The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis
Open accessAbstract
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4) methylase identified over 10 years ago. Since then, it has been demonstrated that Set1/COMPASS and its enzymatic product, H3K4 methylation, is highly conserved across the evolutionary tree. Although there is only one COMPASS in yeast, Drosophila possesses three and humans bear six COMPASS family members, each capable of methylating H3K4 with nonredundant functions. In yeast, the histone H2B monoubiquitinase Rad6/Bre1 is required for proper H3K4 and H3K79 trimethylations. The machineries involved in this process are also highly conserved from yeast to human. In this review, the process of histone H2B monoubiquitination-dependent and -independent histone H3K4 methylation as a mark of active transcription, enhancer signatures, and developmentally poised genes is discussed. The misregulation of histone H2B monoubiquitination and H3K4 methylation result in the pathogenesis of human diseases, including cancer. Recent findings in this regard are also examined.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SET domain-containing histone methyltransferases such as Trithorax/MLL1/2-COMPASS and PRC2 methylate lysine residues in the histone H3 amino-terminal tail and are essential for normal development.
“The SET domain-containing histone methyltransferases such as Trithorax/MLL1/2-COMPASS and Polycomb Repressive Complex 2 (PRC2) methylate lysine residues in the histone H3 amino-terminal tail and are essential for normal development [1].”
From Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling (2014) · cites this paper as [1]
The Introduction identifies trithorax and Polycomb proteins as SET-domain-containing methyltransferases involved in homeotic gene regulation. Sections 3.4 and 3.6 describe MLL1/MLL2-mediated H3K4 methylation, Polycomb-group H3K27 methylation, and embryonic lethality after MLL1 deletion. The copy does not specifically establish that PRC2 itself is essential for normal development. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works
Crystal structure of the nucleosome core particle at 2.8 Å resolution
Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466 · see citing works
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361 · see citing works
Goffeau, A., Barrell, B., Bussey, H., Davis, R. W., Dujon, B., Feldmann, H., Galibert, F., Hoheisel, J., Jacq, C., Johnston, M., et al. (1996) · Science · doi:10.1126/science.274.5287.546 · Cited by 4,420 · see citing works
Functional profiling of the Saccharomyces cerevisiae genome
Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature · doi:10.1038/nature00935 · Cited by 4,316 · see citing works
A gene complex controlling segmentation in Drosophila
Lewis, E. B. (1978) · Nature · doi:10.1038/276565a0 · Cited by 3,813 · see citing works
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · see citing works
The Polycomb complex PRC2 and its mark in life
Margueron, R., & Reinberg, D. (2011) · Nature · doi:10.1038/nature09784 · Cited by 3,347 · see citing works
The complex language of chromatin regulation during transcription
Berger, S. L. (2007) · Nature · doi:10.1038/nature05915 · Cited by 2,768 · see citing works
Chromatin Structure: A Repeating Unit of Histones and DNA
Kornberg, R. D. (1974) · Science · doi:10.1126/science.184.4139.868 · Cited by 2,662 · see citing works
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
Kornberg, R. D., & Lorch, Y. (1999) · Cell · doi:10.1016/s0092-8674(00)81958-3 · Cited by 1,833 · see citing works
Weintraub, H., & Groudine, M. (1976) · Science · doi:10.1126/science.948749 · Cited by 1,809 · see citing works
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
Morin, R. D., Mendez-Lago, M., Mungall, A. J., Goya, R., Mungall, K. L., Corbett, R. D., Johnson, N. A., Severson, T. M., Chiu, R., Field, M., et al. (2011) · Nature · doi:10.1038/nature10351 · Cited by 1,614 · see citing works
Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse
Bernstein, B., Kamal, M., Lindblad‐Toh, K., Bekiranov, S., Bailey, D. K., Huebert, D. J., McMahon, S., Karlsson, E. K., Kulbokas, E. J., Gingeras, T., et al. (2005) · Cell · doi:10.1016/j.cell.2005.01.001 · Cited by 1,509 · see citing works
Genome Regulation by Polycomb and Trithorax Proteins
Schuettengruber, B., Chourrout, D. M., Vervoort, M., Leblanc, B., & Cavalli, G. (2007) · Cell · doi:10.1016/j.cell.2007.02.009 · Cited by 1,433 · see citing works
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
Agger, K., Cloos, P. A., Christensen, J. F., Pasini, D., Rose, S., Rappsilber, J., Issaeva, I., Canaani, E., Salcini, A. E., & Helin, K. (2007) · Nature · doi:10.1038/nature06145 · Cited by 1,392 · see citing works
ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION
Workman, J. L., & Kingston, R. E. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.545 · Cited by 1,129 · see citing works
Shilatifard, A. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142422 · Cited by 1,099 · see citing works
Self-citationNg, H., Robert, F., Young, R. A., & Struhl, K. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00092-3 · Cited by 1,097 · see citing works
Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins
Ringrose, L., & Paro, R. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.091907 · Cited by 1,077 · see citing works
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast
Sun, Z., & Allis, C. D. (2002) · Nature · doi:10.1038/nature00883 · Cited by 1,076 · see citing works
MLL Targets SET Domain Methyltransferase Activity to Hox Gene Promoters
Milne, T. A., Briggs, S. D., Brock, H. W., Martin, M. E., Gibbs, D. Y., Allis, C. D., & Hess, J. L. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00741-4 · Cited by 1,051 · see citing works
New nomenclature for chromatin-modifying enzymes
Allis, C. D., Berger, S. L., Cote, J., Dent, S., Jenuwien, T., Kouzarides, T., Pillus, L., Reinberg, D., Shi, Y., Shiekhattar, R., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.039 · Cited by 957 · see citing works
Self-citationTkachuk, D. C., Köhler, S., & Cleary, M. L. (1992) · Cell · doi:10.1016/0092-8674(92)90602-9 · Cited by 934 · see citing works
Altered Hox expression and segmental identity in Mll-mutant mice
