Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains

Molecular Cloning: A Laboratory Manual

Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589

Isogenic strain construction and gene mapping in Candida albicans.

Fonzi, W. A., & Irwin, M. Y. (1993) · Genetics · doi:10.1093/genetics/134.3.717 · Cited by 1,695

Resistance of Candida species to fluconazole

Rex, J. H., Rinaldi, M. G., & Pfaller, M. A. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.1.1 · Cited by 880

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

Sanglard, D., Kuchler, K., Ischer, F., Pagani, J. L., Monod, M., & Bille, J. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.11.2378 · Cited by 815

Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus

White, T. C. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.7.1482 · Cited by 612

Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene

Sanglard, D., Ischer, F., Monod, M., & Bille, J. (1997) · Microbiology · doi:10.1099/00221287-143-2-405 · Cited by 587

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

Prasad, R., De Wergifosse, P., Goffeau, A., & Balzi, E. (1995) · Current Genetics · doi:10.1007/bf00352101 · Cited by 486

Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14α-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents

Sanglard, D., Ischer, F., Koymans, L. M. H., & Billé, J. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.2.241 · Cited by 465

Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors

Sanglard, D., Ischer, F., Monod, M., & Billé, J. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.10.2300 · Cited by 402

Resistance to fluconazole and cross‐resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol Δ5,6‐desaturation

Kelly, S. L., Lamb, D. C., Kelly, D. E., Manning, N. J., Loeffler, J., Hebart, H., Schumacher, U., & Einsele, H. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01360-9 · Cited by 351

Upregulation of the ERG11 gene in Candida krusei by azoles.

Tavakoli, M., Zaini, F., Kordbacheh, M., Safara, M., Raoofian, R., & Heidari, M. (2010) · Europe PMC (PubMed Central) · Cited by 21

Loss of Heterozygosity of FCY2 Leading to the Development of Flucytosine Resistance in Candida tropicalis

Chen, Y.-N., Lo, H., Wu, C.-C., Ko, H.-C., Chang, T.-P., & Yang, Y.-L. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01777-10 · Cited by 21

Increased expression and hotspot mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from vaginitis patients

Looi, C. Y., d'Silva, E. C., Seow, H. F., Rosli, R., Ng, K. P., & Chong, P. P. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.06.036 · Cited by 20

Loss of Heterozygosity at an Unlinked Genomic Locus Is Responsible for the Phenotype of a Candida albicans sap4 Δ sap5 Δ sap6 Δ Mutant

Dunkel, N., & Morschhäuser, J. (2011) · Eukaryotic Cell · doi:10.1128/ec.00281-10 · Cited by 20

Antifungal resistance, combinations and pipeline: oh my!

Stover, K. R., Hawkins, B. K., Keck, J. M., Barber, K. E., & Cretella, D. A. (2023) · Drugs in Context · doi:10.7573/dic.2023-7-1 · Cited by 20

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans

Zande, P. V., Gautier, C., Kawar, N., Maufrais, C., Metzner, K., Wash, E., Beach, A. K., Bracken, R., Maciel, E. I., de Sá, N. P., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012497 · Cited by 21

Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives

Łącka, I., Konieczny, M. T., Buɬakowska, A., Kodedová, M., Gášková, D., Maurya, I. K., Prasad, R., & Milewski, S. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00783 · Cited by 20

Effect of Micafungin (FK463) on Candida albicans Adherence to Epithelial Cells

Zepelin, M. B., Zaschke, K., Groß, U., Monod, M., & Müller, F. C. (2002) · Chemotherapy · doi:10.1159/000064921 · Cited by 20

Antifungal Activity of Thai Cajuput Oil and Its Effect on Efflux-Pump Gene Expression in Fluconazole-Resistant Candida albicans Clinical Isolates

Keereedach, P., Hrimpeng, K., & Boonbumrung, K. (2020) · International Journal of Microbiology · doi:10.1155/2020/5989206 · Cited by 19

Balancing Positive and Negative Selection: In Vivo Evolution of Candida lusitaniae MRR1

Demers, E. G., Stajich, J., Ashare, A., Occhipinti, P., & Hogan, D. A. (2021) · mBio · doi:10.1128/mbio.03328-20 · Cited by 18

Nucleotide substitutions in the Candida albicans ERG11 gene of azole-susceptible and azole-resistant clinical isolates.

