The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria
Open accessAbstract
Azthreonam (SQ 26,776) is a synthetic monocyclic beta-lactam antimicrobial agent belonging to the monobactam family (Sykes et al., Nature [London] 291:489-491, 1981), members of which are characterized by having the 2-oxoazetidine-1-sulfonic acid moiety. Azthreonam exhibits a high degree of stability to beta-lactamases and is specifically active against aerobic gram-negative bacteria, including Pseudomonas aeruginosa. Its activity against these organisms was in general equal or superior to that observed with the third-generation cephalosporins, cefotaxime and ceftazidime. Like penicillins and cephalosporins, azthreonam interacts with essential penicillin-binding proteins of gram-negative bacteria. Azthreonam protected mice against experimental infections produced by a range of gram-negative bacteria, exhibiting efficacy comparable to that of cefotaxime and ceftazidime.
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Cites
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Cited by
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Self-citationThe Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection
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Metadata
- Authors
- Sykes, R. B., Bonner, D. P., Bush, K., & Georgopapadakou, N. H.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1982-01
- Volume
- 21
- Issue
- 1
- Pages
- 85-92
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2017191752
- Cited by
- 314
- References
- 12
- FWCI
- 25.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Sykes, R. B., Bonner, D. P., Bush, K., & Georgopapadakou, N. H. (1982). Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.21.1.85
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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