The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication
Open accessAbstract
We report the development and isolation of a cell line, termed HepAD38, that replicates human hepatitis B virus (HBV) under conditions that can be regulated with tetracycline. In the presence of the antibiotic, this cell line is free of virus due to the repression of pregenomic (pg) RNA synthesis. Upon removal of tetracycline from the culture medium, the cells express viral pg RNA, accumulate subviral particles in the cytoplasm that contain DNA intermediates characteristic of viral replication, and secrete virus-like particles into the supernatant. Since the HepAD38 cell line can produce high levels of HBV DNA, it should be useful for analyses of the viral replication cycle that depend upon viral DNA synthesis in a synchronized fashion. In addition, this cell line has been formatted into a high-throughput, cell-based assay that permits the large-scale screening of diverse compound libraries for new classes of inhibitors of HBV replication.
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Cites
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Cited by
Lok, A. S., Zoulim, F., Locarnini, S., Bartholomeusz, A., Ghany, M. G., Pawlotsky, J.-M., Liaw, Y.-F., Mizokami, M., & Kuiken, C. (2007) · Hepatology · doi:10.1002/hep.21698 · Cited by 447
Targeting Hepatitis B Virus With CRISPR/Cas9
Seeger, C., & Sohn, J. A. (2014) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2014.68 · Cited by 294
Self-citationKennedy, E. M., Bassit, L. C., Mueller, H., Kornepati, A. V. R., Bogerd, H. P., Nie, T., Chatterjee, P., Javanbakht, H., Schinazi, R. F., & Cullen, B. R. (2015) · Virology · doi:10.1016/j.virol.2014.12.001 · Cited by 209
Donkers, J. M., Zehnder, B., van Westen, G. J. P., Kwakkenbos, M. J., IJzerman, A. P., Oude Elferink, R. P. J., Beuers, U., Urban, S., & van de Graaf, S. F. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-15338-0 · Cited by 90
Zhang, C., Gao, Y., Du, C., Markowitz, G. J., Fu, J., Zhang, Z., Liu, C., Qin, W., Wang, H., Wang, F., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3453 · Cited by 72
Metadata
- Authors
- Ladner, S. K., Otto, M. J., Barker, C. S., Zaifert, K., Wang, G. H., Guo, J. T., Seeger, C., & King, R. W.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1997-08
- Volume
- 41
- Issue
- 8
- Pages
- 1715-1720
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2143233396
- Cited by
- 640
- References
- 16
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication. https://app.cochat.ai/papers/10.1128/aac.41.8.1715
- The paper
- Ladner, S. K., Otto, M. J., Barker, C. S., Zaifert, K., Wang, G. H., Guo, J. T., Seeger, C., & King, R. W. (1997). Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.41.8.1715
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