Strzelczyk, J. K., Ślemp-Migiel, A., Rother, M. B., Gołąbek, K., & Wiczkowski, A. (2013) · Acta Biochimica Polonica · doi:10.18388/abp.2013_2019 · Cited by 19

The Etest Performed Directly on Blood Culture Bottles Is a Reliable Tool for Detection of Fluconazole-Resistant Candida albicans Isolates

Escribano, P., Marcos-Zambrano, L. J., Gómez, A., Sánchez, C., Martínez‐Jiménez, M. D. C., Bouza, E., & Guinea, J. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00400-17 · Cited by 19

Molecular Principles of Antifungal Drug Resistance

Sanglard, D., & White, T. C. (2014) · ASM Press eBooks · doi:10.1128/9781555815776.ch14 · Cited by 19

The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms

Ibrahim, N. H., Melake, N. A., Somily, A. M., Zakaria, A. S., Baddour, M., & Mahmoud, A. Z. (2013) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2013.12.007 · Cited by 20

Proliferation of Intracellular Structure Corresponding to Reduced Affinity of Fluconazole for Cytochrome P‐450 in Two Low‐Susceptibility Strains of Candida albicans Isolated from a Japanese AIDS Patient

Maebashi, K., Kudoh, M., Nishiyama, Y., Makimura, K., Kamai, Y., Uchida, K., & Yamaguchi, H. (2003) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2003.tb02794.x · Cited by 19

Molecular heterogeneity of fluconazole‐resistant and ‐susceptible oral Candida albicans isolates within a single geographic locale

Dassanayake, R. S., Ellepola, A. N. B., Samaranayake, Y. H., & Samaranayake, L. P. (2002) · Apmis · doi:10.1034/j.1600-0463.2002.100406.x · Cited by 19

Functional characterization of CaCBF1, the Candida albicans homolog of centromere binding factor 1

Biswas, K., Rieger, K.-J., & Morschhäuser, J. (2003) · Gene · doi:10.1016/j.gene.2003.09.005 · Cited by 19

The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative

Rząd, K., Paluszkiewicz, E., Neubauer, D., Olszewski, M., Kozłowska-Tylingo, K., Kamysz, W., & Gabriel, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413190 · Cited by 18

Promoter regulation inCandida albicansand related species

Eckert, S. E., & Mühlschlegel, F. A. (2008) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2008.00455.x · Cited by 19

Immunomodulator Tuftsin Augments Anti-fungal Activity of Amphotericin B Against Experimental Murine Candidiasis

Masood, A. K., Faisal, S. M., Haque, W., & Owais, M. (2002) · Journal of drug targeting · doi:10.1080/10611860290022615 · Cited by 18

Zinc supplementation reduces Candida infections in pediatric intensive care unit: a randomized placebo-controlled clinical trial

Xie, J., Zhu, L., Zhu, T., Jian, Y., Ding, Y., Zhou, M., & Feng, X. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.18-74 · Cited by 17

Synthesis of new piperazinyl-pyrrolo[1,2- a ]quinoxaline derivatives as inhibitors of Candida albicans multidrug transporters by a Buchwald–Hartwig cross-coupling reaction

Guillon, J., Nim, S., Moreau, S., Ronga, L., Savrimoutou, S., Thivet, E., Marchivie, M., Pietro, A. D., Prasad, R., & Borgne, M. L. (2020) · RSC Advances · doi:10.1039/c9ra09348f · Cited by 17

The Effect of Gentian Violet on Virulent Properties of Candida albicans

Su, Y., Sun, Q., & Li, C. (2009) · Mycopathologia · doi:10.1007/s11046-009-9258-9 · Cited by 17

Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase

Skwarecki, A. S., Schielmann, M., Martynow, D., Kawczyński, M., Wiśniewska, A., Milewska, M. J., & Milewski, S. (2018) · Journal of Peptide Science · doi:10.1002/psc.3060 · Cited by 16

Vanillin confers antifungal drug synergism in Candida albicans by impeding CaCdr2p driven efflux

Saibabu, V., Fatima, Z., Singh, S., Khan, L. A., & Hameed, S. (2020) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2019.100921 · Cited by 16

Candidacidal Activity of a Novel Killer Toxin from Wickerhamomyces anomalus against Fluconazole-Susceptible and -Resistant Strains

