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Transferable imipenem resistance in Pseudomonas aeruginosa
Open accessAbstract
We isolated an imipenem-resistant strain, GN17203, of Pseudomonas aeruginosa. The strain produced a beta-lactamase that hydrolyzed imipenem. The beta-lactamase was encoded by a 31-MDa plasmid, pMS350, which belongs to incompatibility group P-9. The plasmic conferred resistance to beta-lactams, gentamicin, and sulfonamide and was transferable by conjugation to P. aeruginosa but not to Escherichia coli. The molecular weight of the purified enzyme was estimated to be 28,000, and the isoelectric point was 9.0. The enzyme showed a broad substrate profile, hydrolyzing imipenem, oxyiminocephalosporins, 7-methoxycephalosporins, and penicillins. The enzyme activity was inhibited by EDTA, iodine, p-chloromercuribenzoate, CuSO4, and HgCl2 but not by clavulanic acid or sulbactam.
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cited by
Carbapenem-Resistant Enterobacteriaceae: Epidemiology and Prevention
Gupta, N., Limbago, B. M., Patel, J. B., & Kallen, A. J. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir202 · Cited by 1,033
Epidemiology of β-Lactamase-Producing Pathogens
Bush, K., & Bradford, P. A. (2020) · Clinical Microbiology Reviews · doi:10.1128/cmr.00047-19 · Cited by 938
Detection of Pseudomonas aeruginosa Producing Metallo-β-Lactamases in a Large Centralized Laboratory
Pitout, J. D. D., Gregson, D. B., Poirel, L., McClure, J.-A., Le, P., & Church, D. L. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.7.3129-3135.2005 · Cited by 331
Mobile Carbapenemase Genes in Pseudomonas aeruginosa
Yoon, E.-J., & Jeong, S. H. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.614058 · Cited by 221
PATHOGENS RESISTANT TO ANTIMICROBIAL AGENTS
Fraimow, H. S., & Abrutyn, E. (1995) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(20)30683-8 · Cited by 37
Metadata
- Authors
- Watanabe, M., Iyobe, S., Inoue, M., & Mitsuhashi, S.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1991-01
- Volume
- 35
- Issue
- 1
- Pages
- 147-151
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2014241893
- Cited by
- 619
- References
- 1
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Watanabe, M., Iyobe, S., Inoue, M., & Mitsuhashi, S. (1991). Transferable imipenem resistance in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.35.1.147
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
