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Pseudomonas aeruginosa biofilm as a diffusion barrier to piperacillin
Open accessAbstract
Pseudomonas aeruginosa 579 biofilms formed on dialysis membranes retarded piperacillin diffusion. Treatment of biofilms with 5.0 mM CaCl2.2H2O prevented diffusion. Biofilms permitted equilibration of [14C]glucose. Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca(2+)-treated P. aeruginosa 579 biofilms and fluids distal to a viable P. aeruginosa mutant noninducible for the expression of beta-lactamase did not detect piperacillinoic acid.
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Citations
Cited by
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Self-citationMechanisms of biofilm resistance to antimicrobial agents
Mah, T.-F. C., & O'Toole, G. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01913-2 · Cited by 3,921
Bacterial adhesion: seen any good biofilms lately
Dunne, W. M. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.155-166.2002 · Cited by 1,516
Walters, M. C., Roe, F., Bugnicourt, A., Franklin, M. J., & Stewart, P. S. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.1.317-323.2003 · Cited by 988
Anderl, J. N., Franklin, M. J., & Stewart, P. S. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.7.1818-1824.2000 · Cited by 958
Metadata
- Authors
- Hoyle, B. D., Alcantara, J., & Costerton, J. W.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1992-09
- Volume
- 36
- Issue
- 9
- Pages
- 2054-2056
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2046267646
- Cited by
- 162
- References
- 0
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Pseudomonas aeruginosa biofilm as a diffusion barrier to piperacillin. https://app.cochat.ai/papers/10.1128/aac.36.9.2054
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- Hoyle, B. D., Alcantara, J., & Costerton, J. W. (1992). Pseudomonas aeruginosa biofilm as a diffusion barrier to piperacillin. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.36.9.2054
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