Giovati, L., Santinoli, C., Ferrari, E., Ciociola, T., Martín, E., Bandi, C., Ricci, I., Epis, S., & Conti, S. (2018) · Toxins · doi:10.3390/toxins10020068 · Cited by 16

The amino acid substitution N136Y inCandida albicanssterol 14alpha-demethylase is involved in fluconazole resistance

Alvarez-Rueda, N., Fleury, A., Logé, C., Pagniez, F., Robert, E., Morio, F., & Pape, P. L. (2016) · Medical Mycology · doi:10.1093/mmy/myw023 · Cited by 15

Antifungal Use in Veterinary Practice and Emergence of Resistance

Seyedmousavi, S., Wiederhold, N. P., Ebel, F., Hedayati, M. T., Rafati, H., & Verweij, P. E. (2018) · Springer eBooks · doi:10.1007/978-3-319-72093-7_16 · Cited by 15

Antifungal effect ofEchinophora platylobaon expression of CDR1 and CDR2 genes in fluconazole-resistantCandida albicans

Khajeh, E., Hosseini‐Shokouh, S., Rajabibazl, M., Roudbary, M., Rafiei, S., Aslani, P., & Farahnejad, Z. (2016) · British Journal of Biomedical Science · doi:10.1080/09674845.2016.1155269 · Cited by 15

Chapter 14. Progress with antifungal agents and approaches to combat fungal resistance

Watkins, W. J., & Renau, T. E. (2000) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(00)35015-1 · Cited by 15

FK520 interacts with the discrete intrahelical amino acids of multidrug transporter Cdr1 protein and acts as antagonist to selectively chemosensitize azole-resistant clinical isolates ofCandida albicans

Nim, S., Rawal, M. K., & Prasad, R. (2014) · FEMS Yeast Research · doi:10.1111/1567-1364.12149 · Cited by 14

Cph1p negatively regulates MDR1 involved in drug resistance in Candida albicans

Lo, H., Tseng, K., Kao, Y.-Y., Tsao, M.-Y., Lo, H.-L., & Yang, Y.-L. (2015) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2015.01.017 · Cited by 15

ERG11 mutations and upregulation in clinical itraconazole-resistant isolates of Candida krusei

Feng, W., Yang, J., Wang, Y., Chen, J., Xi, Z., & Qiao, Z. (2016) · Canadian Journal of Microbiology · doi:10.1139/cjm-2016-0055 · Cited by 14

Difference in virulence between fluconazole‐susceptible and fluconazole‐resistant Candida albicans in a mouse model

Schulz, B., Weber, K., Schmidt, A., Zepelin, M. B., & Ruhnke, M. (2011) · Mycoses · doi:10.1111/j.1439-0507.2010.01970.x · Cited by 14

Inducible and Constitutive Activation of Two Polymorphic Promoter Alleles of the Candida albicans Multidrug Efflux Pump MDR1

Sasse, C., Schillig, R., Reimund, A., Merk, J., & Morschhäuser, J. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00264-12 · Cited by 13

Molecular Umbrellas Modulate the Selective Toxicity of Polyene Macrolide Antifungals

Skwarecki, A. S., Skarbek, K., Martynow, D., Serocki, M., Bylińska, I., Milewska, M. J., & Milewski, S. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00136 · Cited by 14

Antifungal Activity of Mammalian Serum Amyloid A1 against Candida albicans

Gong, J., Wu, J., Ikeh, M. A. C., Li, T., Zhang, Y., Bing, J., Nobile, C. J., & Huang, G. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01975-19 · Cited by 13

Activity of fluconazole and its Cu(II) complex towards Candida species

Ząbek, A., Nagaj, J., Grabowiecka, A., Dworniczek, E., Nawrot, U., Młynarz, P., & Jeżowska‐Bojczuk, M. (2014) · Medicinal Chemistry Research · doi:10.1007/s00044-014-1275-7 · Cited by 13

Species of the Metarhizium anisopliae complex with diverse ecological niches display different susceptibilities to antifungal agents

Brancini, G. T. P., Tonani, L., Rangel, D. E. N., Roberts, D. W., & Braga, G. Ú. L. (2017) · Fungal Biology · doi:10.1016/j.funbio.2017.12.004 · Cited by 13

Molecular analysis and dimorphism of azole-susceptible and resistant Candida albicans isolates