Yu, B., Hess, J. L., Horning, S. E., Brown, G. A. J., & Korsmeyer, S. J. (1995) · Nature · doi:10.1038/378505a0 · Cited by 872 · see citing works
Gu, Y., Nakamura, T., Alder, H., Prasad, R., Canaani, O. D., Cimino, G. G., Croce, C. M., & Canaani, E. (1992) · Cell · doi:10.1016/0092-8674(92)90603-a · Cited by 822 · see citing works
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
van Haaften, G., Dalgliesh, G. L., Davies, H., Chen, L., Bignell, G., Greenman, C., Edkins, S., Hardy, C., O'Meara, S., Teague, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.349 · Cited by 784 · see citing works
A histone H3 lysine 27 demethylase regulates animal posterior development
Lan, F., Bayliss, P. E., Rinn, J. L., Whetstine, J. R., Wang, J. K., Chen, S., Iwase, S., Alpatov, R., Issaeva, I., Canaani, E., et al. (2007) · Nature · doi:10.1038/nature06192 · Cited by 782 · see citing works
Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination
Lee, M. G., Villa, R., Trojer, P., Norman, J. A., Yan, K.-P., Reinberg, D., Croce, L. D., & Shiekhattar, R. (2007) · Science · doi:10.1126/science.1149042 · Cited by 772 · see citing works
Pavri, R., Zhu, B., Li, G., Trojer, P., Mandal, S. S., Shilatifard, A., & Reinberg, D. (2006) · Cell · doi:10.1016/j.cell.2006.04.029 · Cited by 708 · see citing works
Self-citationThe Genetic Landscape of the Childhood Cancer Medulloblastoma
Parsons, D. W., Li, M., Zhang, X., Jones, S., Leary, R. J., Lin, J., Boca, S. M., Carter, H. K., Samayoa, J. A., Bettegowda, C., et al. (2010) · Science · doi:10.1126/science.1198056 · Cited by 708 · see citing works
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein–DNA association
Lieb, J. D., Liu, X., Botstein, D., & Brown, P. O. (2001) · Nature Genetics · doi:10.1038/ng569 · Cited by 707 · see citing works
Krogan, N. J., Dover, J., Wood, A., Schneider, J., Heidt, J. W., Boateng, M. A., Dean, K., Ryan, O. W., Golshani, A., Johnston, M., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00091-1 · Cited by 706 · see citing works
Self-citationCovalent modifications of histones during development and disease pathogenesis
Bhaumik, S. R., Smith, E. R., & Shilatifard, A. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1337 · Cited by 683 · see citing works
Self-citationKrogan, N. J., Kim, M., Tong, A. H. Y., Golshani, A., Cagney, G., Canadien, V., Richards, D. P., Beattie, B. K., Emili, A., Boone, C. M., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.12.4207-4218.2003 · Cited by 680 · see citing works
Self-citationDou, Y., Milne, T. A., Tackett, A. J., Smith, E. R., Fukuda, A., Wysocka, J., Allis, C. D., Chait, B. T., Hess, J. L., & Roeder, R. G. (2005) · Cell · doi:10.1016/j.cell.2005.04.031 · Cited by 665 · see citing works
Yokoyama, A., Wang, Z., Wysocka, J., Sanyal, M., Aufiero, D. J., Kitabayashi, I., Herr, W., & Cleary, M. L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5639-5649.2004 · Cited by 661 · see citing works
Menin Associates with a Trithorax Family Histone Methyltransferase Complex and with the Hoxc8 Locus
Hughes, C. M., Rozenblatt–Rosen, O., Milne, T. A., Copeland, T. D., Levine, S. S., Lee, J. C., Hayes, D. N., Shanmugam, K. S., Bhattacharjee, A., Biondi, C., et al. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00081-4 · Cited by 645 · see citing works
COMPASS: A complex of proteins associated with a trithorax-related SET domain protein
Miller, T., Krogan, N. J., Dover, J., Erdjument‐Bromage, H., Tempst, P., Johnston, M., Greenblatt, J., & Shilatifard, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231473398 · Cited by 619 · see citing works
Self-citationGenome-wide analysis of Polycomb targets in Drosophila melanogaster
Schwartz, Y. B., Kahn, T. G., Nix, D. A., Li, X., Bourgon, R., Biggin, M. D., & Pirrotta, V. (2006) · Nature Genetics · doi:10.1038/ng1817 · Cited by 610 · see citing works
Lorch, Y., LaPointe, J. W., & Kornberg, R. D. (1987) · Cell · doi:10.1016/0092-8674(87)90561-7 · Cited by 605 · see citing works
The Language of Histone Crosstalk
Lee, J., Smith, E. R., & Shilatifard, A. (2010) · Cell · doi:10.1016/j.cell.2010.08.011 · Cited by 598 · see citing works
Self-citationder Poel, S. Z.-V., McCabe, N. R., Gill, H. J., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10735 · Cited by 594 · see citing works
Roguev, A., Schaft, D., Shevchenko, A., Pijnappel, W. W. M. P., Wilm, M. S., Aasland, R., & Stewart, A. F. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7137 · Cited by 594 · see citing works
Lin, C., Smith, E. R., Takahashi, H., Lai, K. C., Martin‐Brown, S., Florens, L. A., Washburn, M. P., Conaway, J. W., Conaway, R. C., & Shilatifard, A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.026 · Cited by 574 · see citing works
Self-citationTschiersch, B., Hofmann, A., Krauss, V., Dorn, R., Korge, G., & Reuter, G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06693.x · Cited by 567 · see citing works
Kim, J., Guermah, M., McGinty, R. K., Lee, J., Tang, Z., Milne, T. A., Shilatifard, A., Muir, T. W., & Roeder, R. G. (2009) · Cell · doi:10.1016/j.cell.2009.02.027 · Cited by 555 · see citing works
Self-citationMethylation of Histone H3 by COMPASS Requires Ubiquitination of Histone H2B by Rad6
Dover, J., Schneider, J., Tawiah-Boateng, M. A., Wood, A., Dean, K., Johnston, M., & Shilatifard, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200348200 · Cited by 554 · see citing works
Self-citationGreer, E. L., Maures, T. J., Hauswirth, A. G., Green, E. M., Leeman, D. S., Maro, G. S., Han, S., Banko, M. R., Gozani, O., & Brunet, A. (2010) · Nature · doi:10.1038/nature09195 · Cited by 543 · see citing works
Monoubiquitination of Human Histone H2B: The Factors Involved and Their Roles in HOX Gene Regulation
Zhu, B., Zheng, Y., Pham, A.-D., Mandal, S. S., Erdjument‐Bromage, H., Tempst, P., & Reinberg, D. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.09.025 · Cited by 532 · see citing works
Bre1, an E3 Ubiquitin Ligase Required for Recruitment and Substrate Selection of Rad6 at a Promoter
Wood, A., Krogan, N. J., Dover, J., Schneider, J., Heidt, J. W., Boateng, M. A., Dean, K., Golshani, A., Zhang, Y., Greenblatt, J., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(02)00802-x · Cited by 530 · see citing works
Self-citationPTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex
