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Fatty Acids and Derivatives as Antimicrobial Agents
Open accessAbstract
The structural relationships of 30 straight-chain fatty acids and derivatives and their bactericidal properties were studied with 8 gram-negative and 12 grampositive organisms. Chain length, unsaturation ( cis, trans ), and functional group were all variables considered in this study. Our data indicate that C 12 (lauric acid) is the most inhibitory saturated fatty acid against gram-positive organisms. Monoenoic acid (C 18:1 ) was more inhibitory than saturated fatty acid, but was less active than dienoic derivatives (C 18:2 ). Other unsaturated compounds were less active than C 18:2 . Alcohols and glyceryl esters were active only against gram-positive organisms. In general, esterification of the carboxyl group led to a compound which was less active; monoglycerides were the sole exception. Amine derivatives, contrary to results with fatty acids, esters, and amides, showed activity against both gram-positive and gram-negative organisms.
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Cited by
Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acids
Zheng, C. J., Yoo, J.-S., Lee, T.-G., Cho, H.-Y., Kim, Y.-H., & Kim, W.-G. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.08.028 · Cited by 690
Yoon, B., Jackman, J., Valle-González, E., & Cho, N.-J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041114 · Cited by 637
The Properties of Lauric Acid and Their Significance in Coconut Oil
Dayrit, F. M. (2015) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-014-2562-7 · Cited by 479
de Wit, N., Derrien, M., Bosch-Vermeulen, H., Oosterink, E., Keshtkar, S., Duval, C., de Vogel-van den Bosch, J., Kleerebezem, M., Müller, M., & van der Meer, R. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00488.2011 · Cited by 428
Nakatsuji, T., Kao, M. C., Fang, J.-Y., Zouboulis, C. C., Zhang, L., Gallo, R. L., & Huang, C.-M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.93 · Cited by 378
Metadata
- Authors
- Kabara, J. J., Swieczkowski, D. M., Conley, A. J., & Truant, J. P.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1972-07
- Volume
- 2
- Issue
- 1
- Pages
- 23-28
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2116385303
- Cited by
- 791
- References
- 0
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Kabara, J. J., Swieczkowski, D. M., Conley, A. J., & Truant, J. P. (1972). Fatty Acids and Derivatives as Antimicrobial Agents. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.2.1.23
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