Costa, C. R., Souza, L. K. H. E., Ataídes, F. S., Ferri, P. H., da Costa, M. P., Fernandes, O. D. F. L., & Silva, M. D. R. R. (2011) · Revista da Sociedade Brasileira de Medicina Tropical · doi:10.1590/s0037-86822011005000056 · Cited by 13

Genome-wide expression profiling of the response to terbinafine in Candida albicans using a cDNA microarray analysis

Zeng, Y., Yuan-shu, Q., Ma, L., & Gu, H.-N. (2007) · Chinese Medical Journal · doi:10.1097/00029330-200705010-00013 · Cited by 13

Palmarumycin P3 Reverses Mrr1-Mediated Azole Resistance by Blocking the Efflux Pump Mdr1

Song, M., Zhang, M., Lu, J., Xie, F., Song, J., Luan, X., Hou, X., Lou, H., & Chang, W. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02126-21 · Cited by 12

Small molecule II-6s synergises with fluconazole against Candida albicans

Yang, S., Peng, X., Ren, B., Luo, Y., & Xu, X. (2023) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2023.106820 · Cited by 11

Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values

Rząd, K., Ioannidi, R., Marakos, P., Pouli, N., Olszewski, M., Kostakis, I. K., & Gabriel, I. (2023) · Scientific Reports · doi:10.1038/s41598-023-38963-4 · Cited by 11

Machine Learning for Antimicrobial Resistance Research and Drug Development

Shankarnarayan, S. A., Guthrie, J. D., & Charlebois, D. A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.104841 · Cited by 12

A new 1-nitro-9-aminoacridine derivative targeting yeast topoisomerase II able to overcome fluconazole-resistance

Rząd, K., Paluszkiewicz, E., & Gabriel, I. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.127815 · Cited by 11

Association of T916C (Y257H) mutation inCandida albicans ERG11with fluconazole resistance

Zhao, J., Xu, Y., & Li, C. (2012) · Mycoses · doi:10.1111/myc.12027 · Cited by 11

Quantum Dots-Based Nano-Coatings for Inhibition of Microbial Biofilms: A Mini Review

Priyadarshini, E., Rawat, K., & Bohidar, H. B. (2018) · InTech eBooks · doi:10.5772/intechopen.70785 · Cited by 10

Chain-length-specific anti-Candida activity of cationic lipo-oxazoles: a new class of quaternary ammonium compounds

Jain, T., Muktapuram, P. R., Pochampalli, S., Sharma, K., Pant, G., Mitra, K., Bathula, S. R., & Banerjee, D. (2017) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000610 · Cited by 10

Insights into the modulatory effect of magnesium on efflux mechanisms of Candida albicans reveal inhibition of ATP binding cassette multidrug transporters and dysfunctional mitochondria

Hans, S., Fatima, Z., & Hameed, S. (2021) · BioMetals · doi:10.1007/s10534-020-00282-w · Cited by 9

Targeting yeast topoisomerase II by imidazo and triazoloacridinone derivatives resulting in their antifungal activity

Rząd, K., Gabriel, I., Paluszkiewicz, E., Kuplińska, A., Olszewski, M., Chylewska, A., Dąbrowska, A., & Kozłowska-Tylingo, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-54252-0 · Cited by 9

Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound

Alqahtani, F. M., Arivett, B. A., Taylor, Z. E., Handy, S. T., Farone, A. L., & Farone, M. B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226068 · Cited by 9

Fluconazole-Resistant Candida: Mechanisms and Risk Factor Identification

Déry, M., & Hasbun, R. (2011) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0045-3 · Cited by 9

Characterization of Candida Species from Different Populations in Taiwan

Yang, Y.-L., Hsieh, L.-Y., Wang, A.-H., & Lo, H. (2011) · Mycopathologia · doi:10.1007/s11046-011-9408-8 · Cited by 9

Proteomic analysis of Mrr1p‐ and Tac1p‐associated differential protein expression in azole‐resistant clinical isolates of Candida albicans

Hoehamer, C. F., Cummings, E. D., Hilliard, G. M., Morschhäuser, J., & Rogers, P. D. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200800252 · Cited by 9

Mechanisms of Resistance to Antifungal Agents

White, T. C., & Hoot, S. J. (2011) · Wiley eBooks · doi:10.1128/9781555816728.ch127 · Cited by 9

Criblage phytochimique et activité antimicrobienne des extraits de Thymus serpyllum et de Thymus vulgaris du mont de Tessala (Algérie occidentale)