Cho, Y., Hong, T., Hong, S., Guo, H. W., Yu, H., Kim, D., Guszczynski, T., Dressler, G. R., Copeland, T. D., Kalkum, M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701574200 · Cited by 528 · see citing works
Corral, J., Lavenir, I., Impey, H. L., Warren, A. J., Forster, A. M., Larson, T., Bell, S. E., McKenzie, A. N. J., King, G., & Rabbitts, T. H. (1996) · Cell · doi:10.1016/s0092-8674(00)81269-6 · Cited by 520 · see citing works
Trans-histone regulatory pathway in chromatin
Briggs, S. D., Xiao, T., Sun, Z., Caldwell, J., Shabanowitz, J., Hunt, D. F., Allis, C. D., & Strahl, B. D. (2002) · Nature · doi:10.1038/nature00970 · Cited by 516 · see citing works
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation
Shilatifard, A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.03.019 · Cited by 486 · see citing works
Self-citationNucleosome loss activates yeast downstream promoters in vivo
Han, M., & GRUNSTEIN, M. M. (1988) · Cell · doi:10.1016/0092-8674(88)90258-9 · Cited by 462 · see citing works
Histone Crosstalk between H2B Monoubiquitination and H3 Methylation Mediated by COMPASS
Lee, J., Shukla, A., Schneider, J., Swanson, S. K., Washburn, M. P., Florens, L. A., Bhaumik, S. R., & Shilatifard, A. (2007) · Cell · doi:10.1016/j.cell.2007.09.046 · Cited by 439 · see citing works
Self-citationA Conserved RING Finger Protein Required for Histone H2B Monoubiquitination and Cell Size Control
Hwang, W. W., Venkatasubrahmanyam, S., Ianculescu, A. G., Tong, A. H. Y., Boone, C. M., & Madhani, H. D. (2003) · Molecular Cell · doi:10.1016/s1097-2765(02)00826-2 · Cited by 439 · see citing works
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9Preprint
Ayton, P. M., & Cleary, M. L. (2003) · Genes & Development · doi:10.1101/gad.1111603 · Cited by 438 · see citing works
Ng, H., Xu, R.-M., Zhang, Y., & Struhl, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200433200 · Cited by 432 · see citing works
New insights to the MLL recombinome of acute leukemias
Meyer, C., Kowarz, E., Hofmann, J., Renneville, A., Zuna, J., Trka, J., Abdelali, R. B., Macintyre, E. A., Braekeleer, E. D., Braekeleer, M. D., et al. (2009) · Leukemia · doi:10.1038/leu.2009.33 · Cited by 407 · see citing works
Krogan, N. J., Dover, J., Khorrami, S., Greenblatt, J., Schneider, J., Johnston, M., & Shilatifard, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200023200 · Cited by 403 · see citing works
Self-citationMoyal, L., Lerenthal, Y., Gana‐Weisz, M., Mass, G., So, S., Wang, S., Eppink, B., Chung, Y. M., Shalev, G., Shema, E., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.015 · Cited by 402 · see citing works
Lavau, C., Szilvassy, S. J., Slany, R. K., & Cleary, M. L. (1997) · The EMBO Journal · doi:10.1093/emboj/16.14.4226 · Cited by 401 · see citing works
Wood, A., Schneider, J., Dover, J., Johnston, M., & Shilatifard, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300269200 · Cited by 396 · see citing works
Self-citationA role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
Mueller, D., Bach, C., Zeisig, D. T., García-Cuéllar, M.-P., Monroe, S., Sreekumar, A., Zhou, R., Nesvizhskii, A. I., Chinnaiyan, A. M., Hess, J. L., et al. (2007) · Blood · doi:10.1182/blood-2007-05-090514 · Cited by 396 · see citing works
He, N., Liu, M., Hsu, J. H., Xue, Y., Chou, S., Burlingame, A. L., Krogan, N. J., Alber, T., & Zhou, Q. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.04.013 · Cited by 396 · see citing works
Workman, J. L., & Roeder, R. G. (1987) · Cell · doi:10.1016/0092-8674(87)90130-9 · Cited by 392 · see citing works
THE CRITICAL ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN LEUKEMIAS
Rowley, J. D. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.495 · Cited by 392 · see citing works
Wysocka, J., Myers, M. P., Laherty, C. D., Eisenman, R. N., & Herr, W. (2003) · Genes & Development · doi:10.1101/gad.252103 · Cited by 390 · see citing works
Sobhian, B., Laguette, N., Yatim, A., Nakamura, M., Lévy, Y., Kiernan, R. E., & Benkirane, M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.04.012 · Cited by 382 · see citing works
Issaeva, I., Zonis, Y. A., Rozovskaia, T., Orlovsky, K., Croce, C. M., Nakamura, T., Mazo, A., Eisenbach, L., & Canaani, E. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01506-06 · Cited by 380 · see citing works
Yokoyama, A., Lin, M., Naresh, A., Kitabayashi, I., & Cleary, M. L. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.040 · Cited by 374 · see citing works
The super elongation complex (SEC) and MLL in development and diseasePreprint
Smith, E. R., Lin, C., & Shilatifard, A. (2011) · Genes & Development · doi:10.1101/gad.2015411 · Cited by 362 · see citing works
Self-citationWang, P., Lin, C., Smith, E. R., Guo, H. W., Sanderson, B. W., Wu, M., Gogol, M., Alexander, T. B., Seidel, C. W., Wiedemann, L. M., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00924-09 · Cited by 360 · see citing works
Self-citationHistone H3 lysine 4 (H3K4) methylation in development and differentiation
Eissenberg, J. C., & Shilatifard, A. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.08.017 · Cited by 356 · see citing works
Self-citationRegulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination
Nakamura, K., Kato, A., Kobayashi, J., Yanagihara, H., Sakamoto, S., Oliveira, D. V. N. P., Shimada, M., Tauchi, H., Suzuki, H., Tashiro, S., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.002 · Cited by 351 · see citing works
Polycombing the Genome: PcG, trxG, and Chromatin Silencing
Pirrotta, V. (1998) · Cell · doi:10.1016/s0092-8674(00)81162-9 · Cited by 349 · see citing works
The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro
Knezetic, J. A., & Luse, D. S. (1986) · Cell · doi:10.1016/0092-8674(86)90541-6 · Cited by 345 · see citing works
Polycomb, Epigenomes, and Control of Cell Identity
Orlando, V. (2003) · Cell · doi:10.1016/s0092-8674(03)00157-0 · Cited by 339 · see citing works
Lee, J., & Skalnik, D. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508312200 · Cited by 334 · see citing works
Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization
Zeisig, B. B., Milne, T., García-Cuéllar, M.-P., Schreiner, S., Martin, M.-E., Fuchs, U., Borkhardt, A., Chanda, S. K., Walker, J. R., Soden, R., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.617-628.2004 · Cited by 330 · see citing works
An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene
