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PCR mapping of integrons reveals several novel combinations of resistance genes
Open accessAbstract
The integron is a new type of mobile element which has evolved by a site-specific recombinational mechanism. Integrons consist of two conserved segments of DNA separated by a variable region containing one or more genes integrated as cassettes. Oligonucleotide probes specific for the conserved segments have revealed that integrons are widespread in recently isolated clinical bacteria. Also, by using oligonucleotide probes for several antibiotic resistance genes, we have found novel combinations of resistance genes in these strains. By using PCR, we have determined the content and order of the resistance genes inserted between the conserved segments in the integrons of these clinical isolates. PCR mapping of integrons can be a useful epidemiological tool to study the evolution of multiresistance plasmids and transposons and dissemination of antibiotic resistance genes.
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Citations
Cited by
Trimethoprim and sulfonamide resistance.
Huovinen, P., Sundström, L., Swedberg, G., & Sköld, O. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.2.279 · Cited by 523
Integrons and Gene Cassettes in the Enterobacteriaceae
White, P. A., McIver, C. J., & Rawlinson, W. D. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.9.2658-2661.2001 · Cited by 466
Bass, L., Liebert, C. A., Lee, M. D., Summers, A. O., White, D. G., Thayer, S. G., & Maurer, J. J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.12.2925 · Cited by 293
Detection of a Streptomycin/Spectinomycin Adenylyltransferase Gene ( aadA ) in Enterococcus faecalis
Clark, N. C., Olsvik, Ø., Swenson, J. M., Spiegel, C. A., & Tenover, F. C. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.1.157 · Cited by 202
Dalsgaard, A., Forslund, A., Serichantalergs, O., & Sandvang, D. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.5.1315-1321.2000 · Cited by 118
Metadata
- Authors
- Lévesque, C., Piché, L., Larose, C., & Roy, P. H.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1995-01
- Volume
- 39
- Issue
- 1
- Pages
- 185-191
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2151980628
- Cited by
- 1,018
- References
- 0
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Lévesque, C., Piché, L., Larose, C., & Roy, P. H. (1995). PCR mapping of integrons reveals several novel combinations of resistance genes. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.39.1.185
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