Tamert, A., Latrèche, A., & Aouad, L. (2017) · Phytothérapie · doi:10.1007/s10298-017-1132-1 · Cited by 8

Anti-candidal activity and synergetic interaction of antifungal drugs with differential extract of brown algae Stocheospermum marginatum

Arumugam, G., & Rajaram, R. (2019) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2019.101145 · Cited by 8

Proteomic analysis of cytosolic proteins associated with petite mutations in Candida glabrata

y Penha, C. V. L., Kubitschek-Barreira, P. H., Larcher, G., Perales, J., León, I. R., Lopes-Bezerra, L. M., & Bouchara, J. P. (2010) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2010007500125 · Cited by 8

Incidence and Antifungal Susceptibility of Candida Albicans Infections.

Ungureanu, A. M., Găman, A. E., Turculeanu, A., Mitroi, M., Drocaș, A. I., Dobriţoiu, M., Alexandru, D. O., & Vasile, C. M. (2016) · Europe PMC (PubMed Central) · doi:10.12865/chsj.42.02.08 · Cited by 8

Fungal resistance

Bernhardt, H., Zimmermann, K., & Knoke, M. (1999) · Infection · doi:10.1007/bf02561673 · Cited by 8

Biocompatible Carbon Quantum Dots as Versatile Imaging Nanotrackers of Fungal Pathogen – Candida Albicans

Rais, A., Sharma, S., Mishra, P., Khan, L. A., & Prasad, T. (2024) · Nanomedicine · doi:10.2217/nnm-2023-0292 · Cited by 7

Adaptation of Candida albicans to specific host environments by gain-of-function mutations in transcription factors

Morschhäuser, J. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012643 · Cited by 8

Mechanisms of Resistance to Antifungal Agents

Perlin, D. S. (2015) · ASM Press eBooks · doi:10.1128/9781555817381.ch130 · Cited by 7

Octyl gallate reduces ABC multidrug transporter CaCdr1p expression and leads to its mislocalisation in azole-resistant clinical isolates of Candida albicans

Singh, S., Fatima, Z., & Hameed, S. (2020) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2020.04.013 · Cited by 7

Hb40-61a: Novel analogues help expanding the knowledge on chemistry, properties and candidacidal action of this bovine α-hemoglobin-derived peptide

Carvalho, L. A. D. C., Remuzgo, C., Perez, K. R., & Machini, M. T. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.09.010 · Cited by 7

Adhärenz und Invasion: Zwei Pathogenitätsfaktoren bei pathogenen Bakterien und Pilzen: Adherence and invasion – two pathogenicity factors in bacterial and fungal pathogens

Müller, F. C., Morschhäuser, J., Köhler, G. A., Oelschlaeger, T. A., Ziebuhr, W., & Hacker, J. (1999) · Mycoses · doi:10.1111/j.1439-0507.1999.tb04525.x · Cited by 7

Generation of antifungals to combat drug resistance using language models and diffusion models

Wang, Y., Dong, Y., Zheng, Y., Xu, L., Song, M., Chen, J., Zhang, K., Shen, T., Zhao, W., Lou, H., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.11.046 · Cited by 6

An MDR1 promoter allele with higher promoter activity is common in clinically isolated strains of Candida albicans

Bruzual, I., & Kumamoto, C. A. (2011) · Molecular Genetics and Genomics · doi:10.1007/s00438-011-0650-z · Cited by 7

Análisis cuantitativo de la expresión de genes de resistencia a fluconazol en cepas de Candida albicans aisladas al ingreso de adultos mayores a una unidad de cuidados intensivos de Manizales, Colombia

Rodríguez, A. E. R., Pérez, J. E., Hernandez, J., & Zapata, Y. (2020) · Biomédica · doi:10.7705/biomedica.4723 · Cited by 6

Caracterización de los mecanismos de resistencia a azoles en aislados clínicos chilenos de Candida albicans

Fuentes, M., Hermosilla, G., Claudio Alburquenque, O., Falconer, M. A., Amaro, J., & Tapia, C. V. (2014) · Revista chilena de infectología · doi:10.4067/s0716-10182014000500001 · Cited by 6

Antifungal drug resistance: Significance and mechanisms

Dharmaiah, S., Sherif, R., & Mukherjee, P. K. (2019) · CRC Press eBooks · doi:10.1201/9780429402012-4 · Cited by 6