Shilatifard, A., Lane, W. S., Jackson, K. W., Conaway, R. C., & Conaway, J. W. (1996) · Science · doi:10.1126/science.271.5257.1873 · Cited by 324 · see citing works
Self-citationMolecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS
Wu, M., Wang, P. F., Lee, J. S., Martin‐Brown, S., Florens, L. A., Washburn, M. P., & Shilatifard, A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00976-08 · Cited by 324 · see citing works
Self-citationSquazzo, S. L., Costa, P. J., Lindstrom, D. L., Kumer, K. E., Simic, R., Jennings, J. L., Link, A. J., Arndt, K. M., & Hartzog, G. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1764 · Cited by 322 · see citing works
Kim, J., Hake, S. B., & Roeder, R. G. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.11.012 · Cited by 317 · see citing works
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)Preprint
Mohan, M., Herz, H., Takahashi, Y.-H., Lin, C., Lai, K. C., Zhang, Y., Washburn, M. P., Florens, L. A., & Shilatifard, A. (2010) · Genes & Development · doi:10.1101/gad.1898410 · Cited by 312 · see citing works
Self-citationBitoun, E., Oliver, P. L., & Davies, K. E. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl444 · Cited by 311 · see citing works
Exchange of RNA Polymerase II Initiation and Elongation Factors during Gene Expression In Vivo
Pokholok, D., Hannett, N. M., & Young, R. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00502-6 · Cited by 311 · see citing works
Yu, B., Hanson, R. D., Hess, J. L., Horning, S. E., & Korsmeyer, S. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10632 · Cited by 302 · see citing works
Molecular Regulation of Histone H3 Trimethylation by COMPASS and the Regulation of Gene Expression
Schneider, J., Wood, A., Lee, J., Schuster, R. M., Dueker, J., Maguire, C., Swanson, S. K., Florens, L. A., Washburn, M. P., & Shilatifard, A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.07.024 · Cited by 302 · see citing works
Self-citationAn RNA polymerase II elongation factor encoded by the human ELL gene
(1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81441-7 · Cited by 276 · see citing works
Kim, J., Guermah, M., & Roeder, R. G. (2010) · Cell · doi:10.1016/j.cell.2009.12.050 · Cited by 273 · see citing works
MLL2 Is Required in Oocytes for Bulk Histone 3 Lysine 4 Trimethylation and Transcriptional Silencing
Andreu‐Vieyra, C., Chen, R., Agno, J. E., Glaser, S. P., Anastassiadis, K., Stewart, A. F., & Matzuk, M. M. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000453 · Cited by 270 · see citing works
Identification and Characterization of the Human Set1B Histone H3-Lys4 Methyltransferase Complex
Lee, J., Tate, C. M., You, J., & Skalnik, D. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609809200 · Cited by 266 · see citing works
The RNA Polymerase II Elongation Complex
Shilatifard, A., Conaway, R. C., & Conaway, J. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161551 · Cited by 253 · see citing works
Self-citationChuang, P., Albertson, D. G., & Meyer, B. J. (1994) · Cell · doi:10.1016/0092-8674(94)90255-0 · Cited by 252 · see citing works
MLL-AF9-Induced Leukemogenesis Requires Co-Expression of the Wild Type Mll Allele
Thiel, A. T., Blessington, P., Zou, T., Feather, D., Wu, X.-J., Yan, J.-Z., Zhang, H., Liu, Z.-G., Ernst, P., Koretzky, G., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.034 · Cited by 249 · see citing works
Patel, S. R., Kim, D., Levitan, I., & Dressler, G. R. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.09.004 · Cited by 249 · see citing works
Mets, D. G., & Meyer, B. J. (2009) · Cell · doi:10.1016/j.cell.2009.07.035 · Cited by 248 · see citing works
A Hierarchy of H3K4me3 and H3K27me3 Acquisition in Spatial Gene Regulation in Xenopus Embryos
Akkers, R. C., van Heeringen, S. J., Jacobi, U. G., Janssen‐Megens, E. M., Françoijs, K., Stunnenberg, H. G., & Veenstra, G. J. C. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.08.005 · Cited by 244 · see citing works
Ctr9, Rtf1, and Leo1 Are Components of the Paf1/RNA Polymerase II Complex
Mueller, C. L., & Jaehning, J. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.1971-1980.2002 · Cited by 241 · see citing works
UTX mediates demethylation of H3K27me3 at muscle‐specific genes during myogenesis
Seenundun, S., Rampalli, S., Liu, Q., Aziz, A., Palii, C. G., Hong, S., Blais, A., Brand, M., Ge, K., & Dilworth, F. J. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.37 · Cited by 235 · see citing works
Hsieh, J. J.-D., Ernst, P., Erdjument‐Bromage, H., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.186-194.2003 · Cited by 235 · see citing works
The human PAF complex coordinates transcription with events downstream of RNA synthesisPreprint
Zhu, B., Mandal, S. S., Pham, A.-D., Zheng, Y., Erdjument‐Bromage, H., Batra, S. K., Tempst, P., & Reinberg, D. (2005) · Genes & Development · doi:10.1101/gad.1292105 · Cited by 235 · see citing works
Smith, E. R., & Shilatifard, A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.031 · Cited by 234 · see citing works
Self-citationFinding distal regulatory elements in the human genome
Heintzman, N. D., & Ren, B. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.09.006 · Cited by 234 · see citing works
The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis
Muntean, A. G., Tan, J., Sitwala, K. V., Huang, Y., Bronstein, J. C., Connelly, J. A., Basrur, V., Elenitoba‐Johnson, K. S. J., & Hess, J. L. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.04.012 · Cited by 232 · see citing works
Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis
Milne, T. A., Kim, J., Wang, G. G., Stadler, S. C., Basrur, V., Whitcomb, S. J., Wang, Z., Ruthenburg, A. J., Elenitoba‐Johnson, K. S. J., Roeder, R. G., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.011 · Cited by 231 · see citing works
Goo, Y., Sohn, Y. C., Kim, D., Kim, S., Kang, M., Jung, D.-J., Kwak, E., Barlev, N. A., Berger, S. L., Chow, V. T. K., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.140-149.2003 · Cited by 231 · see citing works
The COMPASS Family of H3K4 Methylases in Drosophila
Mohan, M., Herz, H., Smith, E. R., Zhang, Y., Jackson, J., Washburn, M. P., Florens, L. A., Eissenberg, J. C., & Shilatifard, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06092-11 · Cited by 229 · see citing works
Self-citationDepletion of histone H4 and nucleosomes activates the PHO5 gene in Saccharomyces cerevisiae.
