The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents
Open accessAbstract
A study of the structure-activity relationship of a series of newly synthesized phosphonylmethoxyalkyl purine and pyrimidine derivatives revealed that several adenine derivatives substituted at the N9 position by a 2-phosphonylmethoxyethyl (PME) group inhibited human immunodeficiency virus (HIV)-induced cytopathogenicity and HIV antigen expression in vitro at concentrations significantly below the toxicity threshold for the host cells. In terms of anti-HIV potency in MT-4 cells, the PME 2,6-diaminopurine derivative (50% effective dose [ED50], 1 microM) ranked first, followed by the PME adenine derivative (ED50, 2 microM [MT-4]) and the PME 2-monoaminopurine derivative (ED50, 45 microM). Antiretroviral activity was also demonstrated in ATH8 and H9 cells, which were de novo infected with HIV, and extended to C3H mouse fibroblasts infected with Moloney murine sarcoma virus. Unlike 2',3'-dideoxyadenosine, these compounds were not found to be degraded by deaminases derived from bovine intestine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Barré-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Chamaret, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vézinet-Brun, F., Rouzioux, C., et al. (1983) · Science · doi:10.1126/science.6189183 · Cited by 7,038
Gallo, R. C., Salahuddin, S. Z., Popovic, M., Shearer, G. M., Kaplan, M., Haynes, B. F., Palker, T. J., Redfield, R., Oleske, J., Safai, B., et al. (1984) · Science · doi:10.1126/science.6200936 · Cited by 3,641
Popovic, M., Sarngadharan, M. G., Read, E., & Gallo, R. C. (1984) · Science · doi:10.1126/science.6200935 · Cited by 3,535
The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex
Fischl, M. A., Richman, D. D., Grieco, M. H., Gottlieb, M. S., Volberding, P. A., Laskin, O. L., Leedom, J. M., Groopman, J. E., Mildvan, D., Schooley, R. T., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707233170401 · Cited by 2,995
Mitsuya, H., Weinhold, K. J., Furman, P. A., St Clair, M. H., Lehrman, S. N., Gallo, R. C., Bolognesi, D., Barry, D. W., & Broder, S. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.20.7096 · Cited by 1,866
Mitsuya, H., & Broder, S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.6.1911 · Cited by 1,039
A novel selective broad-spectrum anti-DNA virus agent
Clercq, E. D., Holý, A., Rosenberg, I., Sakuma, T., Balzarini, J., & Maudgal, P. C. (1986) · Nature · doi:10.1038/323464a0 · Cited by 764
Self-citationAntiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines
Clercq, E. D., Sakuma, T., Baba, M., Pauwels, R., Balzarini, J., Rosenberg, I., & Holý, A. (1987) · Antiviral Research · doi:10.1016/s0166-3542(87)80004-9 · Cited by 515
Self-citationStrategies for antiviral therapy in AIDS
Mitsuya, H., & Broder, S. (1987) · Nature · doi:10.1038/325773a0 · Cited by 487
Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus
Pauwels, R., De Clercq, E., Desmyter, J., Balzarini, J., Goubau, P., Herdewijn, P., Vanderhaeghe, H., & Vandeputte, M. (1987) · Journal of Virological Methods · doi:10.1016/0166-0934(87)90002-4 · Cited by 186
Self-citation
Cited by
Molecular Targets for AIDS Therapy
Mitsuya, H., Yarchoan, R., & Broder, S. (1990) · Science · doi:10.1126/science.1699273 · Cited by 732
Acyclic nucleoside phosphonates: a key class of antiviral drugs
Clercq, E. D., & Holý, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1877 · Cited by 688
Lee, W. A., He, G.-X., Eisenberg, E., Cihlar, T., Swaminathan, S., Mulato, A., & Cundy, K. C. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.1898-1906.2005 · Cited by 338
Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy
Tsiang, M., Rooney, J. F., Toole, J. J., & Gibbs, C. S. (1999) · Hepatology · doi:10.1002/hep.510290626 · Cited by 242
Metadata
- Authors
- Pauwels, R., Balzarini, J., Schols, D., Baba, M., Desmyter, J., Rosenberg, I., Holy, A., & De Clercq, E.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1988-07
- Volume
- 32
- Issue
- 7
- Pages
- 1025-1030
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2106371912
- Cited by
- 256
- References
- 10
- FWCI
- 20.79
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents. https://app.cochat.ai/papers/10.1128/aac.32.7.1025
- The paper
- Pauwels, R., Balzarini, J., Schols, D., Baba, M., Desmyter, J., Rosenberg, I., Holy, A., & De Clercq, E. (1988). Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.32.7.1025
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