Molecular Umbrella as a Nanocarrier for Antifungals

Skwarecki, A. S., Martynow, D., Milewska, M. J., & Milewski, S. (2021) · Molecules · doi:10.3390/molecules26185475 · Cited by 6

Substituent effect of fluorine atoms in the 2,4-difluorophenyl group on antifungal activity of CS-758

Kagoshima, Y., & Konosu, T. (2006) · Journal of Fluorine Chemistry · doi:10.1016/j.jfluchem.2005.12.008 · Cited by 6

Antifungal Drug Resistance: Pumps and Permutations

White, T. C., Harry, J. B., & Oliver, B. G. G. (2004) · Springer eBooks · doi:10.1007/978-3-662-10380-7_17 · Cited by 5

The small GTPase Rhb1 is involved in the cell response to fluconazole inCandida albicans

Chen, Y., Yeh, Y.-C., Chen, H.-F., Chen, R.-C., Lin, G.-Y., Chen, Y.-T., & Lan, C. (2019) · FEMS Yeast Research · doi:10.1093/femsyr/foz005 · Cited by 5

Antifungal Resistance: Cellular and Molecular Mechanisms

Araújo, R., & Espinel‐Ingroff, A. (2010) · Springer eBooks · doi:10.1007/978-3-642-12173-9_7 · Cited by 5

Disseminated cryptococcosis and fluconazole resistant oral candidiasis in a patient with acquired immunodeficiency syndrome (AIDS)

Kothavade, R. J., Oberai, C., Valand, A. G., & Panthaki, M. H. (2010) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.725 · Cited by 5

Yeast strains designed for screening of reversal agents and genetic suppressors of multidrug resistance

Kozovská, Z., Hikkel, I., Sidorova, M., & Šubík, J. (2004) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2004.04.014 · Cited by 5

The role of antifungal susceptibility testing in the management of patients with invasive mycoses.

Perea, S. H., & Patterson, T. F. (1999) · PubMed · Cited by 5

Metal (II) Complexes of Fluconazole: Thermal, XRD and Cytotoxicity Studies.

Ali, S. I., Lei, Z., Ali, M., Kojima, K. K. K., Ahmed, M., Peng, R., Yang, D., Haider, S. M., Ayatollahi, S. A., & Chen, Z. (2020) · PubMed Central · doi:10.22037/ijpr.2020.1101142 · Cited by 6

Molecular and Biochemical Mechanisms of Durg Resistance in Fungi.

Yamaguchi, H. (1999) · Nippon Ishinkin Gakkai Zasshi · doi:10.3314/jjmm.40.199 · Cited by 5

Probing gene function in Candida albicans wild-type strains by Cas9-facilitated one-step integration of two dominant selection markers: a systematic analysis of recombination events at the target locus

Ramı́rez-Zavala, B., Hoffmann, A., Krüger, I., Schwanfelder, S., Barker, K. S., Rogers, P. D., & Morschhäuser, J. (2024) · mSphere · doi:10.1128/msphere.00388-24 · Cited by 4

Evaluation of the V404I and V509M amino acid substitutions of ERG11 gene in Candida albicans isolates by pyrosequencing

Kim, T. H. T., & Lee, M. K. (2010) · Folia Microbiologica · doi:10.1007/s12223-010-0045-2 · Cited by 4

Synthesis of Altissimacoumarin D and Other Prenylated Coumarins and Their Ability to Reverse the Multidrug Resistance Phenotype in Candida albicans

Silva, A. C., de Moraes, D. C., do Carmo, D. C., Gomes, G. C. C., Ganesan, A., Lopes, R. S. C., Ferreira‐Pereira, A., & Lopes, C. C. (2023) · Journal of Fungi · doi:10.3390/jof9070758 · Cited by 4

Development and Validation of Simple RP-HPLC Method for Intracellular Determination of Fluconazole Concentration and Its Application to the Study ofCandida albicansAzole Resistance

Davtyan, T. K., Melikyan, L. A., Nikoyan, N. A., Aleksanyan, H. P., & Grigoryan, N. G. (2015) · International Journal of Analytical Chemistry · doi:10.1155/2015/576250 · Cited by 4

Mucocutaneous and Deeply Invasive Candidiasis

Shoham, S., Nucci, M., & Walsh, T. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7020-3935-5.00088-4 · Cited by 4