Han, M., Kim, U. J., Kayne, P. S., & Grunstein, M. R. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03061.x · Cited by 221 · see citing works
Lee, J., & Skalnik, D. G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01356-07 · Cited by 218 · see citing works
Lee, J., Kim, D., Lee, S., Yang, Q.-H., Lee, D. K., Lee, S., Roeder, R. G., & Lee, J. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902873106 · Cited by 215 · see citing works
Terranova, R., Agherbi, H., Boned, A., Méresse, S., & Djabali, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507425103 · Cited by 209 · see citing works
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
Minsky, N., & Oren, M. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.016 · Cited by 204 · see citing works
Trithorax and dCBP Acting in a Complex to Maintain Expression of a Homeotic Gene
Petruk, S., Sedkov, Y., Smith, S. T., Tillib, S. V., Kraevski, V., Nakamura, T., Canaani, E., Croce, C. M., & Mazo, A. (2001) · Science · doi:10.1126/science.1065683 · Cited by 204 · see citing works
Alternative Epigenetic Chromatin States of Polycomb Target Genes
Schwartz, Y. B., Kahn, T. G., Stenberg, P., Ohno, K., Bourgon, R., & Pirrotta, V. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000805 · Cited by 202 · see citing works
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis
Mohan, M., Lin, C., Guest, E. M., & Shilatifard, A. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2915 · Cited by 197 · see citing works
Self-citationDrosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription
Ardehali, M. B., Mei, A., Zobeck, K. L., Caron, M. J., Lis, J. T., & Kusch, T. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.194 · Cited by 195 · see citing works
Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias
So, C. W. E., Lin, M., Ayton, P. M., Chen, E. H., & Cleary, M. L. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00188-0 · Cited by 194 · see citing works
Jiang, D., Kong, N. C., Gu, X., Li, Z., & He, Y. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001330 · Cited by 191 · see citing works
Lee, J., Saha, P., Yang, Q.-H., Lee, S., Park, J. Y., Suh, Y., Lee, S., Chan, L., Roeder, R. G., & Lee, J. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810100105 · Cited by 187 · see citing works
Sex-Specific Assembly of a Dosage Compensation Complex on the Nematode X Chromosome
Chuang, P., Lieb, J. D., & Meyer, B. J. (1996) · Science · doi:10.1126/science.274.5293.1736 · Cited by 184 · see citing works
Nedea, E. C., He, X., Kim, M., Pootoolal, J., Zhong, G., Canadien, V., Hughes, T. R., Buratowski, S., Moore, C. L., & Greenblatt, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304454200 · Cited by 184 · see citing works
Schulze-Hentrich, J. M., Jackson, J., Nakanishi, S., Gardner, J. M., Hentrich, T., Haug, J., Johnston, M., Jaspersen, S. L., Kobor, M. S., & Shilatifard, A. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.07.017 · Cited by 180 · see citing works
Self-citationLin, C., Garrett, A. S., Kumar, B. D., Smith, E. R., Gogol, M., Seidel, C. W., Krumlauf, R. K., & Shilatifard, A. (2011) · Genes & Development · doi:10.1101/gad.2059211 · Cited by 180 · see citing works
Self-citationMethylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila
Sedkov, Y., Cho, E., Petruk, S., Cherbas, L., Smith, S. T., Jones, R. S., Cherbas, P. T., Canaani, E., Jaynes, J. B., & Mazo, A. (2003) · Nature · doi:10.1038/nature02080 · Cited by 176 · see citing works
Glaser, S. P., Lubitz, S., Loveland, K. L., Ohbo, K., Robb, L., Schwenk, F., Seibler, J., Roellig, D., Kranz, A., Anastassiadis, K., et al. (2009) · Epigenetics & Chromatin · doi:10.1186/1756-8935-2-5 · Cited by 175 · see citing works
Dimerization of MLL fusion proteins immortalizes hematopoietic cells
Martin, M. E., Milne, T. A., Bloyer, S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00214-9 · Cited by 169 · see citing works
Lieb, J. D., Albrecht, M. R., Chuang, P., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80920-4 · Cited by 169 · see citing works
Transcriptional Elongation by RNA Polymerase II and Histone Methylation
Gerber, M., & Shilatifard, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300014200 · Cited by 168 · see citing works
Self-citationDehé, P.-M., Dichtl, B., Schaft, D., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603099200 · Cited by 166 · see citing works
Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesisPreprint
Daser, A., & Rabbitts, T. H. (2004) · Genes & Development · doi:10.1101/gad.1195504 · Cited by 164 · see citing works
Chang, M., French-Cornay, D., Fan, H.-Y., Klein, H. L., Denis, C. L., & Jaehning, J. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1056 · Cited by 161 · see citing works
PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination
Daniel, J. A., Santos, M. A., Wang, Z., Zang, C., Schwab, K. R., Janković, M., Filsuf, D., Chen, H. T., Gazumyan, A., Yamane, A., et al. (2010) · Science · doi:10.1126/science.1187942 · Cited by 160 · see citing works
Identification of the MLL2 Complex as a Coactivator for Estrogen Receptor α
Mo, R., Rao, S. M., & Zhu, Y.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513245200 · Cited by 156 · see citing works
Tanny, J. C., Erdjument‐Bromage, H., Tempst, P., & Allis, C. D. (2007) · Genes & Development · doi:10.1101/gad.1516207 · Cited by 156 · see citing works
Polycomb preferentially targets stalled promoters of coding and noncoding transcriptsPreprint
Enderle, D., Beisel, C., Stadler, M. B., Gerstung, M., Athri, P., & Paro, R. (2010) · Genome Research · doi:10.1101/gr.114348.110 · Cited by 156 · see citing works
Ingham, P. W., & Whittle, R. (1980) · Molecular and General Genetics MGG · doi:10.1007/bf00271751 · Cited by 155 · see citing works
THE FREQUENCY OF TRANSLOCATIONS PRODUCED BY X-RAYS IN DROSOPHILA
Muller, H. J., & Altenburg, E. (1930) · Genetics · doi:10.1093/genetics/15.4.283 · Cited by 153 · see citing works
Stassen, M. J., Bailey, D., Nelson, S., Chinwalla, V., & Harte, P. J. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(95)00402-m · Cited by 149 · see citing works
Hox Gene Loss during Dynamic Evolution of the Nematode Cluster
