Effectiveness of dehydroepiandrosterone in reduction of cryptosporidial activity in immunosuppressed rats.
Open accessAbstract
The aim of this study was to evaluate the efficacy of the immunomodulator dehydroepiandrosterone in the treatment of cryptosporidiosis in glucocorticoid-induced immunosuppressed rats. A significant reduction in cryptosporidial activity occurred in treated versus untreated rats as assessed by oocyst shedding intensities and examination of parasite colonization in the small intestine.
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DHEA has immunomodulatory effects in vitro and in vivo in fungal and viral diseases, including HIV, and a stimulatory effect on the immune system in postmenopausal women.
“DHEA has been shown to have immunomodulatory effects in vitro (313) and in vivo in fungal and viral diseases (314), including HIV (315), and a stimulatory effect of DHEA on the immune system has been described in postmenopausal women (316).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [314]
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- Authors
- Rasmussen, K. R., Arrowood, M. J., & Healey, M. C.
- Affiliations
- Utah State University (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1992-01
- Volume
- 36
- Issue
- 1
- Pages
- 220-222
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC189268
- OpenAlex
- W2060773509
- Cited by
- 33
- References
- 10
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2014: 1
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Coccidia and coccidiosis research
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Keywords
- dehydroepiandrosterone, cryptosporidiosis, Cryptosporidium, immunosuppression, glucocorticoid-induced immunosuppression, immunomodulation, oocyst shedding, rats
- MeSH terms
- Animals, Cryptosporidiosis, Dehydroepiandrosterone, Dexamethasone, Female, Ileum, Immunosuppression Therapy, Rats, Inbred Strains, Cryptosporidium parvum, Rats
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