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Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification
Open accessAbstract
Primary duck hepatocytes were infected with a mutant duck hepatitis B virus defective in envelope protein but competent for viral DNA synthesis. Cells infected by this mutant accumulated higher levels of viral covalently closed, circular DNA (cccDNA) than those infected by wild-type virus. The accumulation of high levels of cccDNA was due to a failure of the mutant-infected cells to suppress de novo cccDNA synthesis compared with suppression by cells infected by the wild type. The envelope-defective virus failed to establish a persistent infection in vitro, possibly because of a virus-mediated cell death. Therefore, one or both viral envelope proteins are required for regulation of cccDNA synthesis and for maintenance of persistent infection in vitro.
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Cited by
Yan, H., Zhong, G., Xu, G., He, W., Jing, Z., Gao, Z., Huang, Y., Qi, Y., Peng, B., Wang, H., et al. (2012) · eLife · doi:10.7554/elife.00049 · Cited by 2,115
Seeger, C., & Mason, W. S. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.1.51-68.2000 · Cited by 1,451
Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA
Lucifora, J., Xia, Y., Reisinger, F., Zhang, K., Stadler, D., Cheng, X., Sprinzl, M. F., Koppensteiner, H., Makowska, Z., Volz, T., et al. (2014) · Science · doi:10.1126/science.1243462 · Cited by 893
Ladner, S. K., Otto, M. J., Barker, C. S., Zaifert, K., Wang, G. H., Guo, J. T., Seeger, C., & King, R. W. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.8.1715 · Cited by 640
Control of cccDNA function in hepatitis B virus infection
Levrero, M., Pollicino, T., Petersen, J., Belloni, L., Raimondo, G., & Dandri, M. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.05.022 · Cited by 552
Metadata
- Authors
- Summers, J., Smith, P. M., & Horwich, A. L.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1990-06
- Volume
- 64
- Issue
- 6
- Pages
- 2819-2824
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1569806478
- Cited by
- 328
- References
- 0
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Summers, J., Smith, P. M., & Horwich, A. L. (1990). Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification. Journal of Virology. https://doi.org/10.1128/jvi.64.6.2819-2824.1990
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
