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The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants
Open accessAbstract
Nucleotide sequence analysis of ORF1 from the integron on the broad-host-range plasmid R751 revealed that the first 94 of 110 codons of ORF1 from R751 are identical to ORF4, an open reading frame from the 3' conserved segment of other integrons found in gram-negative bacteria, after which point they diverged completely. The predicted products of both ORF1 and ORF4 share homology with the multidrug exporter QacC. Phenotypic analysis revealed that ORF1 specifies a resistance profile to antiseptics and disinfectants almost identical to that of qacC, whereas ORF4 specifies much lower levels of resistance to these compounds. ORF4, whose product lacks the C-terminal 16 amino acids of the ORF1 protein, may have evolved by the interruption of ORF1 from the insertion of a DNA segment carrying a sulI sulfonamide resistance determinant. Hence, ORF1 was designated qacE, and its partially functional deletion derivative, ORF4, was designated qacE delta 1. Fluorimetric experiments indicated that the mechanism of resistance mediated by QacE, the protein specified by qacE, is active export energized by proton motive force. Amino acid sequence comparisons revealed that QacE is related to a family of small multidrug export proteins with four transmembrane segments.
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Cites
Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288
Cited by
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Jennings, M. C., Minbiole, K. P. C., & Wuest, W. M. (2015) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5b00047 · Cited by 651
Buffet-Bataillon, S., Tattevin, P., Bonnaure-Mallet, M., & Jolivet-Gougeon, A. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2012.01.011 · Cited by 601
Trimethoprim and sulfonamide resistance.
Huovinen, P., Sundström, L., Swedberg, G., & Sköld, O. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.2.279 · Cited by 523
Self-citationHegstad, K., Langsrud, S., Lunestad, B. T., Scheie, A. A., Sunde, M., & Yazdankhah, S. P. (2010) · Microbial Drug Resistance · doi:10.1089/mdr.2009.0120 · Cited by 396
Metadata
- Authors
- Paulsen, I. T., Littlejohn, T. G., Rådström, P., Sundström, L., Sköld, O., Swedberg, G., & Skurray, R. A.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1993-04
- Volume
- 37
- Issue
- 4
- Pages
- 761-768
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2008602286
- Cited by
- 320
- References
- 1
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Paulsen, I. T., Littlejohn, T. G., Rådström, P., Sundström, L., Sköld, O., Swedberg, G., & Skurray, R. A. (1993). The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.37.4.761
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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