Microarray Technologies in Fungal Diagnostics

Rupp, S. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6515-1_22 · Cited by 4

Antifungal Drugs

Seyedmousavi, S. (2021) · Wiley eBooks · doi:10.1002/0471266949.bmc295 · Cited by 4

Experimental Evolution of Pathogenic Candida spp.: Insights into Adaptive Processes and Evolutionary Dynamics

Sousa, G., Correia, I., & Bezerra, A. R. (2026) · Microorganisms · doi:10.3390/microorganisms14020273 · Cited by 3

Voriconazole-Based Salts Are Active against Multidrug-Resistant Human Pathogenic Yeasts

Szepiński, E., Martynow, D., Szweda, P., Milewska, M. J., & Milewski, S. (2019) · Molecules · doi:10.3390/molecules24203635 · Cited by 3

Histopathologic Diagnosis of Fungal Infections of Lab Animals

Shourie, A., Singh, R. K., & Singh, A. (2021) · Fungal biology · doi:10.1007/978-3-030-69507-1_6 · Cited by 3

Specific Chromosome Alterations ofCandida albicans: Mechanisms for Adaptation to Pathogenicity

Rustchenko, E. P. (2014) · ASM Press eBooks · doi:10.1128/9781555815639.ch18 · Cited by 3

In vitroandin vivoantifungal activities of FX0685, a novel triazole antifungal agent with potent activity against fluconazole-resistantCandida albicans

Takahata, S., Okutomi, T., Ohtsuka, K., Hoshiko, S., Uchida, K., & Yamaguchi, H. (2005) · Medical Mycology · doi:10.1080/13693780410001731600 · Cited by 3

Gene Expression Analysis of Key Players Associated with Fluconazole Resistance in Candida albicans

Zhang, H., Xu, Q., Li, S., Ying, Y., Zhang, Z., Zeng, L., Huang, X., & Huang, S. (2019) · Jundishapur Journal of Microbiology · doi:10.5812/jjm.88521 · Cited by 3

Bisacridine derivatives as effective eukaryotic topoisomerase II inhibitors

Kondaka, K., Sappati, S., Rząd, K., Paluszkiewicz, E., Maciejewska, N., Bagiński, M., & Gabriel, I. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118174 · Cited by 2

Prochelators modulate azole activity against Candida albicans in a metal-dependent manner

Merriman, M. A., Denning-Jannace, C. A., Hurtado, A. B., Vaccaro, F. A., Sung, Y., Tomat, E., & Franz, K. J. (2026) · RSC Chemical Biology · doi:10.1039/d6cb00073h · Cited by 2

Reversal of Azole Resistance in Candida albicans by Human Neutrophil Peptide

Khan, M. I., Choudhry, H., Jahan, S., & Rather, I. A. (2023) · Biomedicines · doi:10.3390/biomedicines11020513 · Cited by 4

Antifungal Drug Resistance

Mukherjee, P. K., & Wang, M. (2009) · CRC Press eBooks · doi:10.3109/9780849387869-5 · Cited by 2

Fungal Drug Resistance: Azoles

Lopez-Ribot, J. L., Wiederhold, N. P., & Patterson, T. F. (2017) · Springer eBooks · doi:10.1007/978-3-319-46718-4_27 · Cited by 3

The genetic basis of fluconazole resistance development in Candida albicans

Morschhäuser, J. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00087-x · Cited by 239

Molecular aspects of fluconazole resistance development in Candida albicans

Franz, R., Ruhnke, M., & Morschhäuser, J. (1999) · Mycoses · doi:10.1046/j.1439-0507.1999.00498.x · Cited by 129

Distinct Patterns of Gene Expression Associated with Development of Fluconazole Resistance in Serial Candida albicans Isolates from

Immunodeficiency, H., Patients, V.-I., Candidiasis, O., Lopez-ribot, J. L., Mcatee, R. K., Lee, L. N., Kirkpatrick, W. R., White, T. C., Sanglard, D., & Patterson, T. F. (1998)

Molecular mechanisms for drug resistance of Candida albicans

Yuan-ying, J. (2004) · Chinese New Drugs Journal

Rapid, transient fluconazole resistance in Candida albicans is associated with increased mRNA levels of CDR. Antimicrob. Agents Chemother

Marr, K. A., Lyons, C. N., Rustad, T., Bowden, R. A., Theodore, & White, C. (1998)