The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis
Open accessAbstract
Very abrupt exposure to anaerobic conditions has a lethal effect on actively growing cultures of Mycobacterium tuberculosis. However, incubation under conditions in which oxygen is depleted gradually causes M. tuberculosis to shift down from active replication to dormancy. The dormant bacilli are resistant to the bactericidal effects of anaerobiosis and also exhibit partial or complete resistance to the bactericidal effects of isoniazid and rifampin. On the other hand, metronidazole, a drug specific for anaerobes, kills dormant tubercle bacilli under anaerobic conditions, but it has no effect on actively growing aerobic cultures. The lethal effect of metronidazole under anaerobic conditions is enhanced by rifampin. The possible implications of these findings on the phenomenon of latency in tuberculosis are discussed.
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Cites
Manual of clinical microbiology
Drasar, B. (2003) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(03)90074-5 · Cited by 2,594
Pearson, M. L., Jereb, J. A., Frieden, T. R., Crawford, J. T., Davis, B. J., Dooley, S. W., & Jarvis, W. R. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-3-191 · Cited by 546
Fischl, M. A., Uttamchandani, R. B., Daikos, G. L., Poblete, R. B., Moreno, J. N., Reyes, R. R., Boota, A. M., Thompson, L. M., Cleary, T. J., & Lai, S. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-3-177 · Cited by 371
Wayne, L. G., & Lin, K. Y. (1982) · Infection and Immunity · doi:10.1128/iai.37.3.1042-1049.1982 · Cited by 324
Self-citationMcCune, R. M., Tompsett, R., & McDermott, W. (1956) · The Journal of Experimental Medicine · doi:10.1084/jem.104.5.763 · Cited by 307
Castro, K. G., Hutton, M. D., Mullan, R. J., Polder, J. A., & Snider, D. E. (1990) · PsycEXTRA Dataset · doi:10.1037/e546022006-001 · Cited by 289
McCune, R. M., & Tompsett, R. (1956) · The Journal of Experimental Medicine · doi:10.1084/jem.104.5.737 · Cited by 260
The mycobacteria: a sourcebook
Grange, J. M. (1985) · Tubercle · doi:10.1016/0041-3879(85)90041-8 · Cited by 258
Fischl, M. A., Daikos, G. L., Uttamchandani, R. B., Poblete, R. B., Moreno, J. N., Reyes, R. R., Boota, A. M., Thompson, L. M., Cleary, T. J., Oldham, S. A., et al. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-3-184 · Cited by 248
The sterilizing value of rifampicin and pyrazinamide in experimental short course chemotherapy
Grosset, J. H. E. (1978) · Tubercle · doi:10.1016/0041-3879(78)90007-7 · Cited by 135
Cited by
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
Barry, C. E., Boshoff, H. I., Dartois, V., Dick, T., Ehrt, S., Flynn, J., Schnappinger, D., Wilkinson, R. J., & Young, D. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2236 · Cited by 1,422
Betts, J. C., Lukey, P. T., Robb, L. C., McAdam, R. A., & Duncan, K. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02779.x · Cited by 1,395
Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence
Smith, I. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.463-496.2003 · Cited by 1,154
Wayne, L. G., & Hayes, L. G. (1996) · Infection and Immunity · doi:10.1128/iai.64.6.2062-2069.1996 · Cited by 1,141
Self-citationA small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
Stover, C. K., Warrener, P., VanDevanter, D. R., Sherman, D. R., Arain, T. M., Langhorne, M. H., Anderson, S. W., Towell, J. A., Yuan, Y., McMurray, D. N., et al. (2000) · Nature · doi:10.1038/35016103 · Cited by 1,034
Metadata
- Authors
- Wayne, L. G., & Sramek, H. A.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1994-09
- Volume
- 38
- Issue
- 9
- Pages
- 2054-2058
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2164429494
- Cited by
- 295
- References
- 22
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Wayne, L. G., & Sramek, H. A. (1994). Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.38.9.2054
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
