol demethylation inhibitors

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Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex

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The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus

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Identification of a Cryptococcus neoformans Cytochrome P450 Lanosterol 14α-Demethylase (Erg11) Residue Critical for Differential Susceptibility between Fluconazole/Voriconazole and Itraconazole/Posaconazole

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Identification of ABC Transporter Genes of Fusarium graminearum with Roles in Azole Tolerance and/or Virulence

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Two zinc finger transcription factors, CrzA and SltA, are involved in cation homoeostasis and detoxification in Aspergillus nidulans

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Fungicides induced triazole-resistance in Aspergillus fumigatus associated with mutations of TR46/Y121F/T289A and its appearance in agricultural fields

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MrpacC regulates sporulation, insect cuticle penetration and immune evasion in M etarhizium robertsii

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AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus

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Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance

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Functional analysis of a novel ABC transporter ABC4 fromMagnaporthe grisea

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Emerging threat of triazole-resistant Aspergillus fumigatus

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SREBP-Dependent Triazole Susceptibility in Aspergillus fumigatus Is Mediated through Direct Transcriptional Regulation oferg11A(cyp51A)

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The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility

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Screening and Characterization of a Non- cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance

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Upgrading Fungal Gene Expression on Demand: Improved Systems for Doxycycline-Dependent Silencing in Aspergillus fumigatus

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Deletion of the putative stretch-activated ion channel Mid1 is hypervirulent in Aspergillus fumigatus

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MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates

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Multiple cyp51A -Based Mechanisms Identified in Azole-Resistant Isolates of Aspergillus fumigatus from China

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Identification and properties of plasma membrane azole efflux pumps from the pathogenic fungi Cryptococcus gattii and Cryptococcus neoformans

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The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus

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Invasive Aspergillosis: New Insights into Disease, Diagnostic and Treatment

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TheAspergillus fumigatustranscription factor AceA is involved not only in Cu but also in Zn detoxification through regulating transporters CrpA and ZrcA

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The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition

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Analysis of a novel calcium auxotrophy in Aspergillus nidulans

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Regulation of Ergosterol Biosynthesis in Pathogenic Fungi: Opportunities for Therapeutic Development

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Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus

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Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence

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Genome-Wide Association Analysis for Triazole Resistance in Aspergillus fumigatus

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The Copper Chaperone CcsA, Coupled with Superoxide Dismutase SodA, Mediates the Oxidative Stress Response in Aspergillus fumigatus

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A C2H2 Zinc Finger Protein PlCZF1 Is Necessary for Oospore Development and Virulence in Peronophythora litchii

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Transcriptomics-based investigation of molecular mechanisms underlying synergistic antimicrobial effects of AgNPs and Domiphen on the human fungal pathogen Aspergillus fumigatus

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Efflux Pumps and Multidrug-Resistance in Pyricularia oryzae Triticum Lineage

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The CCAAT‐binding complex mediates azole susceptibility of Aspergillus fumigatus by suppressing SrbA expression and cleavage

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The Transcription Factor FgAtrR Regulates Asexual and Sexual Development, Virulence, and DON Production and Contributes to Intrinsic Resistance to Azole Fungicides in Fusarium graminearum

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Transcription factors SltA and CrzA reversely regulate calcium homeostasis under calcium-limited conditions

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A ubiquitin-mediated post-translational degradation of Cyp51A contributes to a novel azole resistance mode in Aspergillus fumigatus

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In vitro and in vivo antimicrobial effects of domiphen combined with itraconazole against Aspergillus fumigatus

Yang, H., Gu, Y., He, Z., Wu, J., Chen, W., Xie, Y., You, Y., Yang, Y., Zhou, X., Liu, Y., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1264586 · Cited by 5 · see citing works

PWWP domain-containing protein Crf4-3 specifically modulates fungal azole susceptibility by regulating sterol C-14 demethylase ERG11

Yu, P., Ye, S., Zhou, M., Zhang, L., Zhang, Z., Sun, X., Li, S., & Hu, C. (2024) · mSphere · doi:10.1128/msphere.00703-24 · Cited by 4 · see citing works

The metal chaperone protein MtmA plays important roles in antifungal drug susceptibility in Aspergillus fumigatus

Zhai, P., Ma, Y., Du, W., & Lü, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1062282 · Cited by 4 · see citing works

Mechanistic insights into vanillin's inhibitory effects on Fusarium oxysporum induced postharvest disease

Liu, X., He, J., Cui, Y., Aslam, M. M., Xu, J., Li, R., & Li, W. (2026) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2025.114145 · Cited by 3 · see citing works

The EH domain-containing protein, EdeA, is involved in endocytosis, cell wall integrity, and pathogenicity in Aspergillus fumigatus

Dai, M., Liu, X., Goldman, G. H., Lü, L., & Zhang, S. (2024) · mSphere · doi:10.1128/msphere.00057-24 · Cited by 3 · see citing works

Chitosan–silver nanocomposites: promising alternatives for combating azole-resistant Aspergillus fumigatus

Tian, Y., Wu, J., Li, T., Zhu, Y., Xie, Y., Yin, Z., Ma, Y., & Du, W. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1669609 · Cited by 2 · see citing works

Transcription Repressor SsGATA2 Regulates Broad-Spectrum Resistance to Fungicides and Pathogenicity in Sclerotinia sclerotiorum

Xiao, K., Li, Y., Gu, S., Liu, L., Zhang, G., Zhang, Y., Zhang, X., Liu, J., & Pan, H. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c04925 · Cited by 2 · see citing works

Involvement of AoMdr1 in the Regulation of the Fluconazole Resistance, Mycelial Fusion, Conidiation, and Trap Formation of Arthrobotrys oligospora