Aboobaker, A. A., & Blaxter, M. (2003) · Current Biology · doi:10.1016/s0960-9822(02)01399-4 · Cited by 148 · see citing works
The histone demethylase UTX enables RB-dependent cell fate controlPreprint
Wang, J. K., Tsai, M.-C., Poulin, G. B., Adler, A. S., Chen, S., Liu, H., Shi, Y., & Chang, H. Y. (2010) · Genes & Development · doi:10.1101/gad.1882610 · Cited by 145 · see citing works
Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human
Takahashi, Y.-H., Westfield, G., Oleskie, A. N., Trievel, R. C., Shilatifard, A., & Skiniotis, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109360108 · Cited by 144 · see citing works
Self-citationShi, X., Finkelstein, A., Wolf, A. J., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.2.669 · Cited by 143 · see citing works
Explosive Lineage-Specific Expansion of the Orphan Nuclear Receptor HNF4 in Nematodes
Robinson‐Rechavi, M., Maina, C. V., Gissendanner, C. R., Laudet, V., & Sluder, A. E. (2005) · Journal of Molecular Evolution · doi:10.1007/s00239-004-0175-8 · Cited by 141 · see citing works
Bre1 Is Required for Notch Signaling and Histone Modification
Bray, S. J., Musisi, H., & Bienz, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.11.020 · Cited by 139 · see citing works
Chromatin silencing and activation by Polycomb and trithorax group proteins
Mahmoudi, T., & Verrijzer, C. P. (2001) · Oncogene · doi:10.1038/sj.onc.1204330 · Cited by 132 · see citing works
Costa, P. J., & Arndt, K. M. (2000) · Genetics · doi:10.1093/genetics/156.2.535 · Cited by 131 · see citing works
Smith, E. R., Lee, M. G., Winter, B., Droz, N. M., Eissenberg, J. C., Shiekhattar, R., & Shilatifard, A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01504-07 · Cited by 129 · see citing works
Self-citationNedea, E. C., Nalbant, D., Xia, D., Theoharis, N. T., Suter, B., Richardson, C. J., Tatchell, K., Kislinger, T., Greenblatt, J. F., & Nagy, P. L. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.031 · Cited by 128 · see citing works
ELL2, a new member of an ELL family of RNA polymerase II elongation factors
Shilatifard, A., Duan, D. R., Haque, D., Florence, C., Schubach, W. H., Conaway, J. W., & Conaway, R. C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3639 · Cited by 126 · see citing works
Self-citationDPY-26, a Link Between Dosage Compensation and Meiotic Chromosome Segregation in the Nematode
Lieb, J. D., Capowski, E. E., Meneely, P., et al. (1996) · Science · doi:10.1126/science.274.5293.1732 · Cited by 119 · see citing works
Dot1 and Histone H3K79 Methylation in Natural Telomeric and HM Silencing
Takahashi, Y.-H., Schulze-Hentrich, J. M., Jackson, J., Hentrich, T., Seidel, C. W., Jaspersen, S. L., Kobor, M. S., & Shilatifard, A. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.006 · Cited by 116 · see citing works
Self-citationDrosophila Stem Cells Share a Common Requirement for the Histone H2B Ubiquitin Protease Scrawny
Buszczak, M., Paterno, S., & Spradling, A. C. (2008) · Science · doi:10.1126/science.1165678 · Cited by 116 · see citing works
The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila
Herz, H., Madden, L. D., Chen, Z., Bolduc, C., Buff, E. M., Gupta, R., Davuluri, R. V., Shilatifard, A., Hariharan, I. K., & Bergmann, A. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01633-09 · Cited by 112 · see citing works
Self-citationDistinct Genetic Alterations in Colorectal Cancer
Ashktorab, H., Schäffer, A. A., Daremipouran, M., Smoot, D. T., Lee, E. B., & Brim, H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008879 · Cited by 111 · see citing works
Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation
Vitaliano-Prunier, A., Menant, A., Hobeika, M., Géli, V., Gwizdek, C., & Dargemont, C. (2008) · Nature Cell Biology · doi:10.1038/ncb1796 · Cited by 110 · see citing works
Tillib, S. V., Petruk, S., Sedkov, Y., Kuzin, A., Fujioka, M., Goto, T., & Mazo, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.5189 · Cited by 105 · see citing works
Cheng, H.-L. M., He, X., & Moore, C. L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2932-2943.2004 · Cited by 105 · see citing works
Evolutionary diversity and developmental regulation of X-chromosome inactivation
Escamilla-Del-Arenal, M., da Rocha, S. T., & Heard, É. (2011) · Human Genetics · doi:10.1007/s00439-011-1029-2 · Cited by 104 · see citing works
Factors regulating the transcriptional elongation activity of RNA polymerase II
Shilatifard, A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.14.1437 · Cited by 104 · see citing works
Self-citationWang, P., Bowl, M. R., Bender, S., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00654-07 · Cited by 104 · see citing works
DiMartino, J. F., Miller, T., Ayton, P. M., et al. (2000) · Blood · doi:10.1182/blood.v96.12.3887 · Cited by 102 · see citing works
Li, T., & Kelly, W. G. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001349 · Cited by 102 · see citing works
Histone trimethylation by Set1 is coordinated by the RRM, autoinhibitory, and catalytic domains
Schlichter, A., & Cairns, B. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600607 · Cited by 94 · see citing works
Prasad, R., Zhadanov, A. B., Sedkov, Y., et al. (1997) · Oncogene · doi:10.1038/sj.onc.1201211 · Cited by 90 · see citing works
Hsu, D. R., & Meyer, B. J. (1994) · Genetics · doi:10.1093/genetics/137.4.999 · Cited by 84 · see citing works
Tenney, K., & Shilatifard, A. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20421 · Cited by 84 · see citing works
Self-citationThe H3/H4 Tetramer Blocks Transcript Elongation by RNA Polymerase II in Vitro
Chang, C.-H., & Luse, D. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.37.23427 · Cited by 82 · see citing works
HISTONE GENE MULTIPLICITY AND POSITION EFFECT VARIEGATION IN DROSOPHILA MELANOGASTER
Moore, G. D., Sinclair, D. A. R., & Grigliatti, T. A. (1983) · Genetics · doi:10.1093/genetics/105.2.327 · Cited by 80 · see citing works
dELL is an essential RNA polymerase II elongation factor with a general role in development
Eissenberg, J. C., Ma, J., Gerber, M. A., Christensen, A., Kennison, J. A., & Shilatifard, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152193699 · Cited by 79 · see citing works
