Anti-Candida activity of fluoxetine alone and combined with fluconazole: A synergistic action against fluconazole-resistant strains
Open accessAbstract
The purpose of this work was to determine the antimicrobial activity of fluoxetine, alone and combined with fluconazole, against 29 Candida strains isolated from patients with vulvovaginal candidiasis. MIC and minimum lethal concentration values ranged from 9.8 to 625 μg/ml for all strains tested. The combination of fluconazole with fluoxetine resulted in synergistic activity against six Candida strains, with fractional inhibitory index (FIX) values between 0.15 and 0.31. An indifferent effect was found for the remaining strains, with FIX values between 0.63 and 1.
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Fluoxetine is active against bacteria, fungi, and a virus.
“Fluoxetine, an SSRI, was found to be active against bacteria, fungi [50,56,64,67], and, interestingly, even a virus.”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [64]
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- Authors
- Oliveira, A. S., Gaspar, C. A., Palmeira-de-Oliveira, R., Martinez-de-Oliveira, J., & Palmeira-de-Oliveira, A.
- Affiliations
- University of Beira Interior (PT)
- CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2014-07
- Volume
- 58
- Issue
- 7
- Pages
- 4224-4226
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC4068595
- OpenAlex
- W2019764216
- Cited by
- 33
- References
- 19
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- fluoxetine, fluconazole, Candida, vaginal candidiasis, antifungal synergy, drug resistance, minimum inhibitory concentration, combination therapy
- MeSH terms
- Antifungal Agents, Candida, Candidiasis, Vulvovaginal, Drug Synergism, Drug Therapy, Combination, Female, Fluoxetine, Humans, Microbial Sensitivity Tests, Fluconazole, Drug Resistance, Fungal
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