Liu, Y., Yang, X., Zhu, M., Bai, N., Wang, W., & Yang, J. (2023) · Microorganisms · doi:10.3390/microorganisms11061612 · Cited by 2 · see citing works

Gene-specific transcriptional activation by the Aspergillus fumigatus AtrR factor requires a conserved C-terminal domain

Ror, S., Stamnes, M. A., & Moye-Rowley, S. (2024) · mSphere · doi:10.1128/msphere.00425-24 · Cited by 1 · see citing works

Molecular Mechanism of Aflatoxin B1 Synthesis Related AfVerB Regulating the Development, AFB1 Biosyntheis and Virulence of Aspergillus flavus Mainly Through Its CYP Domain

Ye, K., Zhou, S., Wu, D., Ma, D., Yao, Y., Yang, C., Sun, M., Yang, S., Fu, W., Xin, W., et al. (2025) · Journal of Fungi · doi:10.3390/jof11040293 · Cited by 1 · see citing works

Agricultural propiconazole residues promote triazole cross-resistance in Cryptococcus neoformans through ERG11 and efflux pump overexpression

Yu, H., Peng, W., Li, H., Zhang, Y., Fu, X., Gong, X., Wei, H., Zhou, Q., Huang, Y., & Cao, D. (2025) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00765-25 · Cited by 1 · see citing works

Lipid-Based Drug Delivery Systems as Emerging Tools to Overcome Antifungal Resistance

Arana, L., Guridi, A., Sevillano, E., Tamayo, E. H., Eraso, E., Alkorta, I., & Maté, I. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27104487 · Cited by 2 · see citing works

The pangenome of Aspergillus fumigatus highlights the dynamics of gene gain-loss over evolutionary timescales in a human fungal pathogenPreprint

Chown, H., Rhodes, J. L., (17773886), M. C. F., & Bromley, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.14.718449 · Cited by 1 · see citing works

Genomic analysis of Aspergillus cryptic species

Santos, R. (2021) · doi:10.47749/t/unicamp.2021.1234482

Comparative Analysis of Fungal Proteomes for Identifying Resistance Genes: A Preliminary Step Towards Experimental Validation

Segura-Valverde, A., Solano-González, S., & Sancho-Blanco, C. (2023) · 2023 IEEE 5th International Conference on BioInspired Processing (BIP) · doi:10.1109/bip60195.2023.10379369

Loss of a conserved C-terminal region of the Aspergillus fumigatus AtrR transcriptional regulator leads to a gene-specific defect in target gene expressionPreprint

Ror, S., Stamnes, M. A., & Moye-Rowley, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.22.595332

Transcription factor RonA-driven GlcNAc catabolism is essential for growth, cell wall integrity, and pathogenicity in Aspergillus fumigatus

Gong, X., Ge, X., Qin, Q., Wang, B., Wang, L., Jin, C., & Fang, W. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.00122-25

Epidemiology and mechanisms of antifungal resistance in Aspergillus : а review

Avtonomova, A. V., & Валерьевна, К. О. (2025) · Russian Medicine · doi:10.17816/medjrf685079

Antimicrobial effects and mechanism of action of carboxymethyl chitosan-loaded silver ion complexes against drug-resistant Aspergillus fumigatus

Jin, L., Zhou, X., & Du, W. (2026) · The Journal of Microbiology · doi:10.71150/jm.2512001

First Report of Human Infection Caused by Aspergillus steynii and Analysis of Its Whole‐Genome Characteristics

Wang, R., Chen, J., Wu, N., Yang, M., Quan, R., Xia, N., Li, H., Nian, H., Jiang, N., Chu, Y., et al. (2026) · Transboundary and Emerging Diseases · doi:10.1155/tbed/4093308

Antifungals: mechanism of action, resistance, and therapeutic perspectives

Gómez-Gaviria, M., & Mora-Montes, H. M. (2026) · Microbial Pathogenesis · doi:10.1016/j.micpath.2026.108771

The GET pathway modulates azole susceptibility through sterol metabolic remodeling and protein trafficking in filamentous fungi

Ye, S., Cui, Z., Zhou, M., Hu, C., Yu, P., Zhang, L., Li, S., & Sun, X. (2026) · mBio · doi:10.1128/mbio.02021-26

A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions

Hagiwara, D., Miura, D., Shimizu, K., Paul, S., Ohba, A., Gonoi, T., Watanabe, A., Kamei, K., Shintani, T., Moye-Rowley, W. S., et al. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006096 · Cited by 156 · see citing works

The transcription factor RttA contributes to sterol regulation and azole resistance in Aspergillus fumigatus

Birštonas, L., Hortschansky, P., Bauer, I., Alcanzo, E. M., Kühbacher, A., Mertens, B., Müller, C., Brakhage, A. A., & Gsaller, F. (2025) · mBio · doi:10.1128/mbio.01854-25 · Cited by 5 · see citing works

AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus

Paul, S., Stamnes, M., Thomas, G. H., Liu, H., Hagiwara, D., Gomi, K., Filler, S. G., & Moye-Rowley, W. S. (2019) · mBio · doi:10.1128/mbio.02563-18 · Cited by 91 · see citing works

Loss of a conserved C-terminal region of the Aspergillus fumigatus AtrR transcriptional regulator leads to a gene-specific defect in target gene expressionPreprint

Ror, S., Stamnes, M. A., & Moye-Rowley, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.22.595332

The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus

Furukawa, T., van Rhijn, N., Fraczek, M. G., Gsaller, F., Davies, E. A., Carr, P. D., Gago, S., Fortune‐Grant, R., Rahman, S., Gilsenan, J. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14191-1 · Cited by 133 · see citing works