Self-citationHsu, D. R., Chuang, P., & Meyer, B. J. (1995) · Development · doi:10.1242/dev.121.10.3323 · Cited by 77 · see citing works
Miller, T., Williams, K., Johnstone, R. W., & Shilatifard, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005175200 · Cited by 76 · see citing works
Self-citationDrosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling
Tenney, K., Gerber, M., Ilvarsonn, A. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603620103 · Cited by 74 · see citing works
Pferdehirt, R. R., Kruesi, W. S., & Meyer, B. J. (2011) · Genes & Development · doi:10.1101/gad.2016011 · Cited by 69 · see citing works
Ctk Complex-Mediated Regulation of Histone Methylation by COMPASS
Wood, A., Shukla, A., Schneider, J., Lee, J. S., Stanton, J. D., Dzuiba, T., Swanson, S. K., Florens, L. A., Washburn, M. P., Wyrick, J. J., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01627-06 · Cited by 67 · see citing works
Self-citationEvolution of heterochromatic genes of Drosophila
Yasuhara, J. C., DeCrease, C. H., & Wakimoto, B. T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503424102 · Cited by 66 · see citing works
Gerber, M., Ma, J., Dean, K., Eissenberg, J. C., & Shilatifard, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6104 · Cited by 63 · see citing works
Self-citationXiao, T., Shibata, Y., Rao, B., Laribee, R. N., O'Rourke, R., Buck, M. J., Greenblatt, J., Krogan, N. J., Lieb, J. D., & Strahl, B. D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01628-06 · Cited by 60 · see citing works
Genetic Control of the Spatial Pattern of Selector Gene Expression in DrosophilaPreprint
Ingham, P. W. (1985) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1985.050.01.026 · Cited by 55 · see citing works
Histone gene deficiencies and position–effect variegation in Drosophila
Moore, G. D., Procunier, J. D., Cross, D. P., et al. (1979) · Nature · doi:10.1038/282312a0 · Cited by 53 · see citing works
A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans
Poole, R. J., Bashllari, E., Cochella, L., Flowers, E. B., & Hobert, O. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002109 · Cited by 50 · see citing works
Crucial Roles for Interactions between MLL3/4 and INI1 in Nuclear Receptor Transactivation
Lee, S., Kim, D., Goo, Y. H., Lee, Y. C., Lee, S., & Lee, J. W. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0455 · Cited by 48 · see citing works
Zheng, S., Wyrick, J. J., & Reese, J. C. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00324-10 · Cited by 47 · see citing works
Hilliker, A. J., & Holm, D. G. (1975) · Genetics · doi:10.1093/genetics/81.4.705 · Cited by 47 · see citing works
Kim, D., Lee, J., Lee, B., & Lee, J. W. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0099 · Cited by 46 · see citing works
Sedkov, Y., Benes, J. J., Berger, J. R., Riker, K. M., Tillib, S. V., Jones, R. S., & Mazo, A. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00246-9 · Cited by 41 · see citing works
Histone N-terminal Tails Interfere with Nucleosome Traversal by RNA Polymerase II
Újvári, A., Hsieh, F., Luse, S. W., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806636200 · Cited by 41 · see citing works
Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL
Smith, E. R., Winter, B., Eissenberg, J. C., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804379105 · Cited by 39 · see citing works
The MSL complex: X chromosome and beyond
Laverty, C., Lucci, J., & Akhtar, A. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.01.007 · Cited by 31 · see citing works
Schneider, J., Dover, J., Johnston, M., et al. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)77013-x · Cited by 28 · see citing works
The Curious Case of Bivalent Marks
Herz, H., Nakanishi, S., & Shilatifard, A. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.08.014 · Cited by 18 · see citing works
Self-citationMutational Analysis of an RNA Polymerase II Elongation Factor in Drosophila melanogaster
Gerber, M. A., Shilatifard, A., & Eissenberg, J. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7803-7811.2005 · Cited by 11 · see citing works
Self-citationHistone Cross-Talk in Stem Cells
Smith, E. R., & Shilatifard, A. (2009) · Science · doi:10.1126/science.1168660 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 7
- [29]Smith E Shilatifard A 2010 The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes Molecular cell 40 689 701 21145479 PMC3037032
- [66]Wu M Wang PF Lee JS Martin-Brown S Florens L 2008 Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS Molecular and cellular biology 28 7337 44 18838538 PMC2593441
- [72]Lee JH Tate CM You JS Skalnik DG 2007 Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex The Journal of biological chemistry 282 13419 28 17355966
- [74]Eissenberg JC Shilatifard A 2010 Histone H3 lysine 4 (H3K4) methylation in development and differentiation Dev Biol 339 240 9 19703438 PMC3711867
- [80]Lee JH Skalnik DG 2008 Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes Molecular and cellular biology 28 609 18 17998332 PMC2223426
- [162]Mohan M Lin C Guest E Shilatifard A 2010 Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis Nat Rev Cancer 10 721 8 20844554
- [197]Daniel JA Santos MA Wang Z Zang C Schwab KR PTIP promotes chromatin changes critical for immunoglobulin class switch recombination Science 329 917 23 20671152 PMC3008398
Cited by
Sorted by citations
Writing, erasing and reading histone lysine methylations
Hyun, K., Jeon, J., Park, K., & Kim, J. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.11 · Cited by 1,250 · see citing works
De novo mutations in histone-modifying genes in congenital heart disease
Zaidi, S., Choi, M., Wakimoto, H., Ma, L., Jiang, J., Overton, J. D., Romano-Adesman, A., Bjornson, R. D., Breitbart, R. E., Brown, K. K., et al. (2013) · Nature · doi:10.1038/nature12141 · Cited by 934 · see citing works
Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610 · see citing works
Shah, P. P., Donahue, G., Otte, G. L., Capell, B. C., Nelson, D. M., Cao, K., Aggarwala, V., Cruickshanks, H. A., Rai, T. S., McBryan, T., et al. (2013) · Genes & Development · doi:10.1101/gad.223834.113 · Cited by 550 · see citing works
H3K4me3 breadth is linked to cell identity and transcriptional consistency
