The Set1 Histone H3K4 Methyltransferase Contributes to Azole Susceptibility in a Species-Specific Manner by Differentially Altering the Expression of Drug Efflux Pumps and the Ergosterol Gene Pathway

Baker, Kortany M.; Hoda, Smriti; Saha, Debasmita; Gregor, Justin B.; Georgescu, Livia; Serratore, Nina D.; Zhang, Yueping; Cheng, Lizhi; Lanman, Nadia A.; Briggs, Scott D.

doi:10.1128/aac.02250-21

The Set1 Histone H3K4 Methyltransferase Contributes to Azole Susceptibility in a Species-Specific Manner by Differentially Altering the Expression of Drug Efflux Pumps and the Ergosterol Gene Pathway

Fungal infections are a major health concern because of limited antifungal drugs and development of drug resistance. Candida can develop azole drug resistance by overexpression of drug efflux pumps or mutating ERG11 , the target of azoles. However, the role of epigenetic histone modifications in …