Benayoun, B. A., Pollina, E. A., Ucar, D., Mahmoudi, S., Karra, K., Wong, E. D., Devarajan, K., Daugherty, A. C., Kundaje, A. B., Mancini, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.027 · Cited by 536 · see citing works
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
Zhu, J., Sammons, M. A., Donahue, G., Dou, Z., Vedadi, M., Getlik, M., Barsyte-Lovejoy, D., Al-awar, R., Katona, B. W., Shilatifard, A., et al. (2015) · Nature · doi:10.1038/nature15251 · Cited by 493 · see citing works
Self-citationBorn to run: control of transcription elongation by RNA polymerase II
Chen, F. X., Smith, E. R., & Shilatifard, A. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0010-5 · Cited by 447 · see citing works
Self-citationSET for life: biochemical activities and biological functions of SET domain-containing proteins
Herz, H.-M., Garruss, A., & Shilatifard, A. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.09.004 · Cited by 314 · see citing works
Self-citationKMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
Alam, H., Tang, M., Maitituoheti, M., Dhar, S. S., Kumar, M., Han, C. Y., Ambati, C. R., Amin, S. B., Gu, B., Chen, T.-Y., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.03.005 · Cited by 243 · see citing works
Metabolic regulation of chromatin modifications and gene expression
Schvartzman, J. M., Thompson, C. B., & Finley, L. W. S. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201803061 · Cited by 233 · see citing works
Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene
Takata, A., Xu, B., Ionita-Laza, I., Roos, J. L., Gogos, J. A., & Karayiorgou, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.043 · Cited by 204 · see citing works
Determinants of Histone H3K4 Methylation Patterns
Soares, L. M., He, P. C., Chun, Y., Suh, H., Kim, T., & Buratowski, S. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.013 · Cited by 209 · see citing works
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling
Herz, H.-M., Morgan, M., Gao, X., Jackson, J., Rickels, R., Swanson, S. K., Florens, L., Washburn, M. P., Eissenberg, J. C., & Shilatifard, A. (2014) · Science · doi:10.1126/science.1255104 · Cited by 199 · see citing works
Self-citationTee, W.-W., Shen, S. S., Oksuz, O., Narendra, V., & Reinberg, D. (2014) · Cell · doi:10.1016/j.cell.2014.01.009 · Cited by 165 · see citing works
Epigenetic regulation of female puberty
Lomniczi, A., Wright, H., & Ojeda, S. R. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.08.003 · Cited by 136 · see citing works
Histone H2B ubiquitin ligase RNF20 is required for <i>MLL</i> -rearranged leukemia
Wang, E., Kawaoka, S., Yu, M., Shi, J., Ni, T., Yang, W., Zhu, J., Roeder, R. G., & Vakoc, C. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301045110 · Cited by 121 · see citing works
KMT2A and KMT2B Mediate Memory Function by Affecting Distinct Genomic Regions
Kerimoglu, C., Sakib, M. S., Jain, G., Benito, E., Burkhardt, S., Capece, V., Kaurani, L., Halder, R., Agís-Balboa, R. C., Stilling, R., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.072 · Cited by 106 · see citing works
De novo variants in SETD1B are associated with intellectual disability, epilepsy and autism
Hiraide, T., Nakashima, M., Yamoto, K., Fukuda, T., Kato, M., Ikeda, H., Sugie, Y., Aoto, K., Kaname, T., Nakabayashi, K., et al. (2018) · Human Genetics · doi:10.1007/s00439-017-1863-y · Cited by 75 · see citing works
Histone Lysine Methylation Dynamics Control <i>EGFR</i> DNA Copy-Number Amplification
Clarke, T. L., Tang, R., Chakraborty, D., Van Rechem, C., Ji, F., Mishra, S., Ma, A., Kaniskan, H. Ü., Jin, J., Lawrence, M. S., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0463 · Cited by 50 · see citing works
MKL1 is an epigenetic modulator of TGF-β induced fibrogenesis
Fan, Z., Hao, C., Li, M., Dai, X., Qin, H., Li, J., Xu, H., Wu, X., Zhang, L., Fang, M., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.07.013 · Cited by 47 · see citing works
Sera, Y., Nakata, Y., Ueda, T., Yamasaki, N., Koide, S., Kobayashi, H., Ikeda, K.-I., Kobatake, K., Iwasaki, M., Oda, H., et al. (2021) · Blood · doi:10.1182/blood.2019001044 · Cited by 42 · see citing works
Dittmar, G., Hernandez, D. P., Kowenz-Leutz, E., Kirchner, M., Kahlert, G., Wesolowski, R., Baum, K., Knoblich, M., Hofstätter, M., Muller, A., et al. (2019) · iScience · doi:10.1016/j.isci.2019.02.026 · Cited by 41 · see citing works
Baker, K. M., Hoda, S., Saha, D., Gregor, J. B., Georgescu, L., Serratore, N. D., Zhang, Y., Cheng, L., Lanman, N. A., & Briggs, S. D. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02250-21 · Cited by 30 · see citing works
Histone methyltransferase KMT2A: developmental regulation to oncogenic transformation
Ogino, J., & Dou, Y. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107791 · Cited by 21 · see citing works
Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin
Wijeweera, A., Haj, M., Feldman, A., Pnueli, L., Luo, Z., & Melamed, P. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.01.001 · Cited by 17 · see citing works
- Authors
- Shilatifard, A.
- Affiliations
- Stowers Institute for Medical Research (US)
- Corresponding author
- Shilatifard, Ali
- ORCID
- Shilatifard, Ali
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2012-07-07
- Volume
- 81
- Issue
- 1
- Pages
- 65-95
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- PMC
- PMC4010150
- OpenAlex
- W2121910267
- Cited by
- 1,091
- References
- 197
- Citations by year
- 2026: 47 · 2025: 67 · 2024: 91 · 2023: 88 · 2022: 81 · 2021: 91 · 2020: 89 · 2019: 99 · 2018: 75 · 2017: 71 · 2016: 79 · 2015: 80 · 2014: 78 · 2013: 45 · 2012: 10
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA150265, R01CA089455, R01CA89455)
- National Institute of General Medical Sciences (R01GM069905)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- compass, histone H3 lysine 4 methylation, histone H2B monoubiquitination, cancer, epigenetic regulation, Saccharomyces cerevisiae, Drosophila
- MeSH terms
- Histone Methyltransferases, Animals, DNA Repair, Gene Expression Regulation, Humans, Neoplasms, Histone-Lysine N-Methyltransferase, Transcription, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review